Release Process Research Articles

Expression of ALG8 in hepatocellular carcinoma and its diagnostic and prognostic significance

Background Alpha-1,3-glucosyltransferase (ALG8), a key enzyme in protein glycosylation, is implicated in the oncogenesis and progression of several human malignancies. This study aimed to define the role of ALG8 in hepatocellular carcinoma (HCC) and uncover its mechanisms of action. Methods ALG8 expression in HCC and normal tissues was analyzed using the TCGA and GEO databases, validated by RT-qPCR and western blot. Survival outcomes were evaluated via Cox analyses, and ALG8’s impact on HCC behavior was examined through functional assays. GO, KEGG, and GSEA identified ALG8-related pathways, validated by biochemical assays. Results In bioinformatics analyses, ALG8 was overexpressed in HCC tissues (p < 0.05 for all comparisons) and correlated with poorer survival (p = 0.006 and p = 0.025, respectively), establishing its role as an independent prognostic factor. In vitro experiments showed that knockdown of ALG8 reduced HCC cell proliferation, migration, and invasion. Using the STRING platform and TCGA-LIHC dataset, we identified ALG8-interacting genes and their associated differentially expressed genes (DEGs). GO and KEGG analyses further linked ALG8 to genes involved in glycosylation, signal release, and other processes, as well as pathways including neuroactive ligand-receptor interaction and N-Glycan biosynthesis. GSEA, corroborated by western blot and immunofluorescence, points to the Wnt/β-catenin signaling cascade as a probable mechanistic pathway through which ALG8 may modulate HCC progression. Conclusion Elevated ALG8 expression in HCC is linked to worse outcomes and increased tumor aggressiveness, with silencing ALG8 reducing Wnt/β-catenin signaling, highlighting ALG8 as a potential therapeutic target.

A Study of Seismic Cycles of the Strongest Earthquakes in Subduction Zones by Satellite Geodesy Methods

The work is devoted to modeling and studying geodynamic processes occurring in the vicinity of focal zones of the strongest (M ≥ 8) subduction earthquakes at different stages of the seismic cycle based on satellite geodetic data. The processes of preparation and realization of a number of powerful events that occurred in the Kuril–Kamchatka, Chilean, Japanese, and Aleutian subduction zones at the beginning of the 21st century were studied. Apparent spatial relationships have been identified between geodynamic processes occurring at different stages of the seismic cycle. It is shown that structural inhomogeneities of the medium have a direct impact on the processes of accumulation and release of elastic stresses.

A Tetrazine Amplification System for Visual Detection of Trace Analytes via Click‐Release Reactions

Achieving visual detection of analytes at ultra‐low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single‐molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a "click‐release‐oxidation‐cycle" (CROC) cascade amplification process. We systematically describe the construction and synthesis of this system, the kinetic process of click release, the kinetics of oxidation to tetrazine and its cascade amplification effect in trace amounts of tetrazine. This system is capable of amplifying the signal of tetrazine at a concentration as low as 2 nM by 105‐fold, thereby providing a clearly visible purple signal. Finally, as proof of concept, we successfully apply this method to visually detect trace β‐galactosidase (β‐gal) and Pd2+.

A Tetrazine Amplification System for Visual Detection of Trace Analytes via Click-Release Reactions.

Achieving visual detection of analytes at ultra-low concentrations in complex mixtures remains a persistent challenge. While sophisticated techniques offer single-molecule sensitivity, practical hurdles remain, necessitating tailored signal amplification systems for direct visual detection. In this study, we develop a strategy for the visualized detection of tetrazine through a "click-release-oxidation-cycle" (CROC) cascade amplification process. We systematically describe the construction and synthesis of this system, the kinetic process of click release, the kinetics of oxidation to tetrazine and its cascade amplification effect in trace amounts of tetrazine. This system is capable of amplifying the signal of tetrazine at a concentration as low as 2 nM by 105-fold, thereby providing a clearly visible purple signal. Finally, as proof of concept, we successfully apply this method to visually detect trace β-galactosidase (β-gal) and Pd2+.

Optimization of preparation process for seasoning derived from the lees of Shaoxing Huangjiu(Chinese yellow rice wine) based on multi round progressive strategy

Huangjiu lees are rich in flavor compounds, but traditional methods of utilizing them remain inefficient. Developing an efficient process for the rapid release and extraction of these flavor compounds from Huangjiu lees to produce lees-flavored seasonings holds significant promise. To tackle this complex process, a multi-round, progressive optimization strategy was devised. First, four separate orthogonal experiments identified the key factors for pre-fermentation, acid hydrolysis, enzyme hydrolysis, and debittering/decolorization, which were determined to be pre-fermentation time, HCl concentration, flavor enzyme concentration, and activated carbon ratio, respectively. Subsequently, response surface methodology was employed to rank the importance of these four factors in influencing the sensory score of the seasonings. The optimal conditions were determined as follows: pre-fermentation time of 7.785 days, HCl concentration of 14.978 %, flavor enzyme concentration of 6.276 %, activated carbon ratio of 7.496 %, with an expected sensory score of 45.117. Finally, the AI-based ANN-PSO method was applied for further refinement, yielding optimized conditions of a pre-fermentation time of 7.417 days, HCl concentration of 12.569 %, flavor enzyme concentration of 6.843 %, activated carbon ratio of 6.946 %, and an improved expected sensory score of 47.838. Verification experiments confirmed the superiority of the latter conditions. This study not only establishes a novel method for the efficient utilization of the abundant flavor resources in Huangjiu lees, which has substantial market potential, but also demonstrates that combining multiple optimization methods in a stepwise, multi-round approach is effective in addressing complex manufacturing processes involving multiple stages and factors.

Investigation of the kinetics of imidacloprid adsorption onto bimetallic Cu-BTC MOF

Imidacloprid, which is harmful for humans as well as many other aquatic invertebrate species, is extensively present in water worldwide. Hydrophobic Cu-BTCIPA and a novel composite, Ag@Cu-BTCIPA, was synthesized for adsorption of imidacloprid from water. The synthesis of the composite and the increase in surface area and pore volume were confirmed by FTIR, XRD, SEM, and BET analysis. A comparative study of the adsorption efficiencies of the synthesized composites was performed. The maximum adsorption efficiency achieved was 83.6 % at pH 7 by the Ag@Cu-BTCIPA composite. Kinetic and isotherm analyses suggested multilayer chemisorption involving p-p conjugation and pore-filling mechanisms. Intra-particle diffusion was the rate limiting step. Release studies of imidacloprid from water showed that the percentage release amount was 90.2 % at 70 min. Kinetic analysis of the release process suggested release through chemisorption, with swelling-controlled release from the dosage form, corresponding to the super case II transport mechanism.

A molten salt energy storage integrated with combined heat and power system: scheme design and performance analysis

To investigate the flexibility and economic characteristics of a molten salt-combined heat and power (CHP) integrated system under different heat sources, this paper proposes a design scheme for a molten salt-CHP system based on flue gas heat storage, comparing it with main steam heat storage and reheated steam heat source schemes. First, a molten salt heat release sub-loop is designed, where the steam heated by the molten salt can either compensate for heating demands or enter the low-pressure turbine for work, meeting the flexible operation requirements of the unit. Secondly, in response to fluctuations in temperature and pressure parameters of the main steam and reheated steam in the flue gas heat storage scheme, a water-spray desuperheating device is arranged. Finally, a simulation experiment based on a 350 MW CHP was conducted, and the results show that the flue gas molten salt heat storage technology significantly reduces energy loss on the boiler side. Underrated load, compared to the main steam and reheated steam heat storage schemes, the flue gas heat storage scheme has the highest boiler exergy efficiency and total energy utilization efficiency, at 55.8% and 59.1% respectively. During the thermal storage process, the coal consumption index of the flue gas heat storage scheme decreases with increasing load, while conversely, during the heat release process, it increases with the load. The peak-shaving capacity increases with the load, reaching 78.4 MWh under the 75% THA condition. In the steam extraction heating scenario, coupling with the molten salt subsystem can expand the safe heating operation range of the original unit, increasing the maximum peak shaving range by 13.9%, and increasing the maximum heating capacity by 65.4%.

Structural analysis of the siderophore-interacting protein from Vibrio anguillarum and its implications in classification of Vibrio homologs

Bacteria secrete siderophores to sequester the scarce iron in the environments, then the iron is transported into the cell in a siderophore-complexed form, which can be released by siderophore-interacting protein (SIP). Vibrio species comprise an array of serious pathogens, whose iron releasing process by SIP remains poorly understood. Herein, we report the high-resolution (1.2 Å) structure of Vibrio anguillarum SIP (VaSIP) in complex with FAD, representing the first structure of Vibrio SIP. VaSIP consists of a FAD-bound β-barrel domain and a Rossmann-fold domain connected by a linker, like other subgroup I SIPs. FAD is bound to the inter-domain cavity by aromatic stacking and hydrogen bonding interactions. Structural comparison indicated a modified NAD(P)H-binding motif (DxTA–EVL–GE) for subgroup I SIPs. The putative siderophore-binding pocket of VaSIP contains three lysines to form the basic triad to bind siderophore. Phylogenetic analysis shows Vibrio SIPs are mainly divided into two clades, represented by VaSIP and Vibrio cholerae ViuB, respectively. Interestingly, the two clades adopt distinct siderophore-binding basic triads, suggesting functional divergence among Vibrio SIPs. Our results shed light on the structural and phylogenetic characteristics of Vibrio SIPs, providing molecular basis for understanding Vibrio iron metabolism and designing anti-Vibrio drugs.

Electrochemically induced release of a model dye from a pH-sensitive and electroactive microgel monolayer attached to an electrode surface

We present a novel electrochemically-induced release system featuring a pH-responsive and electroactive microgel monolayer specifically designed to enhance drug delivery mechanisms. This microgel, synthesized from acrylic acid and a ferrocene derivative, was formed on a conductive electrode surface, providing a robust platform for controlled release applications. The physical and chemical properties of the microgel were meticulously characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), nuclear magnetic resonance (NMR), and electrochemical techniques. The microgel particles modified the electrode surface by forming a monolayer through interactions between the sulfur present in the crosslinking agent and the gold surface of the electrode. Cyclic voltammetry was used to analyze the properties of the modified electrode, and the morphology of the monolayer was confirmed by scanning electron microscopy (SEM). Notably, we demonstrated that the incorporation of positively charged crystal violet (CV) dye molecules was facilitated through electrostatic interactions with the negatively charged carboxylic groups of the microgel, resulting in effective dye retention. Our investigation revealed that the electrochemical oxidation of the ferrocene groups significantly weakens the interactions between the crystal violet (CV) dye and the polymer chains within the microgel network, facilitating controlled dye release. The release process was successfully monitored using quartz crystal microbalance with dissipation monitoring (QCM-D), confirming the system's potential for innovative drug delivery platforms and implant construction.

Comparative optimization of the thermal performance for H2 – Metal hydride heat storage and heat pump systems

Metal hydride is very promising in hydrogen storage and simultaneously the thermal effect in the reversible hydrogenation process makes it possible in heat storage and heat pump area. The interaction of H2 – Metal – hydride pair and its further applications need comprehensive thermodynamic design and performance optimization. Therefore, this work makes thermodynamic comparative research of heat storage and heat pump systems by adopting H2 – Metal-hydride pair. According to the investigation, the thermodynamically optimal charging-discharging temperatures (Tm1,Tm2), the heat source temperature (Th1) and the ambient temperature (Tc1) meet the relationship of Tm1Tm2=Th1Tc1 for the heat storage system. Given the operating pressure (p), there exists a well-matched temperature (T) range to maximize the exergy performance of metal hydride heat storage system. Meanwhile, the running p-T is positively correlated, e.g., when the charging pressure is set at 0.2 MPa to 0.3 MPa, the well-matched T varies from 307 K to 317 K. When the discharging pressure is set at 0.4 MPa to 0.7 MPa, the well-matched T varies from 304 K to 320 K. For the metal hydride heat pump system, the optimal performance lies in maximizing the transported heat. Given the operating T, there exists a well-matched pressure range for the heat sink device, e.g., for the heat releasing process, when operating T is set at 353 K, 363 K, 373 K, 383 K and 393 K, the well-matched p are 2.3 MPa, 3.3 MPa, 3.8 MPa, 4.6 MPa and 6.1 MPa. Both the heat storage and heat pump performances are also affected by the operating pressure – temperature −transported heat, presenting improved region and degraded region. The optimal thermodynamic criterion and the matchability of the operating parameters provide a theoretical guidance for the MH-based thermodynamic system design and operation.

Can storage-discharge characteristics of karst matrix system quantified through recession analysis be reliable?

Storage and subsequent release of water in matrix system is a key function of karst catchments that controlling baseflow variation. Hydrograph recession analysis is currently the economic way to assess storage-discharge characteristics broadly at the catchment scale. However, there is large uncertainty in the related quantification due to recession data extraction. This study, by combining recursive digital filters with different automatic extraction methods, slow flow recession segments were extracted for hydrograph recession analysis and the further dynamic matrix storage (DMS) and related recession time (RT) assessment. The diversity and consistence among DMS and RT derived from different recession extraction methods (REMs) were analyzed, using hydrometric data in 20 catchments in the Wujiang river Basin in southwest China. Results indicate that the estimates of DMS and RT remarkedly varied between different REMs, however the order in which they ranked was mostly consistent. Moreover, the relationships between the derived DMS and RT with catchment physical features that potentially control storage and release processes are mostly consistent. Larger DMS are strongly associated with catchments featured as lower soil saturated hydraulic conductivity and smoother hydrographs. Longer RT are mostly related with drier catchments characterized as less variation of elevation and lower soil saturated hydraulic conductivity. This study highlights not only the uncertainty in quantifying storage and accompanied release characteristics, but also the reliability of storage-discharge characteristics quantified through recession analysis in terms of catchment comparison. Considering the diversity among catchments, ensemble of multi-method estimates of DMS and RT can enhance our understanding of the storage-discharge processes in the karst matrix system.

The upconversion luminescence biomonitoring and biological properties of rare earth oxide-inorganic composite microspheres enhanced by lithium

Multiple myeloma is the second most common hematologic malignant tumor, which can result in complications such as osteolytic fractures and bacterial infections. The side effects of chemotherapy limit the dosage of drugs, which can easily lead to multidrug resistance. Moreover, the dose and distribution of drugs within the body significantly influence the therapeutic efficacy of drugs. Therefore, it is highly necessary to improve multidrug resistance and bacterial infection in the treatment of multiple myeloma, repair bone defects caused by bone pain, and monitor the real-time dynamics of drugs. This work proposes a novel rare earth oxide-inorganic composite (7Li-MBGs:2Er/2Yb-0.75MTO) as a drug delivery platform for the treatment of multiple myeloma. 7Li-MBG, which have bone repair functions, serve as inorganic matrix materials, while Er2O3 and Yb2O3 act as activators and sensitizers, respectively. MTO is used as a therapeutic drug for treating myeloma. The drug release process of MTO was successfully monitored by upconversion luminescence. Cell experiments confirmed that 7Li-MBGs:2Er/2Yb-0.75MTO has a certain long-term therapeutic effect on multiple myeloma, and its mechanism of action is consistent with its drug release kinetics. Moreover, the synergistic effect of rare earth oxides, alkali metal ions and MTO endows 7Li-MBGs:2Er/2Yb-0.75MTO with high antibacterial and osteoinductive abilities, and thus playing a role in enhancing the drug resistance of infectious bacteria, preventing bacterial infection, repairing bone defects and monitoring the real-time dynamics of drug release during multiple myeloma therapy. Therefore, the 7Li-MBGs:2Er/2Yb-0.75MTO multifunctional drug delivery platform synthesized in this work provides a new idea for the treatment of multiple myeloma and biomonitoring.

On the Role of the 1957 Decrees of the Baltic Soviet Republics in Dismantling the Gulag and Special Settlement System

The article looks at the process of dismantling the Gulag and special settlement system in the USSR from 1953 to 1957. Some of the specific outputs of this process were the decrees adopted by the Presidiums of the Supreme Soviets of the Lithuanian, Latvian and Estonian SSRs in 1957. In all three cases, there were two simultaneously approved legal acts with similar contents: one on the establishment of a Presidium commission to review the cases of special settlers, and one on the ban on the return of convicts. The research paper describes the legal and political framework of the process that led to the adoption of the decrees mentioned, and sheds some light on their application. The relationship between the all-Union and the Soviet republic levels is observed. The reaction to the events of 1956 led to a tightening of the Soviet regime. In the light of the events abroad and in the USSR in 1956, the 1957 decrees of the Baltic Soviet republics were an example of the USSR’s ad hoc approach to governance more generally, and of the release process specifically. The content of these legal acts was evidence of the primacy of political expediency over the law.

Design and thermodynamic performance analysis of a novel adiabatic compressed air energy storage system based on liquid piston re-pressurization

Compressed air energy storage (CAES) is a crucial technology for integrating renewable energy into the grid and supporting the “dual carbon” goals. To further utilize compressed heat and reduce throttling losses, this paper proposes a novel A-CAES energy storage system with liquid piston re-pressurization (LP-A-CAES). During the energy release process, the air in the air storage tank enters the liquid piston directly without passing through the throttle valve, then undergoes further pressurization and expansion. This approach avoids throttling losses while increasing the expansion ratio of the expander, facilitating the efficient use of compressed heat. By establishing thermodynamic models for both the proposed re-pressurized A-CAES and the traditional A-CAES systems, we compare their performance variations with changes in key parameters. Results indicate that under design conditions, the system's energy efficiency is 70.74 %, a 5.07 % improvement over traditional throttle-based A-CAES systems. The total exergy loss of the system is 1.42 × 1010 J, with the compressor and expander units accounting for the largest exergy losses, at 32 % and 31.6 %, respectively. The liquid piston exhibits excellent isothermal performance, maintaining air and water temperature rises within 20 K and 2.5 K, respectively. Reducing the maximum pressure difference in the air storage tank enhances system performance, although the performance improvement of the re-pressurized A-CAES system compared to the traditional A-CAES system diminishes. Increasing the height of the thermal energy storage and reducing the diameter of the thermal storage material both contribute to higher system energy efficiency. When the height of the thermal energy storage increases from 4 m to 8 m, the system's efficiency rises from 70.04 % to 70.74 %. Similarly, reducing the diameter of the thermal storage material from 0.05 m to 0.01 m increases the system's efficiency from 68.85 % to 71.47 %.

Near-infrared AIE chemiluminescence probe for monitoring and evaluating singlet oxygen in vivo

The incorporation a “singlet oxygen (1O2) battery” into photodynamic therapy (PDT) could overcome the deficiency of tumor hypoxia in PDT and enhance its effect. However, real-time monitoring the 1O2 release efficiency of the 1O2 battery still presents a significant challenge in vivo. To address this issue, we have developed a bright aggregation-induced emission (AIE) chemiluminescence (CL) probe (DTLum), which conjugates a luminol unit with a donor-acceptor structured diketopyrrolopyrrole fluorophore, for the specific detection of 1O2. Subsequently, the DTLum nanoparticles (DTLum NPs) were prepared using PEO100-PPO65-PEO100 (Pluronic F127) as the surfactant. The DTLum NPs can detect 1O2 in aqueous solution with a bright near-infrared (NIR) CL signal (651 nm) and great tissue penetration (12.5 mm), making them suitable for the detection of 1O2 both in vitro (quantitative) and in vivo (qualitative). Notably, by utilizing the DTLum NPs, the process of 1O2 release in 1O2 batteries with different release rates can be visually monitored in cells and in vivo. This NIR CL probe provides a powerful platform for real-time monitoring and evaluating the release efficiency of 1O2 battery.

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators

Small extracellular vesicles (sEVs) are important intercellular information transmitters in various biological contexts, but their release processes remain poorly understood. Herein, we describe a high-throughput assay platform, CRISPR-assisted individually barcoded sEV-based release regulator (CIBER) screening, for identifying key players in sEV release. CIBER screening employs sEVs barcoded with CRISPR-gRNA through the interaction of gRNA and dead Cas9 fused with an sEV marker. Barcode quantification enables the estimation of the sEV amount released from each cell in a massively parallel manner. Barcoding sEVs with different sEV markers in a CRISPR pooled-screening format allows genome-wide exploration of sEV release regulators in a subpopulation-specific manner, successfully identifying previously unknown sEV release regulators and uncovering the exosomal/ectosomal nature of CD63+/CD9+ sEVs, respectively, as well as the synchronization of CD9+ sEV release with the cell cycle. CIBER should be a valuable tool for detailed studies on the biogenesis, release, and heterogeneity of sEVs.

Optimization method for nozzle control of governing turbine

The compressed air energy storage (CAES) system necessitates rapid and precise adjustment of turbine operational states to align with fluctuating system loads during the energy release process. As the air storage pressure continuously declines, the adoption of an appropriate air distribution method becomes imperative to enhance turbine performance. This study innovatively investigates the coupled optimal method of nozzle control (NC) and relative stator installation angle (RSIA) to achieve maximum specific work under certain output work conditions, initially proposing the optimal method as a strong candidate for engineering applications. The stator channel has undergone redesign to allow adjustment of the stator installation angle. It is investigated to obtain the response surface model of specific work and output work with base pressure (BP), regulated pressure, inlet nozzle number, and RSIA as independent variables, and the maximum specific work as the optimization objective. The results indicate that, compared with the original NC method at rated output work, the optimized operation markedly elevates the specific work by a maximum of 6.1 % and an average of 3.4 %. Furthermore, the majority of losses within the turbine are attributed to entropy production rate by turbulent dissipation, accounting for up to 88.7 % of the total losses. The optimal method satisfies the output work requirement by adjusting the inlet nozzle number and RSIA without throttling the inlet nozzles under different BP conditions. This is achieved by adopting the 3-nozzle inlet method under high BP and the 4-nozzle inlet method under relatively lower BP conditions. The present study offers theoretical support for the optimal design and operation control of NC turbines, which has broad prospective applications in the optimized air distribution regulation of CAES systems.

Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method

AbstractDevelopment of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy. The purpose of this study is synthesis of polydopamine (PDA) nanocapsules and analyze the adsorption and release properties of doxorubicin (DOX). PDA nanocapsules are manufactured using hard template approach. The influence of various parameters such as pH, adsorption time, and initial DOX content on the adsorption and release process is investigated. The resulting adsorption isotherm is consistent with the Langmuir isotherm, indicating that DOX adsorption on PDA nanocapsules is homogenous, uniform, and monolayer. PDA nanocapsules have an adsorption capacity of 689.6 mg g−1 under alkaline conditions, which is attributed to phenol group deprotonation mechanism and electrostatic repulsion. The adsorption kinetics are more consistent with the pseudo‐second‐order model. Furthermore, raising initial concentration of DOX results in a greatly increased adsorption capacity due to a larger driving force. Among the several parameters that can influence the pace and degree of DOX loading and release, local pH is regarded as a significant environmental component in the processes. Thus, pH‐responsive PDA nanocapsules have a significant potential for usage in locations with aberrant pH level, such as cancer tissue.

Flexible electrochemical sensor based on N-doped helical carbon nanotubes coated manganese oxide nanoparticles for real-time monitoring of cellular hydrogen peroxide release

Electrochemical sensor is a sensitive and fast method to test hydrogen peroxide (H2O2) released from cancer cells. To map a clear understanding of the mechanisms during drug treatment of cancer, it is necessary to in-situ and real-time monitor of H2O2 content in the release process from cancer cells. Herein, N-doped helical carbon nanotubes (HCNTs) coated manganese oxide (MnO) nanoparticles (MnO@HCNTs) were prepared using a high-temperature molten salt method. The ratio of Mn salt to 2-methylimidazole was adjusted to optimize the Mn2+/Mn3+ ratio of the active center. The MnO@HCNTs were further modified on a polydimethylsiloxane (PDMS) based electrode printed by screen printing technique to build a flexible electrochemical sensor (MnO@HCNTs/PDMS). The presence of graphitic N increases the surface electron density, thereby enhancing the electrical conductivity of MnO@HCNTs/PDMS. Simultaneously, graphitic N triggers electronic arrangement in the Mn, leading to an increase in Mn-N coordination. Furthermore, the adsorption performance of MnO@HCNTs/PDMS for H2O2 increases with more N content, which may also enhance the electrocatalytic activity towards H2O2. The sensitivity of this sensor for H2O2 analysis was observed as 636.9 μA μM−1 cm−2 with a limit of detection as 2.6 nmol L−1 in a linear response range from 10.0 nmol L−1 to 1000.0 nmol L−1 and a fast response time of 1.2 s. Finally, the flexible MnO@HCNTs/PDMS was combined with a smart sensing system, which displayed the ability for highly sensitive real-time monitoring of drug-stimulated H2O2 that released from lung cancer cells A549 under the phorbol ester stimulation.

Universal Energy Fluctuations in Inelastic Scattering Processes.

Quantum scattering is used ubiquitously in both experimental and theoretical physics across a wide range of disciplines, from high-energy physics to mesoscopic physics. In this Letter, we uncover universal relations for the energy fluctuations of a quantum system scattering inelastically with a particle at arbitrary kinetic energies. In particular, we prove a fluctuation relation describing an asymmetry between energy absorbing and releasing processes which relies on the nonunital nature of the underlying quantum map. This allows us to derive a bound on the average energy exchanged. We find that energy releasing processes are dominant when the kinetic energy of the particle is comparable to the system energies, but are forbidden at very high kinetic energies where well-known fluctuation relations are recovered. Our Letter provides a unified view of energy fluctuations when the source driving the system is not macroscopic but rather an auxiliary quantum particle in a scattering process.