Primary Lymphosarcoma Research Articles

Primary alimentary lymphosarcoma with metastasis to gall bladder in a Doberman dog

A case of lymphosarcoma involving whole intestine has been described. Grossly, there were multiple variable sized submucosal nodules in the wall of intestine along with multiple mucosal erosions and hemorrhages. Cytological study of these nodules revealed numerouslymphoblasts. Microscopically, there were sheets of proliferating neoplastic lymphocytes in the wall of intestine separated by thin fibrous connective tissue septa.

Concomitant Lymphoma and Carcinoma

Concomitant Lymphoma and Carcinoma

The Postoperative Prognosis of Primary Pulmonary Sarcomas.A Review with a Comparison between the Histological Forms and the Other Primary Endothoracal Sarcomas Based on 474 Cases

On the basis of 41 personally observed cases from 1957 to 1974 and 435 case reports in the literature from 1957 to 1972, a scale of malignancy of the histological forms of primary pulmonary sarcomas is presented. A fairly continuous rise in the rate of malignancy according to the differentiation of the tissues can be convincingly recognized. The more mature a pulmonary sarcoma is, the better is the postoperative prognosis. The rate of malignancy increases from the relatively differentiated and tissue matured fibrosarcomas over the spindle cell sarcomas and round cell sarcomas, to the completely non-differentiated polymorph cell sarcomas. Primary myosarcomas, neurosarcomas and reticulum sarcomas of the lungs take an isolated position within this scale of malignancy. Primary lymphosarcomas are the most common and have clearly the best postoperative prognosis. The greatest malignancy is found with the carcinosarcomas. The characteristics of each of the histomorphological forms of primary sarcoma of the lungs are discussed. At the same time it is shown that the postoperative prognosis of endothoracal sarcomas is determined not only by their histological structure, but also by their localization in the lungs, mediastinum, or chest wall. Forty-one primary pulmonary sarcomas were compared with 22 sarcomas of the mediastinum and 17 sarcomas of the chest wall. Due to their long period of development, with rare symptoms and late diagnosis, sarcomas of the lungs and the mediastinum have a similar postoperative prognosis, in contrast to the endothoracal sarcomas of the chest wall which have a clearly more favourable prognosis.

Primary lymphosarcoma of the lungs- a review of 121 cases.

Lymphosarcomas are the most frequent forms of primary pulmonary sarcomas. A comparison has been made between a total of 121 primary lymphatic sarcomas of the lungs and 314 other histomorphological forms of primary sarcomas of the lungs found in the literature in 15 years, out of which 7 are our own cases. Our results are summarized in a table, which shows the differences. Histomorphology, clinic and prognosis are discussed with special emphasis. The average are is 52 years, the age period 4-80 years, the sex distribution 1:1, the localization of the right side of the lungs 71%, the rate of recidives 4%, the general metastasizing 23%, the number of patients who survived the 5-years limit postoperatively 26.5%. An attempt is made to explain the postoperatively often unusually favorable development of these primarily malignant tumors by the histomorphological and pathophysiological characteristics.

Immunohistological studies on primary reticulosis of the canine brain.

Brains of 17 dogs with primary reticulosis, and of two with metastatic and one with primary lymphosarcoma, were examined by immunohistologic techniques with antisera against the major immunoglobulin classes of the dog. On the basis of immunoglobulin in tumour cells, two reticuloses were reclassified as primary lymphosarcomas of the brain. The tumour cells in three other dogs with neoplastic reticulosis and in six dogs with microgliomatosis did not contained immunoglobulin. Many cells in inflammatory reticulosis were immunoglobulin-bearing. Although some of these lesions could have been lymphosarcomas, insufficient data were available to ascertain either an inflammatory or a neoplastic nature. It was concluded that some lesions previously classified as reticulosis are in fact primary histiocytic lymphosarcomas of the brain, while others may be true reticulosarcomas.

Induction of type C RNA virus from cultured rabbit lymphosarcoma cells.

Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies with other mammalian type C oncornaviruses but appear to also possess unique antigenic determinants. Normal rabbit liver contained DNA homologous to a 3H-labeled complementary DNA transcript of the rabbit viral genome, indicating that type C viral genetic information is present in at least the WH/J strain of rabbits.

Canine gastrointestinal neoplasms.

In a review of 10 270 canine necropsies, 55 neoplasms of the stomach and 64 neoplasms of the small and large intestines were diagnosed. A significant number of these neoplasms were malignant ( P < 0.005) and epithelial ( P < 0.005). Adenocarcinomas of gastric and intestinal origin were in dogs younger than the average age of 10 years. Average age for dogs with connective tissue neoplasms was higher than that for those with adenocarcinomas, and there was a difference in median ages of the various types of neoplasms. There was a higher percentage (65%) of gastric and intestinal adenocarcinomas in male dogs, whereas leiomyosarcomas of the intestines were more frequent in female dogs. Although no breed predisposition was found in dogs with gastric neoplasms, a significant number of the intestinal neoplasms ( P < 0.005), especially the adenocarcinomas, occurred in the Collie ( P < 0.05) and German Shepherd ( P < 0.05) breeds. Twenty-six percent of the leiomyosarcomas also occurred in the German Shepherds. Half of the gastric adenocarcinomas occurred in the pyloric region ( P < 0.005), and the greater curvature was the next most common site. The rectum was the most common site of intestinal adenocarcinomas, then the colon and duodenum. Leiomyosarcomas were more frequent in the intestines and occurred more commonly at sites where adenocarcinomas were less frequent. In contrast to all other types of intestinal neoplasms, primary lymphosarcomas of the intestines usually affected many segments. Four carcinoid tumors of the duodenum and colon were seen. Of the very rare neoplasms, there were two neurilemomas, both of the duodenum and having the same gross and histologic characteristics of this tumor in other locations.

Primary lymphosarcoma of prostate

A case of primary lymphosarcoma of the prostate in a seventy-one-year-old patient is presented. He had palliative surgical treatment and radiotherapy but died seven months later of heart failure with signs of metastatic disease. Treatment of this condition should include surgery and irradiation. Only its early discovery might change the prognosis.

Value of Biopsy in Diagnosis of Primary Lymphosarcoma of Marrow

We report the clinical, hematologic, and survival characteristics of 12 patients with lymphosarcoma primarily involving the marrow but without substantial nodal disease. The importance of the biopsy in establishing this diagnosis is stressed, since in 7 of the 12 cases the diagnosis would not have been made had only a marrow aspiration been performed.

Value of biopsy in diagnosis of primary lymphosarcoma of marrow

Value of biopsy in diagnosis of primary lymphosarcoma of marrow

Primary and borderline brain lymphosarcoma: a neuropathological review of nine cases.

Brain lymphosarcoma may be divided into the circumscribed forms, surrounded by marked oedema with fibrin, and the diffuse or infiltrating forms. Cytology of the former is more uniformly lymphocytic, its clinical course is more rapidly fatal. Anatomically primary diffuse lymphosarcoma of the brain may be secondary to 'cured' systemic lymphoma.

Ultrastructure of primary lymphosarcoma of testis.

A case of primary lymphosarcoma of testis was studied by light and electron microscopy. The fine structure of the lymphosarcoma cells was simple and monotonous. The cytoplasm was scanty and contained normal-looking organelles. Free ribosomes were abundant and the Golgi apparatus was well developed. The nuclei were large and irregular in shape with prominent nucleoli. "Nuclear pockets" enclosing material similar to the cytoplasmic ground substance were found infrequently. Remnants of disintegrating cells were also encountered.

The primary extranodal manifestation of lympho- and reticulosarcoma of the stomach

We report about a group of 11 patients with primary lympho- or reticulosarcoma of the stomach in a group of 94 patients with Non-Hodgkin-Lymphomas. There were 5 patients with reticulosarcoma of the stomach among 44 patients with reticularsarcoma (11 percent) and 6 patients with primary lymphosarcoma of the stomach among a total of 50 patients with lymphosarcoma (12 percent). In most instances the diagnosis was made during surgery. At the time of diagnosis only 4 of the 11 patients had Stage IE disease. All patients who received intensive chemotherapy are living. Patients who died during the observation period had reticulosarcomas. They had not received any chemotherapy or treatment was discontinued early for varying reasons. Results are discussed in view of the diagnosis and treatment, suggestions for therapy are made.

Lymphosarcoma of the bowel masquerading as ulcerative colitis: report of a case.

An unusual case of primary lymphosarcoma which remained localized to the bowel for four years and was confused with “ulcerative colitis” clinically, and was often described as “nonspecific colitis with ulcerations” histologically is presented. The problems of roentgenographic, sigmoidoscopic, and pathologic differential diagnoses are discussed.

Primary ovarian lymphoma.

SummaryA primary ovarian lymphosarcoma in a woman aged 45 years is recorded. The patient is alive and well three years after surgery and radiotherapy. The relevant literature is discussed.

Primary lymphosarcoma of the lung.

<b>Rees, G. M. (1973).</b><i>Thorax</i>, <b>28</b>, 429-432. <b>Primary lymphosarcoma of the lung.</b> All cases of primary lymphosarcoma of the lung seen at Brompton Hospital over the last 20 years are reviewed. Clinical features and the results of special investigations are discussed together with an analysis of the results of different forms of treatment.

Primary lymphosarcoma of the breast in a 75-year-old woman: case report.

ABSTRACT: A case is presented of primary lymphosarcoma of the right breast in a 75-year-old woman. Am extended simple mastectomy was performed as the therapy of choice. In view of the patient's advanced age and the lack of evidence for metastasis from this primary lesion, possibly a five-year survival may be expected.

Primary lymphosarcoma of the ileum and caecum.

Eleven boys with primary ileo-caecal lymphosarcoma had an abdominal mass, anaemia and weight loss. One boy had an intussusception. Localised perforation occured in two boys and one developed an abscess. The palpable abdominal mass due to neoplastic involvement of the intestine and mesentery gave specific features on the abdominal radiograph in four boys. Characteristic findings on barium study permitted distinction from Crohn's disease in all but one instance. Extension of lymphosarcoma into the posterior abdominal wall prevented surgical excision and this type of extension was identified on excretion urography.

Primary lymphosarcoma of the lung.

The cases of four patients with primary lymphosarcoma of lung are recorded. In two of these the disease was bilateral. Two survived, with treatment, for 17 and 25 years respectively. Of the two who died one survived for 13 years without any specific treatment, this was unusual in that the growth contained numbers of plasmacytoid cells, and abnormal serum proteins were demonstrable during life. The general features of the tumour are discussed.

Bilaterality in primary lymphosarcoma of the breast.

Two patients with primary lymphosarcoma of the breast who developed similar lesions in the contralateral breasts after 8 and 10 years, respectively, are reported. An autopsy of one patient failed to reveal lymphosarcoma elsewhere. A review of the literature produced three similar cases with bilaterality. In primary lymphosarcoma of the breast, bilaterality does not appear to worsen chances for survival.