Prognosis Of Neonatal Seizures Research Articles

New trends in neonatal seizures

Seizures are very frequent in neonatal period. A seizure is an abrupt alteration in neurological function of the newborn and it can be due to many different causes. There are new pathogenetic hypothesis that try to clarify the mechanism of neonatal sizures. Leaving aside new four classical types of neonatal seizures (subtle, clonic, tonic, myoclonic), new clinical forms have been recently identified: benign idiopathic neonatal convulsion (fifth day fist), benign familial neonatal convulsion, early epileptic encephalopathy with suppression burst (Ohtahara syndrome); early myoclonic epileptic encephalopathy. Finally, there are some open issues about the treatment and the prognosis of neonatal seizures. This review summarizes current knowledge regarding pathophysiology, treatment and prognosis of neonatal seizures. (J Pediatr Neurol 2004; 2(4): 191-197).

Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures

Neonatal seizures are the most common manifestation of neurological dysfunction in the neonate. The prognosis of neonatal seizures is highly variable, and the controversy remains whether the severity, duration, or frequency of seizures may contribute to brain damage independently of its etiology. Animal data indicates that seizures during development are associated with a high probability of long-term adverse effects such as learning and memory impairment, behavioral changes and even epilepsy, which is strongly age dependent, as well as the severity, duration, and frequency of seizures. In preliminary studies, we demonstrated that adolescent male rats exposed to one-single neonatal status epilepticus (SE) episode showed social behavior impairment, and we proposed the model as relevant for studies of developmental disorders. Based on these facts, the goal of this study was to verify the existence of a persistent deficit and if the anxiety-related behavior could be associated with that impairment. To do so, male Wistar rats at 9 days postnatal were submitted to a single episode of SE by pilocarpine injection (380 mg/kg, i.p.) and control animals received saline (0.9%, 0.1 mL/10 g). It was possible to demonstrate that in adulthood, animals exposed to neonatal SE displayed low preference for social novelty, anxiety-related behavior, and increased stereotyped behavior in anxiogenic environment with no locomotor activity changes. On the balance, these data suggests that neonatal SE in rodents leads to altered anxiety-related and abnormal social behaviors.

Treatment and prognosis of neonatal seizures

Seizures in the neonatal period are common and frequently indicate serious underlying brain injury. Neonatal seizures continue to present a diagnostic and therapeutic challenge to pediatricians because recognition and classification of neonatal seizures remain problematic, particularly when clinicians rely only on clinical criteria. Neonatal seizures can permanently disrupt neuronal development, induce synaptic reorganization, alter plasticity, and 'prime' the brain to increased damage from seizures later in life. Since neonatal seizures predict an increased risk for later epilepsy and other neurological sequelae, accurate diagnoses are needed for aggressive antiepileptic drug use. The present review summarizes the treatment and prognosis of neonatal seizures.

The role of electroencephalography in neonatal seizures

This paper gives an overview of the important role of EEG in detection, classification, management and prognosis of neonatal seizures.

Prognosis of neonatal seizures

Change vs more of the same The economy, stupid Don’t forget health care —James Carville, The War Room Seizures during the neonatal period are relatively common, occurring in approximately 1% of all neonates. Neonatal seizures have long been recognized as an obvious marker of brain dysfunction in newborns. One of the more common questions asked by patients and their pediatrician relates to the long-term prognosis in children with neonatal seizures. For many decades, it has been clear that the etiology of neonatal seizures is critical in determining outcome and prognosis. Infants with transient or correctable metabolic abnormalities, like hypocalcemia, have a favorable outcome, while infants with hypoxic-ischemic encephalopathy (HIE), CNS infections, or brain malformations have a generally unfavorable outcome. Separating out the impact of etiology, clinically obvious seizures, and subclinical seizures seen only on EEG has been a daunting challenge for neonatal neurologists. Twenty years ago, Neurology ® published a landmark study by Mizrahi and Kellaway,1 which brought the traditional clinical diagnosis of neonatal seizures into the modern world of video-EEG monitoring. They studied 415 clinical “seizures” in 71 infants, and found that focal clonic seizures and focal tonic …

Neonatal seizures.

The newborn brain is particularly vulnerable to seizures which are associated with poor neurodevelopmental outcome. The clinical manifestations of seizures in infants differ from those seen in older children and adults. The problem of electro-clinical dissociation, where there is no temporal correspondence between electrical paroxysms and repetitive stereotyped motor phenomena, is common in the newborn. There is at present very little information on which clinicians can base a rational decision about treatment which is often ineffective and does not alter neurodevelopmental outcome. This review summarizes current knowledge regarding investigation, treatment and prognosis of neonatal seizures.

Evolution of Neonatal Seizures

The evolution of the diagnosis, etiology, management, and prognosis of neonatal seizures over the past two decades is reviewed. Seizures in the neonate are unique and require special classification. They result from acquired or congenital abnormalities of the central nervous system. Clustering of prognostic parameters, including seizure characteristics, perinatal factors, neurologic signs, cause, and neuroimaging and electroencephalographic abnormalities, allows neonatal seizures to be viewed as clinical syndromes with predictable outcomes.

A Regression Analysis of the Effects of Options Introduction on Stock Variances

We recruited 275 full term and preterm infants into a prospective evaluation of continuous four channel electroencephalographic (EEG) monitoring in the diagnosis and prognosis of neonatal seizures. EEG seizure activity was found in 55 infants; clinical signs were completely simultaneous in only 12 of these, they were present but limited in another 20, and were completely absent in the remaining 23. EEG seizure activity, with or without clinical signs, were equally associated with serious cerebral lesions and with adverse clinical outcome. The four channel EEG recording provided sufficient data on abnormality to be prognostically specific in 79% of the 43 infants who either died or had serious neurological impairment.

Continuous EEG monitoring of neonatal seizures: diagnostic and prognostic considerations.

We recruited 275 full term and preterm infants into a prospective evaluation of continuous four channel electroencephalographic (EEG) monitoring in the diagnosis and prognosis of neonatal seizures. EEG seizure activity was found in 55 infants; clinical signs were completely simultaneous in only 12 of these, they were present but limited in another 20, and were completely absent in the remaining 23. EEG seizure activity, with or without clinical signs, were equally associated with serious cerebral lesions and with adverse clinical outcome. The four channel EEG recording provided sufficient data on abnormality to be prognostically specific in 79% of the 43 infants who either died or had serious neurological impairment.

Continuous EEG monitoring in the diagnosis and prognosis of neonatal seizures

Continuous EEG monitoring in the diagnosis and prognosis of neonatal seizures

Continuous EEG monitoring in the diagnosis and prognosis of neonatal seizures

Continuous EEG monitoring in the diagnosis and prognosis of neonatal seizures