Remedy For Prevention Research Articles

Varicosities in Pregnancy

Varicose vein is a dilated swelled leg veins with back flow of blood caused by incompetent valve closure which result in venous congestion and vein enlargement. It usually affects the saphenous vein and its branches. The condition may be worsening with menstrual cycle, with pregnancy and response to exogenous hormonal therapy( oral contraceptives).It deals about the causes of varicosities and how it occurs in pregnancy. Varicosities had different signs and symptoms which occurs during the time of delivery and also had preventive treatment alternative remedies and safe treatment option after pregnancy in varicose vein.

Screening of herbal extracts binding with vascular endothelial growth factor by applying HerboChip platform

BackgroundTraditional Chinese medicine (TCM) has been hailed as a rich source of medicine, but many types of herbs and their functions still need to be rapidly discovered and elucidated. HerboChip, a target-based drug screening platform, is an array of different fractions deriving from herbal extracts. This study was designed to identify effective components from TCM that interact with vascular endothelial growth factor (VEGF) as a target using HerboChip.MethodsSelected TCMs that are traditionally used as remedies for cancer prevention and wound healing were determined and extracted with 50% ethanol. Biotinylated-VEGF was hybridized with over 500 chips coated with different HPLC-separated fractions from TCM extracts and straptavidin-Cy5 was applied to identify plant extracts containing VEGF-binding fractions. Cytotoxicity of selected herbal extracts and their activities on VEGF-mediated angiogenic functions were evaluated.ResultsOver 500 chips were screened within a week, and ten positive hits were identified. The interaction of the identified herbal extracts with VEGF was confirmed in cultured endothelial cells. The identified herbs promoted or inhibited VEGF-mediated cell proliferation, migration and tube formation. Results from western blotting analysis demonstrated the identified herbal extracts significantly affected VEGF-triggered phosphorylations of eNOS, Akt and Erk. Five TCMs demonstrated potentiating activities on the VEGF response and five TCMs revealed suppressive activities.ConclusionsThe current results demonstrated the applicability of the HerboChip platform and systematically elucidated the activity of selected TCMs on angiogenesis and its related signal transduction mechanisms.

환경침해에 대한 유지청구의 인정 근거로서 민법 제217조에 대한 고찰

As society develops and becomes more complex, damage caused by environmental infringement activities such as soil pollution and waste pollution is increasing. Environmental issues are considered an important key to determining our future. In the case of damage caused by environmental infringement, the first and foremost remedy is to claim compensation for damages afterwards. However, once damage caused by environmental infringement occurs, it is difficult to recover to its original state, and even if it is recovered, it is bound to take a lot of time and money. For this reason, proactive prevention is more important than follow-up relief in environmental infringement problems. Generally, an “injunction” is presented as a preventive remedy against environmental infringement. An injunction is the right to demand a certain action or inaction from the perpetrator when damage is occurring or is likely to occur due to environmental infringement. However, since it entails the prohibition of certain acts, it can excessively restrict the property rights of the perpetrator. Therefore, a clear legal basis is necessary to recognize an injunction. There are various conflicting views on the legal basis for recognizing an injunction, including the perspective that it is based on right to claim real rights, the perspective that it is based on environmental rights, and the perspective that it is based on personal rights. Supreme Court considers right to claim real rights as the basis for an injunction. The prevailing view also considers right to claim real rights as the basis for an injunction. It is a general interpretation of civil law that Article 217 of the Civil Code cannot serve as the basis for an injunction against environmental infringement, given that it is a regulation established with reference to Article 906 of the German Civil Code and pertains to neighborly relations. Article 217 of the Civil Code imposes an active duty on landowners to prevent infringing activities. Therefore, the interpretation of Article 906 of the German Civil Code, which is structured to limit the scope of the victim’s right to demand the removal of interference, should not be directly applied. Article 217 of the Civil Code provides a limited description of types of environmental infringement and imposes a duty on landowners to prevent infringing activities. Therefore, this paper aims to examine Article 217 of the Civil Code from a new perspective, departing from the traditional interpretation.

Targeting ferroptosis using Chinese herbal compounds to treat respiratory diseases

BackgroundRespiratory diseases pose a grave threat to human life. Therefore, understanding their pathogenesis and therapeutic strategy is important. Ferroptosis is a novel type of iron-dependent programmed cell death, distinct from apoptosis, necroptosis, and autophagy, characterised by iron, reactive oxygen species, and lipid peroxide accumulation, as well as glutathione (GSH) depletion and GSH peroxidase 4 (GPX4) inactivation. A close association between ferroptosis and the onset and progression of respiratory diseases, including chronic obstructive pulmonary disease, acute lung injury, bronchial asthma, pulmonary fibrosis, and lung cancer, has been reported. Recent studies have shown that traditional Chinese medicine (TCM) compounds exhibit unique advantages in the treatment of respiratory diseases owing to their natural properties and potential efficacy. These compounds can effectively regulate ferroptosis by modulating several key signalling pathways such as system Xc− -GSH-GPX4, NCOA4-mediated ferritinophagy, Nrf2-GPX4, and Nrf2/HO-1, thus playing a positive role in improving respiratory diseases. PurposeThis comprehensive review systematically outlines the regulatory role of ferroptosis in the onset and progression of respiratory diseases and provides evidence for treating respiratory diseases by targeting ferroptosis with TCM compounds. These insights aim to offer potential remedies for the clinical prevention and treatment of respiratory diseases. Study design and methodsWe searched scientific databases PubMed, Web of Science, Scopus, and CNKI using keywords such as “ferroptosis”,“respiratory diseases”,“chronic obstructive pulmonary disease”,“bronchial asthma”,“acute lung injury”,“pulmonary fibrosis”,“lung cancer”,“traditional Chinese medicine”,“traditional Chinese medicine compound”,“monomer”, and “natural product” to retrieve studies on the therapeutic potential of TCM compounds in ameliorating respiratory diseases by targeting ferroptosis. The retrieved data followed PRISMA criteria (preferred reporting items for systematic review). ResultsTCM compounds possess unique advantages in treating respiratory diseases, stemming from their natural origins and proven clinical effectiveness. TCM compounds can exert therapeutic effects on respiratory diseases by regulating ferroptosis, which mainly involves modulation of pathways such as system Xc− -GSH-GPX4,NCOA4-mediated ferritinophagy, Nrf2-GPX4, and Nrf2/HO-1. ConclusionTCM compounds have demonstrated promising potential in improving respiratory diseases through the regulation of ferroptosis. The identification of specific TCM-related inducers and inhibitors of ferroptosis holds great significance in developing more effective strategies. However, current research remains confined to animal and cellular studies, emphasizing the imperative for further verifications through high-quality clinical data.

Traditional Chinese Medicine as the Preventive and Therapeutic Remedy for COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic still has tremendous impacts on the global socio-economy and quality of living. The traditional Chinese Medicines (TCM) approach showed encouraging results during previous outbreaks of Severe Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). With limited treatment availability, TCM herbs and formulations could be useful to reduce COVID-19 symptoms and potential sources for discovering novel therapeutic targets. We reviewed 12 TCM herbs and formulations recommended for COVID-19 management by the National Health Commission and as National Administration of Traditional Chinese Medicine of the People's Republic of China. This article explored the Chinese national authorities' guidelines from 2003 to 2020, the scientific data in public databases for the recommended TCM remedies, and their potential mechanistic actions in COVID-19 management. Several TCM herbs and formulations could potentially benefit COVID-19 management. The recommended TCM oral preparations list includes Huoxiang zhengqi, Jinhua Qinggan, Lianhua Qingwen, and Shufeng jiedu; the recommended injection preparations comprise Xiyanping Xuebijing, Re-Du-Ning, Tanreqing, Xingnaojing, Shenfu, Shengmai, and Shenmai. TCM remedies are viable options for symptom alleviation and management of COVID-19. The current SARS-CoV-2 pandemic presents an opportunity to find novel therapeutic targets from TCM-active ingredients. Despite the recommendations in Chinese National guidelines, these remedies warrant further assessments in well-designed clinical trials to ascertain their efficacy in the treatment of COVID-19.

Safety and Efficacy of the Ayurvedic Formulation Guduchi Ghana Vati as a Preventive Remedy in COVID-19.

Background and objectives Guduchi (Tinospora cordifolia) is a well-known Ayurvedic herb used as a preventive and curative remedy for various infections and immunity-related conditions. This study aimed to evaluate Guduchi Ghana Vati as a preventive remedy for COVID-19 and non-COVID-19 infections in a healthy population. Materials and methods An open-labeled, multi-centric, randomized, comparative, interventional, prospective community-based clinical study was conducted on healthy individuals at the community level in five different districts of Rajasthan by the National Institute of Ayurveda (NIA), Jaipur, India. Participants were divided into two groups. One group received Guduchi Ghana Vati as an intervention for 45 days, and the control group did not receive any intervention. Incidences of COVID-19 infection, non-COVID-19 infections, their severity, and hospitalization requirements were assessed. Safety was evaluated through monitoring of adverse reactions. Results Among the 10,022 participants who completed the study, the incidence of COVID-19 infection was found to be lower in those taking Guduchi Ghana Vati compared to the control group; however, the difference was statistically non-significant. The severity of COVID-19 based on the WHO ordinal scale was found to be significantly lower in the Guduchi Ghana Vati group compared to the control group. The number of episodes and severity of non-COVID-19 illness were also significantly lower in participants taking Guduchi Ghana Vati compared to the control group. No major adverse drug reactions were observed. Conclusion Guduchi Ghana Vati has the potential to act as a safe and effective remedy for the prevention of infection and immunity-related conditions, including COVID-19.

Therapeutic Potential of Natural Flavonoids: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective on Parkinson's Disease

Abstract: Parkinson’s disease (PD) is a prominent area of study within the field of neurology, particularly neurodegenerative disease (ND). The peak incidence of PD occurs in those over the age of 45, and the disease’s prevalence rises continuously with age, the incidence of PD has skyrocketed over the world. A slow decline in neural function characterizes NDs, but the pathophysiological mechanisms behind this decline remain elusive. Because the pathophysiological mechanisms behind neurodegeneration are intricate, the clinical issue of finding efficient, multi-target treatments still exists. Furthermore, adequate neuroprotective medicines are currently scarce, necessitating the development of new therapeutic agents. There is currently no medicine for PD that is without side effects. The ability of natural flavonoids to lower the risk of PD has contributed to an increase in their popularity in recent years, models both in vivo and in vitro. Flavonoids are multi-target natural substances that affect distinct pathogenic pathways in neurodegeneration. As a result, the emphasis has turned to discovering natural product inhibitors for the treatment of PD. The majority of the results pointed to flavonoids' beneficial role in the treatment of PD and no adverse events were reported. This review offered scientific data on the protective and preventative functions of flavonoids. It has been demonstrated that flavonoids have a neuroprotective effect by activating anti-apoptotic mechanisms that target mitochondrial dysfunction and produce neurotrophic factors. In addition to having antioxidant, anti-inflammatory, and protective dopaminergic neurons. Even though no evidence using flavonoids as a treatment might reverse the abnormal phenotypes of PD patients, it was also indicated that flavonoids might be promising natural remedies for PD prevention and could be used as therapeutic agents against PD.

Comprehensive analysis of micro and macro-minerals, phytochemicals and proximate composition of Cordia dichotoma G. forst fruits.

Plants have long served as a valuable source of bioactive components in traditional ayurvedic remedies for disease prevention. In our research, we explored an underutilized plant species, Cordia dichotoma G. Forst. Our findings revealed that cordia fruits are rich source of dietary carbohydrates (30.06%), dietary fibers (17.6%) and crude proteins (6.67%). The cordia fruits found in substantial amount of macro-minerals namely K (19,652.04ppm), Na (3755.10ppm), Mg (1763.94ppm) and Ca (1676.81ppm) and micro-minerals including Fe (220.89ppm), Zn (34.87ppm), Mn (15.82ppm) and Cu (10.64ppm). Cordia fruits are also found with phenolic compounds including Gallic acid (4.45μg/mg (CD Aq), 3.76μg/mg (CD 50%), 3.06μg/mg (CD 90%), Caffeic acid (3.14μg/mg (CD Aq), 2.59μg/mg (CD 50%), 1.39μg/mg (CD 90%), Vanillic acid ( 0.15μg/mg (CD Aq), 0.02μg/mg (CD 50%), 0.20μg/mg (CD 90%) and Syringic acid (0.52μg/mg (CD Aq), 0.88μg/mg (CD 50%), 0.01μg/mg (CD 90%). These results suggested the potential role of cordia fruits in our dietary system which not only assist in food security but also provide economic security to the local farmers.

Hydroponic Trough Systems for Maximising Cucumber Production

Abstract: Hydroponics is a promising solution to address the increasing demand for food caused by limited arable land and a growing global population. This article focuses on the use of hydroponics in cucumber cultivation, specifically highlighting the adaptability of hydroponic trough system. It explains the design elements of the trough system in detail, including configuration, growing medium, nutrient solution, and support structures. The article emphasises the advantages of hydroponic trough systems in cucumber cultivation, such as precise nutrient dispensation, space efficiency, water conservation, and potential for automation. It discusses strategies for optimal cucumber production within these systems, including temperature control, pollination techniques, pruning, and pH monitoring. The article also addresses the challenges of insect and pest attacks, introducing common pests and presenting integrated pest management strategies for effective control. It explores diseases that can affect cucumber crops in hydroponic systems, such as powdery mildew, downy mildew, Pythium root rot, and Fusarium wilt. It discusses strategies to prevent these diseases, including preventive measures, disease-resistant cucumber varieties, cultural practices, and bio methods. By considering all these aspects, a comprehensive approach to disease management can be established. Overall, adopting hydroponic trough systems in cucumber cultivation offers a sustainable and efficient solution to traditional farming challenges. By incorporating preventive measures, disease-resistant cultivars, and organic remedies, farmers can ensure a thriving cucumber harvest and contribute to a productive and sustainable agricultural future.

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-the-art antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.

Perceptions and Practices of Herbal Remedy Usage during the COVID-19 Pandemic: A Call for Evidence-Based Healthcare in Pakistan

Objective: To determine the prevalence, perception and practices towards the use of herbal remedies by Pakistani population during the era of covid 19 pandemic. Methodology: This cross-sectional explorative study was conducted at Department of medicine Sir Syed Medical College Karachi 2021 from the month of August 2021 to December 2021. An online google form well written by primary investigator was distributed generally to various what’s up forum throughout Pakistan with no specific inclusion or exclusion criteria. First section of the questionnaire included demographics of participants, second section include about the use of herbal remedy types, perception, beliefs of their use, source of getting them and the remedies used for the prevention of covid virus Results: This study, was conducted from August to December 2021 spread through google online forms, included 332 respondents, 52.1% of participants utilized herbal remedies for COVID-19 prevention, with 55.5% belonging to the 25-45 age group with 81.3% of them were educated females. A significant association (p<0.05) was observed between herbal remedy usage and age group, gender, education, and occupation. Senna Makki (38.8%), ginger (17.7%), and kalonji (10.2%) were commonly used herbs. While 37.7% reported health benefits, 15.1% believed these herbs had no side effects, and 22.3% used them for virus prevention. Attitudes toward herbal remedy usage revealed that 47.4% agreed these herbs could prevent disease, and 36% believed no additional preventive measures were necessary while using them. Family tradition (19.3%), health professionals (14.5%), and internet/media (14.2%) were key sources of information, while Hakeem stores (16.6%) and family members (7.8%) were common herbal remedy providers. Conclusion: This study highlights an urgent need for evidence-based healthcare interventions in Pakistan regarding the utilization of herbal remedies during the virus pandemic especially when there are risks associated with the improper use and potential influence from media. Key words: Covid 19 pandemic, Herbal remedies, Perception, Practices

Assessing the Malaria Burden and Community Response to the Malaria Control and Management Programs in Omoro District, Northern Uganda

Background: Malaria remains the leading cause of hospitalization and death in the healthcare system. This study explored the malaria burden and community response to government malaria control programs in Omoro district.Method: This retrospective study involved 576 patient results from purposely selected health facilities data from health center III (HCIII) of Odek, Bobi, and Lapainat and health center IV (HCIV) of Lalogi. And prospective random section study involved 288 participants from Lutori and Lagude cells and Atyang A and Lagwaya villages who consented to answer the pretested questionnaire.Results: The prevalence of malaria in Omoro district in 2018 and 2019 was 81.6% and 97.2% for hospital record positivity and community surveys, respectively. The participants had 100% knowledge of malaria signs, symptoms, and cause. The average number of malaria attacks an individual received in the district from the health facility and community data was three. Nonadherence to government control programs was associated with an increased incidence of malaria infections. From questionnaire, the proportion of people that used local herbal remedies for treatment and prevention of malaria were 21.2% of the sampled 288 participants.Conclusion: The high rate of malaria attacks indicates that the area has a high prevalence of malaria‐carrying mosquitoes. The increase in the proportion of malaria attacks in 2019 suggests that the burden of malaria increased compared with that in the previous year, with approximately 21% of local herbal remedies for malaria treatment and management. The findings of this study suggest that malaria attacks are associated with household size, age, sex, occupation, and the household head. Participants who did not respond positively to government programs experienced more malaria attacks. These findings can be used to develop interventions to reduce the incidence of malaria in this population.

Nutraceuticals for allergic diseases: A brief overview

Allergic disorders are common diseases characterized by type 2 inflammation and typical symptoms. Although pharmacologic treatment can be effective, prolonged administration of drugs can be associated with adverse reactions and seldom reduction of effectiveness. Therefore, complementary medicine is widespread in clinical practice, mainly in pediatric settings, and pleasing to parents.Nutraceuticals, such as "a food (or part of a food) that provides medical or health benefits, including the prevention and/or treatment of a disease," are commonly prescribed by pediatrics as well as self-prescription by parents. There is evidence that some components exert beneficial effects in allergic diseases. In this regard, the supplementation with some food supplements may significantly reduce symptom severity and functional parameters.Some compounds, including micronutrients, vitamins, probiotics, herbal medicines, could positively and safely be used in children with allergic diseases as add-on or preventive remedies. Nutraceuticals should not substitute drugs.

TINJAUAN TERHADAP PELANGGARAN LALU LINTAS KENDARAAN RODA DUA OLEH ANAK DI BAWAH UMUR DI WILAYAH HUKUM POLRESTA BUKITTINGGI

Two-wheeled vehicle traffic violations committed by minors in the jurisdiction of the City of Bukittinggi still occur a lot and have even increased from year to year. This study aims to find out how law enforcement is against violations of two-wheeled vehicle traffic by minors and the constraints and efforts made to enforce the law on traffic violations of minors. This study uses empirical legal research methods. The results of this study, namely: 1) Law enforcement of traffic violations by minors in the City of Bukittinggi, is by Law Number 22 of 2009 concerning Road Traffic and Transportation, but there are still obstacles in its implementation, 2) Efforts law enforcement of two-wheeled vehicle traffic violations by minors has been carried out to the maximum extent possible by the Bukittinggi Police Traffic Unit, but in making these efforts there are obstacles encountered. These efforts are in the form of pre-emptive (coaching), preventive (counseling), and repressive (action) legal remedies.

Research on Legal Risk Identification, Causes and Remedies for Prevention and Control in China’s Aquaculture Industry

Aquatic products fulfill the protein needs of people and play an important role in food safety. And aquaculture is prized for its high productivity, sustainability and environmental friendliness. Considering the importance of aquaculture, the legal risks exposed during the aquaculture process deserve attention in order to prevent them from hindering the development of the aquaculture industry. Through online research, literature analysis and practical communication, it is shown that the current legal risks with commonalities include land use violations, lack of legal documents, failure to meet tailing water criteria, unquarantined fry and misuse of prohibited agricultural pharmaceuticals through online research, literature analysis and practical communication. By analyzing the reasons for the formation of legal risks and combining the experiences in sustainable development of three major aquaculture countries, which are Korea, Norway and Chile, this paper provides targeted preventive remedies and suggestions for aquaculture operators, administrative parties, legislators and other parties on legal risks. It includes promoting the improvement of the rule of law in multiple aspects, clarifying the positioning of the aquatic breeding certificates, improving and propagating the standards for wastewater discharge, increasing the self-sufficiency rate of aquatic fry and fingerlings, as well as making use of the synergy of soft law and hard law.

Antidiabetic potential of Carica papaya L. and its constituents: From folkloric uses to products development

Carica papaya L. is a plant that has a reputation for being antidiabetic. This review is focused on antidiabetic properties of Carica papaya. A comprehensive search was performed using various electronic databases including Researchgate, PubMed, Google Scholar, Biomedgrid.com and ScienceDirect. 224 publications were downloaded, out of which one 107 relevant publications were reviewed. The fruit, leaves, and seeds of this plant have been reported to possess antidiabetic properties at different dosages via in vivo, in vitro, and ex vivo studies. Fortified papaya cake, MPPB flour (containing C. papaya), and brotowali extract (fortified papaya leaves and sugarcane extracts) displayed significant hypoglycaemic effect. From a clinical trial, the fruit consumed after meals significantly reduced blood glucose level in a quasi-experimental study. Some bioactive compounds found in the plant's extracts have been linked to the antidiabetic effect of the plant. It has been discovered that the leaf extract contains hypoglycemic saponins, alkaloids, flavonoids, triterpenoids, and tannins. Few compounds with antidiabetic characteristics have been identified from the extracts of this plant's seeds, including hexadecanoic acid, methyl ester, 11-octadecenoic acid, N, N-dimethyl-, n-hexadecanoic acid, and oleic acid. Therefore, pawpaw fruit consumption might help to mitigate the symptoms of diabetes. For the development of new natural remedies for management and prevention of diabetes, additional studies, particularly those on the isolation of antidiabetic principles from various portions of C. papaya, will be crucial.Keywords:Carica papaya; Antidiabetics; Phytoconstituents; Clinical trials; Papaya products

Exploring promising electron-shuttling characteristics of Perilla frutescens and potential anti-viral activity via bioenergy generation in microbial fuel cells

To decipher synergistic interactions of herbal medicine for disease treatment, prior studies showed that electron-shuttling catalysis and bioenergy-generating stimulation endow immense significance to the efficacy of herbal medicines on disease treatment. In fact, the electrochemical activity of these herbal medicines is even associated with the antiviral capabilities of traditional Chinese medicine (TCM), making it an effective preventive remedy against virus-caused infections (e.g., COVID-19). Formerly screened Perilla frutescens was thus explored for its electron shuttling capability and bioenergy generation performance to confirm its potential for anti-COVID19 treatment. To evaluate the bioenergy-generating and electron-mediating characteristics of P. frutescens, microbial fuel cells (MFCs) were used as the platform of evaluation. The different extraction process was performed to determine the most promising ES-abundant herbal extract that exhibited maximum bioenergy production and significant antioxidant activity. The findings indicated that the essential oil-removed P. frutescens water extract (GPF-S-H2O) performed the optimal stimulating bioenergy generation and antioxidant activity, as revealed by power density measurement, DPPH, and FRAP assay. The removal of volatile compounds from the herb significantly improved its electrochemical activity. GPF-S-H2O in appropriate amount could generate the maximal bioenergy expression and efficient electron transfer.

Legal Protection For Grab Drivers Due to Default Related to Double Order Payments on Grabfood Services By PT. Indonesian Technology Grab

The development of information technology forces conventional activities to be abandoned and people begin to switch to using information technology, like buying and selling food. GrabFood is a food delivery service provided by the GRAB application. the GrabFood service has a Double Orders. Double Orders funding is below what it should be, so that indicates a default on the agreement.The type of legal research used in this research is normative juridical. This research uses a statutory approach which is carried out by examining all laws and regulation. The data collection method used in this research is library research, papers, articles, the internet, research results, laws and regulations. The data analysis method uses a descriptive analytical research method. In the case of Double Orders on the GrabFood service, the GRAB Applicator has committed a default in the form of carrying out what has been promised but not as promised. Preventive legal remedies that GRAB drivers can take to fulfill rights that are not fully granted are by urging the government to immediately issue laws or regulations prohibiting system fraud which is detrimental to online motorcycle taxi drivers in general. The Partnership Agreement between the GRAB Driver and the GRAB Applicator explains that if a dispute occurs, it will be resolved through a non-litigation route, namely through arbitration.

Accessible and low- to zero-cost remedy

Traditional medicine (TM) has played an essential part in maternity services around the world, which has led to increased utilization among pregnant women. Herbs, herbal preparations, and completed herbal products are examples of TMs that contain active substances such as plant parts or other plant components that are thought to have therapeutic advantages. This study review aimed to identify the herbs commonly used, reasons for use, and effect of use, to make adequate recommendations on herbal medicine use as a remedy for pregnancy and labor. Incorporating evidence from reviews, personal correspondence, and diaries, this study demonstrates that about 80% of people used TM such as herbal remedies for sickness diagnosis, prevention, treatment, and promotion of general well-being. Due to its accessibility, cost, and availability, TM is usually used by expectant mothers. Examples of TM used in pregnancy and labor include honey, aloe, raspberry, jute mallow, and hibiscus leaves. It is important to note that its use in pregnancy and labor can be beneficial or harmful to both mother and child. Lack of standardization, financial risk, lack of safety, and effectiveness are challenges to TM. There is a need of creating awareness of the safe use and effects of TM in pregnancy and labor through the provision of health education programs for women in the community.

Antimutagenic 1,4-Dihydropyridine AV-153 Normalizes Expression of GLUT1, GLUT4, INOS, PARP1, and Gamma H2AX Histone in Myocardium of Rats with Streptozotocin Model of Diabetes Mellitus

Abstract Diabetic cardiomyopathy increases the risk of heart failure and worsens prognosis for diabetes mellitus (DM) patients. Its development depends on many factors, including modification of nitric oxide production and impaired DNA repair. The goal of the present work was to study in vivo effects of a 1,4-dihydropyridine AV-153, known as antimutagen and DNA-binder, on DNA integrity, and on the expression of several proteins involved in glucose transport, nitric oxide metabolism, and DNA repair in myocardium in diabetic rats. DM was induced in rats by streptozotocin (STZ) injection. Expression of proteins was studied by means of immunohistochemistry. Development of the STZ-induced DM significantly induced PARP1 and gamma H2AX histone, markers of DNA breakage, protein expression in heart tissue, while AV-153 administration decreased PARP1 and H2AX protein expression. In this model of diabetes, myocardial expression of iNOS was also significantly increased, but administration of AV-153 reduced it to normal levels. AV-153 also upregulated the expression of insulin-dependent GLUT4 and insulin-independent GLUT1 glucose transporters up to normal level in diabetic rats. Thus, AV-153 appears to be prospective for creation of a remedy for prevention of diabetic cardiomyopathy.