A hydrodynamic thrust bearing could be forced to operate in mixed lubrication regime under various circumstances. At this state, the tribological characteristics of the bearing could be affected significantly and the developed phenomena would have a severe impact on the performance of the mechanism. Until recently, researchers were modeling the hydrodynamic lubrication problem of the thrust bearings either with analytical or with numerical solutions. The analytical solutions are very simple and do not provide enough accuracy in describing the actual problem. To add to that, following only computational methodologies, can lead to time consuming and complex algorithms that need to be repeated every time the operating conditions change, in order to draw safe conclusions. Recent technological advances, especially on the field of computer science, have provided tools that enhance and accelerate the modeling of thrust bearings’ operation. The aim of this study is to examine the application of Artificial Neural Networks as Machine Learning models, that are trained to predict the coefficient of friction for lubricated pad thrust bearings in mixed lubrication regime. The hydrodynamic analysis of the thrust bearing is performed by solving the Average 2-D Reynolds equation numerically. In order to describe the roughness of the profiles, both the flow factors suggested by N. Patir and H.S. Cheng (1978) and the model of J.A. Greenwood and J. H. Tripp (1970) are taken into consideration. Three lubricants, the SAE 0W30, the SAE 10W40 and the SAE 10W60, are tested and compared for a variety of operating velocities and applied coatings. The numerical analysis results are used as training datasets for the machine learning algorithms. Four different ML methods are applied in this investigation: Artificial Neural Networks (ANNs), Multi- Variable Quadratic Polynomial Regression, Quadratic SVM and Regression Trees. The coefficient of determination, R2 is calculated and used to determine the most accurate ML method for the current study. The results showed that ANNs provide very good accuracy in the prediction of friction coefficient compared to the rest of the ML models discussed.