ABSTRACT Objective Substance use disorders have emerged as a remarkable public health problem worldwide in recent years. The present study aimed to determine the severity of substance use disorders of individuals who applied to the counseling unit within the scope of the project “Opening Doors to Hope, Holding on to Life,” and to examine the relationship between their sociodemographic, measured characteristics and the severity of substance use. Methods The data of this descriptive cross-sectional study were collected using the demographic information and substance use characteristics, and Addiction Profile Index-Clinical Form (BAPI-K) during the project implementation between February 2019 and December 2020. Results The findings revealed that 52.7% of the applicants had a low substance use level, while it was high among 23.3%. Significant relationships were detected between the severity of substance use and education level, previous counseling on addiction, level of depression, anxiety, poor anger management, and lack of safe behavior (p < .05). Conclusion This study revealed significant relationships between the severity of substance use disorders and level of depression, anxiety, anger management issues, and lack of safe behaviors. In this context, considering these factors in the substance use disorder treatment process could potentially enhance treatment success.