Problematic Skin Research Articles

Risk Factor Analysis for Anti-epidermal Growth Factor Receptor Monoclonal Antibody-induced Problematic Skin Toxicities in Patients With Liver Metastatic Colorectal Cancer.

We previously reported that patients with metastatic colorectal cancer (mCRC) and baseline liver metastasis are at a higher risk of developing grade ≥2 overall skin toxicities when treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibody. This study aimed to identify additional factors associated with skin toxicities induced by anti-EGFR treatment in patients with liver metastatic CRC. Patients with liver metastatic CRC who initially received anti-EGFR monoclonal antibody-containing treatment (n=77) were retrospectively assessed. The primary endpoint was to identify the factor(s) responsible for the development of grade ≥2 overall skin toxicities. Additionally, factors for grade ≥2 rash and paronychia were evaluated. The incidence of grade ≥2 overall skin symptoms, rash, and paronychia was 62.3%, 31.2%, and 28.6%, respectively. Multivariate Cox proportional hazard regression analyses revealed that age <65 years and anemia were independent baseline risk factors for grade ≥2 overall skin toxicities (adjusted hazard ratio 2.09, 95% confidence interval=1.10-3.97, p=0.02 for age; 2.36, 1.20-4.61, p=0.01 for anemia). In contrast, combination prophylaxis using systemic minocycline and corticosteroid ointment was a preventive factor (0.47, 0.25-0.88, p=0.02). Males and age <65 years were baseline risk factors for grade ≥2 rash, and combination prophylaxis was identified as a preventive factor. No factors were identified for paronychia. Age <65 years and anemia were identified as independent baseline risk factors. Additionally, combination prophylaxis was found to be a preventive factor against anti-EGFR monoclonal antibody-induced grade ≥2 overall skin toxicities in patients with liver metastatic CRC.

Thalassotherapy as a multidirectional form of marine resources therapy

Thalassotherapy is a treatment that uses the natural gifts of the sea (climate, air, sea sand, algae, some species of sea fish, mother of pearl) and physical factors (hydrotherapy, heliotherapy, aerosol therapy, music therapy, kinesitherapy and others). It is mainly intended for people who are stressed, overtired and have sleep problems. Thalassotherapy is also used in the treatment of rheumatism, back pain, lung diseases, heart diseases and skin dermatoses, such as psoriasis or atopic dermatitis. These treatments are widely used in wellness centers as care and therapeutic treatments for problematic skin. In cosmetology, preparations of marine origin are also used in the form of masks, peeling creams intended for dry, oily, gray, mature or poorly nourished skin.

FORMULASI MASKER CLAY EKSTRAK WORTEL DAN TEPUNG BERAS

Dry skin is problematic skin, skin with insufficient and low water content. One easy and practical way to overcome this is to carry out cosmetic treatments using a clay mask with a formulation of carrot extract and rice flour. This research aims to obtain a clay mask preparation from carrot extract and rice flour. Carrot extract contains beta-carotene which is useful for protecting the skin from UV rays and is also rich in vitamin A and antioxidants which are very good for making skin brighter. Meanwhile, rice flour can help improve skin structure thanks to its abundant nutritional content, one of which is vitamin B and can help overcome external pollution and dirt and make skin look brighter. The ethanol extract of carrots and rice flour is formulated in the form of a clay mask with various extract formulations, namely 20%, 25% and 30%. The results of organoleptic testing, physical properties and stability tests of the mask preparations showed that no changes occurred in each formula, namely color, odor and shape during the storage process. All formulations obtained were homogeneous, the average pH was 5.58-6.73, the average spreading power obtained was 3.08-4.7 cm, the average sticking power obtained was 0.82-4.86 seconds, and the average -The average dry preparation produced was 6.21-19.02 minutes. The conclusion of this research is that carrot extract and rice flour can be formulated as a clay mask and are also stable during storage.

Feeling uncomfortable in your own skin: a qualitative study of problematic skin picking in Italian women

Skin picking disorder (SPD) is a body-focused repetitive behavior recently added to the DSM-V. It mainly affects women, with a prevalence ranging from 1.5 to 5.4%. Picking causes skin lesions that can lead to serious infections and permanent skin problems, usually on the face, scalp, arms, and legs. The behavior impairs quality of life and is associated with psychological distress and difficulties in managing emotions. The disorder causes social embarrassment, leading to avoidance and social withdrawal. As the literature on the perspectives of people with SPD is limited, our research aimed to analyze the meanings they attribute to the behavior and its consequences. A second aim was to explore how interacting with an online community can affect the management of the condition. Using a qualitative descriptive approach, we interviewed twenty-one Italian women (aged 18–50) who self-identified as having SPD and were recruited through an online forum dedicated to the disorder. Three themes framed our analysis: “A stick in the wheel of everyday life,” “Other people’s eyes make you realize what you are doing is wrong,” and “The struggling search for control.” These themes highlight the impact of SPD on different areas of life, the difficulties in accessing competent healthcare providers, the stigma experienced by participants, and the usefulness of the online group on an informative, emotional, and social level. A better understanding of these patients’ perspectives can be useful for those providing professional care and those planning services for them in a Health Co-Inquiry approach that values patients’ activation.

Studies on the formulation and functionality of an innovative line of topical products for atopic skin

Dermocosmetics are products intended for sensitive and problematic skin. They are a good solution for additional care of skin affected by conditions such as atopic dermatitis, acne, psoriasis, or for couperose skin. The compounds of particular importance in the care of atopic skin include ceramides, ectoine, hyaluronic acid, vitamins A and E, as well as natural vegetable oils. The aim of this work was to develop a qualitative and quantitative approach and to investigate the characteristics of formulations such as a face cream, a topical cream, a body lotion, and a cleansing foam, dedicated to patients with atopic dermatitis. The newly developed cosmetic formulations showed good physical and chemical characteristics, typical of this type of product. They were also structurally and microbiologically stable during storage at various temperatures. Dermatological tests did not reveal any irritating or allergenic properties. The best data were obtained for the face cream, namely improvement of skin hydration by 21.88%, reduction of transepidermal water loss by 15.86%, alleviation of erythema by 15.77%, and of skin sensitivity by 17.20%. This work resulted in the preparation of innovative dermocosmetics to be used for atopic skin. The cosmetics have a unique composition and delicate formula, show high biofunctionality, and meet all the requirements for cosmetic products intended for marketing.

The Relation between the Perception of Medical Skin Care and the Treatment of Skin Problems: The people with medical skin care experience in Harbin, China

Medical skin care is a system that treats problematic skin as a specialized management by performing medical treatment and skin care at the same time through correct skin diagnosis, and has a high degree of reliability in surgical methods. Therefore, the relationship between problematic skin conditions and treatment methods according to the perception of medical skin care was verified for those with experience in medical skin care. The study consisted of a total of 69 questions, including 8 questions on general characteristics, 23 questions on perceived problem skin conditions, 6 questions on treatment methods for problematic skin, 11 questions on medical skin care awareness, and 21 questions on medical skin care satisfaction. A total of 410 questionnaires were used from December 21, 2020 to January 9, 2021 were anaiyzed WeChat and the Wenjuanxing program. Data analysis was performed using SPSSWIN 21.0 program with Frequency analysis, Reliability test, Cronbach's  coefficient, Descriptive statistical analysis, and one-way ANOVA was also conducted. Among the subjects of the survey, female (67.8%), university (first degree), married (51.7%), students(occupation). Recognition of problematic skin conditions acne (25.6%), melasma pigmentation (24.4%), sensitivity and telangiectasia (18.6%). The self-awareness of problematic skin conditions, acne (25.6%) is the hightest, problematic skin surgical methods MTS (31.0%) for acne, chemical peeling (29.1%) for pores and scars, laser (36.5%) for pigmentation, and injection therapy (20.5%) for wrinkles and skin elasticity. The degree of awareness of medical skin care high awareness (31.2%), medium awareness (38.5%), low awareness (30.2%). The difference in perceived problem skin condition according to medical skin care awareness was high in the high group and normal group for melasma and pigmentation skin, and the lower group has a higher awareness of acne skin. According to different awareness of medical skin care the awareness of physical peeling for acne, laser treatment for pores, scars and pigmentation, injection therapy for wrinkles and skin elasticity, laser treatment for sensitivity skin, and MTS for extremely dry skin was found to be more higher. As for the difference in medical skin care satisfaction according to the recognition of medical skin care, there was no difference in satisfaction of facilities and environment, effects, services, and economic costs. With the awareness of medical skin care, the difference in satisfaction with medical skin care is higher in the group, and the satisfaction with products and surgery is significantly higher. The above results showed that in the group with higher awareness of medical skin care, melasma pigmentation and acne skin, the surgical method was melasma pigmentation skin laser, and the MTS of acne skin was higher. In addition, medical skin care has high satisfaction in terms of products and surgery.

Evaluation of A Novel Topical Formulation for The Treatment of Problematic Skin: Results of An Italian Clinical Study

Problematic skin conditions such as atopic dermatitis, acne vulgaris, and psoriasis are directly linked to microbial imbalance or 'dysbiosis'. Alterations of skin microbial communities along with other contributing factors, cause skin barrier dysfunction triggering immune and inflammatory responses.

Analysis Of Policy Has Been Established By The Minister On Opening The Export Of Lobster Seed In Indonesia

Seakeeping is the ship's ability to stay afloat on the waves. The ship's maneuverability is greatly influenced by external factors related to the state of the sea and the waters in which the ship sails. Calculating seakeeping with various variations of depth, current, and wave height is needed for ship safety when sailing in the calculation of seakeeping using linear strip theory to calculate the response of heaving and pitching movements while roll damping theory for rolling movements. In this study, the ship's motion is calculated using the Finite element method software Hydrodynamic Diffraction and Hydrodynamic Time Response. For variations in wave height and water depth, referring to the conditions of Indonesian waters, from the reference, variations in wave height of 3 m, and 5 m (based on sea state WMO). In contrast, the current variation uses a current with a speed of 10 knots and a current depth of 10 T, 15 T, and 20 T. Based on the data obtained in data processing, it can be seen that the high value of the wave frequency obtained at 90 and 270 degrees wave direction is relatively high. The value of the roll spectrum in the direction of 0 and 270 degrees is large and can cause rolling on the ship. In the direction of 0 and 270 degrees, the wave resistance can be reduced by th Lobsters are animals that enter into crustaceans that have problematic skin. Adult lobsters can generally be found on a stretch of sand with coral spots with a depth of between 5-100 meters. This condition will cause a low number of young lobsters in the waters. This research was conducted with a case study regarding the policy of opening lobster seed export, which aims to find out how the policy is to open the export of lobster seed. The data obtained is done by reviewing the literature on the internet. Based on the analysis, the export profit of lobster seeds has continued to increase every month since it was again allowed by the government in May 2020. Based on data from the Central Statistics Agency (BPS), lobster seeds began to be re-exported in June 2020 at 32 kilograms, costing the US $ 112,990. The government can help with training and outreach on lobster cultivation. The government can offer Lobster a partnership package to help people start a freshwater crayfish business.

The problem with picking: Permittance, escape and shame in problematic skin picking.

Problematic skin picking (SP) is a poorly understood experience characterised by a drive to pick the skin and related psychosocial impact. In the DSM-5, problematic SP is classified as 'excoriation (skin picking) disorder'. The aim of this article is to present a rare qualitative perspective on the lived experience of problematic SP, prioritising participants' voices and sense-making. An in-depth qualitative study of individuals who self-identified as picking their skin problematically and experienced related distress. Seventeen UK-based participants were recruited online and interviewed about their SP. Participants were given choice of interview modality, including instant messenger platforms, telephone, email and Skype, to maximise comfort and improve the accessibility of the study. Transcripts were analysed using thematic analysis. Three themes offering novel insight into the phenomenology of participants' SP are highlighted and explored: (1) how cognitions and circumstances drove and permitted SP, (2) how participants 'zoned out' while SP and the escape or relief that this attentional experience offered and (3) participants' feelings of shame and distress in how they felt their SP may appear to others. This study contributes in-depth and novel ideas to the understanding of SP phenomenology and identifies how environmental factors, cognitions, contextual distress and shame may be considerations in therapeutic intervention. It presents the complexity of SP sense-making and demonstrates the need for individual formulation.

Innovative Concept of Application of Electronic Modeling in Building e-Health Systems

The paper presents a concept of application of electronic modeling in the development of e-Health systems for prevention in the diagnosis of problematic skin wounds, which include prevention and treatment, allowing uniformity in the assessment and increase the reliability of treatment tools to achieve a full life without pain, risk, and stress. Health and disease are two phases, changing smoothly or dramatically. It is to this uniqueness of the influences for their direct or indirect management that the research is directed - providing the practicing medical specialists with an opportunity for alternative and adequate diagnostics to ensure the subsequent normal life of the patient. The developed e-Health systems have been applied in the training of specialists in the specialties "Midwife" and "Nurse" and in the specialty "Electronics" at the University of Ruse. They are used in practical training of future doctors in UMHAT KANEV Ruse.

Issues of therapy for post-acne post-inflammatory hyperpigmentation

Introduction. Post-acne post-inflammatory hyperpigmentation most often develops in patients with moderate to severe acne. Post-acne pigmentation can be persistent and last from months to several years, which has a negative impact on the patients’ quality of life. It occurs at any age with the same frequency in men and women.Aim. To evaluate the effect of dermatocosmetic products – a triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin on the skin condition in patients with moderate and severe post-acne post-inflammatory hyperpigmentation.Material and methods. A total of 57 patients with post-acne post-inflammatory hyperpigmentation localized on the facial skin were under observation. The age of the patients was 22.4 ± 2.7 years. 32 patients were diagnosed with mild post-acne PIH, 25 patients – with moderate post-acne PIH. All patients used dermocosmetic products such as the triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin. Efficacy was evaluated with due account for mexametry findings, GSS, dermatology life quality index. Digital data were processed using standard medical statistical methods: calculation of the arithmetic mean value (X), square deviation (σ), Student’s t-test (t).Results. After 12 weeks the mexometric index decreased: 92.7 and 85.9% in mild and moderate post-acne PIH, respectively. The DLQ index reduced by 84.9 and 83.8% by the end of the treatment,Conclusions. The use of innovative dermocosmetic products containing salicylic acid and licochalcon A effectively reduces post-acne pigmentation. All patients noted good organoleptic properties: skin application comfort and excellent tolerability of the products.

Analysis Of Policy Has Been Established By The Minister On Opening The Export Of Lobster Seed In Indonesia

Seakeeping is the ship's ability to stay afloat on the waves. The ship's maneuverability is greatly influenced by external factors related to the state of the sea and the waters in which the ship sails. Calculating seakeeping with various variations of depth, current, and wave height is needed for ship safety when sailing in the calculation of seakeeping using linear strip theory to calculate the response of heaving and pitching movements while roll damping theory for rolling movements. In this study, the ship's motion is calculated using the Finite element method software Hydrodynamic Diffraction and Hydrodynamic Time Response. For variations in wave height and water depth, referring to the conditions of Indonesian waters, from the reference, variations in wave height of 3 m, and 5 m (based on sea state WMO). In contrast, the current variation uses a current with a speed of 10 knots and a current depth of 10 T, 15 T, and 20 T. Based on the data obtained in data processing, it can be seen that the high value of the wave frequency obtained at 90 and 270 degrees wave direction is relatively high. The value of the roll spectrum in the direction of 0 and 270 degrees is large and can cause rolling on the ship. In the direction of 0 and 270 degrees, the wave resistance can be reduced by th Lobsters are animals that enter into crustaceans that have problematic skin. Adult lobsters can generally be found on a stretch of sand with coral spots with a depth of between 5-100 meters. This condition will cause a low number of young lobsters in the waters. This research was conducted with a case study regarding the policy of opening lobster seed export, which aims to find out how the policy is to open the export of lobster seed. The data obtained is done by reviewing the literature on the internet. Based on the analysis, the export profit of lobster seeds has continued to increase every month since it was again allowed by the government in May 2020. Based on data from the Central Statistics Agency (BPS), lobster seeds began to be re-exported in June 2020 at 32 kilograms, costing the US $ 112,990. The government can help with training and outreach on lobster cultivation. The government can offer Lobster a partnership package to help people start a freshwater crayfish business.

The effectiveness of non­hormonal cream Solivin™ in combination with selective phototherapy in treatment of chronic skin dermatoses

Objective — determining the therapeutic efficacy of a six-week use of Solivin™ cream among patients with plaque psoriasis and eczema. &#x0D; Materials and methods. 60 patients aged 18 to 60 years were monitored. There were 30 people with plaque psoriasis including 10 men and 20 women, and 30 people — with chronic eczema including 12 men and 18 women.&#x0D; Results and discussions. The PASI index decreased from moderate to mild severity in 100 % of patients with psoriasis when using Solivin™ cream (monotherapy), residual effects in the form of erythema were observed in 42 % of patients. The PASI index decreased to mild severity in 100% of patients when using Solivin™ cream in combination with selective phototherapy (SFT 311 nm), and residual erythema was observed in 28 % of patients. The eczema area and severity index (EASI) decreased to moderate severity in 62 % of patients with eczema after using Solivin™ cream (monotherapy) and in 5 % of patients decreased to mild. 33 % of patients had no clinical manifestations. Residual effects expressed as erythema were observed in 24% of patients. The EASI index significantly decreased to mild in 44 % of patients when using Solivin™ cream in combination with SFT (311 nm), and to moderate in 56 % of patients. No side effects were observed. All patients tolerated the treatment well.&#x0D; Conclusions. High efficiency of Solivin™ cream for problematic skin was observed. The balanced combination of organic active ingredients allows long-term use of the cream without restrictions on the size of the area and the amount of application of the product. When used both as monotherapy and in combination with SFT, a significant decrease in PASI and EASI indices as well as all indicators of clinical manifestations of chronic skin diseases were revealed.

Treatment Options for Dupuytren's Disease: Tips and Tricks.

Background:Dupuytren's disease (DD) is a common fibroproliferative condition of the hand.Methods:Management of DD includes observation, non-operative management, and operative management. Operative treatments include percutaneous needle fasciotomy (PNF), open fasciotomy (OF), Clostridium collagenase histolyticum (CCH) injections, limited fasciectomy (LF) and dermofasciectomy (DF). The various methods of DD treatment are reviewed.Results:We summarize the highlights of each treatment option as well as the strengths and weaknesses. PNF has an immediate improvement, but a higher recurrence rate, potential problematic skin tears, and rare tendon or nerve complications. Limited fasciectomy removes the thickened, diseased tissue but has a more prolonged recovery and has a higher rate of significant complications. Dermofasciectomy has the highest complication rate, and the lowest recurrence. Also, secondary fasciectomy after a previous dermofasciectomy has an unexpected amputation rate as high as 8%. Collagenase injections require two visits, have an increased number of minor side effects such as skin tears, and have rare but significant side effects such as tendon rupture.Conclusions:This article gives an overview of different treatment options for DD and each of their strengths and weaknesses and provides procedural tips.

Recent perspectives of nanotechnology in burn wounds management: a review.

The burden of the management of problematic skin wounds characterised by a compromised skin barrier is growing rapidly. Almost six million patients are affected in the US alone, with an estimated market of $25 billion annually. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. Novel strategies are needed for faster healing by reducing infection, moisturising the wound, stimulating the healing mechanisms, speeding up wound closure and reducing scar formation. A systematic review of qualitative studies was conducted on the recent perspectives of nanotechnology in burn wounds management. Pubmed, Scopus, EMBASE, CINAHL and PsychINFO databases were all systematically searched. Authors independently rated the reporting of the qualitative studies included. A comprehensive literature search was conducted covering various resources up to 2018-2019. Traditional techniques aim to simply cover the wound without playing any active role in wound healing. However, nanotechnology-based solutions are being used to create multipurpose biomaterials, not only for regeneration and repair, but also for on-demand delivery of specific molecules. The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue. Nanotechnology-based therapy is in the forefront of next-generation therapy that is able to advance wound healing of hard-to-heal wounds. In this review, we will highlight the developed nanotechnology-based therapeutic agents and assess the viability and efficacy of each treatment. Herein we will explore the unmet needs and future directions of current technologies, while discussing promising strategies that can advance the wound-healing field.

Prevention and Treatment of Potentially Problematic Acute Wounds to Achieve Full Recovery by Using Platelet-Rich Plasma: Research Results

Summary The study presents the outcomes from platelet-rich plasma (PRP) application in treating acute and potentially problematic skin wounds from 2009 to 2016. Fifty-six hospitalized patients with acute skin wounds were divided into two groups: an experimental group of 30 patients treated with platelet-rich plasma and 26 controls with similar wounds, treated by conventional methods. After platelet-rich plasma treatment of 30 acute and potentially problematic wounds in the Experimental Group patients, 29 (96.7%) of the wounds healed for 16 weeks on average. After applying conventional treatment with surgical wound debridement, of the 26 acute, potentially problematic wounds in the controls, only 2 (7.6%) healed. Since acute and potentially problematic wounds are very likely to become chronic and difficult to heal, we recommend PRP application as a preventive treatment in patients at risk.

RESEARCH OF MEDICAL FACTORS AND REASONS FOR HEALING FAILURE OF PROBLEMATIC SKIN WOUNDS TREATED WITH PLATELET–RICH PLASMA

OBJECTIVE: To present our problematic skin wounds cases treated with PRP application of that has not responded to the treatment method. MATERIAL AND METHODS: Out of a total of 154 hospitalized patients with complex skin wounds 83 have been treated with platelet-rich plasma, comprising the Experimental group (EG), and 71 patients with comparable wounds have been treated by utilizing traditional techniques for the respective pathology, comprising the Control Group (CG). Ratings introduced by Cancela AM are used for the evaluation of the respective wound. Statistical analyzes have been performed by using the software SPSS (Statistical Package for the Social Sciences). All cases were treated in a procedure, which includes activated platelet-rich plasma. The treatment algorithm we used is as follows: first, there is surgical treatment and debridement of the wound. Activated plasma is used to infiltrate the wound edges and the fibrin clot is used to fill the wound itself. A sterile dressing soaked with physiological saline is applied. The treatment is repeated on a weekly basis until the wound problem is resolved in full. RESULTS: The results of our research indicate that 77 (92.78%) of patients enjoy a full recovery, while 6 (7.22%) of patients have no positive wound healing outcome (unhealed wound). CONCLUSION: Theoretical and clinical studies prove that the PRP method is a reliable, rational, and modern option for PSW treatment. It should not be seen as the only one and universal.

TREATMENT OF PROBLEMATIC SKIN WOUNDS BASED ON THE PLATELET-RICH PLASMA METHOD. OUR OWN ALGORITHMS FOR APPLICATION

OBJECTIVE: The objective of this paper is to present the application of our own algorithms for prevention and treatment of problematic skin wounds (PSW) by using the platelet-rich plasma (PRP) based on the first study on PRP application carried out in Bulgaria. MATERIAL AND METHODS: The study was carried out at the Clinic of Orthopedics and Traumatology, UMBAL Kanev Ruse, for a period of 84 months - from February 2009 to September 2016. A total of 83 patients with PSW have been treated with platelet-rich plasma. Scores introduced by Cancela AM are used for the assessment of the respective wound. Each of these scores is used for assessing specific wound parameters. RESULTS: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. Prevention algorithm of applying PRP ensures that a high percentage of acute skin wounds will not turn into PSW. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients. They also ensure more predictable skin healing. CONCLUSION: Our own algorithms for prevention and treatment of PSW by PRP increase the percentage of successfully cured wounds. The proposed algorithms for prevention and treatment of PSW by applying PRP are an effective and safe way to reduce the uncured complicated skin wounds and ensure the subsequent normal life of patients.

Algorithm and Software System for Treatment Application of Platelet-Rich Plasma on Problematic Skin Wounds

Abstract Recently a big interest arises to the automated diagnosis and digitalization of clinical data. The purpose of this article is to present treatment algorithm and software system for Problematic Skin Wounds (PSW) by using Platelet-Rich Plasma (PRP), based on the first study on platelet-rich plasma application carried out in Bulgaria. PSW-PRP-Project software system was developed for entering and processing medical data during PRP treatment, visualization of general patient information, treatment trend, as well as a module for training specialists through the created database. For a period of seven years around 100 patients have been treatment at the Department of Orthopaedics and Traumatology, UMBAL KANEV Ruse AD, by applying platelet-rich plasma. The algorithm for the use of platelet-rich plasma for treating problematic skin wounds allows for the proper and accurate treatment of patients with various problematic skin wounds with the purpose of solving the therapeutic problem and their complete recovery. The procedure’s course is determined based on assessment on three digital criteria TWS, TAS and TSWD. The algorithms are based on our results, obtained for the first in Bulgaria while treating problematic skin wounds by using platelet-rich plasma and successfully treating 92.78% of patients to full recovery.

Evaluation of Juglans regia L., root for wound healing via antioxidant, antimicrobial and anti-inflammatory activity

The burden of the management of problematic skin wounds characterized by a compromised skin barrier is growing rapidly. There is an urgent requirement for efficient mechanism-based treatments and more efficacious drug delivery systems. The present study was aimed to examine the wound healing potential of Juglans regia L. root (JR) in rats by incision and excision wound methods via the anti-inflammatory, antioxidant and antimicrobial activities. We have used tensile strength and biochemical parameters for studying the wound healing properties of JR by incision wound methodology. The anti-inflammatory effect was assessed by the measurement of paw edema in carrageenan-induced inflammation in rats. The wound contraction area, antioxidant status, and antimicrobial studies were exhausted excision wound methodology. There was a significant decrease in percent inhibition of paw edema (0.63 ± 0.03 to 0.33 ± 0.02 after 24 h) with an increase in JR concentration. Tensile strength and hydroxyproline level of different concentrations (1, 2.5, 5, and 10% w/w) of JR ointment treated groups were found significantly (P <0.001) comparable to the reference group. Moreover, JR showed significant antimicrobial and antioxidant properties, by its ability to increase antioxidant and antimicrobial levels. In conclusion, the overall results obtained in this study clarify that JR inhibits paw edema and accelerates cutaneous wound healing.