Process Of Human Development Research Articles

Older Adult Education in the Context of Psychological Theories of Ageing

In gerontology, the essence of ageing is traditionally equated with decline and degradation, it is considered a purposeful process of loss of the body's adaptive capacity. Psychologists, in particular representatives of behaviorism, deny this position, instead they consider ageing to be an integral part of the general process of human development. Theories of ageing have progressed from focusing on individuals’ declines and losses in later phase of their life course to considering ageing as a continuous process of human development. Psychological theories of ageing are crucial to understanding older adults as learners ‒ their needs, abilities, motivation of learning and expectations from educational activity. They help us to develop comprehensive approaches to building an effective educational environment and improving the learning process of that age and social group aiming to adapt that environment to the needs of older adult learners. The article analyzes the main provisions of psychological theories of ageing, which substantiate the importance and even the necessity of involving older adults in educational activities, because firstly, mental activity contributes to the preservation and even development of a person’s intellectual capabilities until old age; secondly, in older people (compared to young people), changes in the ability to learn are insignificant and relate rather to the sphere of perception, attention, motivation, and the physiological state of the body; and thirdly, older people have a growing need for a sense of security, which has a significant impact on their quality of life and is largely realized through communication and learning activities. Based on the main tenets of psychological theories of ageing, in our research we consider older adults as a resource and human capital. We believe that the approach to the problem of ageing and old age from the resource perspective, which is based on the ideas of theories of activity and lifelong personality development, allows us to justify the need for education of older adults and is the basis of educational gerontology.

Graspot: a graph attention network for spatial transcriptomics data integration with optimal transport.

Spatial transcriptomics (ST) technologies enable the measurement of mRNA expression while simultaneously capturing spot locations. By integrating ST data, the 3D structure of a tissue can be reconstructed, yielding a comprehensive understanding of the tissue's intricacies. Nevertheless, a computational challenge persists: how to remove batch effects while preserving genuine biological structure variations across ST data. To address this, we introduce Graspot, a graph attention network designed for spatial transcriptomics data integration with unbalanced optimal transport. Graspot adeptly harnesses both gene expression and spatial information to align common structures across multiple ST datasets. It embeds multiple ST datasets into a unified latent space, facilitating the partial alignment of spots from different slices. Demonstrating superior performance compared to existing methods on four real ST datasets, Graspot excels in ST data integration, including tasks that require partial alignment. In particular, Graspot efficiently integrates multiple ST slices and guides coordinate alignment. In addition, Graspot accurately aligns the spatio-temporal transcriptomics data to reconstruct human heart developmental processes. Graspot software is available at https://github.com/zhan009/Graspot.

Bridging human resource development processes through generative Artificial Intelligence

AbstractThis editorial article examines how generative Artificial Intelligence (GAI) can bridge various human resource development (HRD) processes. As GAI adoption increases in human resources practices, understanding its potential to integrate different HRD activities becomes more important. The article reviews recent literature on Artificial Intelligence (AI) applications in HRD and explores GAI‐enabled links between key HRD processes. The linkages include data‐driven decision‐making, real‐time skill gap analysis, job crafting with GAI, GAI‐supported personalized development plans, GAI‐powered employee sentiment analysis, GAI chatbots, GAI‐enabled virtual reality simulations, and GAI‐supported social network analysis in talent and organization development contexts. By highlighting these GAI‐enabled interconnections, the article provides insights into a more integrated approach to HRD. It also discusses implications for HRD practitioners and researchers, analyzing specific applications of GAI in HRD and recommending future research.

The conceptus and its parts: o ntogenetic recapitulation in early human development.

Our understanding of the processes of human development that occur during and just after implantation is still incomplete. The anatomical studies by Erich Blechschmidt (1904-1992) at the University of Göttingen demonstrate the uniqueness and beauty of the early stages of individual human development or ontogeny. The interpretations of human embryology by Blechschmidt offer a simple unifying hypothesis: metabolic and biomechanical events are repeated, and this can be described as an ontogenetic recapitulation. This commentary provides a rationale for using some older terms and introducing new ones in the description of early human development. The product of conception is a conceptus; the outer part of the conceptus is the ectoblast and everything inside is the endoblast; the endocyst arises in the endoblast when the future amniotic fluid is forming. The human embryo arises from the innermost part of the endocyst. Terms such as morula, gastrula, and cyema, which are imported from zoology and ignore the role of the zona pellucida and constrained fluid compartments in the conceptus, can be avoided.

Boolean Network Models of Human Preimplantation Development.

Single-cell transcriptomic studies of differentiating systems allow meaningful understanding, especially in human embryonic development and cell fate determination. We present an innovative method aimed at modeling these intricate processes by leveraging scRNAseq data from various human developmental stages. Our implemented method identifies pseudo-perturbations, since actual perturbations are unavailable due to ethical and technical constraints. By integrating these pseudo-perturbations with prior knowledge of gene interactions, our framework generates stage-specific Boolean networks (BNs). We apply our method to medium and late trophectoderm developmental stages and identify 20 pseudo-perturbations required to infer BNs. The resulting BN families delineate distinct regulatory mechanisms, enabling the differentiation between these developmental stages. We show that our program outperforms existing pseudo-perturbation identification tool. Our framework contributes to comprehending human developmental processes and holds potential applicability to diverse developmental stages and other research scenarios.

In vitro modeling of skeletal muscle ischemia-reperfusion injury based on sphere differentiation culture from human pluripotent stem cells

Skeletal muscle ischemia-reperfusion (IR) injury poses significant challenges due to its local and systemic complications. Traditional studies relying on two-dimensional (2D) cell culture or animal models often fall short of faithfully replicating the human in vivo environment, thereby impeding the translational process from animal research to clinical applications. Three-dimensional (3D) constructs, such as skeletal muscle spheroids with enhanced cell-cell interactions from human pluripotent stem cells (hPSCs) offer a promising alternative by partially mimicking human physiological cellular environment in vivo processes. This study aims to establish an innovative in vitro model, human skeletal muscle spheroids based on sphere differentiation from hPSCs, to investigate human skeletal muscle developmental processes and IR mechanisms within a controlled laboratory setting. By eticulously recapitulating embryonic myogenesis through paraxial mesodermal differentiation of neuro-mesodermal progenitors, we successfully established 3D skeletal muscle spheroids that mirror the dynamic colonization observed during human skeletal muscle development. Co-culturing human skeletal muscle spheroids with spinal cord spheroids facilitated the formation of neuromuscular junctions, providing functional relevance to skeletal muscle spheroids. Furthermore, through oxygen-glucose deprivation/re-oxygenation treatment, 3D skeletal muscle spheroids provide insights into the molecular events and pathogenesis of IR injury. The findings presented in this study significantly contribute to our understanding of skeletal muscle development and offer a robust platform for in vitro studies on skeletal muscle IR injury, holding potential applications in drug testing, therapeutic development, and personalized medicine within the realm of skeletal muscle-related pathologies.

VITAL A FISH: A CRITICAL REVIEW OF ZEBRAFISH MODELS IN DISEASE SCENARIO AND CASE REPORTS SCREENS

ABSTRACT Virtually every major medical advance of the last century and at still has depended upon research with animals. Zebrafish's journey from the ocean to the laboratory leads to major scientific breakthroughs. Transparency structure of zebrafish helps in monitoring their internal structures and are permitting scientist to see effectes of nano particles in fish. Their organs share the same main features as humans and so can be used to study human developmental processes. Zebrafish congruence 70% of their genes with humans, and 84% of ailment-depended genes have zebrafish congruence. The zebrafish embryos can also genetically modified. Certain fishes like zebrafish are able to regenerate damaged retinal nerve cells. Müller galia cells in retina of zebrafish can transform in response to injury and act like stem cells to regrow the retina and replace all damaged neurons. Though humans have the same exact Müller galia cell, they don’t respond to damaged in the same way. Zebrafish are also very responsive to having their genomes edited. Zebrafish regenerate some tissue such as heart in during larval stage. In additionaly zebrafish are used as an animal model to study pharmocology – how drugs work and what they do to an organism’s body. Aim of this review, here, we review current knowledge of how these specialized structures and model organism by focusing on cellular behaviors and molecular mechanisms, highlighting findings from in vivo models and briefly discussing the recent advances in tissue cell culture and organoids. Review discusses the applications of human organoids models of disease on model organism and outlines the ailment treatments.

MATERNAL BREAST MILK AND ITS COMPOSITION FROM THE PERSPECTIVE OF RATIONAL FEEDING OF THE CHILD

MATERNAL BREAST MILK AND ITS COMPOSITION FROM THE PERSPECTIVE OF RATIONAL FEEDING OF THE CHILD

MANAJEMEN SUMBER DAYA MANUSIA DI KANTOR KECAMATAN KANGAYAN

HR (Human Resources) development in sub-district offices refers to efforts to improve the quality, capacity and performance of employees working at the sub-district level. HR development is a strategic process that involves various activities and programs to strengthen the capabilities of individuals, teams and the organization as a whole. The aim is to improve efficiency, effectiveness and services provided to the community. Human resources are one of the most important assets for an organization/company. The role of human resources for organizations/companies is not only seen from the results of work productivity but also seen from the quality of work produced, even further, the superiority of an organization/company is also determined by the superiority of its human competitiveness, not determined by its natural resources. The stronger the knowledge of human resources, the stronger the company's competitiveness. Improving the quality of human resources, and therefore, this paper draws a conclusion, namely "Human Resource Management in the Kangayan District Office". Based on the introduction outlined above, the problem formulation that can be taken is how to manage and empower existing human resources in the Kangayan sub-district office so that it has benefits and functions even though the existing human resources are very limited, it can be achieved through the human resource development process, Human Resource Management (HRDM) is very closely related to HR in an organization or company. HRM itself has many benefits and functions and is useful in managing and empowering existing human resources who are planning to join an organization or company.

PENGEMBANGAN KUALITAS SUMBER DAYA MANUSIA MELALUI PROGRAM INSERVICE TRAININGDI SMK ANNUR FATMAH TRAWAS MOJOKERTO

Low human resources in schools is a problem that often occurs, causing a major impact on the quality of education implementation. To overcome this, it is necessary to develop human resources through in-service training programs which are the right and effective solution to overcome this problem. This research aims to reveal the challenges and opportunities as well as strategies in developing human resources at Annur Fatmah Trawas Vocational School, Mojokerto. This research uses a qualitative approach with data collection techniques through interviews, documentation and observation. The data sources used were school principals, teaching staff and educational staff at Annur Fatmah Trawas Vocational School, Mojokerto. The research results show that there are challenges faced in implementing inservice training such as lack of motivation, limited time, and lack of preparation. However, there are also opportunities that can be utilized, such as support from superiors, competent presenters and supporting facilities. Apart from participating in training at school, teaching and education staff also carry out informal self-development. The human resource development process through the inservice training program is carried out in several steps, namely identifying needs, program design, program implementation and evaluation. In this way, teaching and education staff experience benefits such as increasing insight, abilities, skills, and increasing adaptability. So that the inservice training program provides real benefits, which have an important role in improving the quality of education.

Restructuring of human resource development in IIT libraries of North India in new digital era

Purpose The purpose of this paper is to examine the restructuring of human resources development processes in Indian Institutes of Technology (IIT) libraries in North India, emphasizing the essential information and communications technology (ICT) skills for both recruits and existing staff. Design/methodology/approach The study used a survey research design, with two different sets of structured questionnaires used to collect data. The first set, which was distributed to all heads of seven IIT libraries in North India, received a 100% response rate. Simultaneously, the second set was distributed to library users, yielding a 92% response rate (680 responses out of 700 distributed). The collected data were analyzed and tabulated, with suitable interpretations. Findings The findings of the study reveal that all examined libraries have implemented skill development programs. Moreover, advanced ICT skills are considered essential for staff appointments, and specific institutes (IIT Kanpur, IIT Delhi, IIT Jodhpur and IIT Ropar) took the initiative to provide ICT training to their employees. Trained employees exhibited enhanced performance, attributed to advanced ICT knowledge. The study suggests restructuring selection criteria and introducing structured ICT training programs for library staff, ensuring a more adept workforce for current demands. Research limitations/implications The study can increase the impact globally on human resource development by incorporating soft skills, job satisfaction and leadership development while exploring research opportunities through cross-institutional comparisons and the integration of emerging technologies such as artificial intelligence and virtual reality. Originality/value This study collected primary data from IIT libraries in North India using self-designed questionnaires. The findings provide useful insights into how libraries might restructure human resource development in the digital age.

Centering healthcare workers in digital health design: Usability and acceptability of two-way texting to improve retention in antiretroviral therapy in a public HIV clinic in Lilongwe, Malawi.

New initiates on antiretroviral therapy (ART) are at high risk of treatment discontinuation, putting their health at risk. In low- and middle-income countries, like Malawi, appropriate digital health applications (apps) must fit into local clinic, connectivity and resource constraints. We describe the human centered design (HCD) and development process of an open-source, hybrid, two-way texting (2wT) system to improve ART retention. We detail the critical role of diverse healthcare workers (HCWs) in the HCD process to inform app usability, create buy-in, and ensure appropriate optimization for the local context. We optimized 2wT usability and acceptability over three HCD phases: 1) informal feedback sessions with diverse 2wT stakeholders, 2) a small pilot, and 3) key informant interviews. Phase one included four sessions with diverse HCWs, including "expert ART clients", clinical, technical, supervisory, and evaluation teams to inform 2wT design. In phase 2, a small pilot with 50 participating ART clients aimed to inform implementation improvement. Phase three included interviews with ten HCWs to deepen understanding of 2wT acceptability and usability, documenting strengths and weaknesses to inform optimization. Multi-phase feedback sessions with HCWs helped refine 2wT language and message timing for both weekly and tailored client-specific visit reminders. The pilot led to improvements in educational materials to guide client responses and ease interaction with HCWs. In interviews, the HCWs appreciated the HCD co-creation process, suggested ways to increase access for low-literacy clients or those without consistent phone access, and felt integrating 2wT with other eHealth platforms would improve scalability. Inclusion of HCWs across phases of HCD design, adaption, and optimization increased 2wT usability and acceptability among HCWs in this setting. Engaging HCWs into 2wT co-ownership from inception appears successful in co-creation of an app that will meet HCW needs, and therefore, enhance support for 2wT clients to attend visits and remain in care.

Does geopolitical risk impact sustainable development? A perspective on linkage between geopolitical risk and sustainable development research

The impact of the geopolitical crisis radiates into the area of sustainable development, it has become a major challenge hindering the process of sustainable human development. Thorough research is necessary to determine how global geopolitical concerns affect sustainable development. Based on the methodology and paradigm of bibliometrics, this study incorporated the research of geopolitical influences on sustainable development into the analytical framework, creating and comparing structural changes in the field before and after the outbreak of the Russia-Ukraine conflict, and systematic basic research using data from relevant publications included in Web of Science core collection. The results indicate that the study of geopolitical influences on sustainable development has attracted widespread interest among scientists and that the number of publications on the subject has been on the rise, Environmental Sciences Ecologic have become the most dominant subject in the research field of the topic. The geographical distribution of publications shows that developed countries have more publications in this field. The evolution of the dynamics of international collaboration reveals heterogeneity in the patterns of country and author collaboration before and after the outbreak of the Russia-Ukraine conflict, a decrease in the clustering of country collaboration, and the replacement of the United States by China as the country with the highest intensity of collaboration after the Russia-Ukraine conflict, and author collaboration networks show a lack of high-impact author groups in the subject. Thematic clustering results reveal that geopolitical risks have influenced economic, social, and environmental sustainability, which include impacts on economic development, energy security, global supply chains, the water environment, and many others. At the end of the article, relevant suggestions are proposed for achieving sustainable development goals under geopolitical threats.

Penerapan Barthel Index Terhadap Tingkat Kemandirian Aktivitas Harian Lansia Jamaah Lansia Masjid KH. Ahmad Dahlan Banjarmasin

Elderly is a process of human growth and development does not occur suddenly, namely developing from infants to become elderly. Everyone's physique and behavior changes when they reach a certain age is normal. Elderly is the end of the aging process that has reached the age of 60 and over. As we get older, organ function decreases with age, which has an impact on the ability of the elderly to carry out Activity of Daily Living (ADL). This study will be held on October 22, 2023 at the KH Ahmad Dahlan Mosque Jl. S.Parman, North Belitung, West Banjarmasin District, Banjarmasin City. The purpose of this study is to determine the level of independence of the elderly using the Barthel Index measurement tool through the Question and Answer method. According to the results of the discussion, it can be concluded that the level of independence of the elderly in the independent category is at a good health level in accordance with the results of the study conducted on the elderly congregation of the KH. Ahmad Dahlan Mosque. The results of this service are also expected by all participants to maintain the quality of the ADL that they have done.

Management of the Potential of Silalahi III Tourism Village, Silahisabungan District, Dairi Regency

The aim of this research is to analyze village management as well as supporting and inhibiting factors in the management of potential Silalahi III tourism villages, Silahisabungan sub district, Dairi district, North Sumatra province. The method used in this research is descriptive qualitative research method. The data collection technique in this research is a data collection method in a way that can be used by researchers to collect data according to Riduan (2010:51). The results of research on the potential management of cultural villages as villages in Dairi Regency show that the 5 management functions according to Hendry Fayol, namely Planning, Organizing, Commanding, Coordinating and Controlling, are the initial and important steps. for the human resource development process in Silalahi III village as a cultural tourism village that has been recognized by the regent, so it is hoped that this tourism village can develop and be sustainable. As a result, the main obstacle is human resources being the main reason. The government needs to develop local culture and wisdom, both tangible and intangible, as a trigger for community economic development, especially in the Silalahi III Culture village.

STEM Learning Model’s Impact on Enhancing Critical Thinking Skills and Motivation: A Literature Review

The rapid pace of societal advancement necessitates a robust educational foundation to ensure individuals can effectively navigate and contribute to contemporary developments with their skill sets. Education plays a pivotal role in human development, influenced by a range of internal and external factors, all of which are crucial considerations for optimizing the human development process. Quality education is characterized by its ability to impart critical thinking skills and foster a motivation to learn among its students. STEM (Science, Technology, Engineering, and Mathematics) represents a pedagogical model that supports the cultivation of these skills and motivations. By integrating multiple disciplines into a cohesive framework, STEM aims to produce graduates who are competent and equipped for the challenges of the modern world. This literature review provides a systematic examination and discussion of the theoretical and conceptual underpinnings of STEM, critical thinking skills, and learner motivation. The evidence suggests that STEM is highly effective in enhancing students' critical thinking abilities and their eagerness to engage in learning, thus establishing it as a valuable educational approach.

A Study on the Constraints faced by the Vegetable Growers in Mallawan Block of Hardoi District in Uttar Pradesh, India

Training is the analytical process for human resource development as well as also playsan essential role in hastening of particular attitude among human behaviours. Moreover, training is a tool for accomplishingintervention of thelevel of human resource, that becomesincreasingly and pivotalfor the development substantially in all fields with an extending satisfaction in technology. The present investigation was aimed to observe the constraints faced by the vegetable growers in the production of vegetable cultivation. The data of constraints were assembled and analysed by using Garret’s ranking methodology to develop a quantitative position of each constraint. Likewise, data findings were showed that thevegetable growersfacedtechnological, resource, market and miscellaneous constraints. Among technological constraints, lack of knowledge about improved varieties, seed rate including sowing time were prominent. Similarly,regarding resource constraints, high costs of pesticides were more dominant. Furthermore, in case of market constraints, non- remunerative price and poor marketing facilities results, high risk which wasdominant. And last one is miscellaneous constraint, non-availability of labour during peak season and high wages. Therefore, numerous field level constraints faced by the vegetable growers had been recognized as well as categorized into the circumstances for training needs.

The role of biorhythms in ensuring human life activities and their effects on the mental and physical activity of students

Annotation. In the modern world, more and more people are interested in their health and are looking for ways to improve their quality of life. One of them is the study of biorhythms and their influence on human health. Biorhythms are cyclic physiological processes that occur in our body, and they can have an important impact on our physical and mental health.
 Human biological rhythms are interesting primarily because the maximum and minimum activity of various biological processes do not coincide in time. Of all the cycles found in humans, the most studied was the daily cycle as the main one. The biological clock, triggered by the change of day and night, carries about 50 rhythms that change their characteristics from day to night. All body rhythms are subject to hierarchical dependence — they are divided into leading (main) and subordinate. The biorhythms of the central nervous system are leading. The reason for their «leadership» is clear: they are responsible for communication with the surrounding environment, the safety of the organism depends on the degree of their readiness and ability to respond adequately to the influence of the environment.
 The study aims to determine the impact on human biorhythms for physical training for improvement of the educational process during physical education lessons.
 This paper considers the classification and characterization of human morphology, basic biorhythms of living organisms, including the process of human development in all aspects of life.
 The subject of research is the influence of biorhythms on the formation of human development. Attention is also paid to physical, physiological, genetic, intellectual, emotional, psychological, social adaptive stages and meanings, mechanisms of regulation; as well as – disorders of biorhythms, methods of treatment and prevention.

Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route.

The sympathetic nervous system (SNS) is a crucial branch of the autonomic nervous system (ANS) that is responsible for regulating visceral function and various physiological processes. Dysfunction of the SNS can lead to various diseases, such as hypertension and metabolic disorders. However, obtaining sympathetic neurons from human tissues for research is challenging. The current research aimed at recapitulating the process of human sympathetic neuron development and achieved the successful establishment of a stepwise, highly efficient in vitro differentiation protocol. This protocol facilitated the generation of functional and mature sympathetic neurons from human pluripotent stem cells (hPSCs) using a chemical-defined induction medium. Initially, each differentiation stage was refined to derive sympathoadrenal progenitors (SAPs) from hPSCs through neural epithelial cells (NECs) and trunk neural crest stem cells (NCSCs). hPSC-derived SAPs could be expanded in vitro for at least 12 passages while maintaining the expression of SAP-specific transcription factors and neuronal differentiation potency. SAPs readily generated functional sympathetic neurons (SymNs) when cultured in the neuronal maturation medium for 3-4 weeks. These SymNs expressed sympathetic markers, exhibited electrophysiological properties, and secreted sympathetic neurotransmitters. More importantly, we further demonstrated that hPSC-derived SymNs can efficiently regulate the adipogenesis of human adipose-derived stem cells (ADSCs) and lipid metabolism in vitro. In conclusion, our study provided a simple and robust protocol for generating functional sympathetic neurons from hPSCs, which may be an invaluable tool in unraveling the mechanisms of SNS-related diseases.

Plant fiber‐reinforced composites based on injection molding process: Manufacturing, service life, and remanufacturing

AbstractResource depletion and environmental degradation have become important issues affecting the human development process. Plant fiber‐reinforced composites (PFRCs) are characterized by high natural availability, good mechanical properties, low density, recyclability, and eco‐friendliness. Expanding human applications of plant fibers is an important measure to combat resource and environmental problems. The injection molding process has the characteristics of strong product size adaptability, high molding precision, and high production efficiency. It is suitable for large‐scale production in the industry and is one of the main molding methods of PFRCs. Currently, there are still challenges and opportunities for high‐performance manufacturing of PFRCs based on the injection molding process. This article reviews the complete process of manufacturing‐service life‐remanufacturing of PFRCs based on the injection molding process. Emphasis is placed on the pretreatment technology and selection strategy of multi‐phase blended raw materials, the molding process conditions, functional applications, and simulation analysis, the aging and degradation characteristics during service, and the remanufacturing characteristics of the composites. Finally, the future research focus is summarized and prospected. The research in this paper will help promote the continuous progress of key technologies in the production process of PFRCs and help the industry to truly realize high‐performance green manufacturing in the future.Highlights Plant fibers exhibit variability in morphology and properties. The link between the structure and performance of PFRCs is unclear. The degradability and durability of PFRCs are contradictory. The functionality and mechanical properties of PFRCs are contradictory. PFRCs have good characteristics for remanufacturing.