Process Parameters For Synthesis Research Articles

Improvement of End-of-Synthesis Radiochemical Purity of 177Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization

Background: Radiochemical purity is a key criterion for the quality of radiopharmaceuticals used in clinical practice. The joint improvement of analytical methods capable of identifying related radiochemical impurities and determining the actual radiochemical purity, as well as the improvement of synthesis methods to minimize the formation of possible radiochemical impurities, is integral to the implementation of high-tech nuclear medicine procedures. PSMA-targeted radionuclide therapy with lutetium-177 has emerged as an effective treatment option for prostate cancer, and [177Lu]Lu-PSMA-617 and [177Lu]Lu-PSMAI&T have achieved global recognition as viable radiopharmaceuticals. Recently, it was shown that specific radiochemical impurities can form during the synthesis of [177Lu]Lu-PSMA-617 because of a spontaneous, thermally mediated condensation of the Glu-C(O)-Lys fragment, resulting in the formation of three different cyclic forms (with no affinity for PSMA). During this study, we identified another impurity, a product of detachment of the Glu-CO fragment from PSMA-617, caused by heating. The total content of all four thermally mediated degradation products may reach 9–11% during classical incubation for 30 min at 95 °C, reducing the radiochemical purity to an unacceptable level (albeit with high levels of radiochemical conversion). It is reasonable to assume that the formation of similar impurities is characteristic of all PSMA-specific vectors that contain Glu-C(O)-Lys pharmacophores. Because the formation of these impurities directly depends on the temperature and incubation time, to reduce their content in the reaction mixture at the end of the synthesis, it is necessary to select conditions to achieve a high level of radiochemical conversion for the minimum possible time and/or at the minimum sufficient temperature. Methods: In this study, using [177Lu]Lu-PSMA-617 as an example, we evaluated the efficiency of alternative methods of synthesis with microwave heating and co-solvent (ethanol) addition to ensure radiochemical yield and radiochemical purity in the shortest possible time and at the minimum necessary and sufficient synthesis temperature. Results: Both approaches achieved a significant reduction in the impurities content, while achieving satisfactory synthesis yields in a short time. In addition to improving the synthesis parameters and radiochemical purity, the use of microwave heating and the addition of ethanol reduces the negative influence of other auxiliaries on labeling kinetics. Notably, the addition of ethanol under certain conditions allowed [177Lu]Lu-PSMA-617 to be synthesized at room temperature for only 10 min. This makes it possible to achieve exceptionally high real radiochemical purity of the preparations, determined only by the quality of the original precursor. The approaches considered in this study can be successfully applied to improve the synthesis process and quality parameters of the finished product, both for known radiopharmaceuticals and for those under development.

Role of synthetic process parameters of nano-sized cobalt/nickel oxide in controlling their structural characteristics and electrochemical energy performance as supercapacitor electrodes

The synthesis of nano-sized bimetallic Cobalt/Nickel oxides (Ni1.5Co1.5O4) with a 1:1 Co/Ni atomic ratio has been achieved using a surfactant-free co-precipitation/hydrothermal process. The growth mechanism of Cobalt/Nickel oxides Ni1.5Co1.5O4 is elucidated by tuning the synthesis process parameters, including co-precipitation pH and hydrothermal time. The formation of Cobalt/Nickel oxides Ni1.5Co1.5O4 oxide began with the nucleation of cobalt nickel hydroxide nanoplates through the co-precipitation process, followed by dissolution-recrystallization, stacked hexagonal nano-flakes, and a flower-like microstructure. The electrochemical performances of the oxides were evaluated, with the largest surface area observed at pH 9 being the main factor for the best super-capacitive performance. As hydrothermal time increased, the structural directing growth forward, resulted in the formation of a nano-flower structure with a larger surface area. The as-prepared cobalt nickel oxide exhibited a maximum specific capacitance value of 525.5 F g-1 at a current density of 1 A g-1 and energy and power densities of 88.2 WhKg-1 and 606 WKg-1, respectively.

Anti-solvent materials enhanced structural and optical properties on ambiently fabricated perovskite thin films

Perovskite solar cells (PSCs) hold potential for low-cost, high-efficiency solar energy, but their sensitivity to moisture limits practical application. Current fabrication requires controlled environments, limiting mass production. Researchers aim to develop stable PSCs with longer lifetimes under ambient conditions. In this research work, we investigated the stability of perovskite films and solar cells fabricated and annealed in natural air using four different anti-solvents: toluene, ethyl acetate, diethyl ether, and chlorobenzene. Films (about 300 nm thick) were deposited via single-step spin-coating and subjected to ambient air-atmosphere for up to 30 days. We monitored changes in crystallinity, electrical properties, and optics over time. Results showed a gradual degradation in the films’ crystallinity, morphology, and electro-optical properties. Notably, films made with ethyl acetate exhibited superior stability compared to other solvents. These findings contribute to advancing stable and high-performance PSCs manufactured under normal ambient conditions. In addition, we also discuss the possible machine learning (ML) approach to our future work direction to optimize the materials structures, and synthesis process parameters for future high-efficient perovskite solar cells fabrication.

The investigation of mechanism isoniazid adsorption onto cassia fistula-based activated carbon

The utilization of activated carbon as an efficient adsorbent is well-established, driven by its porous structure and expansive surface area. This study investigates the potential of Cassia fistula (Golden shower) as a precursor for activated carbon synthesis using K2CO3 activation, leveraging its organic properties known for high porosity and adsorption capacity. This research aims to investigate the feasibility of utilizing Cassia fistula-derived activated carbon (GSAC) for isoniazid removal from water. The study encompasses a two-step activation process—chemical and physical—with varying parameters to optimize surface area and porosity. The carbonization process involves hydrothermal and pyrolysis techniques with controlled conditions. The temperature used in this study is based on the TGA analysis to examine its thermal stability. Batch experiments examine the adsorption equilibrium and kinetics of isoniazid onto GSAC samples, revealing high adsorption capacity and rapid equilibrium attainment by GSAC 1:1 (700°C). The study culminates in the identification of a strong chemical bond between GSAC and isoniazid, implying efficient adsorption potential as confirmed by FTIR and SEM analysis before and after adsorption. The adsorption characteristic is examined with an isotherm and kinetic model. The highest predicted GSAC capacity reaches 219,807 mg/g, emphasizing its promising adsorption capabilities. This work underscores Cassia fistula-based activated carbon as a viable, cost-effective, and eco-friendly adsorbent for isoniazid removal, with implications for diverse applications. The synthesis process parameters, activation methods, and insights into the adsorption mechanism contribute to the understanding of effective adsorbent production and enhance the potential of activated carbon for various industrial contexts.

Synthesis, Optimization and Molecular Self-Assembly Behavior of Alginate-g-Oleylamine Derivatives Based on Ugi Reaction for Hydrophobic Drug Delivery.

To achieve the optimal alginate-based oral formulation for delivery of hydrophobic drugs, on the basis of previous research, we further optimized the synthesis process parameters of alginate-g-oleylamine derivatives (Ugi-FOlT) and explored the effects of different degrees of substitution (DSs) on the molecular self-assembly properties of Ugi-FOlT, as well as the in vitro cytotoxicity and drug release behavior of Ugi-FOlT. The resultant Ugi-FOlT exhibited good amphiphilic properties with the critical micelle concentration (CMC) ranging from 0.043 mg/mL to 0.091 mg/mL, which decreased with the increase in the DS of Ugi-FOlT. Furthermore, Ugi-FOlT was able to self-assemble into spherical micellar aggregates in aqueous solution, whose sizes and zeta potentials with various DSs measured by dynamic light scattering (DLS) were in the range of 653 ± 25~710 ± 40 nm and -58.2 ± 1.92~-48.9 ± 2.86 mV, respectively. In addition, RAW 264.7 macrophages were used for MTT assay to evaluate the in vitro cytotoxicity of Ugi-FOlT in the range of 100~500 μg/mL, and the results indicated good cytocompatibility for Ugi-FOlT. Ugi-FOlT micellar aggregates with favorable stability also showed a certain sustained and pH-responsive release behavior for the hydrophobic drug ibuprofen (IBU). Meanwhile, it is feasible to control the drug release rate by regulating the DS of Ugi-FOlT. The influence of different DSs on the properties of Ugi-FOlT is helpful to fully understand the relationship between the micromolecular structure of Ugi-FOlT and its macroscopic properties.

Optimization of Chitosan Synthesis Process Parameters to Enhance PES/Chitosan Membrane Performance for the Treatment of Acid Mine Drainage (AMD).

Acid mine drainage (AMD) is an environmental issue linked with mining activities, causing the release of toxic water from mining areas. Polyethersulphone (PES) membranes are explored for AMD treatment, but their limited hydrophilicity hinders their performance. Chitosan enhances hydrophilicity, addressing this issue. However, the effectiveness depends on chitosan's degree of deacetylation (DD), determined during the deacetylation process for chitosan production. This study optimized the chitin deacetylation temperature, alkaline (NaOH) concentration, and reaction time, yielding the highest chitosan degree of deacetylation (DD) for PES/chitosan membrane applications. Prior research has shown that high DD chitosan enhances membrane antifouling and hydrophilicity, increasing contaminant rejection and permeate flux. Evaluation of the best deacetylation conditions in terms of temperature (80, 100, 120 °C), NaOH concentration (20, 40, 60 wt.%), and time (2, 4, 6 h) was performed. The highest chitosan DD obtained was 87.11% at 80 °C, 40 wt. %NaOH at 4 h of chitin deacetylation. The PES/0.75 chitosan membrane (87.11%DD) showed an increase in surface hydrophilicity (63.62° contact angle) as compared to the pristine PES membrane (72.83° contact angle). This was an indicated improvement in membrane performance. Thus, presumably leading to high contaminant rejection and permeate flux in the AMD treatment context, postulate to literature.

Response surface study on continuous supercritical hydrothermal synthesis of nano-zirconia: Scale-up from laboratory to industrialization

Commercial interest in nanomaterials and their applications lead to the development of many new methods for mass production. Among them, supercritical hydrothermal synthesis (SCHS) is a highly efficient and environmental-friendly technology. In this work, an advanced industrialized device for SCHS was used to verify the synthesis of nano-zirconia particles. The influencing laws and mechanisms of different material parameters (precursor type, precursor concentration, and pH) and process parameters (reaction temperature, reaction pressure, residence time, and Reynolds number) of nano-zirconia synthesis were studied. For the first time, the state changes of zirconium precursors and the precipitation behavior of nano-zirconia particles were in-situ observed by a high-speed camera. Central composite design (CCD) of response surface methodology (RSM) was adopted to investigate interactive effects of reaction temperature (200–420 °C), reactant concentration (0.01–0.6 mol L−1), alkali ratio (0–5) and flow rate (3–15 mL min−1), with particle size (APS), crystal form ratio (k) and reactant conversion rate (α) serving as response values. The influence of key process parameters follows an order of reaction concentration > reaction temperature > system flow > alkali ratio for APS, alkali ratio > system flow > reaction temperature > reaction concentration for k, and reaction temperature > alkali ratio > system flow > reaction concentration for α, respectively. The optimal process parameters were then obtained and further verified at lab and industrial scale. Zirconia powders with particle sizes of 4.98 nm and 8.74 nm were synthesized, respectively, indicating five hundred times magnification of continuous SCHS of nano zirconia from laboratory to industrialization.

Humidity Diode Sensors Based on 1D Nanosized Silicon Structures

Introduction. Humidity measurement is essential in microelectronics, aerospace, biomedical, and food industries, as well as in households for climate control. Currently, various types of devices have been used as humidity sensors: capacitive, resistive, diode, gravimetric, optical structures, field-effect transistors and devices based on surface acoustic waves.Problem Statement. Today, there is a need to develop IC-compatible humidity sensors that have high sensitivityand low cost. To this end, silicon nanowires have been successfully used in resistive and capacitive humidity sensors. However, there is a lack of research on the nanowire effect on device parameters of diode-type humidity sensors.Purpose. To develop diode sensors based on silicon nanowires and to determine the effect of process parameters of synthesis and structural features of nanowires on the performance of humidity sensors.Materials and Methods. The process of sensor fabrication includes several steps: chemical cleaning of silicon wafer, synthesis of silicon nanowires using standard or modified metal-assisted chemical etching, phosphorus diffusion to create a p-n junction, front and back metallization. The surface morphology of the nanostructures has been studied by scanning electron microscopy. The humidity-sensitive characteristics have been studied with theuse of salt hygrostats.Results. It has been shown that the addition of one-dimensional silicon nanostructures to the diode-type sensor signifi cantly improves its characteristics. The rectification ratio increases from 161 to 1807, the response ups from 4.5 to 25, the sensitivity grows from 1.6 to 4.02 (%RH)–1, while the response time and recovery time are reduced from 85/90 to 25/30 s, the hysteresis value goes down from 75 to 16%, the signal deviation after cycling drops from 15to 3%, and the signal fluctuation during continuous device operation decreases from 17 to 15%.Conclusions. The results have shown that the use of a simple and cheap nanowire synthesis technology is effective to produce humidity sensors.

Synthesis of grafted bromoisobutyryl esterified starch using electron transfer atom transfer radical polymerization method with high-performance adhesion and film properties

Nowadays, few investigations on the process parameters of grafted starch synthesized using electron transfer atom transfer radical polymerization (ARGET ATRP) and its applications in warp sizing and paper-making are presented. Therefore, this study aimed to survey the appropriate process parameters of bromoisobutyryl esterified starch-g-poly(acrylic acid) (BBES-g-PAA) synthesized by the ARGET ATRP, and also aimed to provide a new biobased BBES-g-PAA adhesive. The appropriate synthesis process parameters were 1.2, 0.32, and 0.6 in the molar ratios of vitamin C, CuBr2, and pentamethyldivinyltriamine to BBES, respectively, at 40 °C for 5 h. The BBES-g-PAA samples with a grafting ratio range of 4.63–14.14 % exhibited bonding forces of 57.8–64.6 N to wool fibers [55.5 N (BBES) and 53.8 N (ATS)], and their films showed breaking elongations of 3.29–3.80 % [2.74 % (BBES) and 2.49 % (ATS)] and tensile strengths of 29.1–25.4 MPa [30.4 MPa (BBES) and 34.7 MPa (ATS)]. Compared with BBES, significantly increased bonding forces and film elongations, and decreased film strengths for the BBES-g-PAA samples with grafting ratios ≥10.54 % were displayed (p < 0.05). The time (100–42 s) taken for the BBES-g-PAA films was significantly shorter than that of ATS (246 s) and BBES (196 s) films (p < 0.05), corresponding to better desizability.

Evaluation of an Ozone-Induced Free Radical Solution’s Characteristics and Its Efficacy as an Alternative Pest Control Method

In light of the environmental problems stemming from chemical pesticides, a preparation system for an ozone-induced free radical solution was developed to replace chemical pesticides for disease control. The effective synthesis process parameters for the solution under experimental conditions were determined through a single-factor experiment. The mechanism by which the solution eradicates pathogenic bacteria was investigated using electron microscopy, and a disease prevention and control experiment was conducted. Under slightly acidic conditions, the redox potential of the solution was observed to be high, with an air intake of 0.5 L/min and a liquid intake of 1.45 L/min, while the concentration decayed slowly, with a liquid intake of 0.98 L/min. The solution’s destructive effect on the bacteria’s internal and external structures intensified with prolonged action time and an increased number of free radicals. A 1.5 mg/L solution and 5% imidacloprid effectively reduced pest levels to grades 3 and 4, respectively. When the pH is 3, with air intake at 0.5 L/min and liquid intake at 0.98 L/min, the ozone-induced free radical solution exhibits strong oxidation and stability. At a concentration of 1.5 mg/L, the solution demonstrates a superior control effect on diseases and can partially replace chemical pesticides, offering a promising alternative for environmentally sustainable disease control.

Optimization of In-situ Synthesis Process Parameters of LiFePO4/C-MAF-5 Surface Modification for Conductivity Improvement of Lithium-ion Battery Cathode Material by Response Surface Method

Optimization of In-situ Synthesis Process Parameters of LiFePO4/C-MAF-5 Surface Modification for Conductivity Improvement of Lithium-ion Battery Cathode Material by Response Surface Method

Advances in phase change building materials: An overview

Abstract Efficient and sustainable thermal management of buildings is critical since the building sector is considered as the largest energy contributor contributing around 40% of the total energy consumption which is responsible for about 38% of greenhouse gas emission. Utilisation of phase-change material (PCM) in building energy systems can enhance the overall energy performance of buildings, thereby making drastic reduction in greenhouse gas emissions. The major shortcoming of organic PCM is their leakage problem; however, this can be overcome through the employment of either encapsulation or shape stabilisation technology. Numerous papers have prepared unlimited number of form stable PCMs for various applications ranging from textiles to thermal energy storage (TES); however, the factors to consider when selecting PCM for an intended application are not clear and the influence of synthesis techniques and processing parameters on the performance of stabilised PCM is yet to be understood. Also, majority of the publications have focused mainly on the encapsulation of paraffins for TES by employing different encapsulation techniques. Therefore, selecting a suitable technique for the synthesis of form stable PCM is the most challenging. This review aims at providing a comprehensive database addressing these issues, focusing mainly on PCMs, processing techniques, performance of encapsulated and composite PCMs, and phase change building materials prepared in previous studies, since this is the most critical information required to widen the potential usage of PCM technology in building applications. A concise summary of environmentally friendly poly(ethylene glycol)-based composite PCMs is also included.

Recovery of silver in the form of value-added spherical silver powder from spent Ag-Al2O3 catalyst by a novel clean method

The spent Ag-Al2O3 catalyst is an important silver secondary resource due to its high content of Ag. However, the most commonly used nitric acid leaching method produces toxic and harmful NOx gases. Herein, a novel clean method was proposed to treat the spent Ag-Al2O3 catalyst using the green leaching agent cerium ammonium nitrate instead of nitric acid to effectively avoid the generation of toxic NOx gases. More importantly, value-added monodisperse micro-sized uniform spherical particles were synthesized directly from the leaching solution by a simple chemical reduction method. The influence of leaching conditions on the leaching ratio of Ag and leaching kinetics were discussed in detail. The response surface methodology was applied to optimize the synthesis parameters of silver powder and explore the interactions between the synthesis process parameters. Under the optimal leaching parameters, the leaching ratio of Ag reached 99.69 %. The leaching kinetic analysis of leaching indicated that the leaching reaction of spent Ag-Al2O3 catalyst was controlled by chemical reaction. By the response surface methodology design, a fitted mathematical model of the particle size for silver powder and the optimum synthesis parameters of silver powder were obtained. The optimum synthesis parameters of silver powder were as follows: [Fe2+] = 1.08 mol/L, [Ag+] = 1.01 mol/L, and dispersant dosage of 2.05 wt%. The average experimental particle size of 1.337 μm was very close to the predicted value of 1.343 μm obtained from the fitted model, indicating that the fitted model of particle size for silver powders was very good. This process not only provides a clean and value-added method for recycling the spent Ag-Al2O3 catalyst, but also helps to promote the balanced and high-value utilization of high-abundance cerium.

The effect of synthesis conditions and process parameters on aerogel properties.

Aerogels are remarkable nanoporous materials with unique properties such as low density, high porosity, high specific surface area, and interconnected pore networks. In addition, their ability to be synthesized from various precursors such as inorganics, organics, or hybrid, and the tunability of their properties make them very attractive for many applications such as adsorption, thermal insulation, catalysts, tissue engineering, and drug delivery. The physical and chemical properties and pore structure of aerogels are crucial in determining their application areas. Moreover, it is possible to tailor the aerogel properties to meet the specific requirements of each application. This review presents a comprehensive review of synthesis conditions and process parameters in tailoring aerogel properties. The effective parameters from the dissolution of the precursor step to the supercritical drying step, including the carbonization process for carbon aerogels, are investigated from the studies reported in the literature.

Investigation and production of high purity lanthanum and barium hexaaluminate ceramic powders

This study presents synthesis of Lanthanum Hexaaluminate (LHA: LaAl11O18) and Barium Hexaaluminate (BHA: BaAl12O19) with co-precipitation (CP), wet impregnation (W) and solid-state routes with different sintering profiles and carbon templating route. The effect of different synthesis methods and process parameters was investigated on the % of hexaaluminate phase formation confirmed by XRD-Rietveld Refinement and BET surface area measurements with N2 physisorption. LHA with high purity of 95% was successfully prepared confirmed by Rietveld refinement of XRD analysis with a BET surface area of 2 m2/g through co-precipitation (CP) method when the powder was sintered at 1600 °C. Carbon templating increased the surface area to 50 m2/g at a sintering temperature of 1200 °C with a lower LHA content of 77%. It was observed that BHA could be formed at lower temperatures, at 1400 °C, compared to LHA.

Insights into the Effects of Co-Regulated Factors on Li1.3Al0.3Ti1.7(PO4)3 Solid Electrolyte Preparation: Sources, Calcination Temperatures, and Sintering Temperatures.

The ionic conductivity, phase components, and microstructures of LATP depend on its synthesis process. However, their relative importance and their interactions with synthesis process parameters (such as source materials, calcination temperature, and sintering temperature) remain unclear. In this work, different source materials were used to prepare LATP via the solid-state reaction method under different calcination and sintering temperatures, and an analysis via orthogonal experiments and machine learning was used to systematically study the effects of the process parameters. Sintering temperatures had the greatest effect on the total ionic conductivity of LATP pellets, followed by the sources and calcination temperatures. Sources, as the foundational factors, directly determine the composition of a major secondary phase of LATP pellets, which influences the whole process. The calcination temperature had limited impact on the ion conductivity of LATP pellets if pellets were sintered under the optimal temperature. The sintering temperature is the most important factor that influences the ion conductivity by eliminating most secondary phases and altering the microstructure of LATP, including the intergranular contact, grain size, relative densities, etc. This work offers a novel perspective to comprehend the synthesis of solid-state electrolytes beyond LATP.

Optimization of Sintering Temperature for the Synthesis of n-type Mg&lt;sub&gt;3&lt;/sub&gt;SbBi&lt;sub&gt;0.99&lt;/sub&gt;Te&lt;sub&gt;0.01&lt;/sub&gt; Thermoelectric Materials

Mg&lt;sub&gt;3&lt;/sub&gt;Sb&lt;sub&gt;2&lt;/sub&gt;-based materials are promising candidates to replace n-type Bi&lt;sub&gt;2&lt;/sub&gt;Te&lt;sub&gt;3&lt;/sub&gt; for cooling and power generation at low temperatures. Generally, the thermoelectric performance of a material is sensitively affected by synthesis process parameters, and among them, sintering temperature (&lt;i&gt;T&lt;sub&gt;s&lt;/sub&gt;&lt;/i&gt;) is a critical one. In this study, n-type Mg&lt;sub&gt;3&lt;/sub&gt;SbBi&lt;sub&gt;0.99&lt;/sub&gt;Te&lt;sub&gt;0.01&lt;/sub&gt; polycrystalline samples were fabricated by mechanical alloying and spark plasma sintering (SPS), and the effects of varying &lt;i&gt;T&lt;sub&gt;s&lt;/sub&gt;&lt;/i&gt; (923 – 1073 K) on the thermoelectric properties were investigated. Sintering Mg&lt;sub&gt;3&lt;/sub&gt;SbBi&lt;sub&gt;0.99&lt;/sub&gt;Te&lt;sub&gt;0.01&lt;/sub&gt; at an elevated temperature of 1073 K resulted in a notable increase in electrical conductivity at low temperatures below about 423 K. This is ascribed to a sharp reduction in carrier scattering by ionized impurities. For the same reason, the carrier mobility increased sharply at a &lt;i&gt;T&lt;sub&gt;s&lt;/sub&gt;&lt;/i&gt; of 1073 K, which is a critical temperature for sintering in this study. Moreover, the Seebeck coefficient increased and thermal conductivity decreased simultaneously by raising &lt;i&gt;T&lt;sub&gt;s&lt;/sub&gt;&lt;/i&gt;, resulting in the maximum power factor (&lt;i&gt;PF&lt;sub&gt;max&lt;/sub&gt;&lt;/i&gt;) of 2.2 × 10&lt;sup&gt;-3&lt;/sup&gt; W m&lt;sup&gt;-1&lt;/sup&gt;K&lt;sup&gt;-2&lt;/sup&gt; and the maximum dimensionless figure of merit (&lt;i&gt;zT&lt;sub&gt;max&lt;/sub&gt;&lt;/i&gt;) of 1.20 in the sample sintered at 1073 K. Therefore, when &lt;i&gt;T&lt;sub&gt;s&lt;/sub&gt;&lt;/i&gt; was raised from 923 K to 1073 K, the &lt;i&gt;PF&lt;sub&gt;max&lt;/sub&gt;&lt;/i&gt; and &lt;i&gt;zT&lt;sub&gt;max&lt;/sub&gt;&lt;/i&gt; increased by 29 % and 64 %, respectively. This improvement in performance is attributed to the annihilation of defects generated during the mechanical alloying process, which was confirmed by microstructure analysis by transmission electron microscopy (TEM).

Optimization of Azadirachta indica leaf extract mediated cerium oxide nanoparticles synthesis, characterization, and its applications

The present study focuses on the novel synthesis of cerium oxide (CeO2) nanoparticles from cerium nitrate hexahydrate by using Azadirachta indica (neem) leaf extract. The parameters associated with the green synthesis process were optimized utilizing the response surface methodology (RSM) paired with the genetic algorithm (GA) to produce a higher yield rate. The experiment run order for the CeO2 green synthesis is then generated using the central composite design in RSM. The regression equation was used as an optimization function, and the optimal values were identified through GA. Using optimized input process parameters, 0.3 g/10 mL of precursor concentration and 5 mL of Azadirachta indica leaf extract centrifuged for 20 min in the green synthesis process resulted in a maximum yield of 15.49 % CeO2 nanoparticles. The synthesized CeO2 nanoparticles are characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), energy dispersive spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), particle size distribution, and zeta potential analyses, which are used to ensure their presence in the green synthesis process. Subsequently, the green synthesized CeO2 nanoparticles are dosed as an additive to the cotton seed biodiesel (CSB) at different proportions of 25, 50, and 75 ppm, respectively. The prepared biofuel's physico-chemical properties were measured as per ASTM standards and are closer to the diesel fuel. As a result, it was noted that optimizing the green synthesis process parameters gives a maximum rate of CeO2 yield. It is possible to efficiently use the CSB with CeO2 nanoparticles as a suitable replacement for diesel fuel.

Biodiesel production from food waste using insitu transesterification method

The present study deals with the management of waste food with the different approaches in which waste food is used to extract biodiesel and based on this, the work deals with the optimization of process parameters for biodiesel synthesis from food waste with insitu transesterification reaction. The main process parameters selected arecatalyst (KOH) concentration (0.0–2.0% w/w), methanol/food waste ratio (v/v) (50–100%), and reaction duration (60–180 min). The temperature of the reaction was kept constant at 50 °C. The reaction temperature was taken low so that in future this low temperature can be obtained from solar energy or waste process heat. The yield of biodiesel, chosen as the output, has been evaluated using Box-Behnken Design in the Response Surface Methodology. A biodiesel yield of 96.62% has been obtained with methanol/food waste proportion of 98.33% and a catalyst amount of 1.35% (w/w) in 107.06 min of reaction time at 50 °C.

Optimization of the sol gel synthesis process parameters by orthogonal experiment of novel spinel oxide catalyst CuFe1.2Al0.8O4 with improved performance for methanol steam reforming

Optimization of the sol gel synthesis process parameters by orthogonal experiment of novel spinel oxide catalyst CuFe1.2Al0.8O4 with improved performance for methanol steam reforming