The effects of mass asymmetry on the production of superheavy nuclei (SHN), within the dinuclear system model, are investigated in this study. It is observed that the fusion probability decreases with decreasing mass asymmetry. A total of 192 possible combinations of projectiles from O to Ti and targets with half-lives longer than 30 days for producing SHN $$^{264}\text {Db}$$ , $$^{265}\text {Db}$$ , $$^{267}\text {Sg}$$ , $$^{268}\text {Bh}$$ , $$^{268}\text {Sg}$$ , $$^{269}\text {Bh}$$ , $$^{271}\text {Hs}$$ , $$^{271}\text {Mt}$$ , $$^{272}\text {Hs}$$ , $$^{272}\text {Mt}$$ , $$^{273}\text {Mt}$$ , $$^{274}\text {Ds}$$ , $$^{275}\text {Ds}$$ , $$^{275}\text {Rg}$$ , $$^{276}\text {Ds}$$ , $$^{276}\text {Rg}$$ , $$^{277}\text {Rg}$$ , $$^{278}\text {Cn}$$ , $$^{279}\text {Cn}$$ , and $$^{280}\text {Cn}$$ are examined. Further, the optimal combinations and incident energies for synthesizing these nuclei are predicted. Most of the cross sections for production of SHN are larger than 10 pb; therefore, the process can be carried out with the available experimental equipment.
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