Primary Retroperitoneal Teratoma Research Articles

The characteristics of pediatric primary retroperitoneal teratoma and the influencing factors of perioperative complications

To explore the characteristics of pediatric primary retroperitoneal teratoma and the influencing factors of perioperative complications. The clinical data, imaging data, pathology results, perioperative complications, etc of patients with primary retroperitoneal teratoma admitted and treated at Shanxi Children's Hospital from March 2013 to September 2023 were retrospectively analyzed. The patients were divided into no complication group and complication group according to whether there were perioperative complications. The differences between the two groups were compared, and the influencing factors of complications were analyzed by multivariate logistic regression model. A total of 33 patients were included in this study, including 7 males and 26 females, with an age of [M (Q1, Q3), 9.0 (4.0, 24.0)] months. Nineteen cases had tumors located in the left upper abdomen and 14 cases in the right upper abdomen, among which 17 cases grew across the midline, with the maximum tumor diameter of (12.9±4.5) cm. All patients had anatomical displacement of retroperitoneal vessels and organs: the number of anatomical displaced arteries was 3 (3, 4), the number of anatomical displaced veins was 4 (3, 5), the number of anatomical displaced organs was 5 (4, 6). Pathologic examination revealed 28 mature teratomas (Grade 0 and Grade 1) and 5 immature teratomas (Grade 2 and Grade 3). There were 18 cases in no complication group and 15 cases in the complication group. The incidence of perioperative complications was 45.5% (15/33). The number of tumors crossing the midline (6/18 vs 11/15, P=0.037), the number of tumors adhering closely to the surrounding tissues (7/18 vs 12/15, P=0.033), the number of anatomical displaced veins [4 (3, 4) vs 5 (4, 5), P=0.001], and the number of anatomical displaced organs [4 (3, 5) vs 6 (5, 6), P=0.001] were significantly different between the two groups. Multivariate logistic regression model analysis showed that the number of anatomical displaced organs (OR=8.781, 95%CI: 2.155-35.784, P=0.002) was the influencing factor for perioperative complications of pediatric primary retroperitoneal teratoma.

A rare case of retroperitoneal teratoma with evidence of papillary thyroid carcinoma: a case report

BackgroundTeratomas are germ cell tumors composed of somatic tissues from up to three germ layers. Primary retroperitoneal teratomas usually develop during childhood and are uncommon in adults and in the retroperitoneal space. While there are only a few cases of retroperitoneal thyroid tissue, we report a unique case of a retroperitoneal papillary thyroid carcinoma.Case presentationA 41-year-old woman presented in our institution due to intermitted unspecific abdominal pain. Magnetic resonance imaging detected a multi-cystic solid retroperitoneal mass ventral to the psoas muscle and the left iliac artery. After surgical removal of the retroperitoneal mass, histology sections of the specimen indicated evidence of papillary thyroid carcinoma cells. A staging computed tomography scan of the body showed no further manifestations. To reduce the risk of recurrence, total thyroidectomy was performed followed by radioiodine therapy with lifelong hormone substitution.ConclusionsPrimary retroperitoneal teratoma with evidence of papillary thyroid carcinoma is a rare condition. Preoperative diagnosis is difficult due to its non-specific clinical manifestation and lack of specific radiologic findings. Histopathology analysis is necessary for diagnosis. Although surgery is considered the first line treatment, there is still discussion about the extent of resection and the need for total thyroidectomy with adjuvant radioiodine therapy.

Teratoma induced by amlodipine drug in fetus rats

The current study, performed during the period from February 2021 to June 2022 at the University of Thi- Qar/ College of Education for Pure Sciences, and aimed to follow the changes in external morphological features at different Embryonic developmental stages in pregnant rats treated with different doses of amlodipine. Usage In this study, 18 pregnant rats were randomly divided into three groups, each with six pregnant rats. Each group received different concentrations of amlodipine (0.3, 0.5) in oral doses until the 20th day of gestation, while the control group was injected with 0.9% normal saline. Teratomas are bizarre tumors derived from embryonic tissue that are normally found only in the gonadal and sacral regions of adults. Primary retroperitoneal teratomas are rare and present challenging management options. In one outcome, a teratoma was found in one of the amlodipine-treated groups. Complete excision of the teratoma mass was performed.

Retroperitoneal Teratoma in a Transplanted Patient: Case Report and Review

The development of de novo neoplasms in solid organ transplantation is multifactorial. In addition to common factors in the general population, there are specific factors of the disease related or not to chronic renal failure and factors inherent to the transplant itself such as immunosuppression. The aim of this study is to describe the case of a kidney recipient with a retroperitoneal teratoma, his satisfactory treatment, and a brief literature review. The case of 59-year-old male patient who received a living donor transplant in 2011, with conventional immunosuppression, graft protocol biopsy per year reported as normal, and follow-up without eventualities is described. The patient's symptoms began in December 2020 with abdominal pain resistant to analgesics, asthenia, and adynamic. Contrast tomography showed a retroperitoneal tumor 25.8×16.9×19 cm; tumor markers: alpha fetoprotein, 2.16 ng/mL; cancer antigen 19-9, 524.5 UI/ml; and carcinoembryonic antigen, 67.53 ng/mL. Resection of a 25×25×20 cm retroperitoneal tumor between the vena cava and aorta with 2 L of mucus content was performed. The patient was discharged from the hospital on the second day, with uresis 1 mL/kg/h, and at one month with adequate renal function, and 0.94mg/dL of serum creatinine. A definitive histologic report was compatible with retroperitoneal mature teratoma. Primary retroperitoneal mature teratoma is rarely evidenced in adult patients, usually asymptomatic, and the definitive diagnosis always is established after histologic evaluation. Surgical resection is the main treatment with the complete removal of the tumor and long-term monitoring is needed because of the risk of malignancy.

Primary Mature Cystic Teratoma of the Retroperitoneum Presenting as a Suprarenal Mass in an Adult Patient: A Case Report

Introduction: Primary retroperitoneal mature cystic teratomas (PRPMCT) are uncommon in adults. They typically occur in infants under six months old and young females. So far, some limited case reports have been documented in the literature. This case report presents a rare case of an adult patient with PRPMCT aged over 30 years. Case Presentation: The patient was a 34-year-old female with PRPMCT in the site of the left adrenal gland and abdominal discomfort. Computed tomography (CT) scan revealed a 66 mm hypodense lesion with fat attenuation and calcification in the left retroperitoneum. Laparotomy with resection of the retroperitoneal (RP) lesion was done. Gross examination showed a solid multicystic mass measuring 8x6.5x6 cm. Histopathologic examination revealed a neoplastic tissue composed of mature osseous and cartilaginous tissue associated with stratified squamous epithelium and lumens lined by ciliated columnar epithelium, and the diagnosis was mature cystic teratoma. The patient had an uncomplicated postoperative course without recurrence after seven months of follow-up. Conclusions: PRPMCT in adults is extremely rare. RP metastasis of primary gonadal teratoma and non-functioning adrenal tumors should be excluded first. Due to the diagnostic difficulty of posterior peritoneal teratoma with radiological imaging and its risk of malignancy, surgical resection would be the most effective diagnostic and therapeutic option. Complete resection of the mass is important to judge the existence of immature and solid components that require a long-time follow-up because of the increased risk of malignancy.

A CASE REPORT OF RETROPERITONEAL TERATOMA IN A 11 MONTH OLD INFANT:

The incidence of primary retroperitoneal teratoma in infancy is rare but in children it is seen in 3-4% of overall germ cell tumors and 1-11% of primary retroperitoneal neoplasms . Most often they are asymptomatic and diagnosed incidentally and presents clinically only after attaining large size in the form of abdominal distension, abdominal mass with or without compressive symptoms. It is basically diagnosed using the help of radiological investigations like ultrasonography and contrast-enhanced computed tomography(CECT) of abdomen and nal diagnosis is conrmed after a thorough histopathological examination of the specimen. The denitive treatment includes complete surgical removal of teratoma. Here we are reporting a case of primary retroperitoneal teratoma in a 11month old male infant who presented with right sided abdominal mass and treated by complete surgical resection. Histopathological examination suggested the diagnosis of mature cystic teratoma.

Laparoscopic resection of giant retroperitoneal mature cystic teratoma with diaphragm invasion in a 3-month-old girl

Abstract Primary retroperitoneal teratomas are rare, representing only 1%–11% of primary retroperitoneal neoplasms. They typically present as an asymptomatic abdominal mass but can grow to enormous size. The majority of these are benign mature and immature teratomas. We found a large mass in the left abdomen of the child. According to examinations (CT, Ultrasound, Tumor markers, etc.), it was considered to be benign, which was treated by laparoscopic surgery. However, CT revealed that part of the diaphragm was invaded, increasing the difficulty of our operation and intraoperatively confirmed the invasion of the left diaphragm. A frozen section and final histopathologic examination also revealed mature cystic teratoma. This case study highlights the importance of pre-operative imaging and tumor markers. Under the premise of ensuring the safety of the child, laparoscopic procedures have resulted in decreased tissue trauma and accelerated postoperative recovery.

Primary Retroperitoneal Immature Teratoma: A Case Study in Approaching Challenging Minimally Invasive Cases

Introduction: Primary retroperitoneal teratomas are rare and challenging to resect in a minimally invasive manner as they often have a significant accompanying inflammatory reaction.1–3 We depict a...

Adenocarcinomatous Transformation of a Retroperitoneal Teratoma Mimicking an Adrenal Incidentaloma in an Adult Female: a Case Report and Literature Review

Retroperitoneal teratomas are extremely rare in adults and are typically benign tumors. We describe a case of a 48-year-old lady who initially presented with abdominal discomfort 18 years ago and was found to have a large right-sided supra-renal mass suspected to be an adrenal lesion. Following initial biochemical and imaging studies a diagnosis of non-functioning adrenal adenoma was made and she was managed conservatively. After being lost to follow up and remaining clinically well for many years, she once again presented with worsening abdominal pain. A right adrenalectomy was performed and the histology surprisingly confirmed a mature cystic teratoma with malignant transformation into a moderately-differentiated intestinal-type adenocarcinoma as well as having a focus of carcinoid tumour. She was admitted shortly afterwards with widespread metastatic disease and sadly passed away before any treatment could be instituted. Only a handful of cases of primary retroperitoneal teratomas have described adenocarcinomatous transformation. A carcinoid tumour within a teratoma is even less common and typically does not manifest systemic features. This case underlines the broad differential diagnosis of an adrenal mass and highlights several unusual aspects of a teratoma. We present the current literature and discuss the appropriate investigations, management and challenges involved in such rare cases.

Diagnosis and management of primary retroperitoneal teratoma in 36 infants

Objective To investigate the clinical manifestations and surgical effectiveness of the primary retroperitoneal teratoma in infants. Methods The records of 36 patients were retrospectively reviewed who were diagnosed as primary retroperitoneal teratoma and treated at the Department of Pediatric Oncology, Guangzhou Women and Children′s Medical Center between August 2015 and August 2017.The related data were collected, including gender, age, operation time, operational bleeding and tumor weight.All patients took the ultrasound, computed tomography(CT) before surgery, alpha-fetal protein(AFP) and human chorionic gonadotrophin(HCG) were detected during peri-operation period.All cases were classified into 0 to Ⅲ grades according to the Norris classification (27 patients of 0 grade, 1 patient of Ⅰ grade, 4 patients of Ⅱ grade, 4 patients of Ⅲ grade). Results There were 9 males and 27 females in the study.All patients were treated surgically at the age of 11.4 months (7 days-7 years) on the average; the mean weight of incised tumor was 736.47 g (7.90-2 355.00 g); operation time was 2.88 hours (1.08-7.06 hours); the amount of bleeding during operation was 29.11 mL (2-150 mL). All patients received follow-ups for 6.56 months(9 days-23 months) on the average.Radiographs found that tumors in 25 patients (69.4%) were located in the left side of the abdominal cavity, and the rest of them were located in the right side.In addition, tumors in 30 patients (83.3%) were big enough to pass across the mid-line of the body.Average pre-operation AFP was 7 593.1 μg/L(1.7-80 000.0 μg/L), post-operation AFP was 1 339.5 μg/L(1.4-16 519.6 μg/L), and the difference was statistically significant (P=0.001); pre-operation AFP of the mature group was 5 439.6 μg/L(1.7-80 000.0 μg/L), post-operation AFP of the mature group was 1 130.6 μg/L(1.4-16 519.6 μg/L), and the difference was statistically significant (P=0.001); pre-operation AFP of the immature group [11 182.3 μg/L(17.4-80 000.0 μg/L)] was higher than that of the mature group, and the difference was statistically significant(P=0.006). On the final follow-up, AFP was mean 38.3 μg/L(1.4-352.4 μg/L); among them, AFP of the mature group was mean 14.3 μg/L(1.4-43.3 μg/L), the immature group was 78.4 μg/L(1.7-325.4 μg/L), and the difference was statistically significant(P=0.028); AFP of 4 patients in the immature group who underwent chemotherapy was 54.9 μg/L (2.6-116.6 μg/L) on the average, lower than those of post-operation AFP of 265.2 μg/L (206.8-384.1 μg/L), and the difference was statistically significant(P=0.042). All patients were treated surgically, and 3 cases of them received laparoscope technique; no significant relationship was proved between time of surgery and the tumor weight, location, and Norris classification(all P>0.05). The incidence rate of the surgical complications was 42.1%, such as tumor rupture (6 patients), vascular injury (5 patients), digestive tract damage (4 patients) and incomplete incision (1 patient). There was no death case in the serials. Conclusions Primary retroperitoneal teratoma can be completely incised.However, the complications of surgery could appear in many cases.As a predictive index for the recurrence retroperitoneal teratoma, AFP can be diminished by chemotherapy following the surgery. Key words: Primary retroperitoneal teratoma; Infant; Alpha-fetal protein; Complication

Retroperitoneal Teratoma in Infancy; Report of an Unusual Entity

Primary retroperitoneal teratoma in infancy is extremely rare. In children, it accounts for 3.5-4% of all germ cell tumours and 1-11% of primary retroperitoneal neoplasms. Clinical presentation is often asymptomatic or may present as a palpable mass or abdominal distension. The imaging findings of teratoma are characteristic. Early diagnosis is important for prompt surgical resection. We present a case of huge retroperitoneal teratoma in a 5-month-old child presenting with abdominal swelling where computed tomography findings are distinctive. Biopsy led to the definitive diagnosis of mature cystic teratoma of retroperitoneum.

成人に発症した原発性後腹膜囊胞性成熟奇形腫の2切除例

成人発症の原発性後腹膜囊胞性成熟奇形腫は極めてまれな疾患である．外科的切除を施行し上記診断に至った2症例を経験した．症例1は49歳の女性で，30歳妊娠時に仙骨前面に7×6 cmの腫瘍を指摘されたが出産のため経過観察となった．出産後は通院が中断していた．49歳時に尿閉を主訴に当院紹介となった．骨盤内に17 cmに増大した腫瘍を認め尾骨合併腫瘍切除術を施行した．症例2は23歳の女性で，23歳の帝王切開時に後腹膜腫瘍を認めた．その後の精査で仙骨前面に9×7 cmの分葉状囊胞性腫瘍を認め尾骨合併腫瘍切除術を施行した．術後病理組織学的診断はどちらも囊胞性成熟奇形腫であり悪性所見は認められなかった．成人発症の原発性後腹膜囊胞性成熟奇形腫は極めてまれな疾患である．悪性転化症例は予後不良だが，転化前ならば切除により良好な予後が得られており，発見された際は迅速な外科的切除を行うべきである．

Presacral Retroperitoneal Teratoma in a 24-Year-Old Woman

Background: Teratomas are uncommon neoplasms made up of mixed dermal elements derived from the three germ cell layers, and characterized by the presence of any tissue type, often assuming bizarre morphology. Primary retroperitoneal teratomas account for 1%–11% of retroperitoneal neoplasms, and are most commonly found in neonates and young adults. Case: A case of large sacrococcygeal teratoma, in a woman operated on during the 1st year of life and again in early adulthood, is presented. Results: The patient's postoperative course was uneventful. In her case, histologic findings included epidermoid, respiratory, mucinous epithelial, and leiomuscular stromal components. Conclusions: the diagnosis of teratoma can be suggested by computed tomography (CT) findings demonstrating a complex mass with a well-circumscribed fluid volume, fat-fluid level, and calcifications. Transrectal ultrasound may be helpful in the diagnosis of the retroperitoneal location and the relationship with other pelvic structures. Complete surgical resection and careful histologic evaluation are mandatory, and have a prognostic value, because complete surgical resection of a benign teratoma has an excellent prognosis. (J GYNECOL SURG 30:158)

Giant primary retroperitoneal teratoma in an adult male: A rare entity

Introduction: Primary and giant retroperitoneal teratoma is a rare entity in adults which occurs more commonly in females than males. Case Report: Herein, we describe an unusual case of a 28-year-old male patient referred to our hospital for a retroperitoneal tumor diagnosed by computed tomography scan and confirmed by histological examination as a retroperitoneal teratoma. Surgical excision was performed. The patient is doing well after 26 months of follow-up. Conclusion: Primary retroperitoneal teratoma is a rare entity in adults. Preoperatively, the diagnosis can be established by its characteristic appearance on computed tomography scan. Surgery is the mainstay of treatment and the prognosis is excellent for benign retroperitoneal teratoma if complete resection can be accomplished.

Primary Mature Cystıc Teratoma Mimickıng an Adrenal Mass in an Adult Male Patient

Teratomas are bizarre neoplasms derived from embryonic tissues that are typically found only in the gonadal and sacrococcygeal regions of adults. Primary retroperitoneal teratomas are rare and present challenging management options. We report a case of a unilateral primary retroperitoneal mature cystic teratoma mimicking an adrenal mass in a 54-year-old male patient. Complete resection of the adrenal mass was performed by the flank approach by using the 11th rib resection. Because of the risk of malignancy, follow-up radiographic studies were performed to ensure the oncologic efficacy of resection. The patient has been free of recurrence for longer than 12 months.

Giant mature primary retroperitoneal teratoma in a young adult: report of a rare case and literature review.

Teratomas are neoplasms of the embryonic tissues that typically arise in the gonadal and sacrococcygeal regions of adults and children. Primary adult retroperitoneal teratomas are rare and demand challenging management options. We report a case of a unilateral primary retroperitoneal mature cystic teratoma mimicking an adrenal mass in a 28-year-old female patient. Complete resection of the mass was performed by a laparotomy approach. Because of the risk of malignancy, follow-up radiographic studies were performed to ensure the oncologic efficacy of resection. The patient remains free of recurrence to date.

Giant primary retroperitoneal teratoma in an adult female patient: A case report

The retroperitoneum is an uncommon location for teratoma in adults. The current study presents the case of a rare giant primary retroperitoneal teratoma in a 55-year-old female. The clinical manifestations, diagnosis and surgical treatment procedure of this case are retrospectively reviewed. The patient presented with a complaint of an abdominal palpable mass and fullness for 1 month. The patient suffered a massive hemorrhage during the first exploratory laparotomyand only a small section of the tumor was resected. Pathology revealed a mature retroperitoneal teratoma. Eleven months after the first surgery, the tumor was resected successfully at the second laparotomy. The surgical specimen was a large tumor mass measuring 22×18×10 cm in size and weighing 6 kg. At follow-up, the patient was in a stable condition. This case study highlights the importance of imaging for the development of a pre-operative strategy and performing a safe surgical excision in giant retroperitoneal teratoma cases.

Primary retroperitoneal mature cystic teratoma with focal enteric type adenocarcinoma in a post-partum woman: report of a case with literature review

Teratomas are characterized by containing tissue from all three germinal cell layers. Occasionally, somatic type malignancies develop within a mature cystic teratoma. We reported here a rare case of enteric type adenocarcinoma, with associated dysplastic epithelial precursor lesion, arising within a mature cystic teratoma in the retroperitoneum of a 30-year-old woman status post vaginal delivery 11 weeks earlier. The mass is 17.5 cm and cystic. A polypoid mass component measuring 4.7×4.2×2.5 cm was located inside the cystic component. Microscopically, the majority of the specimen was a mature cystic teratoma with all three germinal cell layers. The polypoid mass component was an adenocarcinoma with an adjacent dysplastic epithelial precursor lesion. The adenocarcinoma was diffusely positive for CK20 and CDX-2, and focally positive for CD7, indicating enteric differentiation. A brief review of retroperitoneal mature cystic teratomas with associated somatic type malignancy was performed.

Mature (Benign) Cystic Retroperitoneal Teratoma Involving the Left Adrenal Gland in a 22-Year-Old Male: A Case Report and Literature Review

Primary retroperitoneal teratomas involving adrenal glands are exceedingly uncommon accounting for only 4% of all primary teratomas. They are more common in childhood and rarely occur in adults. Only a very few case reports have been documented in literature so far. Herein, we report a mature (benign) cystic retroperitoneal teratoma in the region of left adrenal gland in a 22-year-old otherwise healthy male patient who presented with a 1-month history of left flank pain. In addition, a literature review on teratomas is included.

Primary carcinoid tumor in a retroperitoneal mature teratoma: report of a case

Primary retroperitoneal teratoma in an adult is rare, as is the occurrence of a malignant tumor within a mature teratoma, known as "malignant transformation". A 24-year-old woman was admitted to our hospital for investigation of an abdominal mass. Computed tomography and magnetic resonance imaging revealed a multilocular mass in the right upper abdomen. The tumor consisted of fat, soft tissue, and bone, with a slightly enhanced solid component. The tumor was diagnosed preoperatively as a retroperitoneal mature teratoma with an immature component, and excised. Histologically, it was composed mainly of mature fat, soft tissue, and bone, accompanied by a solid component of prostate-like tissue. In addition, a latent carcinoid tumor was recognized in the middle of the tumor. The tumor was finally diagnosed as a primary carcinoid tumor within the retroperitoneal mature teratoma. The patient has been followed-up for 24 months since her operation without any evidence of recurrence. We report this case to highlight the possibility of malignant transformation in adult retroperitoneal teratoma, even when the preoperative diagnosis is benign mature teratoma.