There is abundant literature suggesting medical use for phytoestrogen-containing products. There is also published evidence suggesting potentially negative consequences of phytoestrogens use for humans. Substantiation of both concepts appears questionable. Meanwhile, soy products are used liberally in the food also for infants and children. The concept discussed here is that it is not consistent to support soy use for estrogenic effects without concern for its impact on routine use as a foodstuff and livestock fodder. It is important for thorough independent studies to be done to answer these questions. Phytoestrogens are substances of plant origin that are structurally and functionally similar to estrogens. Among them, isoflavones and coumestans are the most extensively studied groups. Isoflavones are present in different edible plants, but are most abundant in soy [13]. Consumption of soy products has been associated with favorable health effects, but potentially adverse effects are underacknowledged [4]. Phytoestrogens are advertised as a natural alternative to estrogens for hormone replacement therapy during menopause [1]. Preclinical trials have demonstrated both genomic and non-genomic action of phytoestrogens including selective but weak binding to the estrogen receptors [5]. Some epidemiological studies suggest that dietary intake of phytoestrogens may contribute to the decreased incidence of postmenopausal cardiovascular disease [6] and that phytoestrogens are significantly more effective than placebo in reducing the frequency of hot flashes [7]. Evidence in support of clinically relevant biological effects has been generally rated as insufficient or absent [5,8-14]. A recent review concluded that in spite of increasing preclinical and clinical studies over the past decade, “appealing evidence is still lacking to support the overall positive risk-benefit profile of phytoestrogens” [15]. Then as now, the conventional menopausal hormone replacement therapy remains the only treatment that has consistently had a greater effect than placebo in controlled trials [16]. As evaluation of earlier works on enrichment the diet with soy products has failed to confirm favorable effects related to the cardiovascular system [17], doubts concerning phytoestrogens have recently increased. There is little evidence to support the hypothesis that phytoestrogens protect against menopausal osteoporosis, with published studies having no controls for confounding factors, the observations generally being of short duration [18,19]. In regard to osteoporosis, the latest review concluded that “evidence points to a lack of a protective role of soy isoflavones in the prevention of postmenopausal bone loss” [20], although in vitro and animal studies show some positive effect of isoflavones on bone which has not been clearly confirmed by long-term human trials [21]. There might be genetic differences in this regard, as equol producers seem to present a more positive response to isoflavone intervention [21]. The use of phytoestrogens as an alternative for hormone replacement therapy is not advocated due to insufficient information on safety [22], and reports of adverse effects and interactions with drugs [23]. Moreover, soy is known as allergenic food [2,24], and soybeanbased oil emulsions have been identified as one of the major causes of cholestasis related to pediatric parenteral nutrition [25]. There is a discrepancy in how phytoestrogens and soy products are viewed in science and medicine. Among edible plants, phytoestrogens are most abundant in soy, and are structurally and functionally analogous to estrogens, with their biological action mediated by estrogen receptors. Soy products are widely used in infant food and other foodstuffs; and, at the same time, phytoestrogens have been applied for compensation of hormone deficiency in menopause. Furthermore, soy is applied as livestock fodder, and residual phytoestrogens and their active metabolites can remain in meats. There are only few reports on modified gender-related behavior or feminization in humans as a result of soy consumption. In animals, the intake of phytoestrogens was reported to impact fertility, sexual development and behavior. Feminizing effects in humans can be subtle and identifiable only statistically in large populations, and may be of particular significance for children and adolescents. This matter should be clarified by independent research, which may affect the future of soy cultivation. Citation: Jargin SV (2014) Concerns about Soy Cultivation: What is Known and What is not Known. J Nutr Health Sci 1(3): 310. doi: 10.15744/2393-9060.1.310
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Sep 27, 2020
Umani S Walallawita + 4
