The significance of global product design as a primary factor in determining supply chain efficiency and natural resource management. This study examines the impact of global product design changes on process and supply chain practices. Specifically, it seeks to understand in promoting sustainable practices across global supply chains. This study, utilizes the fuzzy Analytical Hierarchy Process (AHP) and fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) methods to evaluate the criteria, sub-criteria, and various significant opportunities influencing sustainable product design and supply chain management. The fuzzy AHP method is used to assess the key criteria and their respective sub-criteria. The fuzzy TOPSIS method is used to rank the opportunities in driving sustainable practices across global supply chains. The results of fuzzy AHP show that innovation and product differentiation (C4), economic viability (C1), and supply chain efficiency (C5) are the crucial criteria. While the results of fuzzy TOPSIS present that supply chain transparency (O2) is the most suitable opportunity, followed by circular economy practices (O1) and policy advocacy and compliance (O6) in adopting global product design on supply chain efficiency and natural resources management. Thus, this study is highly relevant to the governments, industry specialists, and policymakers who aim at enhancing the dynamic business environment and sustainable development.