Lacking knowledge concerning the North-Sea's socio-ecological system causes the rapid increase of Offshore Wind Farm (OWF) development to occur under serious uncertainty. Optimising OWF development while minimizing negative effects on the socio-ecological system of the North-Sea thus requires holistic knowledge and its appropriate use in policy. Together with the pressure for OWF development, the subsequently rapid development of an array of scientific knowledge results in a dynamic and multidisciplinary knowledge situation, challenging the integration of knowledge, particularly between research and policy. To ensure policy is based on the latest holistic understanding, knowledge requires integration in strategic Marine Spatial Planning (MSP) policy. While the need for better knowledge processes is widely mentioned as a challenge for MSP, knowledge-integration in MSP remains understudied. This paper responds by studying the role of OWF-related knowledge in MSP while formulating a framework of conditions for knowledge-integration between research and policy in MSP policy and OWF development. These conditions are formulated based on knowledge management and MSP literature and subsequently applied in semi-structured interviews, document research, consortium observations, and focus groups. The case study used for acquiring data is knowledge-integration in Dutch MSP and OWF development. The Dutch maritime area is intensively used and faces important tensions over space due to conflicting stakeholder interests. In addition, while being an early adopter of MSP, the Netherlands also faces serious challenges due to high political pressure promoting Offshore Wind Farm development and a related need for maritime knowledge production. Together with the array of knowledge programs aiming to inform Dutch MSP, this provides a useful case to analyse knowledge-integration in MSP.The framework developed in this paper includes conditions for knowledge-integration ranging from the acceptance of differences between researchers and policymakers, to the need to employ interface managers who can develop a structural and effective knowledge-integration process. Fundamental differences between researchers and policymakers, such as differing timeframes, and differing views on uncertainty were found to form significant risks for knowledge-integration, as such influencing conditions. Additionally, the dynamic, long-term, area specific, and multidisciplinary context of MSP and OWF development was found to significantly influence the knowledge-integration process, underlining the importance of context for knowledge processes.