Probabilistic Neural Network Classifier Research Articles

Feature Importance Analysis and Machine Learning for Alzheimer's Disease Early Detection: Feature Fusion of the Hippocampus, Entorhinal Cortex, and Standardized Uptake Value Ratio.

Alzheimer's disease (AD) is a progressive neurological disorder characterized by mild memory loss and ranks as a leading cause of mortality in the USA, accounting for approximately 120,000 deaths per year. It is also the primary form of dementia. Early detection is critical for timely intervention as the neurodegenerative process often starts 15-20 years before cognitive symptoms manifest. This study focuses on determining feature importance in AD classification using fused texture features from 3D magnetic resonance imaging hippocampal and entorhinal cortex and standardized uptake value ratio (SUVR) derived from positron emission tomography (PET) images. To achieve this objective, we employed four distinct classifiers (Linear Support Vector Classification, Linear Discriminant Analysis, Logistic Regression, and Logistic Regression Classifier with Stochastic Gradient Descent Learning). These classifiers were used to derive both average and top-ranked importance scores for each feature based on their outputs. Our framework is designed to distinguish between two classes, AD-negative (or mild cognitive impairment stable [MCIs]) and AD-positive (or MCI conversion [MCIc]), using a probabilistic neural network classifier and the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The findings from the feature importance highlight the crucial role of the GLCM texture features extracted from the hippocampus and entorhinal cortex, demonstrating their superior performance compared to the volume and SUVR. GLCM texture AD classification achieved approximately 90% sensitivity in identifying MCIc cases while maintaining low false positives (below 30%) when fused with other features. Moreover, the receiver operating characteristic curves validate the GLCMs' superior performance in distinguishing between MCIs and MCIc. Additionally, fusing different types of features improved classification performance compared to relying solely on any single feature category. Our study emphasizes the pivotal role of GLCM texture features in early Alzheimer's detection.

Brain tumor MRI identification and classification using DWT, PCA and kernel support vector machine

Classification, segmentation, and the identification of the infection region in MRI images of brain tumors are labor-intensive and iterative processes. Numerous anatomical structures of the human body may be envisioned using an image processing theory. With basic imaging methods, it is challenging to see the aberrant human brain's structure. The neurological structure of the human brain may be distinguished and made clearer using the magnetic resonance imaging technique. The MRI approach uses a number of imaging techniques to evaluate and record the human brain’s interior features. In this study, we focused on strategies for noise removal, gray-level co-occurrence matrix (GLCM) extraction of features, and segmentation of brain tumor regions based on Discrete Wavelet Transform (DWT) to minimize complexity and enhance performance. In turn, this reduces any noise that could have been left over after segmentation due to morphological filtering. Brain MRI scans were utilized to test the accuracy of the classification and the location of the tumor using probabilistic neural network classifiers. The classifier's accuracy and position detection were tested using MRI brain imaging. The efficiency of the suggested approach is demonstrated by experimental findings, which showed that normal and diseased tissues could be distinguished from one another from brain MRI scans with about 100% accuracy.

Brain Tumor Classification using Probabilistic Neural Network

Brain tumour classification is proposed in this work using probabilistic neural networks to handle images and data processing techniques for autonomous detection. Conventionally, the classification and detection of brain tumours are done by human inspection with a medical resonance image (MRI) of the brain. The manually operated methods could be more practical for massive datasets and non-reproducible. During MRI screening, noise is generated, and it leads to serious accuracy issues in classifying the disease. The real-time difficulties should be overcome with the help of artificial intelligence, which is a better solution for this field. Hence, this paper applied the probabilistic neural network. The proposed work was split into two stages: decision-making, performed in two phases; feature extraction using the principal component analysis; and classification using probabilistic neural network (PNN). The performance evaluation of the PNN classifier was based on the network's training performance and classification results. Probabilistic Neural Network provides better classification and is a promising tool for classifying tumours.

Computer-Aided Discrimination of Glaucoma Patients from Healthy Subjects Using the RETeval Portable Device.

Glaucoma is a chronic, progressive eye disease affecting the optic nerve, which may cause visual damage and blindness. In this study, we present a machine-learning investigation to classify patients with glaucoma (case group) with respect to normal participants (control group). We examined 172 eyes at the Ophthalmology Clinic of the "Elpis" General Hospital of Athens between October 2022 and September 2023. In addition, we investigated the glaucoma classification in terms of the following: (a) eye selection and (b) gender. Our methodology was based on the features extracted via two diagnostic optical systems: (i) conventional optical coherence tomography (OCT) and (ii) a modern RETeval portable device. The machine-learning approach comprised three different classifiers: the Bayesian, the Probabilistic Neural Network (PNN), and Support Vectors Machines (SVMs). For all cases examined, classification accuracy was found to be significantly higher when using the RETeval device with respect to the OCT system, as follows: 14.7% for all participants, 13.4% and 29.3% for eye selection (right and left, respectively), and 25.6% and 22.6% for gender (male and female, respectively). The most efficient classifier was found to be the SVM compared to the PNN and Bayesian classifiers. In summary, all aforementioned comparisons demonstrate that the RETeval device has the advantage over the OCT system for the classification of glaucoma patients by using the machine-learning approach.

Automated Classification of Brain Tumor Images Employing DWT and Deep Neural Networks

Brain tumour classification using conventional techniques involving human intervention is prone to errors. Errors in feature extraction and/or classification may turn out to be fatal. Hence focus has shifted on automated techniques for the feature extraction and classification of brain tumour images. In the present work, a mechanism for the same has been proposed involving Artificial Neural Networks (ANN). Three categories have been incorporated in the present work, viz. normal brain, brain with benign tumour and brain with malignant tumour. In the present case, MRI images of the brain have been used to train an Artificial Neural Network which subsequently predicts the category of some new MRI data. The key challenge in designing such a system is attaining high accuracy of classification. This can be achieved by accurate feature extraction mechanism and then designing an appropriate Neural Network for training and testing. At the outset, segmentation has been employed to separate the region of the tumour (if any). Later the Discrete Wavelet Transform (DWT) is used as a preprocessing tool. The DWT helps in removing the non linearities of the image signal and smoothen it out. Since images exhibit abrupt changes in pixel values, conventional Fourier methods like the Fourier Transform prove to be unfit for image analysis. Subsequently, features like contrast, correlation, energy, homogeneity, mean, standard deviation, entropy, RMS value, variance, smoothness, kurtosis and skewness have been evaluated. Prior to training the Neural Network using the feature values, Principal Component Analysis (PCA) has been employed to find trends in the feature values. A Probabilistic Neural Network (PNN) has been designed and it has been trained using the feature values. I has been found that brain tumour MRI image are classified into normal, benign and malignant category using PNN classifier with an accuracy of 97% for the used data set which can be attributed to the efficacy of the proposed method. Key Words: Brain Tumor Classification, Machine Learning, Feature Extraction, Neural Networks, Confusion Matrix, Classification Accuracy.

Harmonics Extraction Scheme for Power Quality Improvement Using Chbmli-Dstatcom Module

In recent day’s power distribution system is distress from acute power quality issues. In this work, for compensating Power Quality (PQ) disturbances a seven level cascaded H-bridge inverter is implemented in distribution static compensator which protects power quality problems in currents. Distribution Static Compensator (DSTATCOM) aid to enhances power factor and removes total harmonic distortion which is drawn from non-linear load. The D–Q reference theory based hysteresis current controller is employed to generate reference current for compensation of harmonics and reactive power, additionally Probabilistic Neural Network (PNN) classifier is used which easily separates exact harmonics. In the meantime fuzzy logic controller is also used to maintain capacitor DC-link potential. When comparing to PI controller it decreases steady state time and reduces maximum peak overshoot. Cascaded H-bridge multilevel inverter converts direct current to Alternating current, through inductor opposite harmonics are injected in Power Control Centre reduces source current harmonics and reactive power. The implementation of CHBMLI in distribution STATic COMpensator simulation model is simulated by means of MATLAB.

Fire Hawk Optimizer with Deep Learning Enabled Human Activity Recognition

Human-Computer Interaction (HCI) is a sub-area within computer science focused on the study of the communication between people (users) and computers and the evaluation, implementation, and design of user interfaces for computer systems. HCI has accomplished effective incorporation of the human factors and software engineering of computing systems through the methods and concepts of cognitive science. Usability is an aspect of HCI dedicated to guaranteeing that human–computer communication is, amongst other things, efficient, effective, and sustaining for the user. Simultaneously, Human activity recognition (HAR) aim is to identify actions from a sequence of observations on the activities of subjects and the environmental conditions. The vision-based HAR study is the basis of several applications involving health care, HCI, and video surveillance. This article develops a Fire Hawk Optimizer with Deep Learning Enabled Activity Recognition (FHODL-AR) on HCI driven usability. In the presented FHODL-AR technique, the input images are investigated for the identification of different human activities. For feature extraction, a modified SqueezeNet model is introduced by the inclusion of few bypass connections to the SqueezeNet among Fire modules. Besides, the FHO algorithm is utilized as a hyperparameter optimization algorithm, which in turn boosts the classification performance. To detect and categorize different kinds of activities, probabilistic neural network (PNN) classifier is applied. The experimental validation of the FHODL-AR technique is tested using benchmark datasets, and the outcomes reported the improvements of the FHODL-AR technique over other recent approaches.

An Intelligent Intrusion Detection System in Smart Grid Using PRNN Classifier

Typically, smart grid systems enhance the ability of conventional power system networks as it is vulnerable to several kinds of attacks. These vulnerabilities might cause the attackers or intruders to collapse the entire network system thus breaching the confidentiality and integrity of smart grid systems. Thus, for this purpose, Intrusion detection system (IDS) plays a pivotal part in offering a reliable and secured range of services in the smart grid framework. Several existing approaches are there to detect the intrusions in smart grid framework, however they are utilizing an old dataset to detect anomaly thus resulting in reduced rate of detection accuracy in real-time and huge data sources. So as to overcome these limitations, the proposed technique is presented which employs both real-time raw data from the smart grid network and KDD99 dataset thus detecting anomalies in the smart grid network. In the grid side data acquisition, the power transmitted to the grid is checked and enhanced in terms of power quality by eradicating distortion in transmission lines. In this approach, power quality in the smart grid network is enhanced by rectifying the fault using a FACT device termed UPQC (Unified Power Quality Controller) and thereby storing the data in cloud storage. The data from smart grid cloud storage and KDD99 are pre-processed and are optimized using Improved Aquila Swarm Optimization (IASO) to extract optimal features. The probabilistic Recurrent Neural Network (PRNN) classifier is then employed for the prediction and classification of intrusions. At last, the performance is estimated and the outcomes are projected in terms of grid voltage, grid current, Total Harmonic Distortion (THD), voltage sag/swell, accuracy, precision, recall, F-score, false acceptance rate (FAR), and detection rate of the classifier. The analysis is compared with existing techniques to validate the proposed model efficiency.

An Efficient Hybrid Optimization for Skin Cancer Detection Using PNN Classifier

The necessity of on-time cancer detection is extremely high in the recent days as it becomes a threat to human life. The skin cancer is considered as one of the dangerous diseases among other types of cancer since it causes severe health impacts on human beings and hence it is highly mandatory to detect the skin cancer in the early stage for providing adequate treatment. Therefore, an effective image processing approach is employed in this present study for the accurate detection of skin cancer. Initially, the dermoscopy images of skin lesions are retrieved and processed by eliminating the noises with the assistance of Gabor filter. Then, the pre-processed dermoscopy image is segmented into multiple regions by implementing cascaded Fuzzy C-Means (FCM) algorithm, which involves in improving the reliability of cancer detection. The A Gabor Response Co-occurrence Matrix (GRCM) is used to extract melanoma parameters in an efficient manner. A hybrid Particle Swarm Optimization (PSO)-Whale Optimization is then utilized for efficiently optimizing the extracted features. Finally, the features are significantly classified with the assistance of Probabilistic Neural Network (PNN) classifier for classifying the stages of skin lesion in an optimal manner. The whole work is stimulated in MATLAB and the attained outcomes have proved that the introduced approach delivers optimal results with maximal accuracy of 97.83%.

A fuzzy neural network-based automatic fault diagnosis method for permanent magnet synchronous generators.

In recent years, automatic fault diagnosis for various machines has been a hot topic in the industry. This paper focuses on permanent magnet synchronous generators and combines fuzzy decision theory with deep learning for this purpose. Thus, a fuzzy neural network-based automatic fault diagnosis method for permanent magnet synchronous generators is proposed in this paper. The particle swarm algorithm optimizes the smoothing factor of the network for the effect of probabilistic neural network classification, as affected by the complexity of the structure and parameters. And on this basis, the fuzzy C means algorithm is used to obtain the clustering centers of the fault data, and the network model is reconstructed by selecting the samples closest to the clustering centers as the neurons in the probabilistic neural network. The mathematical analysis and derivation of the T-S (Tkagi-Sugneo) fuzzy neural network-based diagnosis strategy are carried out; the T-S fuzzy neural network-based generator fault diagnosis system is designed. The model is implemented on the MATLAB/Simulink platform for simulation and verification, the experiments show that the T-S fuzzy diagnosis strategy is significantly improved, and the design purpose is achieved. The fuzzy neural network has a parallel structure and can perform parallel data processing. This parallel mechanism can solve the problem of large-scale real-time computation in control systems, and the redundancy in parallel computation can make the control system highly fault-tolerant and robust. The fault diagnosis model based on an improved probabilistic neural network is applied to the fault data to verify the effectiveness and accuracy of the model.

Optimized Intelligent Classifier for Early Breast Cancer Detection Using Ultra-Wide Band Transceiver.

Breast cancer is the most common cancer diagnosed in women and the leading cause of cancer-related deaths among women worldwide. The death rate is high because of the lack of early signs. Due to the absence of a cure, immediate treatment is necessary to remove the cancerous cells and prolong life. For early breast cancer detection, it is crucial to propose a robust intelligent classifier with statistical feature analysis that considers parameter existence, size, and location. This paper proposes a novel Multi-Stage Feature Selection with Binary Particle Swarm Optimization (MSFS-BPSO) using Ultra-Wideband (UWB). A collection of 39,000 data samples from non-tumor and with tumor sizes ranging from 2 to 7 mm was created using realistic tissue-like dielectric materials. Subsequently, the tumor models were inserted into the heterogeneous breast phantom. The breast phantom with tumors was imaged and represented in both time and frequency domains using the UWB signal. Consequently, the dataset was fed into the MSFS-BPSO framework and started with feature normalization before it was reduced using feature dimension reduction. Then, the feature selection (based on time/frequency domain) using seven different classifiers selected the frequency domain compared to the time domain and continued to perform feature extraction. Feature selection using Analysis of Variance (ANOVA) is able to distinguish between class-correlated data. Finally, the optimum feature subset was selected using a Probabilistic Neural Network (PNN) classifier with the Binary Particle Swarm Optimization (BPSO) method. The research findings found that the MSFS-BPSO method has increased classification accuracy up to 96.3% and given good dependability even when employing an enormous data sample.

Modified spider monkey optimization algorithm based feature selection and probabilistic neural network classifier in face recognition

AbstractThis paper proposes a novel and robust predictive method using modified spider monkey optimization (MSMO) and probabilistic neural network (PNN) for face recognition. The limitation of the traditional spider monkey optimization (SMO) approach to obtaining an optimal solution for classification problems is overcome by enhancing the performance of SMO by modifying the perturbation rate with a non‐linear function, thereby improving the convergence of SMO. The framework comprises image preprocessing, feature extraction using dual tree complex wavelet transform (DT‐CWT), feature selection using the modified spider monkey optimization algorithm (MSMO), and classification using PNN. The proposed method is tested on the Yale and AR Face datasets. Experimental outcomes reveal that the proposed framework attain an accuracy of 99.4% with appreciable sensitivity, specificity, and G‐mean. To examine the efficacy of MSMO, parametric studies are conducted, which showed that MSMO converges faster with high fitness when compared to similar evolutionary algorithms like Genetic Algorithm (GA), Grey Wolf Optimization Algorithm (GWO), Particle Swarm Algorithm (PSO), and Cuckoo Search (CS) in selecting the optimal feature set. The MSMO‐PNN method outperforms similar state‐of‐the‐art methods, which reveals that the method proposed is competitive. The proposed model is robust to Gaussian and salt–pepper noise, obtaining the highest accuracy of 97.89% for varied noise density and variance.

DE-PNN: Differential Evolution-Based Feature Optimization with Probabilistic Neural Network for Imbalanced Arrhythmia Classification

In this research, a heartbeat classification method is presented based on evolutionary feature optimization using differential evolution (DE) and classification using a probabilistic neural network (PNN) to discriminate between normal and arrhythmic heartbeats. The proposed method follows four steps: (1) preprocessing, (2) heartbeat segmentation, (3) DE feature optimization, and (4) PNN classification. In this method, we have employed direct signal amplitude points constituting the heartbeat acquired from the ECG holter device with no secondary feature extraction step usually used in case of hand-crafted, frequency transformation or other features. The heartbeat types include normal, left bundle branch block, right bundle branch block, premature ventricular contraction, atrial premature, ventricular escape, ventricular flutter and paced beat. Using ECG records from the MIT-BIH, heartbeats are identified to start at 250 ms before and end at 450 ms after the respective R-peak positions. In the next step, the DE method is applied to reduce and optimize the direct heartbeat features. Although complex and highly computational ECG heartbeat classification algorithms have been proposed in the literature, they failed to achieve high performance in detecting some minority heartbeat categories, especially for imbalanced datasets. To overcome this challenge, we propose an optimization step for the deep CNN model using a novel classification metric called the Matthews correlation coefficient (MCC). This function focuses on arrhythmia (minority) heartbeat classes by increasing their importance. Maximum MCC is used as a fitness function to identify the optimum combination of features for the uncorrelated and non-uniformly distributed eight beat class samples. The proposed DE-PNN scheme can provide better classification accuracy considering 8 classes with only 36 features optimized from a 253 element feature set implying an 85.77% reduction in direct amplitude features. Our proposed method achieved overall 99.33% accuracy, 94.56% F1, 93.84% sensitivity, and 99.21% specificity.

Machine Learning and Internet of Things (IoT) for Real-Time Image Classification in Smart Agriculture

A human's ability to survive would be impossible without agriculture. Agriculture provides a means of subsistence for a huge proportion of the global population. It also provides a large number of work opportunities for the locals. Poor yields are a consequence of farmers' desire to rely on old-fashioned farming methods. The long-term development and success of the economy will continue to depend on agricultural and related industries. Crop monitoring and tracking, disease identification and management, and other such issues are among agriculture's most difficult difficulties. In many cases, smart farming is a viable answer. The Internet of Things (IoT) and machine learning methods has made it feasible to implement smart agriculture. This article presents a framework for real-time picture categorization in agriculture. Everything from IoT cameras to mobile applications to machine learning methods is featured. Arduino Uno, sensors, and Wi-Fi devices make up the hardware. Computers may "learn" from previous examples and detect patterns from noisy or complicated datasets using machine learning, a technique that uses a variety of statistical, probabilistic, and optimization methodologies to allow computers to "learn." Because of this, machine learning algorithms are increasingly being utilized to classify photos. Real-time photos linked to smart agriculture were classified using a combination of SVM, K-nearest neighbors, and probabilistic neural network classifiers. Real-time picture classification will assist in the diagnosis of leaf disease, the monitoring of farm staff, the classification of crops, and the tracking of farm product progress.

A new sensor fault diagnosis method for gas leakage monitoring based on the naive Bayes and probabilistic neural network classifier

Gas monitoring sensor is prone to failure and its fault type is difficult to identify due to harsh working condition. In this work, a new sensor fault diagnosis method for gas leakage monitoring has been proposed derived from the Naive Bayes Classifier (NBC) and Probabilistic Neural Network (PNN). Firstly, NBC is used to identify the abnormal safety monitoring data. Then PNN is employed for sensor fault classification. The feasibility and effectiveness of this method are verified by applying it to the urban gas pipeline leakage monitoring system. It is shown that the abnormal monitoring data can be online distinguished, and sensor fault type can be effectively recognized. The global accuracy of abnormal data identification and the global accuracy of sensor fault diagnosis can reach 85% and 95%, respectively. This work can provide a guideline to improve the reliability of the urban gas pipeline monitoring systems.

Multi-Sensor Data Driven with PARAFAC-IPSO-PNN for Identification of Mechanical Nonstationary Multi-Fault Mode

Data analysis has wide applications in eliminating the irrelevant and redundant components in signals to reveal the important informational characteristics that are required. Conventional methods for multi-dimensional data analysis via the decomposition of time and frequency information that ignore the information in signal space include independent component analysis (ICA) and principal component analysis (PCA). We propose the processing of a signal according to the continuous wavelet transform and the construction of a three-dimensional matrix containing the time–frequency–space information of the signal. The dimensions of the three-dimensional matrix are reduced by parallel factor analysis, and the time characteristic matrix, frequency characteristic matrix, and spatial characteristic matrix are obtained with tensor decomposition. Through the comparative analysis of the simulation and the experiment, the time characteristic matrix and the frequency characteristic matrix can accurately characterize the normal and fault states of the mechanical equipment. On this basis, the authors established a probabilistic neural network classification model optimized by the improved particle swarm algorithm (IPSO). The parallel factor (PARAFAC) decomposition algorithm can extract features from the centrifugal pump experimental data for normal and multiple fault states, establish the mapping relationship of different fault features of the centrifugal pump in time, frequency, and space, and import the fault features into the model classification. The above measures can significantly improve the fault identification rate and accuracy for a centrifugal pump.

Fusion of B‐mode and shear wave elastography ultrasound features for automated detection of axillary lymph node metastasis in breast carcinoma

AbstractIn this study, we evaluate and compare the diagnostic performance of ultrasound for non‐invasive axillary lymph node (ALN) metastasis detection. The study was based on fusing shear wave elastography (SWE) and B‐mode ultrasonography (USG) images. These images were subjected to pre‐processing and feature extraction, based on bi‐dimensional empirical mode decomposition and higher order spectra methods. The resulting nonlinear features were ranked according to their p‐value, which was established with Student's t‐test. The ranked features were used to train and test six classification algorithms with 10‐fold cross‐validation. Initially, we considered B‐mode USG images in isolation. A probabilistic neural network (PNN) classifier was able to discriminate positive from negative cases with an accuracy of 74.77% using 15 features. Subsequently, only SWE images were used and as before, the PNN classifier delivered the best result with an accuracy of 87.85% based on 47 features. Finally, we combined SWE and B‐mode USG images. Again, the PNN classifier delivered the best result with an accuracy of 89.72% based on 71 features. These three tests indicate that SWE images contain more diagnostically relevant information when compared with B‐mode USG. Furthermore, there is scope in fusing SWE and B‐mode USG to improve non‐invasive ALN metastasis detection.

An Operative Acute Brain Tumor Recognition by Jointure Inward Unswerving Probabilistic Neural Network Classifier

Brain tumors have to be predicted earlier to avoid the risk of being mortal. For an effective detection an adaptive segmentation with two-tier tumors region extraction is needed. This framework offers preprocessing to avoid noise occurrence by fusing median and wiener filter also utilizes adaptive pillar C-means algorithm for obtaining the essential feature set thus the processing time is reduced. Thus the attained essential feature sets are then classified by means of unswerving PNN (Probabilistic Neural network) classifier where classification is done twice initially to classify whether benign or malignant, Sub sequently to classify different sorts of brain tumor such as Astrocytoma, Meningioma, Glioblastoma and Medulloblastoma. Since the non-linearity of PNN due to distance factor consumes more computation time which is tackled by intruding the radial basis function resulted in LS-SVM (Least Square-Support Vector Machine) as a distance factor which is linear one. Thus computation time is further reduced.

Longitudinal clustering analysis and prediction of Parkinson's disease progression using radiomics and hybrid machine learning.

We employed machine learning approaches to (I) determine distinct progression trajectories in Parkinson's disease (PD) (unsupervised clustering task), and (II) predict progression trajectories (supervised prediction task), from early (years 0 and 1) data, making use of clinical and imaging features. We studied PD-subjects derived from longitudinal datasets (years 0, 1, 2 & 4; Parkinson's Progressive Marker Initiative). We extracted and analyzed 981 features, including motor, non-motor, and radiomics features extracted for each region-of-interest (ROIs: left/right caudate and putamen) using our standardized standardized environment for radiomics analysis (SERA) radiomics software. Segmentation of ROIs on dopamine transposer - single photon emission computed tomography (DAT SPECT) images were performed via magnetic resonance images (MRI). After performing cross-sectional clustering on 885 subjects (original dataset) to identify disease subtypes, we identified optimal longitudinal trajectories using hybrid machine learning systems (HMLS), including principal component analysis (PCA) + K-Means algorithms (KMA) followed by Bayesian information criterion (BIC), Calinski-Harabatz criterion (CHC), and elbow criterion (EC). Subsequently, prediction of the identified trajectories from early year data was performed using multiple HMLSs including 16 Dimension Reduction Algorithms (DRA) and 10 classification algorithms. We identified 3 distinct progression trajectories. Hotelling's t squared test (HTST) showed that the identified trajectories were distinct. The trajectories included those with (I, II) disease escalation (2 trajectories, 27% and 38% of patients) and (III) stable disease (1 trajectory, 35% of patients). For trajectory prediction from early year data, HMLSs including the stochastic neighbor embedding algorithm (SNEA, as a DRA) as well as locally linear embedding algorithm (LLEA, as a DRA), linked with the new probabilistic neural network classifier (NPNNC, as a classifier), resulted in accuracies of 78.4% and 79.2% respectively, while other HMLSs such as SNEA + Lib_SVM (library for support vector machines) and t_SNE (t-distributed stochastic neighbor embedding) + NPNNC resulted in 76.5% and 76.1% respectively. This study moves beyond cross-sectional PD subtyping to clustering of longitudinal disease trajectories. We conclude that combining medical information with SPECT-based radiomics features, and optimal utilization of HMLSs, can identify distinct disease trajectories in PD patients, and enable effective prediction of disease trajectories from early year data.

Modified PNN classifier for diagnosing skin cancer severity condition using SMO optimization technique

<abstract> <p>Skin cancer is a pandemic disease now worldwide, and it is responsible for numerous deaths. Early phase detection is pre-eminent for controlling the spread of tumours throughout the body. However, existing algorithms for skin cancer severity detections still have some drawbacks, such as the analysis of skin lesions is not insignificant, slightly worse than that of dermatologists, and costly and time-consuming. Various machine learning algorithms have been used to detect the severity of the disease diagnosis. But it is more complex when detecting the disease. To overcome these issues, a modified Probabilistic Neural Network (MPNN) classifier has been proposed to determine the severity of skin cancer. The proposed method contains two phases such as training and testing the data. The collected features from the data of infected people are used as input to the modified PNN classifier in the current model. The neural network is also trained using Spider Monkey Optimization (SMO) approach. For analyzing the severity level, the classifier predicts four classes. The degree of skin cancer is determined depending on classifications. According to findings, the system achieved a 0.10% False Positive Rate (FPR), 0.03% error and 0.98% accuracy, while previous methods like KNN, NB, RF and SVM have accuracies of 0.90%, 0.70%, 0.803% and 0.86% correspondingly, which is lesser than the proposed approach.</p> </abstract>