Processing Of Sexual Stimuli Research Articles

Homosexual and Heterosexual men present characteristic patterns of cortical synchronization in response to Visual Sexual Stimuli.

Since several cortical areas participate in the processing of sexual stimuli, this study characterized the electroencephalographic activity of prefrontal, temporal and parietal areas in men with different sexual orientation while observing erotic videos with homosexual (HOV) and heterosexual (HEV) content. The homosexual group presented lower absolute power of theta band in the right temporal cortex and higher right fronto-temporal correlation of beta band when observing the HOV. While the heterosexual group rated only the HEV as pleasant, also presented a higher left fronto-temporal correlation of beta band while watching the HEV, and a lower right fronto-parietal correlation of theta band during observation of the HOV. These results show a characteristic cortical functionality involved in the processing of sexually-relevant stimuli and its possible association with sexual orientation.

Alterations to the copulatory sequence in young adult male Sprague–Dawley rats administered a ketogenic diet

Ketogenic diets (KDs) have shown therapeutic potential for a range of neuropsychiatric disorders; however, there is insufficient data regarding the behavioral impacts of KDs in healthy populations. Here, we examined the impact of a KD on sexual behavior in young adult male Sprague-Dawley rats maintained on either a KD or standard chow diet (SD). We found that KD males exhibited higher mount rates, higher intromission rates (third and fourth tests only), and lower ejaculation likelihood (second test only) compared to SD males. Consequently, it may be that experience-dependent changes in the processing of sexual stimuli are not occurring as efficiently in KD males, thereby yielding the observed copulatory sequence alterations.

Examining Attentional Biases Elicited by Sexual Stimuli Using MouseView.js: An Online Paradigm to Mimic Eye Movements

ABSTRACT Attention is a key mechanism underlying many aspects of sexuality, with eye-tracking studies revealing that attention is both sustained by sexual stimuli and corresponds with sexual interest. Despite its utility, eye-tracking experiments typically require specialized equipment and are conducted in a laboratory setting. The overarching objective of this research was to assess the utility of a novel online method, MouseView.js, for assessing attentional processing of sexual stimuli outside of a laboratory context. MouseView.js is an open-source, web-based application where the display is blurred to mimic peripheral vision and an aperture is directed using a mouse cursor to fixate on regions of interest within the display. Using a discovery (Study 1, n = 239) and replication (Study 2, n = 483) design, we examined attentional biases to sexual stimuli among two diverse samples with respect to gender/sex and sexual orientation. Results revealed strong attentional biases toward processing sexual stimuli relative to nonsexual stimuli, as well as dwell times that correlated with self-report sexuality measures. Results mirror those observed for laboratory-based eye-tracking research, but using a freely available instrument that mirrors gaze tracking. MouseView.js offers important advantages to traditional eye-tracking methods, including the ability to recruit larger and more diverse samples, and minimizes volunteer biases.

Sexual experience induces a preponderance of mushroom spines in the medial prefrontal cortex and nucleus accumbens of male rats

Sexual experience improves copulatory performance in male rats. Copulatory performance has been associated with dendritic spines density in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc), structures involved in the processing of sexual stimuli and the manifestation of sexual behavior. Dendritic spines modulate excitatory synaptic contacts, and their morphology is associated with the ability to learn from experience. This study was designed to determine the effect of sexual experience on the density of different types or shapes of dendritic spines in the mPFC and NAcc of male rats. A total of 16 male rats were used, half of them were sexually experienced while the other half were sexually inexperienced. After three sessions of sexual interaction to ejaculation, the sexually-experienced males presented shorter mount, intromission, and ejaculation latencies. Those rats presented a higher total dendritic density in the mPFC, and a higher numerical density of thin, mushroom, stubby, and wide spines. Sexual experience also increased the numerical density of mushroom spines in the NAcc. In both the mPFC and NAcc of the sexually experienced rats, there was a lower proportional density of thin spines and a higher proportional density of mushroom spines. Results show that the improvement in copulatory efficiency resulting from prior sexual experience in male rats is associated with changes in the proportional density of thin and mushroom dendritic spines in the mPFC and NAcc. This could represent the consolidation of afferent synaptic information in these brain regions, derived from the stimulus-sexual reward association.

Automatic attention to sexual stimuli: exploring the role of neuroticism and sexual excitation/inhibition through event-related potentials.

Previous findings have shown that neuroticism is a higher-order vulnerability factor in the development and maintenance of sexual dysfunctions and can have an impact on the attentional processing of sexual stimuli; however, the influence of psychosexual dimensions on the early automatic phases of such cognitive processes has not been established yet. To examine the mediating role of sexual inhibition/excitation propensity in the relationship between neuroticism and automatic attention to visual erotica and to identify the neuroelectric correlates of such a process. We analyzed the answers provided by 58 individuals on the Neuroticism subscale of the NEO Personality Inventory-Revised and the Sexual Inhibition/Excitation Scales. Event-related potentials (ERPs) were recorded during a modified oddball paradigm containing romantic and sexually explicit pictures. Parallel mediations were performed to simultaneously test the mediating role of sexual inhibition/excitation in the relationship between neuroticism and each ERP. Three early attention ERP components (P1, P2, and N2) were assessed. Findings revealed an indirect effect of neuroticism on automatic attention, via sexual inhibition due to threat of performance failure (SIS1), for romantic and sexually explicit stimuli. This effect was significant only for component N2, which showed increased amplitudes and earlier latencies in participants with high SIS1. Sexual stimuli, due to their emotional valence and arousal potential, might be perceived as virtually threatening by individuals with neuroticism, who may benefit from strategies that decrease hyperarousal and sympathetic activation. This was one of the first studies to analyze neuroelectric activity associated with automatic attention toward sexual stimuli in relation to personality and sexual excitation/inhibition propensity. Nevertheless, the limited number of participants demands caution in generalizing the results. These results provide a better understanding of the relationship between personality and sexual cognition and open new avenues of research in relation to other automatic cognitive phenomena related to human sexual behavior.

Adverse childhood experiences and hormonal contraception: Interactive impact on sexual reward function.

The current literature suggests that some women are uniquely vulnerable to negative effects of hormonal contraception (HC) on affective processes. However, little data exists as to which factors contribute to such vulnerability. The present study evaluated the impact of prepubertal adverse childhood experiences (ACEs) on reward processing in women taking HC (N = 541) compared to naturally cycling women (N = 488). Participants completed an online survey assessing current and past HC use and exposure to 10 different adverse childhood experiences (ACEs) before puberty (ACE Questionnaire), with participants categorized into groups of low (0-1) versus high (≥2) prepubertal ACE exposure. Participants then completed a reward task rating their expected and experienced valence for images that were either erotic, pleasant (non-erotic), or neutral. Significant interactions emerged between prepubertal ACE exposure and HC use on expected (p = 0.028) and experienced (p = 0.025) valence ratings of erotic images but not pleasant or neutral images. Importantly, follow-up analyses considering whether women experienced HC-induced decreases in sexual desire informed the significant interaction for expected valence ratings of erotic images. For current HC users, prepubertal ACEs interacted with HC-induced decreased sexual desire (p = 0.008), such that high ACE women reporting decreased sexual desire on HC showed substantially decreased ratings for anticipated erotic images compared to both high prepubertal ACE women without decreased sexual desire (p < 0.001) and low prepubertal ACE women also reporting decreased sexual desire (p = 0.010). The interaction was not significant in naturally cycling women reporting previous HC use, suggesting that current HC use could be impacting anticipatory reward processing of sexual stimuli among certain women (e.g., high prepubertal ACE women reporting HC-induced decreases in sexual desire). The study provides rationale for future randomized, controlled trials to account for prepubertal ACE exposure to promote contraceptive selection informed by behavioral evidence.

Experimental Sex Research in the Context of Clinical Sexology: Gaps, Strengths, and the Need to Build a Communication Bridge Between Basic Sexology Research and Clinical Practice

Experimental sex research consists of the application of experimental paradigms and laboratory metrics such as psychophysiological assessments, measurement of individuals’ motor responses or brain activity toward stimuli to the study of fundamental processes underpinning sexual (dys)function. Those processes are usually captured by the cognitive and emotional responses involved in the processing of sexual stimuli, usually presented in the form of pictures, film clips, or narratives. With those methodologies, researchers can evaluate low order (eg, automatic responses toward a sexual stimulus) and high order (eg, conscious decisions in the sexual context) phenomena, unveiling pathological and adaptive processes in sexual functioning.

Altered Neural and Behavioral Response to Sexually Implicit Stimuli During a Pictorial-Modified Stroop Task in Pedophilic Disorder

BackgroundPedophilic disorder (PD) entails sexual attraction to prepubertal children. A risk factor for committing child sexual abuse in PD is impaired cognitive control. However, the underlying neurocognitive mechanisms remain unclear. MethodsWe performed a case-control study including 51 self-identified and help-seeking males with PD and 55 matched healthy control subjects. Functional magnetic resonance imaging and a pictorial-modified Stroop task involving computer-generated sexually implicit images were used to measure response time and brain activation. Increases in response time during the pictorial-modified Stroop task are presumably due to image-induced interference in executive functions required for task performance. ResultsIn PD, during the presentation of images of children compared with adults, we found increased response time (p = .005; 848 ± 92 ms vs. 826 ± 88 ms), and compared with healthy control subjects, we found increased activation in the occipital, temporal (bilateral hippocampus), parietal, frontal, cingulate, and left insular cortices; caudate (bilaterally); thalamus (mediodorsal); and cerebellum. ConclusionsPresentation of child images was associated with response interference in PD and increased engagement of brain regions involved in the processing of sexual stimuli, visual perception, self-referential thought, and executive function. We conclude that processing of child images is associated with functional and behavioral alterations in PD.

Effects of Depression on Processing and Evaluation of Sexual Stimuli in Women

BackgroundSexual dysfunctions are commonly associated with depression by which women are particularly affected. AimIn the following study, we looked at which stage–early attention-related processes or later evaluation-related processes–of the processing of sexual stimuli deviations occur in depressed individuals. MethodsWe examined 96 women who either suffered from a major depressive disorder, or had recovered from it, and a healthy control group. The early level of attention processes was represented by reaction time tasks (dot probe, line orientation, picture categorization). In addition, implicit approach and avoidance behavior was tested by the Approach-Avoidance Task. Later evaluation of the visual material was determined with the help of a questionnaire for recording automatic negative thoughts regarding sexuality. OutcomesReaction times and explicit ratings as well as the Becks Depression Inventory (BDI II), the Trait Sexual Motivation Questionnaire (TSMQ), the Sexual Modes Questionnaire (SMQ) and a screening for sexual dysfunction were used. ResultsDepressed women did not differ significantly from healthy women in their attention processes and approach-avoidance behavior. However, there were clear differences in explicit assessment and automatic thoughts about sexual stimuli. Women who had recovered from depression lay between the 2 groups. Clinical ImplicationsThe results indicated that the therapy of sexual dysfunction in depressed patients should focus more on automatic thoughts than on attention processes. Strengths & LimitationsThis study is the first to experimentally research the attention processes of depression towards sexual stimuli. However, participants were only tested on one occasion so that change of attention processes and evaluation of sexual stimuli over the course of a depression could not be assessed. ConclusionOur novel findings demonstrate the role of attention processes in sexual dysfunctions of depressed women and suggest potential mechanisms that may underlie the observed correlation between depression and sexual dysfunction.Baranowski AM, Noll A-K, Golder S, et al. Effects of Depression on Processing and Evaluation of Sexual Stimuli in Women. J Sex Med 2022;19:441–451.

Prenatally stress-exposed male rats present lower theta prefrontal activity during attention behaviors to receptive females

Prenatal stress affects brain functionality and sexual behavior. The medial prefrontal cortex (mPFC) participates in the integration and processing of sexual stimuli. Electroencephalographic (EEG) theta activity has been associated with attention as well as rewarding and sexually motivated states. Considering that the induction of sexual motivation requires attention to, and the adequate processing of, sexual stimuli, this study aimed to evaluate the effects of exposure to stress during the prenatal period on EEG activity in the mPFC during nose pokes in adulthood, actions which are indicators of attention to a receptive female. Eighteen sexually experienced male rats were used, nine stressed prenatally by immobilization during days 14–21 of gestation (stress-exposed group). The other nine formed the control group. All rats were implanted bilaterally in the mPFC (specifically in prelimbic areas) and were allowed one intromission with a receptive female to induce a sexually motivated state before the experimental session. During this session, both nose pokes and non-contact erections in the male rats were evaluated in the presence of an inaccessible receptive female. EEGs were recorded only during nose pokes. The stress-exposed group presented lower nose poke duration, fewer non-contact erections, and lower relative power of the theta band (4–7 Hz) in both prefrontal areas. Considering that the prevalence of this band is associated with attention and motivational processes, these data confirm the deleterious effect of prenatal stress on attention and sexual activation to sexually relevant stimuli in male rats during adulthood.

Neuroticism and Attention Toward Sexual and Non-Sexual Images During an Oddball Task: Evidence from Event-Related Potentials.

While previous research has argued that neuroticism is a vulnerability factor for the experience of sexual difficulties, the basic cognitive processes associated with the impact of such a personality trait on the processing of sexually explicit stimuli are less understood. The current study examined the influence of neuroticism on the attentional processes and its neurophysiological correlates during the perception of sexual and non-sexual images. Event-related potentials from 30 women and 28 men were recorded during a modified oddball paradigm in which participants of both sexes visualized stimuli from three different categories (sexual, non-sexual positive, and non-sexual negative), and two arousal levels (high and low arousal). A P1 latency effect was found for female participants, in which high neuroticism was associated with longer latencies for pornographic compared to romantic sexual images. Higher levels of neuroticism were also associated with higher P3 amplitudes for highly arousing images, with both sexual and non-sexual content. Results were interpreted in light of the information processing model of sexual arousal and showed that neuroticism seems to impact both automatic and conscious pathways of processing of sexual stimuli.

The Impact of Negative Mood on Event-Related Potentials When Viewing Pornographic Pictures.

Background: Negative affective states may increase the risk for problematic pornography use. Underlying neurophysiological mechanisms are, however, not completely understood. Previous research suggests that the participants' emotional state may affect neural processing of sexual stimuli. The aim of this study was to investigate neural correlates of negative affect-induced alterations in sexual cue reactivity in healthy men. The moderating effects of habitual porn consumption, trait sexual motivation, and symptoms of cybersex addiction were also considered.Method: Sixty-four healthy men engaged in a sexual cue reactivity task (passive viewing of explicit sexual pictures and neutral pictures depicting scenes of social interaction) during negative (n = 32) vs. neutral affect (n = 32), induced via tailored feedback on a performance task. Self-reported sexual arousal and event-related brain potentials indicated cue reactivity and motivated attention. Symptoms of cybersex addiction and trait sexual motivation were assessed with the help of the short Internet Addiction Test, adapted to online sexual activities, and the Trait Sexual Motivation Questionnaire.Results: Negative feedback increased negative affect after the performance task. While sexual pictures compared to neutral pictures elicited significantly larger P300 and late positive potential (LPP) amplitudes, there was no general effect of negative feedback on sexual stimuli-related P300 and LPP amplitudes. In the negative feedback group, men with higher solitary sexual motivation levels showed higher P300/LPP difference amplitudes for sexual stimuli compared to men with lower levels of solitary sexual motivation. The opposite effect was found in the group with neutral feedback. There was no link to other aspects of trait sexual motivation and symptoms of cybersex addiction.Conclusions: Results suggest that higher levels of solitary sexual motivation may enhance motivated attention toward sexual stimuli among men receiving negative performance feedback. Other characteristics of sexual behaviors and traits provided no exploratory value. Future studies extending onto men suffering from compulsive sexual behavior disorder will have to closer look at the neurophysiological bases of why and when some men develop an addictive pornography consumption.

The East Asian Erotic Picture Dataset and Gender Differences in Response to Opposite-Sex Erotic Stimuli in Chinese College Students.

Understanding the processing of sexual stimuli has become a significant part of research on human sexuality. In addition to individual characteristics (gender and sexual orientation), empirical studies have shown that cultural factors play an important role in sexual stimuli processing. The attitudes toward sex have been reported to be more conservative in East Asian societies as compared to western countries, and significantly more sexual difficulties are observed among East Asian people. However, stimulus materials, which potentially facilitate human sexuality research on native East Asian people, are relatively not satisfactory. Erotic stimuli depicting East Asian figures are limited in the existing picture datasets. To address this issue, we present a collection of 237 erotic and 108 control pictures, accompanied by self-reported ratings of sexual arousal, pleasantness, and sexual attractiveness for opposite-sex erotic stimuli by heterosexual males and females (n = 40, divided into two equal-sized subsamples). This collection is divided into six categories, depending on their contents: dressed males (44), semi-nude males (65), nude males (64), dressed females (64), semi-nude females (52), and nude females (56). We showed gender differences in sexual arousal, pleasantness, and sexual attractiveness ratings in response to opposite-sex erotic pictures. Males reported the highest levels of sexual arousal, pleasantness, and sexual attractiveness for nude female pictures, whereas females reported the highest levels of sexual arousal, pleasantness, and sexual attractiveness for semi-nude male pictures. The erotic picture dataset may provide a useful resource of erotic stimuli that can be used as stimulus materials in experimental research on sexual function in East Asians.

Response inhibition during processing of sexual stimuli in males with problematic hypersexual behavior.

Background and aimsIndividuals with problematic hypersexual behavior (PHB) are unable to control their sexual cravings, regardless of other situational factors. This inability to control cravings is a common trait in patients with neurological pathologies related to response inhibition. Until recently, however, it was unclear whether individuals with PHB have decreased inhibition and altered neural responses in the brain regions associated with inhibition compared to healthy control individuals, especially in the presence of distracting sexual stimuli. In this study, we examined the neural and psychological underpinnings of inhibition in individuals with PHB.MethodsThirty individuals with PHB and 30 healthy subjects underwent functional magnetic resonance imaging while performing a modified go/no-go task with neutral or sexual backgrounds used as distractors.ResultsIndividuals with PHB showed poorer response inhibition than healthy subjects, especially when sexual distractors were present. Further, compared to healthy control subjects, individuals with PHB showed decreased activation in the right inferior frontal gyrus (IFG) and reduced functional connectivity between the IFG and the pre-supplementary motor area (preSMA) when response inhibition was required. Finally, the reduced activation and connectivity were more pronounced in the presence of sexual distractors than in the presence of neutral distractors.DiscussionThese findings suggest that individuals with PHB show reduced ability to inhibit responses that might be related to lower IFG activation and IFG-preSMA connectivity during response inhibition. Our results provide insights into the neurobiological underpinnings of poor response inhibition in individuals with PHB.

Effects of inactivation of the ventral tegmental area on prefronto-accumbens activity and sexual motivation in male rats

Sexual motivation requires the processing of sexual stimuli. The prefrontal cortex (PFC) and nucleus accumbens (NAcc) receive dopaminergic innervation from the ventral tegmental area (VTA). Both structures participate in processing stimuli, and their adequate functioning is modulated by dopamine and other neurotransmitters. This study was designed to determine the effect of inactivation of the VTA on sexual motivation, relative power (RP) and electroencephalographic (EEG) correlation of the PFC and NAcc in male rats. A total of 20 rats implanted with electrodes in the left medial prefrontal cortex (mPFC) and NAcc, and with bilateral cannulae in the VTA, were divided into two groups of 10 rats each, one injected with tetrodotoxin (TTX), the other with a vehicle solution (VEH). EEGs from the mPFC and NAcc were recorded during the awake-quiet state in the presence of either a receptive or non-receptive female. The TTX group showed a lower preference for the receptive female accompanied by a lower RP of the 8–13 and 14–30 Hz bands in the mPFC. Also, in the presence of the receptive female, the TTX group had a lower RP of the 8–13 Hz band in the NAcc, but a higher prefronto-accumbens correlation in the same band. These results provide evidence that VTA activity is necessary for the adequate functioning of the mPFC and NAcc and, therefore, also for the adequate processing of sexually-relevant stimuli that allows the induction and maintenance of sexual motivation in male rats.

Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain.

Human sexual behavior is mediated by a complex interplay of cerebral and spinal centers, as well as hormonal, peripheral, and autonomic functions. Neuroimaging studies identified central neural signatures of human sexual responses comprising neural emotional, motivational, autonomic, and cognitive components. However, empirical evidence regarding the neuromodulation of these neural signatures of human sexual responses was scarce for decades. Pharmacological functional magnetic resonance imaging (fMRI) provides a valuable tool to examine the interaction between neuromodulator systems and functional network anatomy relevant for human sexual behavior. In addition, this approach enables the examination of potential neural mechanisms regarding treatment-related sexual dysfunction under psychopharmacological agents. In this article, we introduce common neurobiological concepts regarding cerebral sexual responses based on neuroimaging findings and we discuss challenges and findings regarding investigating the neuromodulation of neural sexual stimulus processing. In particular, we summarize findings from our research program investigating how neural correlates of sexual stimulus processing are modulated by serotonergic, dopaminergic, and noradrenergic antidepressant medication in healthy males.

PB9. The ‘functional magnetic resonance imaging’ (fMRI) as a meaningful tool for the differentiation of sexual preferences

Context The research network ‘ Ne ural mechanisms u nderlying p edophilia and sexual offending against children: origins, assessment and therapy’ investigates mechanisms of sexual abuse of children and pedophilia by means of fMRI imaging, clinical interviews, and psychological testing. While pedophiles’ sexual fantasies refer to pre-pubertal children of the first Tanner Stage ( Tanner, 1978 ), hebephilic men prefer partners who are in puberty (Tanner Stage 2–3) ( Blanchard et al., 2009 ). But whether hebephilia can be seen as an independent entity is still controversial. Our previous research showed that the functional brain response patterns to sexual stimuli contain sufficient information to identify pedophiles (compared to teleiophiles) with a mean accuracy of 95% ( Ponseti, 2012 ). However, the treatment relies on a precise measurement of the sexual orientation. To this end, we tested whether standard second level analysis of brain responses to sexual stimuli and/ or whole brain calculations of BOLD-responses to sexual stimuli are useful to differentiate between pedophiles and hebephiles. Design During fMRI, participants (n = 328) were shown same- and opposite-sex images of nude children and adults in Tanner stages 1–5. The images were each shown for one second with a variable inter-stimulus interval of two seconds on average. The previous classification was based on clinical interviews, self-reported details (like sexual/masturbating fantasies) or according to criminal/medical records. We calculated differences in BOLD-signals for the sexual stimuli in the corresponding contrast images (i.e.one hebephiles’ contrast image was defined as ‘pubertal boy/girl’), as well as a whole brain functional BOLD response to each stimulus category. Results Preference specific brain activity was found in hebephilic as well in pedophilic participants in areas known to be involved in sexual stimulus processing. Conclusion Here we present evidence that whole brain response calculation provides a meaningful measure of sexual preferences in healthy and in paraphilic males. Particularly, response differences between pedophilic and hebephilic participants provide evidence that these clinical categories differ at the level of brain function.

The effect of static versus dynamic stimuli on visual processing of sexual cues in androphilic women and gynephilic men.

Models of sexual response posit that attentional processing of sexual cues is requisite for sexual responding. Despite hypothesized similarities in the underlying processes resulting in sexual response, gender differences in sexual arousal patterns are abundant. One such gender difference relates to the stimulus features (e.g. gender cues, sexual activity cues) that elicit a response in men and women. In this study, we examined how stimulus modality (static visual images versus dynamic audiovisual films) and stimulus features (gender, sexual activity and nonsexual contextual cues) influences attentional (i.e. gaze) and elaborative (i.e. self-reported attraction (SRA), self-reported arousal) processing of sexual stimuli. Men's initial and controlled attention was consistently gender-specific (i.e. greater attention towards female targets), and this was not influenced by stimulus modality or the presence of sexual activity cues. By contrast, gender-specificity of women's attention patterns differed as a function of attentional stage, stimulus modality and the features within the stimulus. Degree of specificity was positively predictive of SRA in both genders; however, it was not significantly predictive of self-reported arousal. These findings are discussed in the context of gendered processing of visual sexual information, including a discussion of implications for research designs.

Aberrant baseline brain activity in psychogenic erectile dysfunction patients: a resting state fMRI study

Recent neuroimaging studies have elucidated many interesting and promising findings on sexuality regarding the neural underpinnings of both normal and abnormal sexual processes. Psychogenic erectile dysfunction (pED) consists of a major part of male sexual dysfunction in China, but the understanding of the central mechanism of pED is still in its infancy. It is commonly appreciated that pED is a functional disorder, which can be attributed predominantly or exclusively to psychological factors, such as anxiety, depression, loss of self-esteem, and psychosocial stresses. Most previous studies probed the central response in the brain of pED patients using sexual-related stimuli. However, little concern has been given to a more fundamental issue whether the baseline brain activity is altered in pED or not. With rs-fMRI data, the current study aimed to explain the central mechanism behind pED by investigating the alterations in baseline brain activity in patients with pED, as indexed by the amplitude of low-frequency (0.01–0.08 Hz) fluctuation (ALFF). After the psychological screening and urological examination procedure, 26 pED patients and 26 healthy matched controls were enrolled. Our results explicated significantly lower baseline brain activity in the right anterior insula and right orbitofrontal cortex for pED patients (multiple comparison corrected). Additionally, the voxel-wise correlation analysis showed that ALFF of the right anterior insula was correlated with the outcomes of erectile function (multiple comparison corrected). Our results implied there was impaired cognitive and motivational processing of sexual stimuli in pED patients. Our current findings may shed light on the neural pathology underlying pED. We hope that our study has provided a new angle looking into pED research by investigating resting state brain activity. Furthermore, we suggest that the current study may put forward a more subtle conception of insular influence on pED, which may help foster new specific, mechanistic insights.

Prenatal stress suppresses the prefrontal and amygdaline EEG changes associated with a sexually-motivated state in male rats

The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) participate in the modulation of several motivated behaviors, such as the sexual behavior. Both structures are sensitive to stress when it is experienced mainly in critical periods of the life-cycle, such as the prenatal period. This study evaluated the effects of prenatal stress on electroencephalographic activity (EEG) of the mPFC and BLA during sexual motivation. EEG was recorded in the mPFC and BLA of male rats assigned to either a prenatally-stressed group (SG, dam immobilized from days 14 to 21of pregnancy), or a control group (CG), during the following conditions: awake-quiet state without sexual motivation, and awake-quiet state with sexual motivation. Compared to CG, fewer SG subjects presented copulatory responses and their levels of sexual motivation were lower. The CG subjects with sexual motivation showed a higher absolute power (AP) of the 14–30Hz band in the left mPFC and BLA than those without sexual motivation. The SG showed a lower AP of the 4–7 and 8–13Hz bands in the left BLA. Thus, prenatal stress suppressed the prefrontal and amygdaline EEG changes associated with a sexually-motivated state. EEG data show that stress affects the functioning of these two brain structures and so could interfere with the adequate processing of sexual stimuli. These findings contribute to understanding the brain mechanisms that underlie the effect of prenatal stress on the processing of sexual stimuli in male rats.