Companies have implemented Lean to increase efficiency and competitiveness. However, the importance of Ergonomics is often neglected, resulting in ergonomic problems and lower profitability and acceptance of Lean. This study presents a comprehensive approach to Operations and Production Management (OPM) considering sociotechnical synergies. For Lean and Ergonomics, literature-based main methodologies and categories are defined. These main methodologies/categories are used as search-term combinations in a further literature search. This literature is divided into “Production worker” (PW), “Physical environment” (PE), “Industry 4.0 technology” (i4.0), “Company culture” (CC), and “Manufacturing methods” (MM) based on a metric, the sociotechnical system (STS) concept. This makes it possible to determine the percentage of participation in Lean and Ergonomics articles by STS category. The main differences can be seen in PE (Lean: 10%; Ergonomics: 24%) and i4.0 (Lean: 29%; Ergonomics: 15%). However, for PW (Lean: 18%; Ergonomics: 21%), CC (Lean: 19%; Ergonomics: 20%), and MM (Lean: 26%; Ergonomics: 20%), there are similarities between Lean and Ergonomics. The OPM user should manage the PW, CC, and MM factors equally with Lean and Ergonomics, as the objective is the same. For PW, CC, and MM measures, a professional separation into Lean/OPM and Ergonomics/Occupational Medicine does not make sense. Concerning i4.0, there is a danger that the human factor in (especially innovation-oriented) OPM will be unjustly neglected and that too much emphasis will be placed on supposedly human-free technology.