Aim: This study was designed as a descriptive study using the "in-depth interview technique" to determine psychosocial problems and coping methods experienced by nurses working in Covid 19 pandemic clinics. Materials and Methods: The universe of the study consisted of 871 nurses working in pandemic clinics of a city hospital in the western part of Turkey between September 2021 and October 2021; and the sample consisted of 21 nurses working in pandemic clinics. "Personal Information Form" and "Psychosocial Health Evaluation Form in Nurses" were used as data collection tools in the study. Data were analyzed by using content analysis. Results: Mean age of the nurses participated in the study was 31.85 years old; and 76.20% were women. A total of five main themes and subthemes for each theme were identified at the end of data analysis. Five main themes identified were “Emotional Problems”, “Behavioral Problems”, “Coping Strategies”, “Occupational Changes” and “An Isolated Life”. Conclusion: Nurses experienced various psychosocial problems in their working environment during the pandemic. It is suggested to plan preventive psychosocial interventions in order to decrease and prevent psychosocial problems experienced by the nurses under challenging conditions.