In today's highly competitive and rapidly evolving business environment, optimizing supply chain management (SCM) has become a critical imperative for organizations aiming to enhance operational efficiency, reduce costs, and improve customer satisfaction. SAP S/4HANA, a next-generation enterprise resource planning (ERP) suite, offers a comprehensive and integrated platform for streamlining and modernizing SCM processes. This review explores the strategic business models and solutions facilitated by SAP S/4HANA, focusing on its impact on various facets of supply chain operations, including procurement, manufacturing, logistics, and inventory management. The implementation of SAP S/4HANA enables organizations to leverage advanced analytics, real-time data processing, and intelligent automation to optimize supply chain functions. By providing a unified view of supply chain activities, SAP S/4HANA enhances visibility, enabling proactive decision-making and fostering a more responsive and agile supply chain. Key features such as predictive analytics and machine learning algorithms facilitate demand forecasting and inventory optimization, reducing the risk of stockouts and overstock situations. Furthermore, SAP S/4HANA supports the integration of Internet of Things (IoT) technologies, allowing for real-time monitoring of assets and operations. This connectivity enhances the ability to manage logistics and transportation more efficiently, reducing lead times and improving delivery performance. The platform's ability to harmonize data from various sources also aids in supplier collaboration, ensuring better alignment with suppliers' capabilities and enhancing the overall supply chain resilience. Strategic business models enabled by SAP S/4HANA include just-in-time (JIT) production, which minimizes inventory costs, and demand-driven replenishment, which aligns production schedules with actual customer demand. Additionally, the adoption of digital twin technology within SAP S/4HANA allows for virtual modeling and simulation of supply chain scenarios, facilitating strategic planning and risk management. In conclusion, SAP S/4HANA provides a robust foundation for optimizing supply chain management through its advanced technological capabilities and integrated approach. Organizations adopting SAP S/4HANA can achieve significant improvements in supply chain efficiency, agility, and resilience, positioning themselves for sustained competitive advantage in the dynamic global market. This exploration highlights the transformative potential of SAP S/4HANA in redefining supply chain strategies and operational excellence.