Unlike traditional approaches that analyse an actor’s foreign policy by focusing on the search for physical security and material interests, ontological security advocates a more nuanced approach that considers identity politics, regime security, issues of legitimacy, and emotional motives. This article aims to examine Iran’s Axis of Resistance from the perspective of ontological security, without rescinding the possibility of power struggles or ideological motivations in influencing Iran’s foreign policymaking process. This study posits that the Axis of Resistance embodies a profound meaning and overarching significance for Iran that transcends mere considerations of physical security or sectarian-ideological inclinations. The pursuit of the Axis of Resistance by Iran serves to provide the regime with ontological security, achieved through the utilisation of national narratives, the establishment of routines, concerns pertaining to domestic order, and the incorporation of emotional underpinnings of the Islamic regime. The existential significance that Iran ascribes to the Axis of Resistance is of crucial importance in maintaining this paradigm, despite all its costs.