Previous Season Research Articles

HiCorr: an influenza surveillance model using over-the-counter sales from community pharmacies

Abstract Background In large-scale community transmission, such as seasonal influenza, monitoring geographic trends and estimating the transmission intensity are critical to support public health decision-making. Previous studies have successfully used sales data from over-the-counter (OTC) products in community pharmacies to detect and monitor different epidemiological outbreaks, developing surveillance systems that are able to anticipate the load on primary care services and hospitals by up to 3 weeks. Methods The subset of OTC products sold in Portuguese community pharmacies was selected by correlating sales data to primary care attendance in previous flu seasons. This data pertained to daily coded episodes of influenza-like-illness (International Classification of Primary Care, 2nd Edition, code R80) in the Portuguese health cluster Oeste Sul. By fitting a moving epidemic method to historical sales data and then applying it to daily collected sales data, the developed index was used to anticipate the relative load to the primary care system as well as the start and the peak of epidemic activity for the current flu season. Results were compared to the public health data available on respiratory infections in Portugal. Results The model pinpointed the onset of the 2023-2024 flu epidemic in week 47 and its peak in week 52. The index curve showed a high correlation with the data published by the Portuguese national health service, with no time lag. However, the availability of consolidated public data was delayed, on average, by approximately two weeks. Discussion and conclusions Data from community pharmacies significantly enhance the early detection of seasonal flu trends, while reflecting population distribution. This underscores their invaluable contribution to public health assessments and the potential for improving the timeliness and accuracy of seasonal flu surveillance. Key messages • Community pharmacy data significantly enhance the early detection of seasonal flu trends. • Real world sales data maybe useful to support epidemic surveillance in public health.

Reality TV, Nigerian Idol, and cultural preferences for Afrobeats music

ABSTRACT Reality TV, particularly Music Reality Shows (MRSs) like Nigerian Idol, has emerged as a significant dimension of television programming, providing a platform for cultural representation and interactivity. Afrobeats, a music genre that originated in West Africa, has gained global acceptance and recognition in recent years with great influence on the global cultural landscape. This study examined the cultural preferences of viewers towards the use of Afrobeats music in the Nigerian Idol reality TV show. Cultivation theory was adopted as the theoretical framework to investigate the level of viewership of Nigerian Idol among residents of Lagos, Nigeria, and explore their cultural preferences for Afrobeats music. Through a mixed methods approach involving a quantitative survey and focus group discussions (FGD), the study gathered data from residents of Lagos, Nigeria. The results reveal a reduction in viewership of Nigerian Idol compared to previous seasons, indicating shifting audience interests. However, there is a significant cultural preference for Afrobeats music compared to other genres of music, particularly those of foreign origin, among viewers who have encountered the Nigerian Idol. This also confirms the growing influence and acceptance of the fast-rising Afrobeats genre. The findings underscore the role of media, particularly television programmes such as Reality TV Shows, in shaping cultural identity and preferences. The correlation analysis confirms a strong relationship between viewership levels and cultural preferences for Afrobeats music in Nigerian Idol, highlighting the impact of television programming on audience perceptions and tastes for cultural artifacts like music. The study contributes to understanding cultural dynamics in the context of Reality TV Shows, music, and cultural entertainment, emphasizing the need for producers to adapt to evolving audience preferences and embrace digital innovations to sustain viewer interest.

Sweet cherry response in absorption and mobility of 10B applied to soil and flowers under two soil boron conditions

AbstractBackgroundBoron (B) is an essential micronutrient for plants, and B deficiency reduces fruit set in sweet cherry trees. Several studies showed the advantages of foliar and soil B applications in fruit trees, but there is little information on the distribution of B in the plant, becoming an important issue when nutritional corrections are needed.AimsThe study aims to determine B mobility and distribution in sweet cherry trees, applying 10B to the flowers and soil, at different timings and under two levels of soil B availability.MethodsTwo experiments were conducted with sweet cherry trees. In the two previous seasons, the plants were managed in two soil B availability conditions (deficient and adequate). The experiments consisted of the applications of 10B solution to the flowers and the soil at different timings and under both soil B conditions.ResultsHigher 10B absorption occurred when the 10B was applied to the soil at full bloom than when it was applied before leaf senescence. Boron was mobilized to all the tissues, but mainly to the leaves. Nevertheless, the fruit presented no differences in 10B excess for both application timings. Irrespective of soil B conditions, the 10B applied to the soil at full bloom was absorbed and mobilized to different tissues, that is, roots + rootstock + trunk (39%–44%) and stems + leaves (53%–55%), showing no differences between them. A lower percentage of B was located in the fruit, with 1% and 8% at soil B‐deficient and B‐adequate conditions, respectively. The highest percentage of the 10B applied to the flowers remained in the fruit (∼70%), and nearly 20% and 10% were mobilized to stems + leaves and roots + rootstock + trunk, respectively, independent of the soil B condition.ConclusionsBoron applied to soil at full bloom or before leaf senescence, under B‐deficient soil condition, is absorbed and mobilized to all the plant tissues, enhancing the B status in sweet cherry trees particularly when it is applied at full bloom. However, B soil application before leaf senescence would improve the availability of B (reserves) to the flowers in the following season. Boron applied to the flowers, at full bloom, remains in a high proportion in the fruit, becoming an effective complementary method to meet the fruit demands of the growing season, independent of the soil B conditions.

Psychological distress among healthcare providers during the COVID-19 pandemic: patterns over time

BackgroundCOVID-19 added to healthcare provider (HCP) distress, but patterns of change remain unclear. This study sought to determine if and how emotional distress varied among HCP between March 28, 2021 and December 1, 2023.MethodsThis longitudinal study was embedded within the 42-month prospective COVID-19 Cohort Study that recruited HCP from four Canadian provinces. Information was collected at enrollment, from annual exposure surveys, and vaccination and illness surveys. The 10-item Kessler Psychological Distress Scale (K10) was completed approximately every six months after March 28, 2021. Linear mixed effects models, specifically random intercept models, were generated to determine the impact of time on emotional distress while accounting for demographic and work-related factors.ResultsBetween 2021 and 2023, the mean K10 score fell by 3.1 points, indicating decreased distress, but scores increased during periods of high levels of mitigation strategies against transmission of SARS-CoV-2, during winter months, and if taking antidepression, anti-anxiety or anti-insomnia medications. K10 scores were significantly lower for HCP who were male, older, had more children in their household, experienced prior COVID-19 illness(es), and for non-physician but regulated HCP versus nurses. A sensitivity analysis that included only those who had submitted at least five K10 surveys consisted of the factors in the full model excluding previous COVID-19 illness, occupation, and season, after adjustment. Models were also created for K10 anxiety and depression subscales.ConclusionsK10 scores decreased as the COVID-19 pandemic continued but increased during periods of high mitigation and the winter months. Personal and work-place factors also impacted HCP distress scores. Further research into best practices in distress identification and remediation is warranted to ensure future public health disasters are met with healthcare systems that are able to buffer HCP against short- and long-term mental health issues.

A Case of Facultative Polygyny in an Enigmatic Monogamous Species, the European Nightjar (Caprimulgus europaeus).

In many socially monogamous bird species with biparental care, occasional social polygyny has been detected. We provide information about a case of facultative polygyny in the European Nightjar (Caprimulgus europaeus). The male nightjar (I96) formed a pair with two females (I95: the presumed primary female with whom he already bred since 2018; M042: the presumed secondary female, an inexperienced yearling). GPS and accelerometer data demonstrate how the male only sang in proximity of the primary nest, while assisting both females during incubation, as well as during the nestling period. When the male came to the nest, the primary and/or secondary female went foraging, but the secondary female received less assistance during incubation than the primary female, and her eggs were often left unattended. However, once the chicks of the secondary female hatched, male assistance suddenly increased, presumably at a cost to the primary female. Being only the second record of social polygyny in the European Nightjar, we do not have a direct explication for the occurrence of this polygynous event. We note that male density at the study site was lower than that observed in previous seasons. The male may have taken over the female that was initially paired to a neighbouring territory holder that then died. Alternatively, the inexperienced female might have mated with an already paired male, either because she was not aware of the mating status of the male, or because she could not find an unpaired male, or because mating with this paired male was better than mating with another unpaired male. In any case, the breeding ecology and mating behaviour of this crepuscular bird species remains little understood.

Introduction of nirsevimab in Catalonia, Spain: description of the incidence of bronchiolitis and respiratory syncytial virus in the 2023/2024 season.

Respiratory syncytial virus (RSV) causes most of the cases of bronchiolitis and thousands of deaths annually, particularly in infants less than 6months old. In Catalonia (Spain), infants born between April 2023 and March 2024 aged 0-6months during their first RSV season have been candidates to receive nirsevimab, the novel monoclonal antibody against RSV, since October 2023. We aimed to analyse the dynamics of all-causes bronchiolitis diagnoses and RSV community infections in the current season and compare them to pre-nirsevimab epidemics. We collected epidemiological data from the Information System for Surveillance of Infections in Catalonia (SIVIC) on daily all-causes bronchiolitis clinical diagnoses and RSV-confirmed cases provided by rapid antigen tests in primary care practices. We calculated the rate ratio (RR) for the incidence of all-causes bronchiolitis for children aged 0-11m-old with respect to 12-35m-old between September 2014 and January 2024. We analysed the RR of the incidence of RSV-confirmed infection for 0-11m-old and 12-35m-old with respect to the > 35m-old, from January 2021 to January 2024. We then computed the relative difference of the RR, designated as percentage of reduction of risk, between season 2023/2024 and former epidemics. With a global coverage recorded rate for nirsevimab of 82.2% in January 2024, the age-specific 0-11m-old RR (95% CI) of RSV infection incidence for > 35m-old was 1.7 (1.5-2.0) in season 2023/2024. The RR (95% CI) had been 7.4 (5.6-9.9), 8.8 (6.9-11.3), and 7.1 (5.7-8.9) in 2020/2021, 2021/2022, and 2022/2023, respectively. Regarding the incidence of all-causes bronchiolitis for the 0-11m-old group compared to the 12-35m-old, the pre-pandemic (2014/2015-2019/2020) and 2022/2023 RR (95% CI) were 9.4 (9.2-9.6) and 6.0 (5.7-6.2), respectively, significantly higher than the RR of 3.6 (3.4-3.8) for the most recent season, 2023/2024. Conclusion: Concurring with the introduction of nirsevimab, the risk of RSV infection for infants aged 0-11m-old compared to > 35m-old has been reduced by 75.6% (73.4-77.5) in last season, and the risk for all-causes bronchiolitis for 12-35m-old by 61.9% (60.9-62.9) from the pre-pandemic period and by 39.8% (39.3-40.2) from the 2022/2023 epidemic, despite high RSV community transmission, especially in older infants What is Known: • RSV is responsible for approximately 70% of bronchiolitis cases and causes severe disease, particularly in infants < 6months of age. • Nirsevimab effectiveness against RSV-associated disease, particularly hospitalisations, was expected to be around 80%; other Spanish regions, such as Galicia and Valencia, and European countries including Luxembourg and Germany, have already reported good results in implementing nirsevimab to prevent RSV-associated hospitalisations and PICU stays. What is New: • We provide insight into the community incidence of RSV and all-causes bronchiolitis for season 2023/2024, when nirsevimab has been introduced to the Catalan population, using. primary healthcare data, which enabled us to assess the burden of RSV infections and bronchiolitis in the commonly seasonally saturated primary healthcare practices. • Our study reveals that the risk of all-causes bronchiolitis for infants aged 0-11m-old compared to older infants was reduced by 40% compared to the previous season and 62% compared to pre-pandemic standards, and for RSV infection it was reduced by 76%.

Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase.

Seasonal influenza viruses continuously evolve via antigenic drift. This leads to recurring epidemics, globally significant mortality rates, and the need for annually updated vaccines. Co-occurring mutations in hemagglutinin (HA) and neuraminidase (NA) are suggested to have synergistic interactions where mutations can increase the chances of immune escape and viral fitness. Association rule mining was used to identify temporal relationships of co-occurring HA-NA mutations of influenza virus A/H3N2 and its role in antigenic evolution. A total of 64 clusters were found. These included well-known mutations responsible for antigenic drift, as well as previously undiscovered groups. A majority (41/64) were associated with known antigenic sites, and 38/64 involved mutations across both HA and NA. The emergence and disappearance of N-glycosylation sites in the pattern of N-X-[S/T] were also identified, which are crucial post-translational processes to maintain protein stability and functional balance (e.g., emergence of NA:339ASP and disappearance of HA:187ASP). Our study offers an alternative approach to the existing mutual-information and phylogenetic methods used to identify co-occurring mutations, enabling faster processing of large amounts of data. Our approach can facilitate the prediction of critical mutations given their occurrence in a previous season, facilitating vaccine development for the next flu season and leading to better preparation for future pandemics.

Combined Effects of Fishing and Environment on the Growth of Larimichthys polyactis in Coastal Regions of China

In fisheries’ stock assessments, the concept of “growth plasticity”—the ability of organisms to modulate their growth rates in response to environmental conditions—has gained attention in recent years. Historically, the impacts of fishing activities and environmental fluctuations were considered separately, while their combined effects have recently come into focus. This study collected 834 adult small yellow croakers (Larimichthys polyactis) from the northern Yellow Sea, the central Yellow Sea, the southern Yellow Sea, and the northern East Sea by trawling during 2020–2021. Using otolith increments as a proxy for annual somatic growth, the study reconstructed otolith chronologies during 2015–2020 for these four stocks. The results of the mixed-effects modeling suggested that temperature during spawning and previous overwintering seasons had comparable importance for the annual growth of small yellow croakers, with higher temperature promoting growth. The growth of small yellow croakers was also found to be correlated with ENSO events, with a lag of 1 to 2 years. A further investigation into combined effects revealed that higher fishing pressure might inhibit the small yellow croaker’s response to favorable environmental conditions. Furthermore, considering the potential differences in growth plasticity among stocks, an analysis was conducted on the spatial variations in growth response to these factors. The analysis revealed that, compared to the stocks in the Yellow Sea, the stock from the East China Sea could exhibit higher growth, superior adaptability to temperature, and a distinctive response to fishing pressure. In conclusion, the present study, while primarily focusing on temperature, preliminarily analyzed the combined effects of fishing and environment and underscored the differences in growth plasticity between stocks in the Yellow Sea and the East China Sea. Despite the limited factors analyzed in this study, it suggests a direction for future studies, highlighting the necessity to include more environmental factors, and even population factors (e.g., the biomass of preys), for a more comprehensive understanding of the combined effects. Based on the observed differences between the two potential subpopulations, this study also provides new insights for the management of the small yellow croaker based on metapopulation dynamics.

Naivety dies with the calf: calf loss to human hunters imposes behavioral change in a long-lived but heavily harvested ungulate

BackgroundIn prey, patterns of individual habitat selection and movement can be a consequence of an individuals’ anti-predator behavior. Adjustments of anti-predator behavior are important for prey to increase their survival. Hunters may alter the anti-predator behavior of prey. In long-lived animals, experience may cause behavioral changes during individuals’ lifetime, which may result in altered habitat selection and movement. Our knowledge of which specific events related to hunting activity induce behavioral changes in solitary living species is still limited.MethodsWe used offspring loss in a solitary and long-lived ungulate species, moose (Alces alces), as our model system. We investigated whether offspring loss to hunters induces behavioral changes in a species subjected to heavy human harvest but free from natural predation. To test for behavioral change in relation to two proxies for experience (calf fate and age), we combined movement data from 51 adult female moose with data on their offspring survival and female age. We tested for adjustments in females’ habitat selection and movement following calf harvest using Hidden Markov Models and integrated Step Selection Analysis to obtain behavioral state specific habitat selection coefficients.ResultsWe found that females with a harvested calf modified habitat selection and movement during the following hunting season. Female moose selected for shorter distance to roads during the night, selected for shorter distance to forests and greater distance to human settlements following calf harvest than females who had not lost a calf. The survival of twins in a given hunting season was related to female age. Older females we more likely to have twins survive the hunting season.ConclusionsOur findings suggest that losing offspring to human harvest imposes behavioral changes in a long-lived ungulate species, leading to adjustments in females' habitat selection and movement behavior, which may lower the risk of encountering hunters. In our study, female moose that experienced calf loss selected for lower distance to forest and selected for greater distance to human settlements during periods of high hunting pressure compared to females without the experience of calf loss during the previous hunting season. We interpret this as potential learning effects.

Investigation of the effects of polyethylene microplastics at environmentally relevant concentrations on the plant-soil-microbiota system: A two-year field trial

Microplastics are a potential threat to agricultural sustainability. However, the effects of microplastics at environmentally relevant concentrations on the plant-soil-microbiota system in realistic field conditions are largely unknown. Herein, we conducted a two-year field trial to study the effects of polyethylene (PE) microplastics at 0, 100, and 600 mg/kg on crop growth, soil properties, and the composition and function of microbial communities in a farmland with rice-wheat rotation. PE did not affect wheat growth but it increased the rice grain weight by 42.5 % at 600 mg/kg, and enhanced rice height by 35.4 % and 30.2 % at 100 and 600 mg/kg, respectively. The presence of PE significantly decreased soil available phosphorus during the wheat season, while it reduced soil total nitrogen, NH4+-N and available phosphorus during the rice season. There were five and sixteen bacterial orders identified changed by PE in wheat and rice soils, respectively. Specifically, PE at different concentrations differentially altered the abundances of sulfate-reducing bacteria Thermodesulfovibrionia, Thermoactinomycetales and Syntrophobacterales, and further modified soil sulfate respiration in wheat soils. During the rice season, PE (100 mg/kg) increased the abundance of Xanthomonadales by 98.0 % and enriched the functional groups of intracellular parasites, while PE (600 mg/kg) inhibited twelve cluster of orthologous group function classes and disturbed bacterial metabolism. This study suggests that PE exhibits a greater impact on the plant-soil-microbiota system during the rice season compared to the previous year's wheat season, highlighting the importance of crop type and cultivation practices in determining the environmental risks of microplastics in agroecosystems.

First report of Gnomoniopsis castaneae associated with branch dieback on chestnut tree (Castanea sativa) in Southern Chile.

European chestnut (Castanea sativa Mill.) currently reaches 1,470 ha, distributed from the Maule region to the Los Rios region in Chile. Almost 3000 tons of fruit have been exported in the last three years. A survey was carried out in January 2023 in an eight-year-old orchard located in Vilcún (38°34'46.22"S 72° 9'58.61"O), Araucanía Region. Chestnut trees with branch die back and reduced growth and vigor were detected. The incidence in the orchard was 3% (6 out of 200 trees) estimated by visual observation. Cross and longitudinal sections of the woody trunk of two trees were collected and examined, and an internal dark-brown discoloration to partial necrosis lesion was observed. To identify the causal agent, small pieces of wood from the edge of the symptomatic area were surface sterilized with 70% ethanol, rinsed twice with sterile distilled water, blotted on dry sterile filter paper, plated on potato dextrose agar (PDA) and incubated at 22°C. Fungal colonies were consistently isolated, and after 5 days, pure cultures were obtained by transferring mycelium to new PDA plates, preliminarily identified as Gnomoniopsis sp. (Visentin et al. 2012, Shuttleworth 2012). All cultures exhibited characteristics consistent with the description of G. castaneae (Syn. G. smithogilvyi), such as concentric development of greyish-brown mycelium, abundant stroma, hyaline conidia of 7.2 ±0.54 (6.1-8.1) X 2.3 ±0.26 (1.5-2.9) µm (n= 30), mainly biguttulate and fusoid. Total DNA was extracted, rDNA amplified using ITS1/ITS4 primers (White et al. 1990), and the fragment was Sanger sequenced and the sequence was deposited in GenBank (OR665735). BLAST analysis revealed a 99% identity to G. castaneae (MH384925). In addition, the DNA of the isolate was evaluated in a species-specific multiplex PCR (Silva-Campos et al. 2022), and the amplicons were electrophoretically separated, giving a similar band profile to G. smithogilvyi RGM 2903 and RGM 2904 strain from Chilean Collection of Microbial Genetic Resources. Pathogenicity of G. castaneae isolate (CV-11) was tested on ten replicates of 3-year-old C. sativa plants. Two wounds were made on the same season growing shoot and two on the previous season shoot. Longitudinal wounds (5 mm long, 4 mm wide and 2 mm depth) were made using a scalpel without removing the outer bark to inoculate the plants. Each wound was inoculated with a 5-mm mycelium plug, covered with the outer bark, and wrapped with Parafilm. Plugs of PDA were placed onto the wounds of two plants as control. The plants were kept in a growth chamber (22 ±1 0C and 90± 5% RH). All plants showed dark brown cankers measuring 20 to 40 mm long two weeks after inoculation. Also, most plants inoculated in the same season shoot presented wilted and chlorotic foliage. Mature conidiomata with cirri developed in most of the cankers. No symptoms were observed in the control. Fungal colonies of G. castaneae were reisolated on PDA from all inoculated chestnut plants and were not recovered from the controls. Recently, G. smithogilvyi has been identified as the causal agent of brown rot on chestnut nuts in Chile (Cisterna Oyarce et al. 2022); however, in several countries, it has also been associated as the causal agent of cankers in branch and stem of chestnut, as well as an endophyte in different hardwood species. Future studies on the incidence of this pathogen and its impact on chestnut yield should be carried out in the producing regions because it represents an emerging threat to Chilean chestnut production.

Four decades in the vineyard: the impact of climate change on grapevine phenology and wine quality in northern Italy

The wine sector, among the most profitable agricultural segments, has been markedly affected by the ongoing climate change impacts, such as warmer climate conditions with higher frequency of extreme temperatures and a trend of decreasing precipitation. All this results in higher evaporative demand and therefore higher occurrence of water stress events leading to advancement of temperature-sensitive phenological stages (e.g., budburst and ripening). Such negative effects eventually affect berry development and quality, especially in historically valuable viticultural areas, forcing winegrowers to work within a compressed harvest period to maintain wine typicity. In this work we examined the relationship between environmental variables (air and soil temperature, relative humidity, precipitation, and solar radiation), phenology, berry, and wine quality for the two varieties (Chardonnay and Teroldego) in Trentino Alto-Adige/South Tyrol (Italy) over 36 years. Huglin Index (a bioclimatic heat index), growing degree days (measure of heat accumulation), and overall mean temperature showed linear increase (p &lt; 0.001) in the last years, while no variations were recorded for precipitations. Despite no major effects being observed for phenological interval lengths, the onset of most of the phenological stages for both varieties had significantly (p &lt; 0.001) advanced. However, i) early budburst pushed the budburst-flowering interphase by -1.2 days every two years toward putative colder periods with increased late frost probability and potential slower phenological progression towards flowering, and ii) early veraison shifted the veraison-ripening interphase by 0.25 day per year into warmer periods that oppositely impose faster phenological advancement. Hence, a substantial equilibrium in the seasonal growing length over years was maintained. Potential carry-over effects from the previous season were observed, particularly associated with heat requirements to unlock early phenological events, raising additional concerns on the additive effects of climate change to viticulture. Generally, white wine quality increased (p &lt; 0.05) over the years, while red and sparkling wines remained unaffected. This was putatively related to accurate harvest date decision-making dictated by berry quality parameters: sugar-to-acidity ratio for Chardonnay and bunch sanitary status for Teroldego. Overall, this work provides evidence of the dynamics involved in climate change, and, to our knowledge, its overlooked effects on viticulture, thus providing new insights that can contribute to further developing adaptive strategies.

Spatiotemporal change of lake shrinkage and its response to the unprecedented heat waves in the middle and lower Yangtze River Basin

ABSTRACT Due to the joint influence of human activities and climate change, lakes experience significant shrinkage or expansion, posing enormous challenges for water resource management and the ecological balance of lake ecosystems. As an important region abundant in water resources in China, the balance of water resources in the middle and lower Yangtze River Basin (MLY) is crucial for region sustainable development. However, to date, few studies have quantitatively analysed the lake area during heat waves in the MLY. To fill this gap, this study selected the summer of 2022, which encountered unprecedented heat waves, to analyse the changes of lake area in the MLY. Specifically, Sentinel-1 images were used as data sources, and the Random Forest (RF) model was applied to extract the monthly area of 62 lakes (area >10 km2) in the MLY from 2019 to 2022. The results showed that: (1) Compared to the Support Vector Machine (SVM) model and the Otsu method, the RF model had the highest accuracy, with its accuracy and Kappa coefficient in the testing samples of 97.14% and 0.94, respectively. During the period from June to September in 2022, the total area of 62 lakes decreased by 3475.50 km2. (2) Compared to the same period in the summer of 2019–2021, 23 lakes (37.10%) were observed to experience shrinkage. Among them, the area of Poyang Lake and Dongting Lake decreased to the level of the previous winter dry seasons in August 2022. (3) Temperature was the most important meteorological factor that caused changes in the lake area in the MLY, compared to precipitation, evaporation, and runoff. This research can help understand the impact of climate change on lakes and provide references for decision-making in the MLY to formulate the strategies of water resource management under the changing climate.

Nirsevimab and Acute Bronchiolitis Episodes in Pediatric Emergency Departments.

In the 2023-2024 respiratory syncytial virus (RSV) season, Spain became one of the first countries to introduce universal RSV prophylaxis, during which all infants born at this time were eligible to receive nirsevimab. Locally, most Spanish regions also immunized infants younger than age 6 months at the start of the season (extended catch-up). The aim of this study was to assess how RSV prophylaxis affected the number of infants presenting to pediatric emergency departments with acute respiratory infections. A retrospective study was conducted in 15 Spanish pediatric emergency departments from 9 different regions between the 2018 and 2024 epidemic seasons (November-January). We compared the seasons occurring in 2018-2023 and the 2023-2024 season regarding the number of episodes of lower respiratory tract infection and acute bronchiolitis, acute bronchiolitis-related hospital admissions, and PICU admissions. A comparison with the average rates for the previous epidemic seasons revealed a 57.7% decrease in episodes of lower respiratory tract infection in 2023-2024 (95% CI, 56.5-58.8; P < .001; range among hospitals, 4.8-82.8), a 59.2% decrease in episodes of acute bronchiolitis (95% CI, 57.9-60.4; P < .001; range, 6.9-84.1), a 63.1% reduction in acute bronchiolitis-related hospital admissions (95% CI, 60.9-65.2; P < .001; range, 31.4-86.8), and a 63.1% reduction in PICU admissions (95% CI, 58.1-67.9; P < .001; range, 18.2-81.8). Hospitals in regions applying extended catch-up showed better results. Nirsevimab can protect a broad infant population against RSV infection with high effectiveness. Approaches including extended catch-up are the most effective, although cost- effectiveness must be considered.

Econometric Analysis of Factors Affecting Access to Market by Yam Farmers in Benue State

It is evident that in developing countries, agriculture serves as a foundation for economic activities. It plays an active role in determining the wealth, social and political system of a society. Therefore, policies and programmes as well as research and development in the sector is necessary for increased productivity and marketing. This study examines the variables influencing yam farmers’ access to markets in Benue State. The level to which the produce intended for sale the previous season was actually sold was used to determine whether or not the market was accessible. Data were collected with the use of a structured questionnaire from three local governments in Sankera Zone, the dominant yam producing zone of Benue state. The results of the logistic regression analysis showed the variables that affected the likelihood that a farmer in the study area would have easy access to markets. Gender, educational attainment, prior farming experience, vehicle ownership, and market space all showed positive and had a significant impact on the likelihood that a farmer would have simple access to the market. However, the age of the household and size had a negative effect, and were statistically significant. A farmer training programme is strongly recommended to equip farmers with modern farming techniques. Additionally, the establishment of infrastructural facilities, market boards, and yam processing factories were recommended to support their endeavors.

Changes in entire acute bronchiolitis seasons before, during, and after the COVID-19 pandemic in Spain

Paediatric acute bronchiolitis normally occurs from October to April in the temperate northern hemisphere, peaking in January. Nonpharmacological measures to control the spread of COVID-19 resulted in a decrease in the number of cases of bronchiolitis during the 2020-21 season. The discontinuation of these measures created an uncertain scenario. To describe the epidemiological evolution of acute bronchiolitis seasons and the changes in the demographics of the affected population before, during, and after the implementation of nonpharmacological interventions for COVID-19 in Spain. This was a multicentre and descriptive study. A total of 6,334 infants aged up to 12 months who were diagnosed with acute bronchiolitis were recruited from sixteen Spanish hospitals. We collected data from participants from September 1st, 2021, through August 31st, 2023, as part of the ECEALHBA research project. The study periods were before (P1), during (P2), and after (P3) the COVID-19 pandemic. In P2 and after the discontinuation of nonpharmacological interventions, an unexpected increase in the number of acute bronchiolitis cases was observed from June-August 2021, resulting in an out-of-season peak. A subsequent peak was observed in November 2021, earlier than expected for the 2021-22 season. In the 2022-23 season, admissions followed a historical trend, with a greater number of cases than in the two previous seasons. Statistically significant differences in the length of stay (p<0.001), number of RSV infections (p=0.021), and number of paediatric intensive care unit admissions (p<0.001) were observed among the periods. Two out-of-season peaks in the number of acute bronchiolitis cases were observed in 2020-2021 and 2021-2022. However, following the relaxation of nonpharmacological intervention measures, the peak observed in 2022-2023, although occurring 2-6 weeks earlier, was more similar to the peaks observed in the prepandemic seasons. Additionally, increased case severity was observed during these periods.

Management of the vaccination campaign in a population of frail older outpatients affected by cognitive or endocrinological conditions: a pilot study in Italy

Vaccination, particularly against pneumococcus and influenza, is a low-cost primary prevention, useful to avoid hard complications, particularly among frail older people. In this pilot study, we aimed to assess the effect of a strategy for influenza and pneumococcal vaccination for outpatients mainly affected by cognitive or endocrinological conditions, evaluating what could stimulate or demotivate vaccination among older people. This study was conducted during the 2023–2024 influenza season at the outpatient clinics in Palermo, Italy. A total 76 patients were included. More than half of the patients could be considered as pre-frail and about 20% frail, according to a comprehensive geriatric evaluation. Among patients, 46.05% received only vaccination against pneumococcus, 28.95% both vaccinations, and 25.0% only against influenza. Compared with the previous seasons, a 19.5% increase of influenza and 90.2% of pneumococcal vaccine uptake was observed. Side effects of vaccination were the main reason of the previous rejection, namely 76.9% for influenza and 53.8% for anti-pneumococcal vaccination. In conclusion, our study indicates how a new vaccination strategy in different settings could be feasible. Proposing influenza and pneumococcal vaccination for frail older outpatients could be an effective instrument to improve immunization coverage that is still low among older people.

Seasonal variations in household food security and consumption affect women's nutritional status in rural South Ethiopia.

Food availability varies seasonally in most rural areas of developing nations, especially in areas affected by drought and climate change, with women being one of the most vulnerable groups. This study aimed to assess the effect of seasonal variation in household food security, adequate dietary diversity, food consumption, and wealth on the nutritional status of women of reproductive age in a rural community in South Ethiopia. Further, the study aimed at identifying associated factors with women's nutrition status. An open cohort study was conducted from June 2021 to June 2022, with follow-up visits every three months. Anthropometric measurements were carried out along with interviews. Data were analyzed using STATA version 15. Multilevel, multiple linear regressions were employed. Findings revealed that women's average body mass index (BMI) was 20.4 kg/m2 (95% CI: 20.4-20.5). The highest (20.6 kg/m2, 95% CI: 20.5-20.8) was observed in December, while the lowest (20.2 kg/m2, 95% CI: 20-20.3) occurred in September. During the main postharvest period in December, the household food insecurity score was the lowest (median: 4, Inter quartile range (IQR): 0-9), while the household dietary diversity score (median: 6, IQR: 5-7), and the household food consumption score were the highest (median: 50.5, IQR: 44-70). Factors such as household food security, food consumption, previous season BMI, age, marital status, and membership in safety net programs were identified as determinants of women's BMI. The study showed the vulnerability of women in drought-prone areas to seasonal undernutrition. We recommend collaborative work among stakeholders to ensure sustainable food access and minimize seasonal food shortages' effect on women's nutrition and overall well-being.

A simple load model based on hybrid mechanism and data-driven approach for district heating in building complex

Accurate prediction of heating loads in district heating systems is essential for the implementation of demand-driven heating. This work presents a novel heating load prediction model that is particularly suitable for complex multi-user buildings. The input characteristics of the model are established through the heat transfer mechanism, considering factors such as the cumulative impact of outdoor temperature and user demand (indoor temperature). The specific form of the heating load function is determined using the MLR-PSO (Multiple Linear Regression-Particle Swarm Optimization) method. Only the indoor and outdoor temperatures need to be provided for the model to calculate future heating loads. Practical engineering tests demonstrated that the model achieved normalized mean bias errors of daily loads between 4.98 % and 5.54 % across different heating seasons, with a minimum annual relative deviation of 0.75 % for annual loads. Additionally, the model helps guide the operation of heating systems. For example, during the 2021–2022 heating season, setting the target indoor temperature at 18 °C reduced weekly energy consumption by 15.3 % compared to the previous season. This approach may be employed to construct a simple load model for existing heating systems to accurately predict both short-term and long-term loads, providing valuable insights into the management and control of heating systems.

Influenza Vaccination of Nursing Students: A Cross-Sectional Study of Uptake, Knowledge, Attitudes, and Practices in Greece.

Influenza immunization includes a yearly repeated vaccine offered to every healthcare worker, including nursing students, with a high risk of contracting this viral disease. This study aimed to investigate the vaccination coverage, knowledge, attitudes, and practices of nursing students against influenza in Greece. A cross-sectional study was conducted in the Attica region between September 2022 and July 2023, with the use of an anonymous reference questionnaire. Data from 1261 nursing students were recorded (response rate: 68.6%). The study found that 23% of the sample were vaccinated against influenza for the flu season 2022-2023, and 42% were vaccinated for the previous flu season. Knowledge scores regarding influenza ranged from 0% to 100%, with a mean value of 55 (SD = 18.8%). A higher level of knowledge about influenza was associated with more appropriate attitudes and practices toward the disease (p < 0.001). Notably, participants in their second, third, or fourth year of study and beyond exhibited more suitable attitudes and practices towards the flu compared to those in their first year of study (p < 0.05). The emergence of low vaccination coverage identifies the need for departments of nursing studies to proceed with the design of educational and intervention programs on infection control.