Probable Antiphospholipid Syndrome Research Articles

Anemia hemolítica autoimune por anticorpos frios: um caso de Lúpus Eritematoso Sistémico

Cold antibody-mediated autoimmune haemolytic anaemia is rarely associated with systemic lupus erythematosus. A 35-year-old woman was admitted with one week of progressive asthenia, right pleuritic pain and a nonproductive cough history. Macrocytic anaemia of autoimmune aetiology was noticed with self-aggregation at room temperature. The patient revealed a positive clinical and analytical response to systemic corticosteroid therapy and blood transfusion support. An acute pulmonary thromboembolism was diagnosed on computed tomography, and the serologies were positive for anti-glycoprotein, lupus anticoagulant, anti-cardiolipin, antinuclear, SSA and thyroid antibodies. Systemic lupus erythematosus associated with autoimmune haemolytic anaemia mediated by cold antibodies associated with probable antiphospholipid syndrome was diagnosed, a rare situation described through a literature review.

Anticoagulation Rationale in an Elderly Patient with Stroke, Cerebral Amyloid Angiopathy, and Antiphospholipid Syndrome: A Case Report

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history suggests a very high ICH recurrence rate, probably contra-indicating the use of OAC.

Devic's syndrome in systemic lupus erythematosus and probable antiphospholipid syndrome: reply

Devic's syndrome in systemic lupus erythematosus and probable antiphospholipid syndrome: reply

Devic's syndrome in systemic lupus erythematosus and probable antiphospholipid syndrome

as the immunomodulatory drugs typically used for MS will beineffective for relapse prevention in NMO and severe refractoryattacks in NMO usually necessitate rescue plasmapheresis or moreeffective immunosuppressive therapies [3].In the management of this suspected case of NMO, the authorsmade use of investigatory tools such as cerebrospinal fluid analysisand MRI of the brain/spinal cord in diagnosis. However, asindicated by de Seze et al. [2], even when all these investigatoryarmaments are summoned there is still the pitfall of misdiagnosisand the inability to distinguish the two. Recently, using thetechnique of dual immunostaining, Lennon et al. [4] havedemonstrated that a serum autoantibody marker, NMO-IgG,is highly specific for neuromyelitis optica and can significantlycurtail the diagnostic ambiguity.Perhaps, with the aid of a specific autoantibody marker, themanagement of this patient might have been more streamlined.The authors have declared no conflicts of interest.A. Y. K. C

Devic's syndrome in systemic lupus erythematosus and probable antiphospholipid syndrome

as the immunomodulatory drugs typically used for MS will beineffective for relapse prevention in NMO and severe refractoryattacks in NMO usually necessitate rescue plasmapheresis or moreeffective immunosuppressive therapies [3].In the management of this suspected case of NMO, the authorsmade use of investigatory tools such as cerebrospinal fluid analysisand MRI of the brain/spinal cord in diagnosis. However, asindicated by de Seze et al. [2], even when all these investigatoryarmaments are summoned there is still the pitfall of misdiagnosisand the inability to distinguish the two. Recently, using thetechnique of dual immunostaining, Lennon et al. [4] havedemonstrated that a serum autoantibody marker, NMO-IgG,is highly specific for neuromyelitis optica and can significantlycurtail the diagnostic ambiguity.Perhaps, with the aid of a specific autoantibody marker, themanagement of this patient might have been more streamlined.The authors have declared no conflicts of interest.A. Y. K. C