Background: The Johns Hopkins Hospital, the first U.S. institution to integrate medical education with practice, has served as a critical case study in understanding the evolution of American medical institutions in response to advancements in medical science, education, and technology. However, the role of architecture and design in informing those institutional practices has not been sufficiently explored. Aim: This study examines the intricate interplay between architecture and medicine in the late nineteenth century through a historical analysis of the design, construction, and early operation of the Johns Hopkins Hospital in Baltimore, focusing on how this interdisciplinary relationship shaped both the hospital’s physical environment and institutional practices. Methods: This paper utilizes historical analysis to investigate the design, construction, and operations of the Johns Hopkins Hospital. By examining primary archival materials, it details how architectural strategies addressed scientific, technological, and educational advancements. Results: The investigation reveals that the hospital’s architecture not only facilitated medical research, experimentation, and education but also embodied a novel blend of scientific inquiry and architectural design. Conclusions: The Johns Hopkins Hospital exemplifies the transformative potential of integrating architectural design with medical science. This case study underscores the enduring significance of interdisciplinary collaboration, offering insights into contemporary practices and the future of hospital design and medical education and practice in academic communities.
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