Problem-Based Learning (PBL) has emerged as a transformative instructional approach, emphasizing active, student-centered learning through real-world problem-solving. This literature review delves into the potential of PBL to cultivate Autonomous Learning Ability (ALA) among middle school students—a critical yet often overlooked developmental phase. Drawing from diverse studies, the review highlights the synergy between PBL and adolescents' evolving cognitive capacities, such as self-directed inquiry, metacognition, and critical analysis. However, the efficacy of PBL is contingent upon its alignment with students' transitional developmental needs, achieved through adaptive project scaffolding, adept facilitation, and dynamic assessment. While PBL can harness adolescents' budding cognitive abilities, its success is intricately tied to responsive design, ensuring projects, scaffolding, facilitation, and assessment cater to students' unique developmental trajectories. Practical strategies, such as aligning with educational standards, providing incremental teacher training, and emphasizing knowledge application in assessments, can mitigate potential barriers to PBL adoption. Furthermore, the review suggests that while PBL holds promise in fostering autonomous learning skills, its long-term benefits remain a topic of debate. The need for rigorous mixed-methods research examining the enduring academic and career outcomes of PBL is emphasized. Additionally, the potential of emerging technologies to augment PBL's adaptability and inclusivity for a diverse student population is highlighted as a promising avenue for future exploration. In conclusion, this synthesis underscores that PBL, when implemented with developmental considerations at its core, stands out as a potent instructional model, primed to nurture engaged, self-motivated learners in middle school settings.