Prevention Of Radiation-induced Lung Injury Research Articles

Study on the Potential Mechanism of Traditional Marine Chinese Medicine Beishashen in Preventing Lung Injury Induced by Radiotherapy and Chemotherapy

Lung injury after chemoradiotherapy is a common adverse reaction that is caused by radiation and chemotherapy drugs. Beishashen is a traditional marine Chinese medicine with multiple pharmacological properties. The previous research reported that it has a potential prevention effect on injuries caused by radiation and chemotherapy drugs, but the specific mechanism is unknown. Consequently, this study is based on bioinformatics and other methods, focusing on exploring the potential targets and molecular mechanisms of Beishashen in preventing lung injury after radiotherapy and chemotherapy. This study used network pharmacology methods to identify the bioactive compounds of Beishashen in order to better understand its therapeutic radiation-induced lung injury (RILI) and chemotherapy-induced lung injury (CILI) molecular mechanisms. We found that the role of Beishashen in preventing RILI and CILI involved several main pathways, especially the PI3K-AKT signaling pathway. PTGS2, PIK3CG, and RXRA were considered as key targets. Molecular docking and molecular dynamics showed good binding between the active ingredients and key targets, especially between alloisoimperatorin and RXRA. This study revealed the role of Beishashen in some potential regulating signal pathways in the treatment and prevention of RILI and CILI. Quercetin and alloisoimperatorin were the main active ingredients with low toxicity and can effectively bind with key targets. These findings provided important insights into the potential use of Beishashen for RILI and CILI.

Analysis of lncRNA-miRNA-mRNA Expression in the Troxerutin-Mediated Prevention of Radiation-Induced Lung Injury in Mice.

Radiation-induced lung injury (RILI) is a critical factor that leads to pulmonary fibrosis and other diseases. LncRNAs and miRNAs contribute to normal tissue damage caused by ionizing radiation. Troxerutin offers protection against radiation; however, its underlying mechanism remains largely undetermined. We established a model of RILI in mice pretreated with troxerutin. The lung tissue was extracted for RNA sequencing, and an RNA library was constructed. Next, we estimated the target miRNAs of differentially expressed (DE) lncRNAs, and the target mRNAs of DE miRNAs. Then, functional annotations of these target mRNAs were performed using GO and KEGG. Compared to the control group, 150 lncRNA, 43 miRNA, and 184 mRNA were significantly up-regulated, whereas, 189 lncRNA, 15 miRNA, and 146 mRNA were markedly down-regulated following troxerutin pretreatment. Our results revealed that the Wnt, cAMP, and tumor-related signaling pathways played an essential role in RILI prevention via troxerutin using lncRNA-miRNA-mRNA network. These evidences revealed that the abnormal regulation of RNA potentially leads to pulmonary fibrosis. Therefore, targeting lncRNA and miRNA, along with a closer examination of competitive endogenous RNA (ceRNA) networks are of great significance to the identification of troxerutin targets that can protect against RILI.

Pirfenidone for the prevention of radiation-induced lung injury in patients with locally advanced oesophageal squamous cell carcinoma: a protocol for a randomised controlled trial

IntroductionRadiation-induced lung injury (RILI) is one of the most clinically-challenging toxicities and dose-limiting factors during and/or after thoracic radiation therapy for oesophageal squamous cell carcinoma (ESCC). With limited effective protective...

Inhaled amifostine for the prevention of radiation-induced lung injury

ObjectiveTo alleviate radiation-induced lung injury and prevent the related pneumonitis and pulmonary fibrosis by inhaled amifostine (AMI). Methods15 ​Gy 60Co γ-ray irradiation was performed on the thoracic area of rats once to establish the radiation injury model. AMI was intraperitoneally (i.p.) injected or intratracheally (i.t.) administered to the rats 30 ​min pre-irradiation. The protective effects of the two AMI administration manners were compared in the aspects of hematopoietic system, lung edema, and histopathological examination, and the mechanisms were explored. ResultsCompared to i.p. AMI, i.t. AMI remarkably alleviated radiation-induced lung injury and prevented consequent pneumonitis or pulmonary fibrosis. Specifically, i.t. AMI notably protected white blood cells and platelets, reduced the lung wet/dry weight ratio, and decreased collagen volume fractions compared to the model group (P ​< ​0.05), while i.p. AMI showed no significant difference with the model group (P ​> ​0.05). The high therapeutic efficiency of i.t. AMI was related to its high antioxidation and anti-inflammation effects with downregulation of pro-inflammatory cytokines, the enhanced superoxide dismutase activity, the low levels of malondialdehyde and total proteins. ConclusionInhaled AMI is a promising medicine for preventing radiation-induced lung injury, including pneumonitis and pulmonary fibrosis.

Prevention and treatment of radiation-induced lung injury.

Radiation-induced lung injury (RILI) is a common complication in cancer patients receiving local thoracic radiation and bone marrow transplantation conditioning. It is divided into early-stage radiation pneumonitis and advanced radiation fibrosis of thelung. This severely hampers the quality of life and survival of cancer patients. Meanwhile, RILI is a major factor limiting radiation doses in clinical practice, which affects the local control of cancer. Unfortunately, the mechanism of RILI is still not well defined, and there are no treatment options available for these patients. In this reviewwe summarizethe methods and agents used for the treatment and prevention of RILI, with theaim of increasingunderstanding ofRILI.

Mesenchymal stem cells in radiation-induced lung injury treatment

Radiotherapy plays a significant role in the treatment of lung malignant tumor.However,as the most main complication of radiotherapy used to treat lung malignant tumor,radiation-induced lung injury is an important influencing factor in impeding further and higher dose radiotherapy.Previous studies show that mesenchymal stem cells (MSCs) have the characteristics of self-replication,multiple differentiation,immunoregulation and directional migration. MSCs can help to repair many kinds of acute and chronic lung injury,meanwhile stem cell transplantation stimulates production of many cytokines to attenuate acute lung injury.So stem cell therapy provides a new kind of thinking in the prevention and treatment of radiation-induced lung injury. Key words: Mesenchymal stem cells; Radiation pneumonitis; Cytokines

740. Prevention of Radiation-Induced Lung Injury by Administration of Gene-Modified Mesenchymal Stem Cells

740. Prevention of Radiation-Induced Lung Injury by Administration of Gene-Modified Mesenchymal Stem Cells

Prevention of Radiation-Induced Lung Injury in Mice by Ulinastatin

Prevention of Radiation-Induced Lung Injury in Mice by Ulinastatin