Skin care in children has been a problem exercising the minds of both parents and doctors from the moment of birth. Why are they so interested in knowing about the infant skin and care for it? Consideration must be given to the anatomical and physiological features of the newborn skin structure and differences from the adult skin structure. Its weight accounts for 10–13% of the newborn body weight as compared to 3% of the adult body weight. Anatomical maturity only partially correlates with functional maturity, these differences concern both barrier function and thermoregulation. The epidermis in newborns and infants is much thinner, looser, the layers are underdeveloped. The epidermal basement membrane connecting the epidermis and the dermis is made up of four poorly differentiated sublayers, the cells are of small size, the number of desmosomes at the cell-cell junctions is also much lower, which results in the unstable connection between the epidermis and the dermis. These distinctive features explain the difference in the newborn skin care, the choice of care products, the prevention of various pathological conditions, and even the subtleties of treatment. The variety of skin care products for newborns, the difference in composition and different dosage forms can cause confusion in young parents, and improper use of such products and various disturbing factors can lead to impairment of the normal state and function of the skin. And as a consequence of this, various pathological conditions may develop that already require active and even long-term treatment. The purpose of this article is to give the reader a brief picture of the anatomical and functional features of the skin structure, any changes developing in the postnatal period, and the need for the use of skin care products. It provides the skincare rules, compliance with which will not lead to the opposite effect.