Prevention Sciences Research Articles

Practical, Economic, and Policy Implications of the Leve et al. Paper.

This commentary responds to the paper recently published in Prevention Science, entitled "The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research" by Leve and colleagues (2024). A framework is advanced to provide a rationale for and facilitate the difficult and oft-avoided task of integrating concepts, techniques, methods, and datasets from diverse disciplines. The unfortunate reality is that disciplines germane to prevention continue to be highly siloed. The field of prevention science stands to benefit from knowledge that leads to greater precision-based-and thereby more effective-approaches to intervention. What is particularly underappreciated is the potential for this information to also guide policymaking based on what we could learn about the social-ecological conditions that impact child and youth brain and behavioral development and are alterable in response to evidence-informed public health policies. In this commentary, we offer some context for and appraisal of the paper and provide additional rationale for a precision-based approach with appropriate precautions for the research and utility of findings. Discussion ensues on the economic pros and cons and the policy implications of this integrative "neuroprevention" strategy should the field of prevention science accept the challenge.

The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research

Beginning with the successful sequencing of the human genome two decades ago, the possibility of developing personalized health interventions based on one’s biology has captured the imagination of researchers, medical providers, and individuals seeking health care services. However, the application of a personalized medicine approach to emotional and behavioral health has lagged behind the development of personalized approaches for physical health conditions. There is potential value in developing improved methods for integrating biological science with prevention science to identify risk and protective mechanisms that have biological underpinnings, and then applying that knowledge to inform prevention and intervention services for emotional and behavioral health. This report represents the work of a task force appointed by the Board of the Society for Prevention Research to explore challenges and recommendations for the integration of biological and prevention sciences. We present the state of the science and barriers to progress in integrating the two approaches, followed by recommended strategies that would promote the responsible integration of biological and prevention sciences. Recommendations are grounded in Community-Based Participatory Research approaches, with the goal of centering equity in future research aimed at integrating the two disciplines to ultimately improve the well-being of those who have disproportionately experienced or are at risk for experiencing emotional and behavioral problems.

A case study in developmental discontinuity: PROSPER Interventions and adolescent substance use trajectories shape young adult substance use and mental health problems.

The loss of John Schulenberg reverberates across the developmental and prevention sciences. In honor of his many contributions, this paper applies his ideas of developmental continuity and discontinuity to understand the process by which PROSPER delivered universal prevention programs (delivered in Grades 6 and 7) affect young adult outcomes. Guided by these developmental models, we deconstructed adolescent substance use initiation trajectories into two discrete phases-early and late adolescence, demarcated by substance use initiation levels at the end of 9th grade. We evaluated the effects of PROSPER interventions on these phases, and in turn, the effects of adolescent substance use initiation on young adult antisocial behavior, alcohol and drug use consequences, and depression symptoms. This sample included 1,984 young adults who participated in the PROSPER intervention trial in Grade 6 (two cohorts, 2002 and 2003), followed over 8 adolescent measurement occasions (Fall and Spring of Grade 6; Spring of Grades 7-12). Young adult outcomes were averaged across three waves (collected at ages 20, 23, and 25). PROSPER interventions were associated with reduced substance use initiation in early adolescence, but not escalation during late adolescence. In turn, substance use in both early and late adolescence was uniquely associated with young adult antisocial behavior, depression symptoms, and substance use consequences. PROSPER interventions were associated with young adult antisocial behavior and problematic substance use via reduced risk for early initiation status. Findings are discussed in terms of developmental continuity and discontinuity.

Small CBPR Grants Program: An Innovative Model to Build Sustainable Academic-Community Partnerships.

Community-based participatory research (CBPR) is an effective approach for addressing health disparities by integrating diverse knowledge and expertise from both academic and community partners throughout the research process. However, more is needed to invest in the foundational infrastructure and resources that are necessary for building and maintaining lasting trusting research partnerships and supporting them to generate impactful CBPR-based research knowledge and solutions. Small CBPR Grants Program is a CBPR-seed-funding program that may be particularly helpful to minority-serving institutions' and universities' goal to invest in genuine community-engaged participatory research. Between 2016 and 2019, the Morgan State University Prevention Sciences Research Center, in collaboration with other community and academic organizations, provided 14 small CBPR awards to new partnerships, and evaluated the success and challenges of the program over a period of three years. To achieve our goal, technical support and training were provided to these partnerships to help with their growth and success. The expected outcomes included trusting relationships and equitable partnerships, as well as publications, presentations, and new proposals and awards to work on mutually identified issues. The program's resulted in continued partnerships beyond the program (in most cases), a founded CBPR Center namely ASCEND, and several secured additional fundings. Keys to the program's success were supporting the formation of research partnerships through networking opportunities and information sessions, as well as providing small grants to incentivize the development of innovative concepts and projects. A learning network and local support group were also created to enhance productivity and the overall impact of each project.

Medicaid expansion increases survival for patients with cancer.

Medicaid expansion increases survival for patients with cancer.

Designing for Youth-Centered Moderation and Community Governance in Minecraft

Online settings have been suggested as viable sites for youth to develop social, emotional, and technical skills that can positively shape their behavior online. However, little work has been done to understand how online governance structures might support (or hinder) such learning. Using mixed-methods research, we report findings from a 2-year, in-the-wild study of 8–13 year olds on a custom multiplayer Minecraft server. The two-part study focuses on the design of youth-centered models of community governance drawn from evidence-based offline practices in the prevention and learning sciences. Preliminary results point to a set of socio-technical design approaches shaping player behavior while also supporting youth interest in Minecraft-like online environments. More broadly, the findings suggest an alternative vision of youth’s capacity for ownership and control of mechanisms shaping the culture and climate of their online communities: managing player behavior while challenging current norms around adult control and surveillance of youth activity.

A Decade of Nutrition and Health Disparities Research at NIH, 2010–2019

ObjectivesNutrition health disparities include the differences in incidence, prevalence, morbidity, and mortality of diet-related diseases and conditions that disproportionally affect disadvantaged groups (e.g., race, ethnicity, socioeconomic status, disability, rural, immigration status). These disparities arise from the complex interaction of individual, interpersonal, community, and societal factors within the biological, behavioral, and environmental domains. The purpose of this study is to describe the scope of nutrition health disparities research supported by the National Institutes of Health (NIH) over the past decade to identify research gaps and opportunities relevant to NIH’s mission. MethodsData were extracted from an internal reporting system from 2010 to 2019 using the Research, Condition, and Disease Categorization (RCDC) spending categories for “Nutrition” and “Health Disparities.” ResultsOver the past decade, the number of NIH supported nutrition and health disparities research studies have generally increased, with 860 grants funded in 2010 and 937 grants in 2019, while total nutrition and health disparities funding remained relatively stable. The top 5 Institutes/Centers that funded nutrition and health disparities research included the National Institute of Diabetes and Digestive and Kidney Diseases, National Heart Lung and Blood Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute, and National Institute on Minority Health and Health Disparities. ConclusionsConsistent with the mission of the top funding ICs, the top research areas were obesity, diabetes, digestive diseases, cancer, heart disease, clinical research, prevention, and behavioral and social sciences. Cross-cutting topics relevant to all NIH ICs included special populations areas such as pediatric and minority health followed by aging and women’s health. Consistent with the Strategic Plan for NIH Nutrition Research, it is critical to advance health equity through the application of precision nutrition approaches that acknowledge the influence of biologic, behavioral, psychosocial, environmental, and social factors on nutrition health disparities, and to develop effective targeted interventions to address these disparities. Funding SourcesNone.

Youth and the COVID-19 crisis: Lessons learned from a human rights-based prevention programme for youths in São Paulo, Brazil

ABSTRACT Youths living in crowded impoverished urban areas face higher risk of infection by SARS-CoV-2. This article presents lessons learned from a preventive intervention project intersected by the COVID-19 crisis that moved from a mix-methods study design to online ethnography. The ‘home-officed’ research team e-witnessed high-school students’ daily lives and collaborated in youths’ and community-based organisations’ responses in the territories where they study and live. Psychosocial distress increased, also driven by the disastrous governmental response to the health and economic crises. There was growing anxiety about meeting friends and dating, with structural limits for sustaining the recommended social distancing, which added to gender/sexuality-based violence. Simultaneously, we observed students becoming relevant actors through co-producing preventive practices, surpassing risk-group notions and combining SARS-CoV-2 prevention with sexuality, gender, racism and mental-health issues. They managed internet-mediated applications to promote critical thinking and collective actions aimed at health promotion among their peers, from their homes. Freire’s concept of ‘untested-feasibility’ fostered researchers’, students’ and community leaders’ imaginations in the face of this unprecedented crisis, thereby enhancing social responses to the epidemic to become rights-based comprehensive dialogical preventive activities. This ongoing intervention-research stresses how prevention sciences can go beyond reduction of this pandemic to a viral event.

Applying Principles from Prevention and Implementation Sciences to Optimize the Dissemination of Family Feeding Interventions.

Because families are the primary food socialization agent for children, they are a key target for nutrition interventions promoting healthy eating development. Although researchers and clinicians have developed and tested successful family nutrition interventions, few have gained widespread dissemination. Prevention and implementation science disciplines can inform the design, testing, and dissemination of feeding interventions to advance the goals of widespread adoption and population health impact. We review concepts and frameworks from prevention science and dissemination and implementation (D&I) research that are useful to consider in designing, implementing, and evaluating feeding interventions. Risk and protective factor frameworks, types of translation processes, and implementation dimensions are explained. Specifically, we address how research–practice partnerships can reduce time to dissemination, how designing for modularity can allow for contextual adaptation, how articulating core components can strengthen fidelity and guide adaptation, and how establishing technical assistance infrastructure supports these processes. Finally, we review strategies for building capacity in D&I research and practice for nutrition professionals. In sum, the research and knowledge bases from prevention and implementation sciences offer guidance on designing and delivering family interventions in ways that maximize the potential for their broad dissemination, reducing time to translation and optimizing interventions for real-world settings.

Psychometric models for scoring multiple reporter assessments: Applications to integrative data analysis in prevention science and beyond

Conducting valid and reliable empirical research in the prevention sciences is an inherently difficult and challenging task. Chief among these is the need to obtain numerical scores of underlying theoretical constructs for use in subsequent analysis. This challenge is further exacerbated by the increasingly common need to consider multiple reporter assessments, particularly when using integrative data analysis to fit models to data that have been pooled across two or more independent samples. The current article uses both simulated and real data to examine the utility of a recently proposed psychometric model for multiple reporter data called the trifactor model (TFM) in settings that might be commonly found in prevention research. Results suggest that numerical scores obtained using the TFM are superior to more traditional methods, particularly when pooling samples that contribute different reporter perspectives.

Preventing leisure from being overlooked: Intersecting leisure and prevention sciences

Leisure opportunities and experiences make powerful contributions to individual and community health by promoting positive and reducing negative health outcomes at individual, community, state, and national levels. Leisure researchers have long promoted the health benefits of parks and recreation, reflecting leisure’s role in public health. However, the idea that leisure can make a contribution to prevention has received less attention. Thus, we advocate incorporating a prevention science perspective to help researchers hone an agenda focused on leisure, health, and well-being across the lifespan. We review the evolution of leisure and prevention science as separate fields, identify where they intersect, and offer considerations for moving forward. We conclude by providing three main considerations for adopting prevention science approaches and promoting the context and experience of leisure, followed by six actionable recommendation steps to more effectively understand and promote health.

Sri Lanka Journal of Sexual Health and HIV Medicine (Sri Lanka JoSHH)

Welcome to the first issue of the Sri Lanka Journal of Sexual Health and HIV Medicine (Sri Lanka JoSHHM). This is the official journal of Sri Lanka College of Venereologists and the continuation of the Sri Lanka Journal of Venereology. Members of the Sri Lanka College of Venereologists (Sri Lanka CoSHHM) decided to publish its official journal under this new name to accommodate wider perspectives of sexual health, sexually transmitted infections including HIV medicine, prevention and programme sciences, in keeping up with the global trends. Sri Lanka Journal of Sexual Health and HIV Medicine Vol.1 2015

Efficient Exploration of Many Variables and Interactions Using Regularized Regression

The prevention sciences often face several situations that can compromise the statistical power and validity of a study. Among these, research can (1) have data with many variables, sometimes with low sample sizes, (2) have highly correlated predictors, (3) have unclear theory or empirical evidence related to the research questions, and/or (4) have difficulty selecting the proper covariates in observational studies. Modeling in these situations is difficult-and at times impossible-with conventional methods. Fortunately, regularized regression-a machine learning technique-can aid in exploring datasets that are otherwise difficult to analyze, allowing researchers to draw insights from these data. Although many of these methods have existed for several decades, prevention researchers rarely use them. As a gentle introduction, we discuss the utility of regularized regression to the field of prevention science and apply the technique to a real dataset. The data (n = 7979) for the demonstration consisted of 76 variables (151 including the modeled interactions) from the Youth Risk-Behavior Surveillance System (YRBSS) from 2015. Overall, it is clear that regularized regression can be an important tool in analyzing and gaining insight from data in the prevention sciences.

The dentist-scientist career pathway in Africa: opportunities and obstacles.

The future of evidence-based dentistry in developing Africa heavily depends on a sustainable establishment of a vibrant dentist-scientist workforce. A dentist scientist is saddled with the responsibility of carrying out robust cutting edge research projects that are inspired by clinical experience. Currently, there are no pipelines in place to systematically train such dentists, neither are there programs in place to allow trained African dentists choose such a career pathway. A dentist-scientist is a person who studied oral, dental, maxillofacial (or craniofacial) diseases, prevention, and population sciences (obtaining a medical degrees such as bachelor of dental surgery [BDS] or BChD) alone; or in combination with other advanced degrees such as doctor of dental surgery (DDS)/doctor of philosophy (PhD) or BDS/PhD. This situation has resulted in overdependence of African clinical practice on research findings from technologically advanced Western countries and a decline in clinical research capacity building. The career path of a dentist-scientist should involve research along the spectrum of basic biomedical sciences, translational, clinical and public health sciences. There are several factors responsible for the ultra-low count of dentist-scientist in the heterogeneous African communities such as: poor biomedical research infrastructure; lack of funding; absence of structured dentist scientist career pathways; lack of personnel, inter alia. Hence, this review hopes to discuss the opportunities of setting up a dentist-scientist training pathway in Africa (as obtains in most developed world settings), identify opportunities and prospects of developing an African dentist-scientist workforce, and finally discuss the challenges involved.

A developmental cascade perspective of paediatric obesity: a conceptual model and scoping review

ABSTRACTConsidering the immense challenge of preventing obesity, the time has come to reconceptualise the way we study the obesity development in childhood. The developmental cascade model offers a longitudinal framework to elucidate the way cumulative consequences and spreading effects of risk and protective factors, across and within biopsychosocial spheres and phases of development, can propel individuals towards obesity. In this article, we use a theory-driven model-building approach and a scoping review that included 310 published studies to propose a developmental cascade model of paediatric obesity. The proposed model provides a basis for testing hypothesised cascades with multiple intervening variables and complex longitudinal processes. Moreover, the model informs future research by resolving seemingly contradictory findings on pathways to obesity previously thought to be distinct (low self-esteem, consuming sugary foods, and poor sleep cause obesity) that are actually processes working together over time (low self-esteem causes consumption of sugary foods which disrupts sleep quality and contributes to obesity). The findings of such inquiries can aid in identifying the timing and specific targets of preventive interventions across and within developmental phases. The implications of such a cascade model of paediatric obesity for health psychology and developmental and prevention sciences are discussed.

Principled Missing Data Treatments.

We review a number of issues regarding missing data treatments for intervention and prevention researchers. Many of the common missing data practices in prevention research are still, unfortunately, ill-advised (e.g., use of listwise and pairwise deletion, insufficient use of auxiliary variables). Our goal is to promote better practice in the handling of missing data. We review the current state of missing data methodology and recent missing data reporting in prevention research. We describe antiquated, ad hoc missing data treatments and discuss their limitations. We discuss two modern, principled missing data treatments: multiple imputation and full information maximum likelihood, and we offer practical tips on how to best employ these methods in prevention research. The principled missing data treatments that we discuss are couched in terms of how they improve causal and statistical inference in the prevention sciences. Our recommendations are firmly grounded in missing data theory and well-validated statistical principles for handling the missing data issues that are ubiquitous in biosocial and prevention research. We augment our broad survey of missing data analysis with references to more exhaustive resources.

Sri Lanka Journal of Sexual Health and HIV Medicine (Sri Lanka JoSHHM)

Welcome to the first issue of the Sri Lanka Journal of Sexual Health and HIV Medicine (Sri Lanka JoSHHM). This is the official journal of Sri Lanka College of Venereologists and the continuation of the Sri Lanka Journal of Venereology. Members of the Sri Lanka College of Venereologists (Sri Lanka CoSHHM) decided to publish its official journal under this new name to accommodate wider perspectives of sexual health, sexually transmitted infections including HIV medicine, prevention and programme sciences, in keeping up with the global trends. Sri Lanka Journal of Sexual Health and HIV Medicine Vol.1 2015

HIV infection.

More than 75 million people worldwide have been infected with human immunodeficiency virus (HIV), and there are now approximately 37 million individuals living with the infection. Untreated HIV replication causes progressive CD4(+) T cell loss and a wide range of immunological abnormalities, leading to an increased risk of infectious and oncological complications. HIV infection also contributes to cardiovascular disease, bone disease, renal and hepatic dysfunction and several other common morbidities. Antiretroviral drugs are highly effective at inhibiting HIV replication, and for individuals who can access and adhere to these drugs, combination antiretroviral therapy leads to durable (and probably lifelong) suppression of viral replication. Viral suppression enables immune recovery and the near elimination of the risk for developing acquired immune deficiency syndrome (AIDS). Despite effective treatment, HIV-infected individuals have a higher than expected risk of heart, bone, liver, kidney and neurological disease. When used optimally by an infected (or by an uninfected) person, antiretroviral drugs can virtually eliminate the risk of HIV transmission. Despite major advances in prevention sciences, HIV transmission remains common in many vulnerable populations, including men who have sex with men, injection drug users and sex workers. Owing to a lack of widespread HIV testing and the costs and toxicities associated with antiretroviral drugs, the majority of the infected population is not on effective antiretroviral therapy. To reverse the pandemic, improved prevention, treatment and implementation approaches are necessary.

Abstract PP01-01: A funny thing happened to me while trying to cure ovarian cancer; I became a cancer prevention research specialist

Abstract PP01-01: A funny thing happened to me while trying to cure ovarian cancer; I became a cancer prevention research specialist

Haemoglobinopathies in tribal populations of India.

Haemoglobinopathies particularly haemoglobin S and E (HbS, HbE) and β-thalassaemia are important challenges for tribal populations in India. The HbS, HbE and β-thalassaemia genes are variably distributed across various tribal populations of India. HbE is mainly restricted in tribals of North-East, West Bengal, Odisha and those in Andaman and Nicobar islands. HbS has more extensive distribution in the country (10-40% trait frequency) and the homozygotes and double heterozygotes present with a wide array of morbidities. The morbidity varies greatly in different areas of the country due to differential co-inheritance of α-thalassaemia gene and interaction of various epistatic and environmental factors. Though substantial data on prevalence of these disorders exist, there is an urgent need to develop integrated hierarchical core facilities to manage the disease. Such centres will generate more data and will also explore areas of management which need more local attention. Newborn screening, genetic counselling, carrier detection, prenatal diagnosis along with management of cases should form the basic infrastructure of haemoglobinopathy management. Research in this areas should continue focusing on various challenges in care delivery, prevention and basic sciences on interaction of haemoglobinopathies with various other infections.