The importance of biological printing is in tissue structures that imitate the micro and real environment of human tissues and organs. This is very important in medicinal tests and clinical tests. In biological printing, cells or molecules are printed directly on a substrate in a particular pattern so that the cells can be kept together and formed the required 3D structure. This technology is widely used in medical science, including tissue regeneration, diagnosis of drugs, tissue transplantation, cosmetic surgery, and more. In this study, we have tried to point out existing damage and safety tips in this technology. Studies show the challenges facing this technology, such as high clarity in cell construction, lack of mechanical resistance and adequate integration of bio -printing structures made with soft hydrogel, material printing speed, recurreability and cell preservation. Also, work safety instructions with bio -printers including personal hygiene, printer cleaning, work room cleaning, ventilation system, periodic medical tests for operators are provided. Bioprinting technology is developing and requires further research to remove restrictions and reduce risk management
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