Marine algae have a well deserved reputation as a source of interesting and diversified natural products, which present many challenges to the structural and synthetic organic chemist. While many classes of compounds are known, more notable groups are the sesquiterpeniods and diterpeniods and the fatty acid derived hydrocarbons, with halogenation being a frequent feature. The marine environment has long been known to biologists as a Pandora's Box of organismic interactions, especially between algae and herbivorous invertebrates. These interactions are well documented, frequently involving specific genera or families. Typical examples are toxicity or protection, chemoreception or chemosensing, site recognition, and communication. The molecular and cellular bases for these interactions are very poorly understood. In the last 10 years numerous investigations have implicated many of the odd natural products as the responsible agent. A full understanding of, and solutions to, these problems requires close collaboration between biologists and chemists. Biologists must provide careful observations of the phenomena and chemists must recognize isolate and characterize presumptive causative agents. Biologists must then test the chemists' hypotheses by carefully controlled field and laboratory experiments. A number of examples will be considered to illustrate these points. 1. (A) Genus specific (e.g., Plocamium, Laurencia, Dictyota, Lyngbya) herbivory exhibited by Opisthobranch molluscs (sea hares) e.g., Aplysia, Dolabella, Stylocheilus and the production of their defensive mechanisms. 2. (B) Larval settling and site recognition of algae by molluscs (e.g., Haliotis, Aplysia). 3. (C) Production of anti-predator toxins by algae (e.g., Caulerpa). 4. (D) Chemotactic substances produced by sexual gametes of brown algae (e.g., Ectocarpus, Fucus, Cutleria). There are other examples that might prove to be profitable areas of investigation. All will serve to emphasize that the ocean is more than just an oversized reaction flask producing exotic chemicals and that it is far more than just an assemblage of organisms waiting for a mathematical analysis. It is where biology and chemistry come together at the organismic level.