Abstract Background Gastroesophageal reflux disease (GORD) has an influence on patients’ health related quality of life, affecting 20% of adults in high income countries (1)(2). Despite first line therapy, proton pump inhibitors, approximately 20-30% of patients have persistent symptoms (3). Anti-reflux surgery is by its very nature a lifestyle related procedure, thus there must be a robust and duplicatable method for assessment of the severity of symptoms to facilitate patient selection. We launched a clinician delivered high-resolution pH oesophageal manometry and ambulatory pH impedance service in January 2021 at our Specialist Anti-Reflux Centre. Here we present our preliminary data. Methods This is a retrospective analysis of patients who underwent ambulatory pH manometry within our department between January 2021 and June 2023. Analysis to date was undertaken of patient’s outcomes from their pH manometry. Patients with previous anti-reflux surgery were excluded. We reviewed those who were offered surgery versus those who were not. Each group had further analysis of the DeMeester score, Symptom Index (SI) and Symptom Association Probability (SAP). A two sample T-test was performed, with p<0.05 considered statistically significant. Results Of the 141 patients that underwent ambulatory pH manometry, 62% (n=88) had sufficient data for analysis. 33% (n=29) of these were subsequently offered surgical intervention; 14 underwent fundoplication (48%) and 12 LINX procedures (41%); the remaining patients, 1 referred for POEM, 1 awaited surgical planning and 1 required Gastroenterology review. Those who progressed to surgery had a greater DeMeester score than those who were not offered surgery (45.2 vs 28.5). Patients in the surgical group also had a higher mean SI than those in the non-surgical group (57.0% vs 38.6%, p=0.01), and higher SAP (94.1% vs 80.3%, p=0.03). Conclusions This clinician-led in-house clinic has had significant impact upon our service. It has enabled collation of quantitative data to facilitate the decision-making process in the provision of anti-reflux surgery, thus aiding appropriate patient selection. Going forward, further work is being undertaken into quality of life questionnaires post anti-reflux surgery, both before and after introduction of our new service.