The efficient and stable removal of indoor formaldehyde (HCHO) a low concentration, as required by the national standard (≤ 0.08 mg/m3), remains a significant challenge. In this study, we investigated a novel hexagonal prism structure of MnCe-MOFs catalysts, synthesized via the hydrothermal method using DMF (N, N-Dimethylformamide), for the complete degradation of HCHO at ambient temperature. Monometallic and bimetallic MOFs materials, as well as the effects of calcination temperature and the stability of these high-performance catalysts in degrading HCHO were investigated and characterized using EDS, XPS, H2-TPR, IR and ESR. Results demonstrated that HCHO degradation using MnCe-MOFs achieved 97.2% efficiency within 48 hours, maintaining above 96% efficiency after three experimental cycles, exhibiting the highest activity and stability. The high performance was attributed to the columnar structure with abundant pores and a high specific surface area, lower initial reduction temperature, and an abundant presence of surface hydroxyl groups. Moreover, the spherical nanoparticles of MnCe-MOFs were uniformly distributed, and the highly dispersed CeOx provided plentiful active sites, contributing to the catalysts’ high activity and stability.