Background. The relevance of the problem of stress urinary incontinence (SUI) in combination with cystocele has increased significantly over the past decades, due to the high prevalence of the disease in the population, as well as increased awareness of patients about treatment options. It is known that one-stage surgical treatment significantly reduces the need for re-intervention and, accordingly, the rehabilitation period. The identification of significant criteria that are decisive in the effectiveness of various methods of surgical correction of SUI in combination with cystocele dictates the need for further research in this direction.The purpose of the study. To determine outcome criteria for surgical treatment of stress urinary incontinence in combination with cystocele in postmenopausal women based on a comprehensive preoperative examination.Materials and methods. A prospective randomized study was conducted, which included 80 women with stress urinary incontinence in combination with postmenopausal cystocele, who were routinely hospitalized in the gynecological department of the Federal State Budgetary Institution Research Institute of OMM for surgical treatment. All patients, after signing voluntary informed consent to participate in the study and conducting a comprehensive preoperative examination using a random number generator, were randomized into two groups of equal size. The first group included 40 women who received surgical treatment including anterior colporrhaphy in combination with urethropexy with a synthetic loop; the second group consisted of 40 patients who underwent surgical treatment using the method of paraurethral injection of a volume-forming gel in combination with anterior colporrhaphy.Results and discussion. Criteria for predicting the outcome of surgical treatment of stress urinary incontinence in combination with cystocele in postmenopausal women were determined based on a comprehensive preoperative examination. Conclusion: Analysis of complex urodynamic and ultrasound examination methods in women revealed statistically significant differences between groups of women with positive and negative outcomes of surgical treatment. The identified criteria for predicting the outcome of surgical treatment serve to assist the clinician in choosing the optimal, most effective method of treating SUI in combination with cystocele in postmenopausal women.Conclusions. Analysis of complex urodynamic and ultrasound methods of examination in women revealed statistically significant differences between groups of women with positive and negative outcomes of surgical treatment. The identified criteria for predicting the out-come of surgical treatment serve to assist the clinician in choosing the optimal, most effective method of treating SUI in combination with cystocele in postmenopausal women.