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Edited by J. Krieglstein & S. KlumppPublished by Medpharm Scientific Publishers, Stuttgart, 2000. Price DM 248. ISBN 3-88763-087-4 Every second year scientists in the field of pharmacology of cerebral ischaemia meet in Marburg, Germany. Over the past 14 years this meeting which lasts 3 days has acquired such a high reputation, that all leading laboratories in the field follow the invitation of Josef Kriegelstein, to present and discuss their ongoing work. The proceedings of the symposia are published shortly after each meeting as a book by Medpharm Scientific Publishers. The 51 chapters of the proceedings, each consisting of approximately 10 pages, have a special format. In every chapter one of the laboratories presents its work over the last 2 years as an overview. Some of these chapters have the character of a mini-review about their topic. Others present a series of experiments, combining the introduction into a certain issue with the presentation of basic science data. Together, these chapters represent the state of the art in the field of pharmacology of cerebral ischaemia. Looking through the eight volumes of proceedings published so far, it can be seen how the focus of research has shifted over the years. During the early years, beginning from 1986, research about calcium and NMDA antagonists played a great role. Later, studies on oxygen free radicals, platelet activating factor, adenosine and monoamine transmitters were predominant. In 1992, the hot topic was the NO-system and nerve growth factors were recognized as neuroprotectants. From 1994 on, molecular biology entered the arena, gene expression was an important topic and apoptosis was discovered as a mechanism of cell death in cerebral ischaemia. More recently, research on transgenic animals and gene therapy, cytokines and inflammatory mechanisms moved to the centre of the field. At the 8th meeting in July 2000 the most important novelties were stem cell therapy and neurogenesis. Furthermore, the volume contains excellent updates on caspases in cerebral ischaemia, cytokines as therapeutic targets in stroke and experimental insights into functional recovery after brain injury. Only a few chapters are so limited in their scope that they will not attract readers with a more general interest in cerebral ischaemia. It is to the credit of the editors that they included contributions on the problem as to why all the progress in stroke research and in neuroprotection in particular so far has not translated into the clinical availability of a single therapeutic agent. The scientific merit of the contributions must be categorized as very high. This implies that the uninitiated reader may have difficulties to fully comprehend all articles. There is no general introduction into basic mechanisms and the transition from one chapter to the next is not elaborated, every single one standing very much on its own. Therefore, the volume is more likely to be used as a reference book for active scientists to get updated on the state of a certain topic. In this respect the volume is a very efficient and valuable source of information.

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTHouben-Weyl: Methods of Organic Chemistry. Additional and Supplementary Volumes to the 4th Edition. Volume E 23c/Part 2. Substance Index. Aliphatic Compounds I. Carbonyl Compounds II George Thieme Verlag: Stuttgart, New York. 2000. viii + 1220 pp. DM 3000 (series subscription price DM 2970). ISBN 3-13-12514-3.Cite this: J. Am. Chem. Soc. 2000, 122, 30, 7434Publication Date (Web):June 6, 2000Publication History Published online6 June 2000Published inissue 1 August 2000https://doi.org/10.1021/ja004765iCopyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views37Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (11 KB) Get e-AlertsSUBJECTS:Aldehydes,Carbonyls,Ketones,Organic chemistry,Reaction products Get e-Alerts

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Computer Applications in Chemistry: An Introduction for PC Users By K. Ebert, H. Ederer and T. L. Isenhour, VCH Verlagsgesellschaft, Weinheim, 1989, pp. 1 + 714 (+ 2 5$1/4 floppy discs), price DM 98.00. ISBN 3-527-27807-9

Enzymes in Industry-Production and Applications Edited by W. Gerhartz, VCH Weinheim, 1990. pp. xv + 321, price DM 118.00. ISBN 3 527 279849

Pharmacology of cerebral ischemia 2000

Houben-Weyl. Methods of Organic Chemistry. Additional and Supplementary Volumes to the 4th Edition. Volume E 10c/Part 1. Organo-Fluorine Compounds. Methods Index Georg Thieme Verlag: Stuttgart. 2000. lxxxiv + 812 pp. $1940 (series subscription price DM 2970). ISBN: 3-13-117494-3.

Light scattering in inhomogeneous atmospheres. By Edward G. Yanovitskij. Springer‐Verlag, Heidelberg. 1997. xvii + 371 pp. Price DM 128.00 (hardback). ISBN 3 540 61362 5

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P.R. Ehrlich A world of wounds: ecologists and the human dilemma, xxiv, 210p. Oldendorfe/Luhe, Germany: Ecology Institute, 1997. (Excellence in Ecology no. 8). Price DM 6300.

Germany. German Federal Agency for Nature Conservation. Biodiversity and tourism. Conflicts on the world's seacoasts and strategies for their solution. xxii, 343p. Berlin: Springer-Verlag, 1997. Price DM 98.00.

D.H. Cushing Towards a science of recruitment in fish populations, xix, 175p. Nordbünte, Germany: Ecology Institute, 1996. (Excellence in Ecology no. 7). Price DM 58.

Advances in polymer science 122: Biopolymers II. Edited by N. A. Peppas and R. S. Langer. Springer-Verlag, Heidelberg, 1995. pp. x + 287, price DM 238.00, sFr 224.00,öS 1856.40. ISBN 3-540-58788-8

Polymer fractionation. F. Francuskiewicz. Springer, Berlin, 1994. pp. xvii + 215, price DM 98.00. ISBN 3‐540‐57539‐1

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Polymer networks. (11th Polymer Networks Group Meeting). Die Makromolekulare Chemie, Macromolecular Symposia, 76. Edited by Bruce E. Eichinger. Hüthing & Wepf Verlag, Basle, Heidelburg, New York, 1993. pp. ix + 290, price DM 148.00. ISBN 3‐85739‐273‐8

Makromoleküle, vol. 2: Technologie (5th edition), Hans‐Georg Elias, Hüthig & Wepf Verlag, Basel, Heidelberg, New York, 1992, p. 792, price DM 248,–. ISBN 3‐85739‐102‐2.

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Plastics ‐ how structure determines properties, by G. Gruenwald. Hanser‐Verlag, München 1993, p. 357. Price DM 118. ISBN 3‐446‐16520‐7

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Computer Applications in Chemistry: An Introduction for PC Users By K. Ebert, H. Ederer and T. L. Isenhour, VCH Verlagsgesellschaft, Weinheim, 1989, pp. 1 + 714 (+ 2 5$1/4 floppy discs), price DM 98.00. ISBN 3-527-27807-9

Enzymes in Industry-Production and Applications Edited by W. Gerhartz, VCH Weinheim, 1990. pp. xv + 321, price DM 118.00. ISBN 3 527 279849

Pharmacology of cerebral ischemia 2000

Houben-Weyl. Methods of Organic Chemistry. Additional and Supplementary Volumes to the 4th Edition. Volume E 10c/Part 1. Organo-Fluorine Compounds. Methods Index Georg Thieme Verlag: Stuttgart. 2000. lxxxiv + 812 pp. $1940 (series subscription price DM 2970). ISBN: 3-13-117494-3.

Light scattering in inhomogeneous atmospheres. By Edward G. Yanovitskij. Springer‐Verlag, Heidelberg. 1997. xvii + 371 pp. Price DM 128.00 (hardback). ISBN 3 540 61362 5

SHORT REVIEWS

P.R. Ehrlich A world of wounds: ecologists and the human dilemma, xxiv, 210p. Oldendorfe/Luhe, Germany: Ecology Institute, 1997. (Excellence in Ecology no. 8). Price DM 6300.

Germany. German Federal Agency for Nature Conservation. Biodiversity and tourism. Conflicts on the world's seacoasts and strategies for their solution. xxii, 343p. Berlin: Springer-Verlag, 1997. Price DM 98.00.

D.H. Cushing Towards a science of recruitment in fish populations, xix, 175p. Nordbünte, Germany: Ecology Institute, 1996. (Excellence in Ecology no. 7). Price DM 58.

Advances in polymer science 122: Biopolymers II. Edited by N. A. Peppas and R. S. Langer. Springer-Verlag, Heidelberg, 1995. pp. x + 287, price DM 238.00, sFr 224.00,öS 1856.40. ISBN 3-540-58788-8

Polymer fractionation. F. Francuskiewicz. Springer, Berlin, 1994. pp. xvii + 215, price DM 98.00. ISBN 3‐540‐57539‐1

Book Reviews

Polymer networks. (11th Polymer Networks Group Meeting). Die Makromolekulare Chemie, Macromolecular Symposia, 76. Edited by Bruce E. Eichinger. Hüthing &amp; Wepf Verlag, Basle, Heidelburg, New York, 1993. pp. ix + 290, price DM 148.00. ISBN 3‐85739‐273‐8

Makromoleküle, vol. 2: Technologie (5th edition), Hans‐Georg Elias, Hüthig &amp; Wepf Verlag, Basel, Heidelberg, New York, 1992, p. 792, price DM 248,–. ISBN 3‐85739‐102‐2.

Review

Plastics ‐ how structure determines properties, by G. Gruenwald. Hanser‐Verlag, München 1993, p. 357. Price DM 118. ISBN 3‐446‐16520‐7

Polymer networks. (11th Polymer Networks Group Meeting). Die Makromolekulare Chemie, Macromolecular Symposia, 76. Edited by Bruce E. Eichinger. Hüthing & Wepf Verlag, Basle, Heidelburg, New York, 1993. pp. ix + 290, price DM 148.00. ISBN 3‐85739‐273‐8

Makromoleküle, vol. 2: Technologie (5th edition), Hans‐Georg Elias, Hüthig & Wepf Verlag, Basel, Heidelberg, New York, 1992, p. 792, price DM 248,–. ISBN 3‐85739‐102‐2.