A key technology for soft landing of powered descent of aircraft is to solve the six-degree-of-freedom powered descent guidance problem in real time, which can be described as the fuel-saving trajectory optimization problem under multiple constraints. Three optimization models are established by selecting three independent variables: flight time, time substitution variable, and trajectory height. The original trajectory optimization problem is transformed into a solvable form of sequential convex optimization for iterative solution, forming three online guidance methods. The three guidance methods are compared in terms of convergence, real-time performance, optimality, and solution accuracy. The results show that all three guidance methods can solve the six-degree-of-freedom powered descent problem. The guidance method with flight time as the independent variable has the shortest calculation time and the least fuel consumption, but the powered descent flight time needs to be determined in advance. The guidance methods based on the other two types of independent variables can optimize the powered descent flight time, but they are all suboptimal solutions, and the calculation time is significantly increased. The solution accuracy of the three methods is similar under the same number of discrete points. If sequential convex optimization is used as the online guidance scheme for powered descent, how to determine the optimal flight time, approach the optimal solution for fuel, and further shorten the calculation time still needs to be further studied.