Primary Adenocarcinoma Of Seminal Vesicles Research Articles

Durable response to docetaxel in a case of primary seminal vesicle adenocarcinoma with zinner syndrome.

Primary adenocarcinoma of the seminal vesicles is a rare tumor. Congenital seminal vesicle cysts are often associated with unilateral renal dysgenesis or agenesis (Zinner syndrome). Zinner syndrome is a rare congenital malformation represented by a group of characteristics: ipsilateral renal agenesis, ejaculatory duct obstruction, and seminal vesicle cyst. There have been 214 cases in the literature with abdominal pain and lower urinary tract symptoms as the most common presentation. Most cases are diagnosed incidentally. We report a case of a 39-year-old male presenting with recurrent hematuria for 12 years, diagnosed as metastatic primary clear cell adenocarcinoma of seminal vesicle with Zinner syndrome. He was managed symptomatically with radiation therapy, hormonal therapy, and palliative chemotherapy. He is living with a well-controlled disease at present.

Primary adenocarcinoma of the seminal vesicles in Port Harcourt, Nigeria; Our experiences: Review of current diagnosis, treatment methods and outcome

Introduction: Primary tumors of the seminal vesicles are rare. The aims of this study are to present the case of a 32-year old man with advanced primary adenocarcinoma of the left seminal vesicle (PSVCA) that simulated features of prostatic neoplasm. Challenges encountered in its diagnosis are highlighted, and the literature reviewed to compare our experiences with current views of others on precise diagnosis of the tumor, its treatment methods and outcome. Materials and Methods: Consecutive male urology patients seen at UPTH, Port Harcourt, Nigeria were evaluated clinically and with relevant investigations. Two patients who had provisional diagnosis of PSVCA had operations/ post-operative specimen histology. One had confirmed diagnosis of PSVCA, was further treated, followed up and reported. Data were collected simultaneously with patients’ services. The PubMed/Medline and PubMed Central databases were searched for articles on clinical, immune histochemical features, treatment and outcome of PSVCA. Data on these features were presented in tables. Results: Of two presumptively diagnosed patients, one (32-year-old) had histological confirmation of primary adenocarcinoma of the left seminal vesicle. Radical surgery with urinary diversion, and either neoadjuvant or adjuvant androgen deprivation therapy, or cytotoxic chemotherapy, or adjuvant radiotherapy were the common treatment options found on literature review. Conclusion: The reported patient in this study had good post-operative performance but follow-up period was short. Currently, histopathologic and radiologic diagnostic methods are reinforced with immune histochemical techniques for precise diagnosis of PSVCA. Radical surgical therapy with neoadjuvant or adjuvant therapy are currently favored. Immune histochemical facilities should be provided at our center.

Metastatic primary seminal vesicle adenocarcinoma: management of a rare tumour with multiagent chemotherapy and hormonal therapy

Primary seminal vesicle adenocarcinoma is one of the rarest genitourinary cancers. The pathogenesis is unknown and clinical manifestations are protean. There is no defined treatment for this disease and various...

Primary adenocarcinoma of the seminal vesicles – Case report

Primary adenocarcinoma of the seminal vesicles – Case report

Mesenchymal hamartoma of the larynx: A rare case report and review of literature

Conclusion: We are reporting an extremely rare case of primary adenocarcinoma arising probably from the left seminal vesicle associated with ipsilateral renal agenesis. The lesion was detected on ultrasound and contrast enhanced CT and confirmed histologically with ultrasound guided biopsy. Serum markers i.e., CA19-9 and CA125 were elevated, while PSA and CEA were within normal limits. Such a constellation of markers strengthened the diagnosis. Our patient unfortunately presented very late in the course of the disease, we decided to initiate anti-androgen therapy and best supportive care in a hospice setting. Only early detection seems to be the key factor which may result in improved cure rates for cancer of the seminal vesicles. We also perform a literature search for current concepts related to the diagnosis and clinical management of primary adenocarcinoma of seminal vesicles.

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report

Primary tumors of the seminal vesicle are extremely rare lesions, and adenocarcinoma is the most common histology found. We report the case of a 54-year-old patient who has consulted with a bladder outlet obstruction and two episodes of initial hematuria for 3 months. Digital rectal examination revealed a hard, palpable mass in the prostate wall. The prostate-specific antigen (PSA), the serum carcinoembryonic antigen and the cancer antigen 125 (CA125) were normal. On imaging, a prostatic abscess, granulomatous prostatitis or a prostatic cancer were highly suspected at first. But the patient was afebrile and PSA was normal. Transrectal ultrasound-guided biopsies of the mass were performed. The pathological examination showed a poorly differentiated adenocarcinoma. Immunohistological analysis was strongly suggestive of adenocarcinoma of the seminal vesicle. At surgical exploration, it was impossible to make cystoprostato-vesiculectomy because the tumor was locally advanced. We decided to make hormonal blockage by antiandrogen and five sessions of radiotherapy. Unfortunately, the patient died 5 months later. Adenocarcinoma of the seminal vesicles is a rare diagnosis. We must think in this diagnosis when relatively young patient is presented with dysuria, hematuria or hemospermia and when we found hard palpable mass on digital rectal examination associated to normal PSA level. On histology, specific immunohistochemical markers would be helpful in this differential diagnosis. Actually, surgical excision is the mainstay of the treatment. Radiotherapy and androgen deprivation therapy can be an alternative in locally advanced and metastatic carcinomas. World J Nephrol Urol. 2015;4(3):242-246 doi: http://dx.doi.org/10.14740/wjnu204e

Primary seminal vesicle adenocarcinoma: a case description and analysis

Primary seminal vesicle adenocarcinoma (PSVA) is an extremely rare disease without any unified diagnostic criterion. Differential diagnosis of PSVA from prostate cancer, colon cancer, and bladder cancer is necessary but difficult because of the lack of standard management. Radical resection is considered the mainstay of primary treatment that offers satisfactory prognosis. Most cases with PSVA are diagnosed at advanced stages because its early manifestation is nonspecific and it is rarely diagnosed in clinic. In this study, we described the case of a 52 year-old PSVA patient who was treated at the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, in July 2012. The patient underwent local excision, with tumor residuals visible under the naked eye. The patient benefits from a six-cycle paclitaxel (175 mg/m2) therapeutic regimen combined with cisplatin (60 mg/m2), as well as pelvic modulated radiotherapy with a radiation dose of 60 Gy/30 F. At present, the patient is disease-free and undergoes regu-

The role of imaging in the diagnosis of recurrence of primary seminal vesicle adenocarcinoma.

Primary seminal vesicle (SV) adenocarcinoma is a rare tumor. A small amount of data about the role of imaging to detect tumor recurrence is available. We report the case of a 58-year-old patient with primary SV clear-cell well-differentiated adenocarcinoma. Clinical and instrumental examinations were negative for the 32 months after treatments when computed tomography scan, [18F]fluoro-D-glucose positron emission tomography/computed tomography and pelvic magnetic resonance imaging showed the appearance of a lesion in the left perineal muscle suspected for recurrence. Patient was symptomless. Cytology of the suspected lesion confirmed SV adenocarcinoma recurrence. The combined approach, using radiological and nuclear medicine techniques, seems to be effective in the follow-up of SV adenocarcinoma. Technological advances, together with awareness of this rare tumor, have the potential of improving patients outcomes not only by providing earlier detection and accurate staging, but also by detecting recurrence and thereby avoiding delays and therapeutic dilemmas.

An unusual cause of hematospermia: Primary adenocarcinoma of the seminal vesicle.

Adenocarcinoma of the seminal vesicles is one of the rare causes of hematospermia. Primary seminal vesicle adenocarcinoma is extremely rare and difficult to diagnose due to frequent invasion of adenocarcinomas of the surrounding organs, especially the prostate. In the present study, a case of a primary seminal vesicle adenocarcinoma will be discussed in the light of the current literature.

An unusual cause of hematospermia: Primary adenocarcinoma of the seminal vesicle

Adenocarcinoma of the seminal vesicles is one of the rare causes of hematospermia. Primary seminal vesicle adenocarcinoma is extremely rare and difficult to diagnose due to frequent invasion of adenocarcinomas of the surrounding organs, especially the prostate. In the present study, a case of a primary seminal vesicle adenocarcinoma will be discussed in the light of the current literature.

Vesiculectomy with laparoscopic partial prostatectomy in the treatment of primary adenocarcinoma of the seminal vesicle with carcinomatous transformation of the ejaculatory duct

IntroductionPrimary adenocarcinoma of the seminal vesicle is an extremely rare condition. Some cases have been described in relation to congenital seminal vesicle cysts, which is often also associated with agenesia or ipsilateral renal disgenesia. The rareness of this type of lesions makes it difficult to plan a regulated surgical approach for them, although they are often treated by simple exeresis or exenteration, depending on their stage at the beginning. Materials and methodsWe present a new surgical technique that consists of radical vesiculectomy associated with laparoscopic partial prostatectomy (total segmentary) of the central area to successfully treat primary seminal vesicle adenocarcinoma in a young man who was diagnosed through an azoospermia study. ResultsA study of the scan (MRI) with diffusion and the transrectal biopsy of the mass allowed us to make a thorough preoperative evaluation of the case, confirming the malignity and precociousness of the lesion. The laparoscopic approach allowed us to perform a pelvic lymphadenectomy and transperitoneal exeresis, including the central prostate area and suture of the posterior face of the urethra at the height of the apex of the prostate. The wall of the seminal cyst lesion confirmed infiltrating clear cell adenocarcinoma and non-invasive adenocarcinoma in the prostate segment of the central gland in the light of the ejaculatory conduct with “in situ” growth. Thus, the surgical specimen allowed radical exeresis with negative margins, guaranteeing minimally invasive surgery with preservation of continence and erection. ConclusionWe describe a new integral approach for the radical surgery of localized primary adenocarcinoma of the seminal vesicle. Despite its exceptional nature, the case allowed for a double reflection: (a) the study of diffusion with MRI may suggest the diagnosis of malignity in this type of lesions; and (b) radical surgical treatment must include exeresis of the central portion of the prostate gland.

Vesiculectomía con prostatectomía parcial laparoscópica en el tratamiento del adenocarcinoma primario de vesícula seminal con transformación carcinomatosa del conducto eyaculador

Introduction Primary adenocarcinoma of the seminal vesicle is an extremely rare condition. Some cases have been described in relation to congenital seminal vesicle cysts, which is often also associated with agenesia or ipsilateral renal disgenesia. The rareness of this type of lesions makes it difficult to plan a regulated surgical approach for them, although they are often treated by simple exeresis or exenteration, depending on their stage at the beginning. Materials and methods We present a new surgical technique that consists of radical vesiculectomy associated with laparoscopic partial prostatectomy (total segmentary) of the central area to successfully treat primary seminal vesicle adenocarcinoma in a young man who was diagnosed through an azoospermia study. Results A study of the scan (MRI) with diffusion and the transrectal biopsy of the mass allowed us to make a thorough preoperative evaluation of the case, confirming the malignity and precociousness of the lesion. The laparoscopic approach allowed us to perform a pelvic lymphadenectomy and transperitoneal exeresis, including the central prostate area and suture of the posterior face of the urethra at the height of the apex of the prostate. The wall of the seminal cyst lesion confirmed infiltrating clear cell adenocarcinoma and non-invasive adenocarcinoma in the prostate segment of the central gland in the light of the ejaculatory conduct with “in situ” growth. Thus, the surgical specimen allowed radical exeresis with negative margins, guaranteeing minimally invasive surgery with preservation of continence and erection. Conclusion We describe a new integral approach for the radical surgery of localized primary adenocarcinoma of the seminal vesicle. Despite its exceptional nature, the case allowed for a double reflection: a) The study of diffusion with MRI may suggest the diagnosis of malignity in this type of lesions; and b) Radical surgical treatment must include exeresis of the central portion of the prostate gland.

Primary Seminal Vesicle Adenocarcinoma Presenting as Isolated Metastasis to Penis Responding to Chemotherapy and Hormonal Therapy

We report a rare case of isolated penile metastasis from seminal vesicle adenocarcinoma associated with ipsilateral renal agenesis in a 62-year-old man. Imaging studies confirmed seminal vesicle origin, and biopsy revealed a papillary mucin-secreting adenocarcinoma, with cytokeratin 20 positivity and prostate-specific antigen negativity. The sigmoidoscopy and metastatic workup findings were normal. The patient received six cycles of 5-fluorouracil, leucovorin, and oxaliplatin chemotherapy and underwent bilateral orchiectomy. The patient was symptomatically better, and the penile swelling and seminal vesicle mass had regressed considerably. He later developed multiple lung metastases and died of the disease.

Primary adenocarcinoma of seminal vesicle presenting as bladder tumor

A case of primary seminal vesicle carcinoma is described and is discussed in the context of current knowledge regarding the clinicopathologic features of this rare neoplasm.

若年者原発性精嚢腺癌の１例

若年者原発性精嚢腺癌の１例