Processing Of Contextual Cues Research Articles

Role of dorsal hippocampal muscarinic receptor activity in acquisition and retention of single- versus multiple-trial contextual fear conditioning in adolescent rats.

The present study examined the effects of the muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, on standard contextual fear conditioning (sCFC). It compared effects of the drug on acquisition (post-shock freezing) versus 24-hr retention of a context-shock association acquired after one or three pairings of a context with unsignaled shock. During single-trial sCFC, systemic scopolamine (0.5 mg/kg, i.p.) prior to training abolished both post-shock and retention freezing (Experiment 1). This same injection during multiple-trial sCFC also abolished post-shock freezing and impaired 24-hr retention freezing (Experiment 2). These results indicate that cholinergic signaling mediates both acquisition and 24-hr retention of a context-shock association across different trial parameters. Experiment 3 further explored these effects by infusing scopolamine (35 μg per side) into the dorsal hippocampus (dHPC) prior to training in single versus multiple-trial sCFC. This infusion spared post-shock but abolished retention test freezing in single-trial sCFC (Experiment 3A), and had no effect on multiple-trial sCFC (Experiment 3B). The current findings suggest that brain-wide cholinergic signaling mediates acquisition and retention of single-trial sCFC. Despite this, while muscarinic cholinergic signaling in the dHPC does mediate retention of single-trial sCFC, it is not required for acquisition of either variant, or retention of multiple-trial sCFC. These findings also rule out impaired sensory processing of contextual cues as a mechanism of impaired context learning by dHPC scopolamine. The results are discussed in relation to the role of cholinergic function across multiple brain memory systems in elemental versus configural forms of contextual fear conditioning (Fanselow, 2010; Rudy, 2009). (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Research thematic and emerging trends of contextual cues: a bibliometrics and visualization approach

PurposeThe paper aims to clarify the importance of the psychological processing of contextual cues in the mining of individual attention resources. In recent years, the research of more open spatial perspective, such as spatial and scene perception, has gradually turned to the recognition of contextual cues, accumulating rich literature and becoming a hotspot of interdisciplinary research. Nevertheless, besides the fields of psychology and neuroscience, researchers in other fields lack systematic knowledge of contextual cues. The purpose of this study is to expand the research field of contextual cues.Design/methodology/approachWe retrieved 494 papers on contextual cues from SCI/SSCI core database of the Web of Science in 1992–2019. Then, we used several bibliometric and sophisticated network analysis tools, such as HistCite, CiteSpace, VOSviewe and Pajek, to identify the time-and-space knowledge map, research hotspots, evolution process, emerging trends and primary path of contextual cues.FindingsThe paper found the core scholars, major journals, research institutions, and the popularity of citation to be closely related to the research of contextual cues. In addition, we constructed a co-word network of contextual cues, confirming the concept of behavior implementation intentions and filling in the research gap in the field of behavior science. Then, the quantitative analysis of the burst literature on contextual cues revealed that the research on it that focused more on multi-objective cues. Furthermore, an analysis of the main path helped researchers clearly understand and grasp in the development trend and evolution track of contextual cues.Originality/valueGiven academic research usually lags behind management practice, our systematic review of the literature to a certain extent make a bridge between theory and practice.

Predictive Impact of Contextual Objects during Action Observation: Evidence from Functional Magnetic Resonance Imaging.

The processing of congruent stimuli, such as an object or action in its typical location, is usually associated with reduced neural activity, probably due to facilitated recognition. However, in some situations, congruency increases neural activity-for example, when objects next to observed actions are likely versus unlikely to be involved in forthcoming action steps. Here, we investigated using fMRI whether the processing of contextual cues during action perception is driven by their (in)congruency and, thus, informative value to make sense of an observed scene. Specifically, we tested whether both highly congruent contextual objects (COs), which strongly indicate a future action step, and highly incongruent COs, which require updating predictions about possible forthcoming action steps, provide more anticipatory information about the action course than moderately congruent COs. In line with our hypothesis that especially the inferior frontal gyrus (IFG) subserves the integration of the additional information into the predictive model of the action, we found highly congruent and incongruent COs to increase bilateral activity in action observation nodes, that is, the IFG, the occipitotemporal cortex, and the intraparietal sulcus. Intriguingly, BA 47 was significantly stronger engaged for incongruent COs reflecting the updating of prediction in response to conflicting information. Our findings imply that the IFG reflects the informative impact of COs on observed actions by using contextual information to supply and update the currently operating predictive model. In the case of an incongruent CO, this model has to be reconsidered and extended toward a new overarching action goal.

Default-mode network activation underlies accurate contextual processing of exclusive disjunctions in older but not younger adults

Young adults proactively engage frontoparietal processing of contextual cues to preempt subsequent events. Rather than being preemptive, older adults engage these brain areas reactively upon event occurrences. Reactive frontoparietal processes in older adults, however, might be insufficient for complex contextual neural computations where utilities of contexts are not straightforward but dependent on a set of stimulus-response rules. Applying non-linear logic (XOR) rules in an fMRI experiment, we found higher default-mode network (DMN) activity critical for correctly responding to such contingency in older but not younger adults. Moreover, older individuals with higher proactive cue processing showed better performances with less DMN activity. Thus, DMN processing provides critical support when older adults are faced with complex contextual contingencies. These findings suggest an age-related change in the neurocomputational role of introspective processes in decision-making from young to older adulthood.

Dressing Up for a BBQ on a Blurry Street: #TheDress Is Not Only Ambiguous in Terms of Illumination But Also in Terms of Scene Content.

Explicit or implicit assumptions about the source of illumination are a key determinant of perceived colours from the image of #TheDress. In addition, previous work showed that the extent of the processing of contextual cues in the image may be reduced in blue and black perceivers. This is a brief report of a questionnaire study which focused on the ambiguity of light direction as well as on the ambiguity of the content of #TheDress photograph itself. We replicated previous reports about the importance of perceived light direction: White and gold perceivers were more likely to report light from the back than sideways light. Descriptions of #TheDress image did not relate to perceived colour or light direction, but there were many erroneous reports and a high level of ambiguity. It is highly likely that the ambiguity of image content feeds into the importance of implicit factors that influence perceived illumination as determinants of dress colour.

Young and older adults adapt automatic postural responses equivalently to repetitive perturbations but are unable to use predictive cueing to optimize recovery of balance stability

Processing of contextual cues has been proposed to modulate the generation of automatic postural responses to unanticipated balance perturbations. In this investigation, we compared young and older individuals in responses to sudden rotations of the support base inducing either planti- or dorsiflexion of the ankles. Assessment was made in conditions resulting from the combination of visual directional cueing of the forthcoming platform rotation, and block versus random sequences of platform rotation directions. Results showed that, for both rotation directions, the block sequence led to reduced magnitude of activation of distal agonist muscles and direction-specific modulation of ground reaction forces to recover body balance. Visual directional cueing, conversely, failed to modulate either muscular responses or forces applied to the support base through the feet for balance recovery. Effects were similar between ages, suggesting that aging does not increase the influence of cognition on the generation of automatic postural responses, and that adaptation to repeated postural perturbations over trials is preserved in healthy older individuals.

Disambiguating the cognitive and adaptive effects of contextual cues of an impending balance perturbation

Contextual cueing advancing the characteristics of an impending balance perturbation has been thought to induce optimized automatic postural responses. In this investigation, we aimed to disambiguate the cognitive and adaptive components of cueing a balance perturbation through the direction sequence of a series of base of support translations. We compared three experimental conditions: (a) block, with one perturbation cueing that the following one would be in the same direction; (b) serial, with one perturbation cueing that the following one would be in the opposite direction; and (c) random, representing a control uncued condition. Participants were instructed about the perturbation sequences. With this arrangement, at the cognitive level there was no directional uncertainty both in the block and serial sequences, while at the non-cognitive level only the block sequence was expected to lead to optimized responses in comparison to the random sequence. Results showed that the block sequence led to the generation of more stable automatic postural responses in comparison to the serial and random sequences, as indicated by lower amplitudes of body sway and lower velocity of center of pressure displacement. Increased balance stability in the block sequence was associated with longer delays of activation onset of leg distal muscles. Comparisons between the serial and random perturbation sequences failed to show any significant differences. These results indicate that optimized postural responses in the block sequence are due to adaptive processes underlying repetitive perturbations over trials rather than to processing of contextual cues at the cognitive level reducing uncertainty about characteristics of an impending perturbation.

The role of stop-signal probability and expectation in proactive inhibition.

The subjective belief of what will happen plays an important role across many cognitive domains, including response inhibition. However, tasks that study inhibition do not distinguish between the processing of objective contextual cues indicating stop-signal probability and the subjective expectation that a stop-signal will or will not occur. Here we investigated the effects of stop-signal probability and the expectation of a stop-signal on proactive inhibition. Twenty participants performed a modified stop-signal anticipation task while being scanned with functional magnetic resonance imaging. At the beginning of each trial, the stop-signal probability was indicated by a cue (0% or >0%), and participants had to indicate whether they expected a stop-signal to occur (yes/no/don't know). Participants slowed down responding on trials with a >0% stop-signal probability, but this proactive response slowing was even greater when they expected a stop-signal to occur. Analyses were performed in brain regions previously associated with proactive inhibition. Activation in the striatum, supplementary motor area and left dorsal premotor cortex during the cue period was increased when participants expected a stop-signal to occur. In contrast, activation in the right inferior frontal gyrus and right inferior parietal cortex activity during the stimulus-response period was related to the processing of contextual cues signalling objective stop-signal probability, regardless of expectation. These data show that proactive inhibition depends on both the processing of objective contextual task information and the subjective expectation of stop-signals.

Subliminal Instrumental Conditioning Demonstrated in the Human Brain

SummaryHow the brain uses success and failure to optimize future decisions is a long-standing question in neuroscience. One computational solution involves updating the values of context-action associations in proportion to a reward prediction error. Previous evidence suggests that such computations are expressed in the striatum and, as they are cognitively impenetrable, represent an unconscious learning mechanism. Here, we formally test this by studying instrumental conditioning in a situation where we masked contextual cues, such that they were not consciously perceived. Behavioral data showed that subjects nonetheless developed a significant propensity to choose cues associated with monetary rewards relative to punishments. Functional neuroimaging revealed that during conditioning cue values and prediction errors, generated from a computational model, both correlated with activity in ventral striatum. We conclude that, even without conscious processing of contextual cues, our brain can learn their reward value and use them to provide a bias on decision making.

Dissociated roles for the lateral and medial septum in elemental and contextual fear conditioning

Extensive evidence indicates that the septum plays a predominant role in fear learning, yet the direction of this control is still a matter of debate. Increasing data suggest that the medial (MS) and lateral septum (LS) would be differentially required in fear conditioning depending on whether a discrete conditional stimulus (CS) predicts, or not, the occurrence of an aversive unconditional stimulus (US). Here, using a tone CS-US pairing (predictive discrete CS, context in background) or unpairing (context in foreground) conditioning procedure, we show, in mice, that pretraining inactivation of the LS totally disrupted tone fear conditioning, which, otherwise, was spared by inactivation of the MS. Inactivating the LS also reduced foreground contextual fear conditioning, while sparing the higher level of conditioned freezing to the foreground (CS-US unpairing) than to the background context (CS-US pairing). In contrast, inactivation of the MS totally abolished this training-dependent level of contextual freezing. Interestingly, inactivation of the MS enhanced background contextual conditioning under the pairing condition, whereas it reduced foreground contextual conditioning under the unpairing condition. Hence, the present findings reveal a functional dissociation between the LS and the MS in Pavlovian fear conditioning depending on the predictive value of the discrete CS. While the requirement of the LS is crucial for the appropriate processing of the tone CS-US association, the MS is crucial for an appropriate processing of contextual cues as foreground or background information.

Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function

A significant subgroup of individuals with posttraumatic stress disorder (PTSD) exhibits chronic, unremitting symptomatology that has also been associated with smaller hippocampal volume. The hippocampus plays a significant role in configural processing of contextual cues that facilitates context-appropriate extinction of conditioned fear. We test the hypothesis that hippocampus-based configural processing deficits are a pre-existing vulnerability factor for unremitting forms of PTSD. Participants included male monozygotic twin pairs who were discordant for combat trauma. In 18 twin pairs the combat-exposed brother developed unremitting PTSD, whereas in 23 pairs the combat-exposed brother never developed PTSD. Participants were compared in the capacity to solve allocentric spatial processing tasks, and this performance was examined for its relationship to the severity of PTSD symptomatology and hippocampal volume. Although not completely differentiated from overall IQ, PTSD combat veterans demonstrated significantly impaired performance in configural processing relative to non-PTSD combat veterans. Despite having neither combat-exposure nor PTSD, the unexposed co-twins of combat veterans with PTSD displayed the same decrements as their brothers. Deficits were significantly related to PTSD severity and hippocampal volume. The current study provides the first evidence that the relevance of the hippocampus in PTSD might be related to pre-existing configural cue processing deficits that predispose individuals to develop unremitting forms of the disorder.

Early Stage Alzheimer's Disease Disrupts Encoding of Contextual Information

Two experiments examined whether impairments in recognition memory in early stage Alzheimer's disease (AD) were due to deficits in encoding contextual information. Normal elderly (NE) and patients diagnosed with mild stage AD learned one of two tasks. In Experiment 1 correct recognition memory required participants to remember not only what items they had experienced on a given trial but also when they had experienced them; Experiment 2 required that participants remember only what they had seen, not when they had seen it. Large recognition memory differences were found between the AD and NE groups in the experiment where time tagging was crucial for successful performance. An error analysis indicated that this was not due to the perseveration of previous learned responses. In Experiment 2, the only requisite for successful recognition was remembering what one had experienced; memory of the temporal record was not necessary for successful performance. In this instance, recognition memory for the NE and AD groups was identical. Taken together these results suggest that memory deficits found in early stage AD are partly due to impaired processing of contextual cues that provide crucial information about when events occur.

Contingent versus incidental context processing during conditioning: dissociation after excitotoxic hippocampal plus dentate gyrus lesions.

This experiment explored whether excitotoxic hippocampus plus dentate gyrus (HPC/DG) lesions in rats would dissociate the differential processing of contextual cues during the performance of learned associations when (1) their processing during training is incidental to successful learning or (2) the solution of a discrimination problem is contingent on their processing. A series of training stages were conducted, beginning with appetitive conditioning to two stimuli (X and Y), each of which was trained in one of two different contexts (operant chambers A and B) (i.e., AX+, BY+). Conditioning was indexed as appetitive responding. The animals were then trained on a biconditional contextual discrimination with these same stimuli (AX+, AY-; BY+, BX-). The next stage involved conditioning trials to two new stimuli (W and Z), one in each context, while the animals were actively discriminating contexts A and B by continuing to perform the original biconditional discrimination (AX+, AY-, AW+; BY+, BX-, BZ+). Finally, they were trained on a second biconditional discrimination involving these new stimuli (AX+, AY-, AW+, AZ-; BY+, BX-, BZ+, BW-). The incidental use of context cues was examined by looking at the rate of conditioned responding to cues X, Y, W, and Z in their original training contexts or a different context; HPC/DG lesioned rats differed from controls in being unaffected by a change of context. The contingent use of context cues was examined by looking at performance of each of the two biconditional tasks; HPC/DG lesioned rats reached levels of conditional performance indistinguishable from those of controls. These findings point to two distinct ways in which contextual information is processed in the brain, revealing a dissociation between incidental and contingent processing of contextual cues after HPC/DG lesions.