Competitive Products Research Articles

Lactobacilli-host interactions inhibit Staphylococcus aureus and Escherichia coli-induced cell death and invasion in a cellular model of infection

Probiotic lactobacilli exert antimicrobial and antibiofilm activity through a plethora of mechanisms, including the production of inhibitory compounds and competition for nutrients and adhesion sites on the host mucosa. Their ability to interfere with pathogen-host interactions may mitigate the harmful effects of infection. Lactiplantibacillus pentosus L33 (L33) and Lactiplantibacillus plantarum L125 (L125) are two potential probiotic lactic acid bacteria (LAB) strains, previously shown to reduce pathogen viability and biofilm formation in vitro. The present study aims to investigate their ability to limit cell death induced by Staphylococcus aureus and Escherichia coli in the human colon adenocarcinoma cell line HT-29. To this end, we examined the protective effects of the two strains using in silico, in vitro and omic approaches, with Lacticaseibacillus rhamnosus GG (LGG) serving as a reference strain, due to its well-documented antimicrobial properties. Based on the findings of our study, direct contact of HT-29 cells with L125 for 4 h prior to the addition of S. aureus or E. coli prevented pathogen-induced cell death at rates comparable to LGG. In contrast, L33 failed to exert a protective effect. Moreover, L125 significantly reduced adherence of S. aureus to HT-29 cells, and the internalization capacity of both pathogens (>1.5 Log CFU/mL). Dual RNA-seq and protein microarrays were used to determine expression changes in L125 and host cells during co-incubation. L125 expressed high levels of adhesins and moonlighting proteins, homologous to those encoded by the pathogens. Pathways involved in pathogen adhesion and internalization, endocytosis, cell–cell and cell-extracellular matrix (ECM) adhesion, were downregulated in HT-29 cells. Finally, L125 reduced the secretion of various pro-inflammatory mediators. Our findings highlight the strain-specific protective effects of LAB against pathogen-induced cell death achieved through competitive exclusion and priming of host cell responses. Future studies will focus on elucidating the specific surface components of L125 involved in these events, paving the way for targeted interventions at the host-pathogen interface.

INFLUENCE OF HELICAL CUTTING-EDGE ANGLE ON END-MILLING STABILITY

Increasing productivity, machining accuracy and efficient use of resources are important priorities for companies that manufacture competitive products. One of the main problems that hinders these processes is the vibration that occurs during cutting. Various methods are used to suppress vibration, one of which is the use of tools with a variable helical cutting-edge angle. However, when choosing the cutting-edge angle, it is important to consider the types of vibrations that occur during cutting, as they directly affect the efficiency of the milling process. In addition, the use of tools with different cutting-edge geometries, such as wavy, gives positive results in roughing, but becomes ineffective in finishing. The purpose of this paper is to study the effect of the helical cutting-edge angle on the stability of the end-milling at different cutting speeds. Both theoretical aspects and experimental data are considered, which make it possible to evaluate the effectiveness of using tools with different angles of inclination to ensure the stability of the machining process and increase productivity while minimizing vibrations in the most unfavorable third speed zone of oscillations for cutting. To conduct the experiments, a special stand was used to adjust the stiffness of the workpiece, record the vibrations that occur during cutting, and the time of contact between the workpiece and the tool. The milling was performed in the third high-speed oscillation zone using a tool whose design provides for the possibility of adjusting the angle of inclination of the helical cutting edge. Studies confirm that changing the angle of inclination can significantly affect the stability of the milling process, reducing the intensity of oscillations and improving machining accuracy. However, this effect depends on the initial cutting conditions, such as the cutting speed. With its increase, the amplitude of the accompanying free oscillations increases, regardless of the value of the angle of inclination. Ensuring the stability of the end-milling in the third speed zone by changing the angle of inclination is possible only at the speeds that determine the beginning of this zone. However, within the entire speed range covered by the third speed zone, it is impossible to ensure a stable milling process only due to the angle of inclination. The study emphasizes the importance of an integrated approach to selecting cutting parameters to achieve process stability.

Research on Paths to Enhance the Quality of Cultural, Sports, and Tourism Consumption Scenarios in Liaoning

With the continuous improvement of the socio-economic development level, people's living standards have been ensured, leading to a greater focus on spiritual satisfaction. This shift provides new opportunities for the tourism industry. During the process of driving economic growth and social development, the integration of culture, sports, and tourism industries has emerged as an important force. The development of these integrated industries, as a new model of industry integration in China, has been found to have a high degree of industry fit through systematic practical application. This integration not only enables effective resource consolidation and optimal allocation but also creates more attractive and competitive products and services to meet diverse consumer demands. Analyzing from the consumer perspective, the integration of culture, sports, and tourism can further stimulate consumers' potential, and how to leverage this integration to enhance consumption levels has become an urgent issue for relevant departments and enterprises. This paper comprehensively analyzes the importance of improving the quality of cultural, sports, and tourism consumption scenarios, proposes solutions to problems encountered during development, and thus promotes high-quality development of the industry.

Research Possibilities for Efficient Capitalization in Construction Eco-Products, of Mineral Additions Generated by the Local Romanian Industries as Wastes or By-Products

The current paper intends to present the directory lines and paths for the development and implementing construction eco-products, with advanced functionality (materials, elements and structures, models and technologies), considering the efficient and customized valorization of by-products and generated waste of local industries, in the context of National Strategy for Research, Innovation and Smart Specialization 2022-2027 regarding the transition to Circular Economy (EC). This represents one of the two main axes of the research project Nucleu Programme of the National Research Development and Innovation Plan 2022-2027, supported by MCID, "ECODIGICONS" project no. PN 23 35 04 01: “Fundamental-applied research into the sustainable development of construction products (materials, elements, and structures, as well as methods and technologies) that utilizes current national resources to enhance the eco-innovative and durable aspects of Romania's civil and transport infrastructure”, financed by the Romanian Government starting with the beginning of 2023. One of the novelties of the proposed approach of the project is considering the entrepreneurial environment of construction industry or complementary branches as essential stakeholders for the future results of the current scientific research. This dramatically changes the dynamic of the project, in terms of specific objectives, namely their focus on solving the current wastes’ problem by innovatively integrating them into competitive construction products with fast applicability and in accordance with support market requests. By the use of strategic management specific methods (e.g., External Environment (EE) and Internal Environment (IE) evaluation, SWOT analysis and derived specific strategies, etc.), four research directions have been identified for the valorization, at regional or even national level, of mineral additions (inert/hydraulically latent/pozzolanic, etc., derived from waste and industrial by-products (metallurgy, processing industry, construction/demolition, etc.)) by development of eco-smart materials and products for construction. The three directions are related to the considered mineral additions: Power plant ashes (fly ash and/or bottom ash), Steel slag and Garnet type residue Hence, the paper is willing to present the identification and the preliminary analyses of the specified research axes, plotted as necessary steps for achieving an intelligent and sustainable transition of the Romanian construction infrastructure. This approach implicitly ensures in the short and medium term, the increase of the degree of implementation of the principles of the Circular Economy (EC) in Romania, in the existing context which includes relevant factors like: geo-political, industrial and economic, urban and demographic, scientific, socio-cultural and environmental, in accordance with the imperatives of National, European and World Sustainable Development strategies.

ON THE BENEFITS OF USING FLEXIBLE MANUFACTURING PROCESSES BY MANUFACTURERS TO PRODUCE HIGH-QUALITY AND COMPETITIVE PRODUCTS

ON THE BENEFITS OF USING FLEXIBLE MANUFACTURING PROCESSES BY MANUFACTURERS TO PRODUCE HIGH-QUALITY AND COMPETITIVE PRODUCTS

Strategic Approaches to University Product Marketing in the Global Market

This community service program, conducted by Universitas Syiah Kuala (USK) in collaboration with Thaksin University (TSU), aimed to promote effective marketing strategies for university best local products to expand their presence in global markets. The program focused on the utilization of Aceh's patchouli oil, a product with substantial international demand, as an example of how local resources can be developed into competitive products for the global market. The methods used included dissemination sessions, interactive discussions, and demonstrations of products produced by the cooperative to both local farmers and academic partners in Thailand. The results indicated increased participant awareness of the potential of local products, with the Inovac ARC Cooperative playing a key role in the development and marketing of these products. The success of the program was attributed to the integration of product innovation, strategic marketing, and collaboration with international partners. Future programs should focus on strengthening international partnerships and exploring digital marketing strategies to enhance market access for local products. Decision-makers are encouraged to support cooperative initiatives that combine local expertise with global market standards.

Corrosion-resistant NiFe anode towards kilowatt-scale alkaline seawater electrolysis

Development of large-scale alkaline seawater electrolysis requires robust and corrosion-resistant anodes. Here we propose engineering NiFe layered double hydroxide (LDH)-based anodes by incorporating a series of anions into the LDH interlayers. The most optimal NiFe LDH anode with intercalated phosphates demonstrates stable operation at a high current density of 1.0 A cm−2 for over 1000 hours in a 2 W-scale alkaline seawater electrolyzer (ASWE). Fundamental studies indicate that the basicity, indicated by pKa values, of the intercalated anions in NiFe LDH governs its oxygen evolution reaction activity and corrosion resistance. Highly basic anions (i.e., phosphates) securely anchor Fe sites and facilitate proton transfer to boost both durability and activity. Notably, we demonstrate the proof-of-concept for the NiFe anode in an industrial 1 kW-scale ASWE stack (1,081.2 cm2 anode area in total). This unit achieves a stable operating current density of 0.5 A cm−2 at about 2.0 V, twice that of the commercial alkaline pure water electrolyzer, contributing to an economically competitive hydrogen production cost of US$ 1.96 kgH2−1.

Pricing Strategies and Customer Satisfaction in Coffee Shops: A Case Study in Camarines Norte, Philippines

This study examines the impact of pricing strategies on customer sat-isfaction, aiming to improve customer experiences and foster long term loyalty within the coffee shops business in Camarines Norte, Philippines for the year 2022. Utilizing a descriptive correlational research design, data was collected through face-to-face interviews with 150 respondents selected via purposive sampling. The findings reveal that the majority of respondents were females aged 15-30, vis-ited coffee shops weekly. Sixty-two (62) percent of the respondents describe that coffee shops establishments used competitive-based pricing. Among various pricing strategies, value-based pricing was perceived as the most effective, with an average rating of 4.60. Re-spondents strongly agreed that service quality aligned with pricing strategies significantly influences customer satisfaction, scoring an average of 4.26. A test of significant relationship using Biserial corre-lation coefficient between competitive pricing, value-based pricing, and product bundle pricing regarding the impact on customer satis-faction cues indicate a statistically significant relationship at p<0.05, denoting a positive relationship between the pricing strategies and customer satisfaction. The study concludes that pricing strategies is a crucial element of the marketing mix that directly affects customer satisfaction and business profitability. Although, no universal pricing strategy may exist, understanding customer satisfaction is essential for identifying effective pricing policies. Therefore, it is recommended that coffee shops need to develop comprehensive business models to enhance pricing strategies aimed at increasing market share and sus-taining growth in the coffee shop sector.

Oxygen vacancy enriched and Cu single-atom contained covalent organic frameworks: A competitive photocatalyst to promote hydrogen evolution under visible light

Single-atom loaded covalent organic frameworks (COFs) have been rapidly developed in the field of photocatalytic hydrogen production in recent years. Despite the insufficient active sites has been introduced, the high recombination rate of photogenerated carriers has hindered the progress of catalyst development. In this work, a novel approach is proposed to construct oxygen vacancies (OVs) on single atom Cu contained COF-TpPa, acting as an electron collector to facilitate the transfer and utilization of electrons. The Cu-OV-TpPa can provide a remarkable H2 production rate of 2.77 mmol g−1 h−1 under visible light, which is 2.6 times of Cu-P-TpPa (a H2 production rate of 1.02 mmol g−1 h−1). It achieves a high apparent quantum efficiency (AQE) of 20 % at 420 nm with no noble metal cocatalyst. A thorough analysis of carrier lifetime, recombination rate, electric conductivity and charge density reveals that the synergistic effect between OVs and single-atom Cu significantly enhances photogenerated carrier separation efficiency and reduces activation energy. This study presents a new strategy to design COF-based photocatalysts towards a competitive H2 production under visible light.

Structural Challenges and a Role Innew Health Policy Management in Future India

Objectives: This paper aims to investigate the evolution of supply chain management (SCM) in the globalization era, which is typified by the focus on global supplier relationship systems and the growth of supply chains across national borders and continents. Methods: The introduction of the mathematical models, which include a broad range of linear, integer, and non-linear programming models, is the first section of this paper. Location modeling and transportation planning are two common applications for heuristic models. Although mathematical and heuristic models are best suited for analytical problem solving, complex real-world issues frequently call for basic assumptions. In simulation models, the intricacies of the problem and the relationships between different variables are represented by equations, and then an attempt is made to discuss a comparative analysis of the results. Results: Once put into place, the system always has a lifespan that is determined by the previously mentioned factors and problems. It would be more accurate to say that all developed systems should be reviewed on a regular basis and any necessary adjustments made to maintain their functionality and effectiveness. Conclusion: According to this paper, the fiercely competitive food production market is largely driven by time-based competition, and a producer's or farmer's ability to offer a customer a flexible and responsive supply determines its competitive edge. These businesses understand that providing creative products and outstanding customer service is essential to retaining clients and opening up new revenue streams.

Identification of rice samples with rice blast resistance genes Pi-2 and Pi-b

Since rice blast is a disease that causes significant damage to rice all over the world, the intensive development of disease-resistant genotypes is of great urgency. The use of molecular biology technologies, new biotechnological approaches and molecular genetic methods allows creating disease-resistant varieties while reducing the time of their development, which plays an important role in growing competitive products. The current paper has highlighted the results of estimating rice samples developed at the FSBSI “ARC “Donskoy” for blast resistance. The objects of the study were new samples developed in the laboratory of rice breeding and seed production. In 2022–2023, there were screened one hundred eighty-seven rice samples. They were identified on a presence of the blast resistance gene Pi-2. One hundred fifteen samples were estimated for the blast resistance gene Pi-b. Genomic DNA was isolated from young rice leaves. After estimating the quantity and quality of the isolated DNA there was conducted a polymerase chain reaction for the target genes Pi-2 and Pi-b. In order to identify the alleles of the desired genes there were used specific intragenic molecular SSR markers of dominant (for Pi-2) and codominant (for Pi-b) types. Electrophoresis of the obtained amplicons was performed on 2 % agarose gels during an hour. The results of the analysis were recorded in ultraviolet light and processed in ImageLab 5.1 software. As a result of the conducted study, there were identified new rice breeding samples that carry blast resistance genes Pi-2 and Pi-b. These samples are recommended for use in the further breeding process for blast resistance.

The role of the construction industry in the recovery of processing enterprises during the crisis

The article discusses the consequences of the crisis period for the work of processing enterprises in Ukraine. It is established that hostilities on the territory of our state and general instability lead to a decrease in production and force processing enterprises to cease their activities. Many enterprises are experiencing serious financial difficulties due to work restrictions, problems with the supply of raw materials, and the loss of industrial facilities. In the summer of 2022, the percentage of companies that closed or were in the process of ceasing operations was 46.8 %. A significant consequence of the war for the Ukrainian economy at the moment is the rapid changes in the territorial location and the change in the symmetry of the processing industry of Ukraine. The war also affected the sectoral structure of the processing industry, producing significant shifts and changes in the volume of products sold. The current political situation in Ukraine and the severance of business chains with the temporarily occupied territories require processing enterprises to search for new markets for products, sources of supply of raw materials, change logistics links, increase the production of raw materials and their own products. During the study, it was found that certain key aspects of the impact on the activities of processing enterprises were previously insufficiently studied. It is determined that the construction industry is of critical importance for the processing industry of the State during the crisis, which is designed to contribute to the recovery of this industry: to develop infrastructure, to build and modernize production facilities, which allows to introduce new technologies and optimize production processes, to improve the conditions of production itself, to build energy facilities to provide processing enterprises with stable and affordable energy supply, to apply modern construction technologies that will create environmentally friendly and energy-efficient production. For the restoration and development of the processing industry of Ukraine, taking into account the impact of the construction industry, we propose to apply the following measures: widespread implementation of the enterprise relocation program with the expansion of state support; the use of state programs for the reconstruction of property and lending, the development of international communications and the European vector for the recovery of the post-war industry based on the ESG concept and the principles of building back better, compliance with the principles of energy efficiency and energy saving, and the application of decarbonization measures. These tools are designed to provide stimulating processes in the processing industry to achieve and exceed the prewar level of the volume of competitive and high-quality products. The development of the construction industry plays an important role in the restoration of processing enterprises in Ukraine, so it is important to create favorable conditions for their cooperation, to develop comprehensive development strategies aimed at ensuring sustainable economic growth and support.

FOSTERING ENVIRONMENTAL AND ECONOMIC RESILIENCE THROUGH CATFISH FLOSS PRODUCTION IN WEST JAKARTA

This community empowerment program seeks to stimulate economic growth in Meruya Selatan, West Jakarta, by promoting the production of catfish floss, a product that aligns with both environmental sustainability and market expansion goals. The initiative capitalizes on locally available catfish, promoting sustainable practices by minimizing waste and offering an alternative to conventional protein sources. The program is designed to train participants in key areas such as efficient production methods, preserving product quality, packaging, and marketing strategies, all aimed at making catfish floss a competitive product in both local and regional markets. The main objectives include boosting household income, increasing consumer awareness of fish-based products, and fostering the growth of local businesses through skill development. The project employed a comprehensive approach involving initial surveys, educational seminars, hands-on training, and ongoing monitoring to ensure the effectiveness of the training. As a result, participants have gained valuable food processing skills, contributing not only to their economic well-being but also to local food security and sustainable business practices. This initiative successfully demonstrates the potential for community-driven efforts to support both economic development and environmental stewardship.

Application of Public-Private Partnership Mechanisms to Ensure Innovative Development of the Healthcare Sector

INTRODUCTION. The pursuit of technological sovereignty in the current geopolitical situation has led to a growing emphasis on studying relations in the field of government support for healthcare innovation, in particular, the institute of public–private partnership (PPP). In the face of the challenges presented by sanctions, the economic crisis, and a potential deficit in sustainably competitive national innovative medical products, the Russian government is confronted with the necessity of financing the development and production of innovative medical products, including through involving private partners (investors). The use of PPP mechanisms is essential for the achievement of technological sovereignty. In addition to attracting private capital and competences, PPP mechanisms can significantly accelerate the development, realisation, and introduction of innovative medical products, improve the quality of medical care, and increase the production of medicines and medical devices.AIM. This study aimed to analyse existing PPP mechanisms for the development of the Russian healthcare, science, and technology sectors within the framework of state–business relations and to identify optimal models for the development, realisation, introduction, and production of innovative medical products.MATERIALS AND METHODS. The study analysed Russian federal legislation using an information-based analytical approach to identify the most promising mechanisms for innovative development in healthcare, with a focus on PPP models.RESULTS. The article considers frequently encountered forms of possible government involvement in and support of innovative healthcare development with the aim of increasing efficiency and scaling up the realisation and introduction of innovative medical products. Additional aspects covered include the funding of technological sovereignty projects, the expansion of preferential regimes, and the concept of using PPP models. The article presents various PPP realisation mechanisms, including special investment contracts, concession agreements, and PPP agreements, which allow placing infrastructure facilities under the management of private partners. The transferred facilities may include production facilities, research centres, and other facilities necessary for innovative development. The article pays particular attention to the terms and features of concession agreements in the healthcare sector, considers the distribution of duties and responsibilities between the parties involved, and investigates the use of the risk-based approach. Additionally, the article analyses established business practices to identify conditions that are necessary for the parties to a concession agreement.CONCLUSIONS. The realisation of PPP projects in the innovative development of the healthcare sector requires taking into account and overcoming constraining factors, including technological and administrative barriers that may hinder effective development. The authors believe that the most preferable PPP form is the concession agreement model.

МАТЕРИАЛЬНО-ТЕХНИЧЕСКОЕ ОБЕСПЕЧЕНИЕ СЕЛЬСКОГО ХОЗЯЙСТВА: СОСТОЯНИЕ, ПРОБЛЕМЫ, НАПРАВЛЕНИЯ СОВЕРШЕНСТВОВАНИЯ

One of the determining conditions for competitive domestic agricultural production in foreign markets is the technical and technological modernization of the industry. However, despite the significance of the problem, over the past two decades, a stable trend of reduction in the number of employees in agricultural organizations in Russia has developed for all types of agricultural machinery. The highest rates of reduction in agricultural machinery were observed until 2010, and in subsequent periods the downward trend has significantly decreased. At the same time, it is not entirely correct to assess the current situation unambiguously, since the reduction in the fleet of machinery and equipment in agricultural organizations is due to certain objective circumstances and conditions: the area of cultivated land and cultivation of specific crops has decreased; the number of animals has decreased; the technical means used have become more energy-intensive and productive, which is especially important in the context of a shortage of personnel in rural areas. In 2018-2022 the production of domestic agricultural machinery in value terms increased by almost 2.5 times, while in physical terms the changes are insignificant. At the same time, domestic mechanical engineering practically does not produce machinery and equipment for pig farming, poultry farming, milk processing, potato harvesters, beet harvesting equipment, equipment for gardening, vegetable growing. As a result of the outstripping rate of disposal of agricultural machinery and equipment over the rate of their production and replenishment, the energy capacity of the industry is declining. The sanctions imposed on the Russian economy have led to increased risks of non-receipt of critical components and spare parts; disruption of stable logistics and distribution chains that have functioned for a long time, their rise in price; revision of contract terms, failure to meet delivery deadlines. Sanctions against the use of foreign high technologies used in precision farming, genetics, selection, enterprise management, etc. have a negative impact on the development of the agro-industrial complex.

Design, Operation and Simulation of a Passive Osmosis-Integrated Electrolyzer for Seawater Electrolysis

Utilizing abundant seawater for green hydrogen production through electrolysis is a promising pathway to produce a sustainable energy carrier. However, modern seawater electrolyzers have shown insufficient durability due to electrode corrosion and/or competitive production of chlorinated products that result from the presence of Cl−. In this work, a new cell, driven by osmotic separation, was designed and operated that can passively draw fresh water from seawater into compartments with high acid and/or alkaline concentration for electrolysis, thereby eliminating the need for an external energy source for desalination. The work focuses first on demonstrating the passive transport of water through membranes over a wide range of acid and base concentrations. Then, electrodes are integrated, and the cells are operated under multiple configurations and current densities. It is observed that some co-ion diffusion occurs, which is quantified through pH measurements and quantitative Cl− titration. Water transport and ion crossover experiments are supported by comprehensive continuum-level modeling. Finally, strategies for improving future performance are discussed. The findings in this work, a first step in the development of an osmosis-driven electrolyzer cell (ODEC), showcase the promise of this novel electrolyzer design for future direct seawater electrolysis.

Perancangan Value Proposition Canvas untuk Produk Indibiz PT Telkom

This Indibiz is a digital service aimed at micro, small, and medium enterprises (MSMEs) in Indonesia. This service provides consistent and high-quality internet connectivity to support various MSME businesses. Indibiz is designed to offer affordable internet, helping to reduce operational costs and boost MSME productivity in the digital era. However, over the past year, Indibiz has not met its sales targets. The main cause is that Indibiz has yet to fully meet the desired customer profile. To address this, the author designed a Value Proposition Canvas by collecting data on Indibiz's services, customer profiles, and competitor products through observation, literature review, and interviews with 10 MSMEs. These data were used to create a customer profile and value map for Indibiz's products. A strategy canvas analysis and ERRC framework were applied to develop a new Value Proposition Canvas. The proposed solution includes adding an all-in-one MSME digitalization package, bundling digital marketing services, and offering a sales guarantee for each digitalization service purchase.

DEVELOPMENT OF AGRICULTURAL SCIENCE ON THE PLATFORM OF INNOVATIVE BIOECONOMY

Ukraine's economy is in a state of crisis caused by the war. The agricultural sector in extreme conditions is trying to fulfill its function of ensuring the food security of the state, supporting its export potential despite limited resources and logistical problems. Agrarian science in the conditions of budget funding deficit is trying to find ways to use the scientific and experimental base, developed varieties and technologies to promote the stabilization and revival of agro-industrial production in the industry and regions. Effective models of implementing the innovative potential of agrarian science on a business basis are necessary.The purpose of the study is to justify the platform of market adaptation of science to crisis conditions and the mobilization of scientific potential in the breakthrough directions of the development of the agrarian sphere on the basis of innovative bioeconomy and close cooperation between science and business.To realize the set goal, the work assessed the possibilities of integrating science and business on the platform of innovative bioeconomy in the crisis economic and legal conditions of Ukraine; the bio-ecosystem of the platform and its operational mechanism of the partnership of science and business for the implementation of joint innovation and investment projects are substantiated. For the introduction of a well-founded bioecosystem, a set of measures is proposed for the formation of a platform in the system of agrarian science on the basis of conducted tests and adopted organizational decisions based on the example of the National Academy of Agrarian Sciences of Ukraine. Cooperation between agricultural science and business on the basis of the proposed public-private partnership platform ensures the mobilization of scientific potential to solve pressing issues of innovative development of agricultural production, rural areas through the creation and transfer of breakthrough and supporting bioinnovations, the production of competitive innovative agro-food products.

INNOVATION DEVELOPMENT STRATEGY FOR KARANGPATIHAN CIPRAT BATIK AS AN EFFORT TO IMPROVE THE LOCAL ECONOMY

The batik industry is an industry that is relied upon in the local market as well as the export market in the textile sector. Likewise, Karangpatihan ciprat batik (splashed motif in batik) is deliberately empowered as a form of local government concern for disabled residents who have limitations. This research aims to analyze the strategy for developing Ponorogo's typical Karangpatihan ciprat batik in order to increase industrial competitiveness batik industry in Ponorogo Regency. The method used in this research is a qualitative approach using the SWOT analysis method and a survey conducted on the Karangpatihan village head and the chairman of Rumah Harapan Mulya as the Karangpatihan Social Welfare Institution. The results of the research analysis conclude that the strategies that can be used are determining market opportunities based on geographic location, demographics and consumer behavior, identifying the target market to be addressed both within and outside the city of Ponorogo by understanding consumer preferences and needs regarding batik, increasing human resource development in order to achieve this. more innovative quality batik products that can increase consumer appeal. Determining sales channels by considering the place and method to be used. Then determine competitive prices by adjusting product quality and competition in the market, protection of rights to regional typical batik products with Intellectual Property Rights, promotional program innovations aimed at introducing batik on the national and international stage to encourage sales and establishing good relationships with consumers and distributors so that it can expand the marketing of batik products.

The Impact of Market Orientation, Product Innovation, and Competitive Advantage on the Marketing Performance of Culinary Enterprises

In this study, the impact of product innovation and market orientation on the marketing performance and competitive advantage of micro-entrepreneurs in Kampar Regency's culinary industry will be examined. Additionally, this study assesses how competitive advantage influences marketing effectiveness by acting as a mediating factor between market orientation and product innovation. Tests of the direct and indirect effects between variables are conducted quantitatively using the SEM-PLS (Structural Equation Modeling - Partial Least Squares) analytical methodology. Questionnaires and interviews with micro-entrepreneurs in Kampar Regency's culinary industry were used to gather data. A total of 378 respondents were chosen as relevant samples using the purposeful sampling approach. The findings indicated that competitive advantage was significantly enhanced by market focus and product innovation. Furthermore, marketing performance was significantly improved by competitive advantage, product innovation, and market orientation. Additionally, the link between market orientation and product innovation on marketing success was shown to be reinforced by competitive advantage acting as a mediator.