Previous Tests Research Articles

Improving Adherence to Clinical Practice Guidelines for Managing Gastric Intestinal Metaplasia Among Gastroenterologists at a US Academic Institution.

Clinical guidelines reserve endoscopic surveillance after a gastric intestinal metaplasia (GIM) diagnosis for high-risk patients. However, it is unclear how closely guidelines are followed in clinical practice. We examined the effectiveness of a standardized protocol for the management of GIM among gastroenterologists at a US hospital. This was a preintervention and postintervention study, which included developing a protocol and education of gastroenterologists on GIM management. For the preintervention study, 50 patients with GIM were randomly selected from a histopathology database at the Houston VA Hospital between January 2016 and December 2019. For the postintervention study, we assessed change in GIM management in a cohort of 50 patients with GIM between April 2020 and January 2021 and surveyed 10 gastroenterologists. The durability of the intervention was assessed in a cohort of 50 GIM patients diagnosed between April 2021 and July 2021. In the preintervention cohort, GIM location was specified (antrum and corpus separated) in 11 patients (22%), and Helicobacter pylori testing was recommended in 11 of 26 patients (42%) without previous testing. Gastric mapping biopsies were recommended in 14% and surveillance endoscopy in 2%. In the postintervention cohort, gastric biopsy location was specified in 45 patients (90%, P <0.001) and H. pylori testing was recommended in 26 of 27 patients without prior testing (96%, P <0.001). Because gastric biopsy location was known in 90% of patients ( P <0.001), gastric mapping was not necessary, and surveillance endoscopy was recommended in 42% ( P <0.001). One year after the intervention, all metrics remained elevated compared with the preintervention cohort. GIM management guidelines are not consistently followed. A protocol for GIM management and education of gastroenterologists increased adherence to H. pylori testing and GIM surveillance recommendations.

Comparison of Iris dataset classification with Gaussian naïve Bayes and decision tree algorithms

In this study, we apply two classification algorithm methods, namely the Gaussian naïve Bayes (GNB) and the decision tree (DT) classifiers. The Gaussian naïve Bayes classifier is a probability-based classification model that predicts future probabilities based on past experiences. Whereas the decision tree classifier is based on a decision tree, a series of tests that are performed adaptively where the previous test affects the next test. Both of these methods are simulated on the Iris dataset where the dataset consists of three types of Iris: setosa, virginica, and versicolor. The data is divided into two parts, namely training and testing data, in which there are several features as information on flower characteristics. Furthermore, to evaluate the performance of the algorithms on both methods and determine the best algorithm for the dataset, we evaluate it using several metrics on the training and testing data for each method. Some of these metrics are recall, precision, F1-score, and accuracy where the higher the value, the better the algorithm's performance. The results show that the performance of the decision tree classifier algorithm is the most outperformed on the Iris dataset.

Numerical Analysis of Rubberized Steel Fiber Reinforced Concrete Beams Subjected to Static and Blast Loadings

In recent years, the alarming number of terrorist attacks has highlighted the critical need for extensive research aimed at fortifying structures against explosion-induced loads. However, the insufficient energy absorption and brittleness of conventional concrete make it ineffective in withstanding blast loading, encouraging researchers to explore innovative strategies for augmenting the energy dissipation capabilities of construction materials. This study specifically delves into the incorporation of recycled rubber, a sustainable and environmentally friendly solution to the pressing issue of scrap tire disposal. The primary focus of this research revolves around the integration of rubber recycling and steel fibers into concrete, with the ultimate goal of enhancing the dynamic response of reinforced concrete (RC) beams. This novel approach not only contributes to the structural resilience required for resisting blast impacts, but also aligns with eco-friendly practices by reusing recycled rubber. A meticulous numerical investigation was undertaken to comprehensively assess the static and blast response of these augmented beams. The numerical study involved developing finite element (FE) models using ABAQUS version 6.14 for static implicit analysis and LS-DYNA R11 for blast explicit simulations. The ABAQUS model was validated against previous experimental testing for load–displacement and failure patterns. Similarly, the LS-DYNA model was validated for blast pressure in accordance with UFC-3-340 standards and for material response under blast loading, utilizing existing experimental data. The numerical models were designed to accommodate varying weight percentages of rubber, ranging from 5% to 20%, and a consistent 1.0% incorporation of steel fibers. This comprehensive analysis aims to provide valuable insights into the efficacy of these materials in improving the structural integrity and blast resistance of RC beams, thereby contributing to the development of more secure and sustainable construction practices. By reducing the reinforcement ratio in order to meet the minimum code requirements, it became evident that the failures of the rubberized RC beams tended to exhibit ductility on the tension side under static loading. In addition, the increase in the reinforcement ratio correlated with a higher failure load and decreased deflection. Furthermore, the findings indicated an optimal concrete mixture characterized by improved ductility, energy absorption, and blast load capacity, achieved by combining 5–10% rubber with steel fibers.

Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences.

Because interventions are available to prevent further recurrence in patients with recurrent Clostridioides difficile infection (rCDI), we identified predictors of multiple rCDI (mrCDI) in adults at the time of presentation with initial CDI (iCDI). iCDI was defined as a positive C difficile test in any clinical setting during January 2018-August 2019 in a person aged ≥18 years with no known prior positive test. rCDI was defined as a positive test ≥14 days from the previous positive test within 180 days after iCDI; mrCDI was defined as ≥2 rCDI. We performed multivariable logistic regression analysis. Of 18 829 patients with iCDI, 882 (4.7%) had mrCDI; 437 with mrCDI and 7484 without mrCDI had full chart reviews. A higher proportion of patients with mrCDI than without mrCDI were aged ≥65 years (57.2% vs 40.7%; P < .0001) and had healthcare (59.1% vs 46.9%; P < .0001) and antibiotic (77.3% vs 67.3%; P < .0001) exposures in the 12 weeks preceding iCDI. In multivariable analysis, age ≥65 years (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.55-2.35), chronic hemodialysis (aOR, 2.28; 95% CI, 1.48-3.51), hospitalization (aOR, 1.64; 95% CI, 1.33-2.01), and nitrofurantoin use (aOR, 1.95; 95% CI, 1.18-3.23) in the 12 weeks preceding iCDI were associated with mrCDI. Patients with iCDI who are older, on hemodialysis, or had recent hospitalization or nitrofurantoin use had increased risk of mrCDI and may benefit from early use of adjunctive therapy to prevent mrCDI. If confirmed, these findings could aid in clinical decision making and interventional study designs.

Global stability design of concrete-filled corrugated steel tubular columns

In recent years, various types of concrete-filled steel tubular (CFST) columns were proposed and they have been widely used in engineering practice. Considering the great confinement effect of corrugated steel plate on the concrete, a novel type of CFST column called concrete-filled corrugated steel tubular (CFCST) column was proposed. The CFCST column consists of horizontally corrugated steel plates, corner steel bars and infilled concrete. In this paper, the stability performance of CFCST columns is studied. Firstly, a finite element (FE) model was developed for numerical simulation. The ultimate resistances, load-displacement curves and failure modes obtained from the FE models were compared with previous test results to verify the validity of the FE model. Subsequently, seven sets of numerical examples were analyzed to investigate the impact of key parameters on the global stability performance of CFCST columns. These examples involved variations in geometric dimensions, corrugation shapes and material strengths. Finally, the stability coefficients φ of CFCST columns obtained from FE numerical simulation were compared to several existing stability curves. On this basis, a new stability curve was proposed for predicting the global stability resistance of CFCST columns with good accuracy and reasonable redundancy.

Late Onset of Severe Demyelinating Peripheral Neuropathy in a 62-Year-Old African American Woman.

Hereditary neuropathies are typically associated with an early onset of symptoms, but same types of neuropathies may also manifest late, after the age 50 years. A 62-year-old African American woman presented with a 6-year history of gait unsteadiness and has been using a walker since the age 57 years after an unwitnessed fall. Gradual worsening of walking difficulties was later followed by decreased dexterity. The family history was negative for neuromuscular disorders, including neuropathy. On examination, the patient had both distal and proximal weakness with distal sensory loss to all modalities and hyporeflexia. Charcot Marie Tooth Examination Score was 12. Previous electrodiagnostic testing at the age 60 years showed severe sensorimotor demyelinating polyneuropathy with bilateral severe carpal tunnel syndrome. Genetic testing showed a homozygous pathogenic mutation in SH3TC2 gene (c.2860C>T; p.Arg954*), associated with CMT4C. CMT4C is the most common recessive demyelinating sensorimotor polyneuropathy and overall comprises 0.4%-1.7% of all patients with Charcot-Marie-Tooth disease. It is more common in French Canadians and Spanish Roma and in recent natural history study; only 1 of 56 patients was African American. This report demonstrates sporadic occurrence of CMT4C in other ethnic groups as well.

Association of Timely Comprehensive Genomic Profiling With Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer.

Timely biomarker testing remains out of reach for many patients with advanced non-small-cell lung cancer (aNSCLC). Here, we studied the quality-of-care implications of closing the gap in timely receipt of comprehensive genomic profiling (CGP) to inform first-line (1L) decisions. Using a real-world clinicogenomic database, we studied testing and 1L treatment patterns in aNSCLC after the approval of pembrolizumab in combination with pemetrexed and carboplatin (May 10, 2017). To estimate the association of timely CGP results with therapy selection and patient outcomes, we identified patients with no previous genomic testing beyond PD-L1 immunohistochemistry and dichotomized patients by whether CGP results were available before or after 1L therapy initiation. In total, 2,694 patients were included in the 1L therapy decision impact assessment. Timely CGP increased matched targeted therapy use by 14 percentage points (17% with CGP v 2.8% without) and precision immune checkpoint inhibitor (ICPI) use by 14 percentage points (18% with CGP v 3.9% without). Receipt of timely CGP resulted in an estimated 31 percentage point decrease in ICPI use among ALK/EGFR/RET/ROS1-positive patients at an expected per-patient reduction in ineffective ICPI therapy cost of $13,659.37 with timely CGP to inform 1L treatment selection. Patient benefit of CGP extended to real-world time to therapy discontinuation (median time to therapy discontinuation: 3.9 v 10 months [hazard ratio, HR, 0.54 [95% CI, 0.42 to 0.70]; P = 1.9E-06; adjusted hazard ratio [aHR], 0.50 [95% CI, 0.38 to 0.67]; P = 2.0E-06) in 1L driver-positive patients. This effect was not significant for real-world overall survival (median overall survival: 32 v 29 months [HR, 1.2 [95% CI, 0.84 to 1.67]; P = .33; aHR, 1.4 [95% CI, 0.92 to 1.99]; P = .12). Timely CGP is associated with the quality of patient care as measured by 1L matched targeted therapy use, time to therapy discontinuation, and avoidance of ineffective, costly ICPIs.

Realization of a composite ferroelectric characterization test system using a modified constant current method and a modified virtual ground method.

A composite ferroelectric characterization test system constructed using a modified constant current method (CCM) and a modified virtual ground method (VGM) has been successfully designed and implemented. By sending instructions to the microcontroller through software, the system's test mode can be easily changed by arranging the switching status of six switching elements. When validating the system, a dual-channel precision source/measure unit B2912B was used to verify this design. There is also parasitic capacitance that cannot be ignored in this commercial machine. This parasitic capacitance affects the appearance of the entire hysteresis curve. However, the parasitic capacitance values also differ in various test current ranges. In addition, to confirm the data credibility of this composite ferroelectric test system, Keysight B1530A and Radiant Premier II were used to conduct cross-verification between different systems. The results obtained between different systems show good consistency. Furthermore, reproducible and recoverable imprint phenomena were found in this composite system during interactive validation using VGM and CCM methods. After designing different voltage profiles for verification, it was found that the root cause of this imprint phenomenon was the difference between the final polarization state of the previous test and the pre-initialized polarization state. This imprint phenomenon exists in traditional Pb(Zr, Ti)O3(PZT) ferroelectric capacitors and Hf0.5Zr0.5O2-based ferroelectric capacitors. Fortunately, this imprint phenomenon is reversible. Moreover, this imprint phenomenon disappears through the design of the time-varying voltage profile on the ferroelectric capacitor of the CCM method.

A higher proportion of children aged 4 years were referred to speech and language therapists after the introduction of a new language screening tool.

Language difficulties in children can have enduring impacts on their academic and emotional well-being. Consequently, early identification and intervention are critical. This study aimed to investigate the impact of introducing Språkfyran, a language screening tool, on the identification and referral rates for speech and language assessment compared to the previous method. An observational study was conducted in Gotland, Sweden, using the medical records of 3537 children (53% boys) who were 3-4 years of age. The study period lasted between 5 January 2016 and 29 April 2022, encompassing data collection both before and after the introduction of Språkfyran. Following the introduction of Språkfyran, 15% failed the screening, compared to 20% with the previous speech test. However, referrals for assessment increased significantly with Språkfyran, rising to 7% compared to 3% with the speech test. The proportion of children who failed the Språkfyran screening was consistent with findings from previous studies. Children who failed the screening were more likely to be referred for speech and language assessment after the introduction of Språkfyran. This indicates that Språkfyran is a clinically relevant tool that promotes children's language development through increased referral rates.

Effectiveness of Screening Models in Improving the Quality of Cenrana River Water as a Drinking Water

The objective of this study is to assess the quality of the Cenrana River water as a potential drinking water source for a community in the Cenrana watershed Wajo, as well as to evaluate the effectiveness of a basic water purification system in improving its condition. Cenrana River is located in the Maros Regency and Bone Regency, South Sulawesi Province, Indonesia. The study was conducted at the Laboratory of Material Testing, Faculty of Engineering Universitas Negeri Makassar, and the Makassar Health Laboratory Center. Water samples are taken in the Walanae River located in Bone Regency and tested in the abovementioned laboratory. This type of research is experimental, which involves assembling a simple clarification tool in the material testing laboratory, and then raw water is purified with the device. Water samples, both raw water and purified water, are tested at the Makassar Health Laboratory Center. The data analysis used is qualitative descriptive, which compares the results of laboratory tests of raw water that have not been clarified and the results of laboratory tests of water that have been purified with the parameters of clean water standard criteria based on the regulation by the Ministry of Health of the Republic of Indonesia. The results showed that although the water had been cleaned through two filters, several parameters tended to increase from the previous year's test results with one filter, such as the No2 content from 0.017 to 0.034, No3 from 0.01 to 0.39, dissolved solids from 152 to 156, Fe from 0.01 to 0.17, Mn from 0.01 to 0.15, SO4 from 14.39 to 15, 54, and Ammonia from 0.05 to 0.29 even though it still meets the standards of the Ministry of Health of the Republic of Indonesia. In addition, the raw water coliform content also increased from an average of 6,600/100 ml in 2016 to 20,050/100 ml in 2019. This means that there is a tendency for Cenrana River water pollution may increase every year.

Predictors of prior HIV testing and acceptance of a community-based HIV test offer among male bar patrons in northern Tanzania.

Community-based HIV testing offers an alternative approach to encourage HIV testing among men in sub-Saharan Africa. In this study, we evaluated a community-based HIV testing strategy targeting male bar patrons in northern Tanzania to assess factors predictive of prior HIV testing and factors predictive of accepting a real-time HIV test offer. Participants completed a detailed survey and were offered HIV testing upon survey completion. Poisson regression was used to identify prevalence ratios for the association between potential predictors and prior HIV testing or real-time testing uptake. Of 359 participants analyzed, the median age was 41 (range 19-82) years, 257 (71.6%) reported a previous HIV test, and 321 (89.4%) accepted the real-time testing offer. Factors associated with previous testing for HIV (adjusted prevalence ratio [aPR], 95% CI) were wealth scores in the upper-middle quartile (1.25, 1.03-1.52) or upper quartile (1.35, 1.12-1.62) and HIV knowledge (1.04, 1.01-1.07). Factors that predicted real-time testing uptake were lower scores on the Gender-Equitable Men scale (0.99, 0.98-0.99), never testing for HIV (1.16, 1.03-1.31), and testing for HIV > 12 months prior (1.18, 1.06-1.31). We show that individual-level factors that influence the testing-seeking behaviors of men are not likely to impact their acceptance of an HIV offer.

A Longitudinal Look at Student Attitude, Perceived Competence, and Fitness Test Performance of Elementary Students

The purpose of this study was to assess relationships between students’ attitudes toward physical education (PE), their perceived competence toward PE, and their fitness test performance, as well as how these relationships change over time. Measurements were conducted with validated instruments across five time points during two school years with fourth and fifth grade students across ten schools (n = 636, 48% = female). This study was developed to address a need for examining how attitudes and perceived competence change over time. Descriptive statistics and latent growth models were run with the variables of interest to investigate four research questions. We found that greater fitness scores are associated with greater competence scores at all time points and that fitness testing may have an impactful, yet brief impact on overall attitudes toward PE. Results showed that fitness test scores predicted higher levels of perceived competence but not higher positive attitudes. Greater attitude levels were predictive of higher competence. Results suggested that previous fitness test experiences shaped future attitudes over time as opposed to “in the moment” attitude scores, a finding not identified in previous research. This study used multiple data points to study PE attitudes and competence, two pillars of behavioral intention. Attitudes can shift and how previous PE content, like fitness testing, can predict future attitudes in PE. The actual relationship between competence and attitude over time is also identified. The results also point to attitude as more of a developed attribute as compared to one that changes only from one event.

Measurement of levitation force of high-temperature superconducting maglev under high-speed operation condition

High-temperature superconducting (HTS) pinning magnetic levitation (maglev) has garnered significant attention in high-speed maglev transportation due to its inherent self-stability, low energy consumption, and absence of mechanical friction. Ensuring the safe and stable operation of HTS pinning maglev systems necessitates a dedicated focus on the performance and stability of HTS bulks levitated above the permanent magnetic guideway (PMG). Previous research has indicated that variations in the temperature within the HTS bulk can impact the levitation performance of the system. This temperature-related phenomenon occurs when the external magnetic field applied to the HTS bulk changes. However, it is noteworthy that previous levitation force tests for HTS magnetic levitation systems have been limited to quasi-static or low-speed studies. The exploration of dynamic levitation forces, particularly at high speeds, has remained constrained due to the associated high costs. Therefore, the objective of this study is to investigate dynamic levitation forces while the HTS pinning maglev system is in motion at high speeds, utilizing a self-developed ultra-high-speed maglev test rig. Initially, the relationship between the levitation force and the vertical displacement of the HTS pinning maglev system is examined based on quasi-static experiments. Subsequently, comparative studies are conducted to measure levitation forces at varying speeds. Finally, the correlation between running speed and dynamic levitation force is discussed. The investigation reveals that the levitation force experiences only a marginal decrease as the running speed increases. At a running speed of 240 km/h, the attenuation rate of the levitation force is approximately 2.478 %, demonstrating the commendable stability of HTS pinning maglev systems. The article concludes by presenting the dynamic levitation characteristics and their attenuation trends to speed. These findings can serve as valuable references for future design and practical implementation of HTS pinning maglev systems.

Patterns of C-reactive protein trends during clozapine titration and the onset of clozapine-induced inflammation: a case series of weekly and daily C-reactive protein monitoring.

International guidelines for clozapine titration recommend measuring C-reactive protein (CRP) weekly for 4 weeks after clozapine initiation to prevent fatal inflammatory adverse events, including myocarditis. However, limited evidence exists regarding whether weekly CRP monitoring can prevent clozapine-induced inflammation. We examined the relationship between CRP trends and the development of clozapine-induced inflammation. We also explored the usefulness and limitations of CRP monitoring during clozapine titration. This study presents 17 and 4 cases of weekly and daily CRP monitoring during clozapine initiation, respectively. Among 17 patients with weekly CRP measurements, 7 had fever. Elevated CRP levels were detected before the onset of fever in two of the seven patients. Of the five remaining patients, the CRP levels on a previous test had been low; however, the fever developed suddenly. Of the 10 patients with no fever under weekly CRP monitoring, three had elevated CRP levels >3.0 mg/dL. Refraining from increasing the clozapine dose may have prevented fever in these patients. Among four patients with daily CRP measurements, two became febrile. In both cases, CRP levels increased almost simultaneously with the onset of fever. Weekly and daily CRP monitoring during clozapine titration is valuable for preventing clozapine-induced inflammation, assessing its severity, and guiding clozapine dose adjustments. Weekly CRP monitoring may not adequately predict clozapine-induced inflammation in some cases. Consequently, clinicians should be aware of the sudden onset of clozapine-induced inflammation, even if CRP levels are low. Daily CRP monitoring is better for detecting clozapine-induced inflammation.

Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method including 25 novel synthetic opioids in hair and subsequent analysis of a Swiss opioid consumer cohort.

Major public health concern is raised by the evidence that common drugs like heroin are now frequently laced or replaced with highly potent novel synthetic opioids (NSOs). The objective of this study was to explore the prevalence and patterns of NSOs in a cohort of Swiss opioid users by hair analysis. Hair analysis is considered an ideal tool for retrospective consumption monitoring. Hair samples from 439 opioid users in Zurich were analyzed. Study inclusion required a previous positive hair test result for heroin metabolites, oxycodone, fentanyl, methadone, or tramadol. The samples were extracted with a two-step extraction procedure, followed by a targeted LC-MS/MS (QTRAP® 6500+) analysis in multiple reaction monitoring mode for a total of 25 NSOs. The method underwent full validation and demonstrated good selectivity and sensitivity with limits of detection (LOD) as low as 0.1pg/mg. The analyzed sample cohort demonstrated a positivity rate for NSOs of 2.5%, including the following NSOs: butyrylfentanyl, acrylfentanyl, furanylfentanyl, methoxyacetylfentanyl, ocfentanil, U-47700, isobutyrylfentanyl and benzylfentanyl. Furthermore, we were able to identify specific consumption patterns among drug users. The results indicate that hair analysis is a valuable tool for investigating the prevalence of NSOs in drug-using populations, which seems to be low in the case of Swiss opioid users. Nevertheless, the results highlight the need for sensitive analytical detection methods in forensic toxicology to identify and monitor substance distribution in different populations.

Study on risk factors of mycobacterium tuberculosis infection among health workers in medical institutions

Objective: To understand the infection status of mycobacterium tuberculosis among health workers in tuberculosis designated medical institutions and explore the risk factors of infection. Methods: From September 2021 to June 2022, a questionnaire survey was conducted among health workers in relevant departments of 4 tuberculosis designated medical institutions by cluster stratified sampling, including the implementation of hospital infection control measures in medical institutions and occupational exposure of medical staff to mycobacterium tuberculosis. Peripheral blood interferon gamma release assays (IGRAs) and lung imaging examination were performed to determine the mycobacterium tuberculosis infection. Factors with statistical significance in univariate analysis were included in multivariate logistic regression to analyze the risk factors of mycobacterium tuberculosis infection. Results: A total of 657 people completed the lung imaging examination and questionnaire, of which 654 people had peripheral blood IGRAs detection, and the latent infection rate of tuberculosis was 39.45% (258/654) . Univariate analysis showed that age, sex, marital status, economic income, occupational category, professional title, length of service, and other variables had statistical significances in tuberculosis latent infection (P<0.05) . In terms of personal health status, there were statistically significant differences in the distribution of health workers in terms of their tuberculosis history, tuberculosis history of their immediate family members, previous tuberculin skin test (TST) (P<0.05) . Multivariate analysis showed that there were four risk factors related to tuberculosis, including professional title (X(1)) , years of tuberculosis related works (X(2)) , tuberculosis history (X(3)) and previous TST (X(4)) . The regression equation of the probability of tuberculosis among health workers was y=-1.920+0.246X(1)+0.046X(2)+1.231X(3)+0.478X(4). Conclusion: The latent infection rate of tuberculosis among health workers in tuberculosis designated medical institutions is high. It is necessary to strengthen the management of infection control, carry out regular screening, enhance the self-protection awareness of health workers, and reduce their exposure to mycobacterium tuberculosis and infection risk.

Constraining the interaction history of Arp 269 using stellar population synthesis modelling

ABSTRACT We present stellar population synthesis modelling of the nearby interacting galaxy system NGC 4485/90 or Arp 269 using Code Investigating GALaxy Emission. Model results are used to constrain its interaction history and to examine the origin of structures within the system. We have used multiwavelength observations ranging from far-ultraviolet to radio wavelengths to create, model, and fit spectral energy distributions and obtain physical properties of different regions. Our analysis reveals a young and an underlying much older stellar population in both NGC 4485 and 4490. We find the bridge connecting the two galaxies to be formed quite recently, after the second perigalactic encounter between the two. Our analysis shows that the previously identified faint stellar extension associated with NGC 4490 was also formed after the second encounter, which agrees with previous N-body and test-particle simulations. Additionally, we investigate the H i gas distribution in NGC 4485 and find that a mass of H i gas comparable to a dwarf galaxy has been relocated to the south-west part of NGC 4485. This is consistent with the scenario in which the interstellar medium of NGC 4485 is being removed via ram pressure stripping.

Real world outcomes of distributing Lucira Check-It® COVID self-tests in Ontario, Canada: the GetaKit COVID study

BackgroundIn Ontario, Canada we developed and implemented an online screening algorithm for the distribution of HIV self-tests, known as GetaKit. During the COVID pandemic, we adapted the GetaKit algorithm to screen for COVID based on population and infection data and distributed COVID rt-LAMP self-tests (using the Lucira Check-It®) to eligible participants.MethodsGetaKit/COVID was a prospective observational study that occurred over a 7-month period from September 2021 to April 2022. All potential participants completed an online registration and risk assessment, including demographic information, COVID symptoms and risk factors, and vaccination status. Bivariate comparisons were performed for three outcomes: results reporting status, vaccination status, and COVID diagnosis status. Data were analysed using Chi-Square for categorial covariates and Independent Samples T-Test and Mann-Whitney U test for continuous covariates. Bivariate logistic regression models were applied to examine associations between the covariates and outcomes.ResultsDuring the study period, we distributed 6469 COVID self-tests to 4160 eligible participants; 46% identified as Black, Indigenous or a Person of Colour (BIPOC). Nearly 70% of participants reported their COVID self-test results; 304 of which were positive. Overall, 91% also reported being vaccinated against COVID. Statistical analysis found living with five or fewer people, having tested for COVID previously, and being fully vaccinated were positive factors in results reporting. For COVID vaccination, people from large urban centers, who identified their ethnicity as white, and who reported previous COVID testing were more likely to be fully vaccinated. Finally, being identified as a contact of someone who had tested positive for COVID and the presence of COVID-related symptoms were found to be positive factors in diagnosis.ConclusionsWhile most participants who accessed this service were vaccinated against COVID and the majority of diagnoses were identified in participants who had symptoms of, or an exposure to, COVID, our program was able to appropriately link participants to recommended follow-up based on reported risks and results. These findings highlight the utility of online screening algorithms to provide health services, particularly for persons with historical barriers to healthcare access, such as BIPOC or lower-income groups.

Validation of the abbreviated version of the Profile of Musical Perception Skills (Mini-PROMS) in a Spanish sample of musicians and non-musicians

Despite the efforts made throughout the 20th century to develop standardized batteries to measure musical ability, there seems to be no consensus as to the construct’s gold standard. The Profile of Music Perception Skills (PROMS) was created with the aim of overcoming some of the limitations of previous assessment tests. The Mini-PROMS is the shortened version of the full battery and has a shorter application time. The aim of the present study was to validate the Mini-PROMS battery with a sample of Spanish musicians and non-musicians in order to provide useful scales for the development of research in the field of musical skills in the Spanish population. The results show that Mini-PROMS in Spanish is a reliable and valid tool for measuring the musical ability of musicians and non-musicians. Furthermore, this study provides information on some of the differences between musicians and non-musicians, offering useful scales for comparing the results of individuals with those of their reference population.

A stress-controlled soil column test equipment for investigating water seepage-consolidation characteristics of the compacted soil

For deep-filled building site, it is not acceptable to neglect water seepage and land settlement caused by the coupling effect of wetting and loading. However, previous soil column tests employed in investigating the water seepage always failed to consider the vertical stress. In this article, a stress-controlled soil column test was conducted to investigate the effect of vertical stress on water seepage and deformation of the compacted soil. The soil column was equipped with a vertical loading device and a water-recharge device to control the boundary conditions and water sensors, tensiometers, dial indicators and a data collector to monitor the displacement and water movement. The soil column test was utilised to perform seepage tests on compacted loess with vertical stresses of 0 and 400 kPa. The time-history data of wetting front depth, volumetric water content (VWC), suction and vertical displacement have been monitored directly. The VWC and suction profiles, soil–water characteristic curves and hydraulic conductivity curves were then obtained with the monitored data. The test results demonstrated that the vertical stress affected the water seepage and consolidation of the compacted soil, but this effect gradually decreased as the depth of the soil column increased. Moreover, the reliability of the proposed test method was verified by the comparison of some available test results. The findings of this study contribute to a better understanding of water seepage and consolidation characteristics of the compacted soil subjected to vertical stress.