Prevention Of Chronic Illness Research Articles

Optimizing the resveratrol fragments for novel in silico hepatocellular carcinoma de novo drug design

Hepatocellular carcinoma (HCC) incidence varies widely around the world and is impacted by factors such as the prevalence of chronic hepatitis B and C infections, alcohol intake, and access to healthcare. The proteins (BRAF_human, VGFR3_human, EGFR_human and UFO_human) play a vital role in hepatocellular carcinoma prognosis, which involves cell proliferation, cell growth, transmission of extracellular signals to the cell nucleus and consequently regulating many other cellular processes. Fostamatinib has been studied for its possible use in the treatment of hepatocellular cancer because it is a more convenient therapy choice for patients and has minor side effects on the human body. However, resveratrol phytochemical has been investigated for its potential use in the prevention and treatment of a wide range of disorders, including cancer, cardiovascular disease, diabetes, and neurological problems due to its frequently antioxidant, anti-inflammatory, and immune-modulating characteristics, which can aid in the prevention of chronic illnesses. This study developed de novo-based fragment-optimized resveratrol (FOR), enhancing therapeutic potential and lowering toxicity. The docking study was performed with four target proteins, and the findings reveal that the vascular endothelial growth factor receptor 3 protein possessed the highest binding energy values of −7.6 kcal/mol with FOR. Additionally, it completely fulfills the criteria of drug-likeliness rules. Thus, FOR proves to be an efficient drug candidate for future in-vivo studies against hepatocellular carcinoma.

Effect of a structured health promotional program using the self-support groups on lifestyle behavior: The Ath Waas Interventional Trial.

Ath Waas is a one-of-a-kind health promotion intervention that focuses on chronic disease prevention behaviors through peer support and social support network development. The goal of the study was to see how effective Ath Waas was in a city setting in India. From July 2018 to July 2019, we used a mixed-methods intervention research design including many sites. At 0, 2, 3, 5, 7, 9, and 12 months, data were collected using participant surveys and in-person interviews. Throughout the research period, participants met in groups at least once a month to self-monitor health indicators, prepare and share a healthy snack, engage in physical activity, create a healthy lifestyle goal, and socialize. Data were analyzed using a paired t-test, and inferences were drawn thereof. There were statistically significant improvements in the majority of the domains of health from pre- to post-program, and 59% of participants reported specific behavioral changes as a result of their participation in the Ath Waas. Peer support, obtaining particular health knowledge, inspiration, motivation, or accountability, the empowering effect of monitoring one's own health indicators, overcoming social isolation, and knowing how to better access resources were all positive health outcomes. The mean knowledge scores for diabetes, hypertension, and nutrition in the first survey were 20.3 ± 2.1 and 5.2 ± 1.9 and in the last survey were 22.6 ± 3.1 (P < 0.05), 5.8 ± 2.4 (<.05), and 44.3 ± 3.9 (<0.001) after the intervention, respectively. The necessity to find novel approaches to chronic illness prevention and management drove the implementation and evaluation of Ath Waas. While more research is needed to confirm the current findings, it looks like Ath Waas could be a useful tool for empowering community members to support one another while promoting healthy lifestyle choices and recognizing early changes.Clinical Trial Registry of India: CTRI/2019/01/017028 (registered on 10/01/2019).

A Multi-State Analysis of the Fiscal Impact of Commercial Insurance Coverage for General-Use &amp; Activity-Specific Prosthetic &amp; Orthotic Devices in the United States

Prosthetic and orthotic devices are assistive devices utilized by individuals with limb loss, limb difference, and mobility impairment. Research has shown these devices improve mobility and functionality, independence, and overall quality of life for individuals with disabilities who depend on them. This report focuses on two use types of prosthetic and orthotic devices: general-use and activity-specific. General-use prostheses and orthoses are designed to achieve the basic needs of ambulation and upper-limb functionality. In contrast, activity-specific devices are designed to support higher-intensity physical activities and recreation. Currently, 29 states do not require insurance coverage for general-use prosthetic and orthotic devices, and 45 states do not require insurance coverage for activity-specific devices, hindering individuals with limb loss, limb difference, and mobility impairment from essential life functions, including regular exercise required to prevent chronic illnesses. This study analyzes proposed legislation in 11 states, aiming to expand state-regulated coverage for prosthetic and orthotic devices for the purpose of improving quality of life and longevity of health, including chronic illness prevention. The methodology includes estimating the per member per month (PMPM) and net cost variations per state based on U.S. Census populations, Center of Medicare and Medicaid Services (CMS) Public Use Data Files and state-specific Medicaid fee schedules. The authors hypothesize that expanded insurance coverage could yield long-term social and fiscal benefits to the patient and healthcare systems. Results show PMPM estimates for states pursuing various levels of coverage, encompassing both general-use and activity-specific devices. The analysis conservatively estimates small PMPM increases based on assumptions related to device coverage costs and utilization. The results further emphasize potential overall healthcare savings from insurance coverage for these devices with the implementation of the 11 legislative initiatives, from improved health outcomes, with minimal fiscal impact.

Effects of Carob Extract on the Intestinal Microbiome and Glucose Metabolism: A Systematic Review and Meta-Analysis.

The legume tree known as carob (Ceratonia siliqua L.) is indigenous to the Mediterranean area and over the centuries its pods had been traditionally used mostly as animal feed. However, it has gained great attention in human nutrition due to the molecular compounds it contains, which could offer many potential health benefits: for example, carob is renowned for its high content of fiber, vitamins, and minerals. Moreover, in traditional medicine it is credited with the ability to control glucose metabolism and gut microbiome. Modern science has also extensively acknowledged the numerous health advantages deriving from its consumption, including its anti-diabetic, anti-inflammatory, and antioxidant properties. Due to its abundant contents of pectin, gums, and polyphenols (such as pinitol), carob has garnered significant attention as a well-researched plant with remarkable therapeutic properties. Notably, carob is extensively used in the production of semi-finished pastry products, particularly in ice cream and other creams (especially as a substitute for cocoa/chocolate): these applications indeed facilitate the exploration of its positive effects on glucose metabolism. Our study aimed at examining the effects of carob extract on intestinal microbiota and glucose metabolism. In this review, we conducted a thorough examination, comprising in vitro, in vivo, and clinical trials to appraise the consequences on human health of polyphenols and pectin from different carob species, including recently discovered ones with high polyphenol contents. Our goal was to learn more about the mechanisms through which carob extract can support a balanced gut flora and improve one's glucose metabolism. These results could influence the creation of novel functional foods and dietary supplements, to help with the management and prevention of chronic illnesses like diabetes and obesity.

Berberis microphylla G. Forst Intake Reduces the Cardiovascular Disease Plasmatic Markers Associated with a High-Fat Diet in a Mice Model

Polyphenols are bioactive substances that participate in the prevention of chronic illnesses. High content has been described in Berberis microphylla G. Forst (calafate), a wild berry extensively distributed in Chilean-Argentine Patagonia. We evaluated its beneficial effect through the study of mouse plasma metabolome changes after chronic consumption of this fruit. Characterized calafate extract was administered in water, for four months, to a group of mice fed with a high-fat diet and compared with a control diet. Metabolome changes were studied using UHPLC-DAD-QTOF-based untargeted metabolomics. The study was complemented by the analysis of protein biomarkers determined using Luminex technology, and quantification of OH radicals by electron paramagnetic resonance spectroscopy. Thirteen features were identified with a maximum annotation level-A, revealing an increase in succinic acid, activation of tricarboxylic acid and reduction of carnitine accumulation. Changes in plasma biomarkers were related to inflammation and cardiovascular disease, with changes in thrombomodulin (-24%), adiponectin (+68%), sE-selectin (-34%), sICAM-1 (-24%) and proMMP-9 (-31%) levels. The production of OH radicals in plasma was reduced after calafate intake (-17%), especially for the group fed with a high-fat diet. These changes could be associated with protection against atherosclerosis due to calafate consumption, which is discussed from a holistic and integrative point of view.

The Molecular Mechanism of Yam Polysaccharide Protected H2O2-Induced Oxidative Damage in IEC-6 Cells.

Oxidative stress is involved in maintaining homeostasis of the body, and an in-depth study of its mechanism of action is beneficial for the prevention of chronic illnesses. This study aimed to investigate the protective mechanism of yam polysaccharide (CYP) against H2O2-induced oxidative damage by an RNA-seq technique. The expression of genes and the function of the genome in the process of oxidative damage by H2O2 in IEC-6 cells were explored through transcriptomic analysis. The results illustrated that H2O2 damaged cells by promoting cell differentiation and affecting tight junction proteins, and CYP could achieve cell protection via restraining the activation of the MAPK signaling pathway. RNA-seq analysis revealed that H2O2 may damage cells by promoting the IL-17 signaling pathway and the MAPK signaling pathway and so forth. The Western blot showed that the pretreatment of CYP could restrain the activation of the MAPK signaling pathway. In summary, this study demonstrates that the efficacy of CYP in modulating the MAPK signaling pathway against excessive oxidative stress, with a corresponding preventive role against injury to the intestinal barrier. It provides a new perspective for the understanding of the preventive role of CYP on intestinal damage. These findings suggest that CYP could be used as oxidation protectant and may have potential application prospects in the food and pharmaceutical industries.

Impact of COVID-19 on a Community Health Coalition and Its Residents in Allegheny County, Pennsylvania: Insights Into Adaptation From Focus Groups and Evaluation Reports.

Live Well Allegheny: Lifting Wellness for African Americans (LWA2) is a coalition in Allegheny County, Pennsylvania, funded by the Centers for Disease Control and Prevention's (CDC) Racial and Ethnic Approaches to Community Health (REACH) initiative. LWA2 consists of partner organizations addressing chronic disease prevention in six Black communities through nutrition, physical activity, and community-clinical linkage strategies. This analysis focuses on qualitative data exploring the influence of COVID-19 on coalition functioning and communities. We conducted focus groups with residents in REACH communities and collected evaluation reports from partner organizations. Three focus groups assessed awareness of and participation in the REACH initiative, feedback, and the impact of COVID-19 when applicable. An additional focus group included questions related to flu vaccine messaging and the COVID-19 vaccine. These data sources provided insight regarding how COVID-19 affected planned tasks. Evaluation team members analyzed focus groups and collated summaries as part of a larger comprehensive evaluation. Partner organizations experienced an increase in food stamp applications, delays in opening farmers' markets, a shift to virtual preventive health programs, canceled in-person events, and programmatic interruptions that shifted long-term goals. Community resident concerns included difficulty accessing public transportation, decreased physical activity, fear of in-person interactions, and increased wait times for mental health services. Coalition members developed methods to continue functioning and sustaining program activities. Residents were able to engage differently with chronic illness prevention techniques. Reports from the ongoing analysis will be used to adapt coalition functioning.

P05-12 Objectively measured physical activity, chronic illness and health service utilisation - a latent class analysis of activity behaviours in older adults

BackgroundPhysical activity contributes to the prevention of chronic illness as well as promotion of physical and mental health, but most adults remain inactive. Chronic illness affects mainly middle aged and older adults, and very little objectively measured data on physical activity behaviours and associated health outcomes of this population is published. The aims of this study are to: 1. Objectively measure physical behaviour outcomes of adults participating in the Move for Life study; 2. Develop distinct activity profiles based on six behaviour variables; 3. Investigate whether health outcomes differ across the activity profiles.MethodsParticipants were Irish adults aged 50 years and older. Using the activPAL, objectively measured data were collected on average daily: light intensity physical activity (hours); moderate to vigorous intensity physical activity (minutes); step count; time in bed (hours); standing time (hours); and waking sedentary time (hours). Data were obtained on chronic illness and health service utilisation. Validated questionnaires were used to collect data on wellbeing, loneliness and social isolation. Hierarchical cluster analysis using squared Euclidian distance was used to cluster behaviours based on similarity, using SPSS version 26. Regression models explored associations between health outcomes and activity profiles, adjusted for age and sex.ResultsData from 485 participants were analysed, and four activity profiles were identified: sedentary (n = 50, 10.3% of total), low active (n = 295, 60.8%), moderate active (111, 22.9%) and higher active (n = 29, 6%). We will present the differences across the activity profiles for chronic illnesses, multi-morbidity, health service utilisation and validated health tools, comparing to data from the Irish Longitudinal Study on Ageing (TILDA) and the English Longitudinal Study on Ageing (ELSA).ConclusionsThe use of physical activity behaviour clusters may identify people with multi-morbidity and higher utilisation of health services. These findings could be factored into the development of future targeted physical activity interventions.

Foresight study on online health community: The perspective of knowledge empowerment for patients with chronic diseases.

Patient empowerment is an indispensable precondition for patients to self-manage their disease. The article takes the position that patients are empowered for disease self-management through patient knowledge empowerment when sharing knowledge. One of the most important instruments to successfully empower a patient to manage a chronic disease and maintain social relations, which are also a precondition for the prevention of chronic illnesses, is the possibility to access online health communities (OHCs) and participate in them. The aim of the article is to model possible development scenarios of OHCs as enablers of patient knowledge in relation to other digital health technologies (DHTs). A foresight methodology was used to achieve the goal, employing a technology scanning approach after selecting 10 foresight studies, which resulted in four future scenario models for the empowerment of patients wcith chronic diseases through digital health communities. They reveal options for the future interoperability of OHCs with other DHTs and highlight their importance and significance for the healthcare system as a technology for balancing patient self-efficacy and social relations as well as the need to maintain and develop them.

Applying the comprehensive model of information seeking to understand chronic illness information scanning: Hong Kong evidence

AbstractChronic illness is the most prevalent and costly global public health challenge. To address this challenge, health information is essential for individuals to make informed decisions to self‐manage their health and prevent and monitor chronic illness. Although previous studies show that health information scanning—a form of information gathering behavior to obtain health information, incidentally, when health topics of interest arise during daily conversations with others or through regular use of the media—positively influenced health decisions, little is known about information scanning in the context of chronic illness. This study applied the Comprehensive Model of Information Seeking to examine factors that influence individuals' use of different channels for health information scanning. Using quota sampling to resemble population demographic characteristics, we collected 1100 online survey responses from Chinese‐speaking Hong Kong residents aged from 18 to 65 or older. Three structural equation modeling analyses were performed to examine how antecedent factors and information carrier factors influenced the use of interpersonal/group channels, the Internet‐related channels, and the traditional media channels for scanning chronic illness‐related information. The findings supported that channel utility was an important determinant of health scanning behavior, and channel characteristics were strong predictors of channel utility. However, mixed findings were observed on the relationship between antecedent factors and channel utility across the three‐channel categories, because some antecedent factors had direct influence on health information scanning. These findings will inform the information dissemination and promotional message design for chronic illness prevention and care.

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements.

Bovine colostrum (BC) is the initial mammary secretion after parturition, which is nature’s bountiful source consisting of nutritional and bioactive components present in a highly concentrated low-volume format. All mammalian newborns require colostrum to enhance physiological processes such as lifelong immunity, gastrointestinal development, and resistance to microbial infections. The genetic, environmental, and processing methods can all have an impact on the biochemical contents of BC and its supplements. BC and its derivatives have been intensively researched for their potential use in functional foods, medicines, and animal feed. Evidence from clinical studies suggests that BC products are well-tolerated, nontoxic, and safe for human ingestion. Functional foods, feed, and pharmaceutical formulations based on bovine colostrum are playing noteworthy roles in the development of innovative products for promoting health and the prevention of chronic illnesses. This systematic review sheds light on recent research on (a) the effects of processing techniques on BC components, (b) emerging techniques used in the isolation and identification of novel components, (c) BC-based functional foods for human consumption and animal feed supplements, and (d) the role of BC in current drug delivery, as well as future recommendations.

Physical Activity and Its Determinants among Senior Residents of Podlasie, a Green Region of Poland, Based on the National PolSenior Study.

Physical activity is essential at all stages of life, and particularly so in the later years. The main objectives of the present work was to evaluate the physical activity of seniors, aged 65 years and older, living in the area of the Podlaskie voivodeship (Podlasie), Poland, based on the results of the nationwide PolSenior project, and to formulate recommendations for health policies implemented by both national and local government units. The study was performed as part of the national PolSenior project, whose aim was to evaluate various aspects of aging in Poland. The physical activity of a group of 186 randomly-selected people aged 65 years and above, 94 men and 92 women, was evaluated by questionnaire. The analysis included participants who took part in physical activity at least several times a week. Although all participants reported a decline in physical activity with age, the men remained physically active for longer. Among the respondents, 68.3% of women and 62.7% of men took short walks around the house as the main form of exercise, with working on the allotment or garden being another frequent activity; however, this was more common among men (53.9%) than women (34.7%). In addition, men were nearly twice as likely to take part in cycling (31.5%) than women (13.1%). The greatest motivation for physical activity given by the respondents was health, as noted by 73.8% of the men and 77.7% of the women. The physical activity of seniors in Podlasie is unsatisfactory and does not fulfil the WHO recommendations regarding the prophylaxis and prevention of chronic illness. This level does not, however, significantly differ from that reported in the nationwide PolSenior study or in other European countries in the Eurobarometer study. The decline in physical activity with age highlights the need for its greater promotion among seniors by local authorities. Such initiatives will help maintain the physical fitness and independence of this age group and contribute to a greater quality of life.

Catastrophic Out-of-Pocket Health Expenditure Among Rural Households in the Semi-Pastoral Community, Western Ethiopia: A Community-Based Cross-Sectional Study.

BackgroundEvery year, 808 million people face catastrophic health expenditure (CHE), and 122 million people were pushed into poverty. It aggravates healthcare inequalities, incurs double burden opportunity costs, and pushes households to sit in a deep poverty trap. A few studies have been done so far; however, it is not enough to inform policy decisions. Therefore, this study aimed to assess the catastrophic out-of-pocket health expenditure and associated factors among rural households in Mandura District, Western Ethiopia.MethodsWe conducted a community-based cross-sectional study among the Mandura district’s 488 rural households from April to May 2017. We used a multistage systematic sampling technique to select the participants. We fitted a binary logistic regression model to identify the factors associated with catastrophic out-of-pocket health expenditure. We used the adjusted odds ratio (AOR) with 95% CI and the p-value <0.05 to determine the variables associated with catastrophic out-of-pocket health expenditure.ResultsCatastrophic health expenditure (CHE) with a 40% capacity to pay (CTP) households in the study area was 22.5%. Female household head (AOR = 2.92; 95% CI: 1.44, 5.93) and household with chronic illnesses (AOR = 3.93; 95% CI: 1.78, 9.14) were positively associated with CHE and, while households who had adult household members (AOR = 0.32; 95% CI: 0.16, 0.63) were negatively associated.ConclusionThe overall CHE, with a 40% CTP threshold, was high. Prevention of chronic illness might help to reduce the burden of the expenditure. Strengthening financial risk protection mechanisms, such as community-based health insurance, could help bring healthcare services equity.

Community nurses and chronic disease in Israel: Professional dominance as a social justice issue.

Chronic diseases are major causes of health inequalities. Community nurses can potentially make large contributions to chronic illness prevention and management in Israel but may be obstructed by professional dominance of physicians. However, insufficient research exists about community nursing in Israel, and how it may differ from other countries. This study aims to document chronic disease-related community nursing roles in Israel, identify changes and trends in community nursing roles that may increase social justice, and understand how the roles and trends in community health nursing in Israel may differ from developments in other countries. In-depth interviews were performed with 55 Israeli health system professionals, and 692 nurse care-givers were asked open-ended questions. Interview answers were analyzed to find themes and trends. The study found that community nurse roles in Israel have expanded, especially for chronic disease control. Commonalities exist with countries such as the United States and the UK, albeit with important differences. However, continued conflicts with physicians exist, which can limit nurses' contributions to reducing health inequalities. Community nurses' importance is growing. Enabling them to overcome professional dominance and improve chronic disease control can help reduce health inequalities in Israel and elsewhere.

Relationship between the self-concept and physical activity towards the prevention of chronic illnesses.

The objective of this work is to verify the relationship between the self-perception of health and the self-concept of physical appearance in adolescents, in order to check their influence on the physical activity they perform with the aim of preventing chronic illnesses. To this end, an observational, cross-sectional descriptive study with analytical components was carried out. Opportunistic activity, in which young people, between the ages of 16 and 22, were recruited from 5 secondary schools of the municipality of San Cristóbal de La Laguna, on the island of Tenerife (Spain). Data were collected through the General Health Questionnaire, the Rosemberg Self-esteem Scale, and the physical exercise habits test physical activity questionnaire for adolescents-A, revealing the first 2 that most percentage of responses were grouped on the positive side. The physical exercise habits test physical activity questionnaire for adolescents-A described that the most commonly performed physical activity was walking (75%).

P74 A Community-Based Intervention Reduces Diabetes Risk in a Low-Income Community

<h3>Objective</h3> Promote diabetes prevention in a low-income community by offering Cooking Matters (CM) in coordination with the Diabetes Prevention Program (DPP). <h3>Use of Theory or Research</h3> Reducing food insecurity is important for reducing chronic disease rates. DPP is a validated and effective intervention that reduces progression to type 2 diabetes. However, there is an outcome disparity for DPP in low-income communities. Our research aims to improve DPP outcomes in low-income communities. <h3>Target Audience</h3> Pre-diabetic participants ≥18 years old in low-income communities in Detroit, Michigan. <h3>Program Description</h3> This study represents partnerships between Gleaners Community Food Bank (GCFB), National Kidney Foundation of Michigan (NKFM), and Wayne State University. DPP, administered by NKFM, is a community-based intervention that significantly reduces diabetes risk. CM, locally administered through GCFB, is another effective community program that teaches food skills, and provides food provisions. We hypothesize that combining DPP and CM in a low-income setting will improve program completion, and thereby reduce the risks for progressing to type 2 diabetes. <h3>Evaluation Methods</h3> Over 12 months, low-income individuals participated in the study. Demographics were collected at the onset of the study. Survey information was collected for diet and physical activity at 4 time-points throughout the study. Body weight was collected at every session, and HbA1C was collected at the onset and conclusion of the program. <h3>Results</h3> Combining DPP and CM resulted in a 79% completion rate, compared to the <50% completion rate observed for DPP alone in low-income communities. Mean HbA1C dropped 10.6% (paired t-test, <i>P</i> < .01), from pre-diabetic to normal levels, and every participant demonstrated lower post-test HbA1C values. Participants experienced a mean weight loss of 7.6% (paired t-test, <i>P</i> < .01), and >75% of participants exceeded 5% weight loss at 12 months. <h3>Conclusions</h3> Combining DPP and CM is effective at reducing diabetes risk in low-income communities. Food bank services, which already serve low-income vulnerable communities, can be coupled to existing chronic illness prevention programs to improve disease risk in vulnerable populations.

A Community-Based Intervention Reduces Diabetes Risk in a Low-Income Community

Abstract Objectives Promote diabetes prevention in low-income communities by offering Cooking MattersTM (CM) in coordination with the Diabetes Prevention Program (DPP). Reducing food insecurity is necessary for reducing chronic disease rates. DPP is a validated and effective intervention for reducing progression to Type II diabetes, but significant outcome disparities occur in low-income communities. Our research aims to address these outcome disparities. This study is a partnership between Gleaners Community Food Bank (GCFB), National Kidney Foundation of Michigan (NKFM), and Wayne State University. DPP, administered by NKFM, is a community-based intervention that significantly reduces diabetes risk. CM, locally administered through GCFB, is also an effective community program that teaches food skills, and provides food provisions. We hypothesize that combining DPP and CM in a low-income setting will improve program completion, and effectively reduce risk for progressing to Type 2 diabetes. Methods Over 12 months, low-income individuals participated in the combined DPP/CM study. Demographics were collected at the onset of the study. Survey information was collected for diet and physical activity at four time-points throughout the study. Body weight was collected at every session, and HbA1C was collected at the onset and conclusion of the program. Results Combining DPP and CM resulted in a 79% program completion rate. Mean HbA1C dropped 10.6% (paired t-test, P &amp;lt; 0.01), and each participant demonstrated lower post-test HbA1C values. Participants experienced a mean weight loss of 7.6% (paired t-test, P &amp;lt; 0.01), and &amp;gt;75% of participants exceeded the 5% DPP weight loss outcome objective at 12 months. Conclusions Cooking Matters TM coupled with the Diabetes Prevention Program is an effective strategy to improve outcomes and reduce diabetes risk in low-income communities. Food bank resources can be coupled with existing chronic illness prevention programs to improve both disease risk and food security. Funding Sources Gleaners Community Food Bank and National Kidney Foundation of Michigan provided funding for this study.

The roles and potential of lentil prebiotic carbohydrates in human and plant health

Societal Impact StatementLentils are not only rich in protein and micronutrients, but they also have significant amounts of prebiotic carbohydrates, which provide benefits to human health. Beneficial microorganisms ferment lentil prebiotic carbohydrates in the colon, which impart gut health benefits to the consumer. In addition, prebiotic carbohydrates provide benefits to lentil plant health through their roles in carbon transport, storage, and abiotic stress tolerance. Advantageous to both human and plant health, prebiotic carbohydrates should be a prominent target for breeding efforts to improve lentil as a crop, as well as its nutritional value to consumers. Summary Diet‐related ailments, such as obesity and micronutrient deficiencies, have global adverse impacts on society. Lentil is an important staple crop, especially in South Asia and Africa, and has been associated with the prevention of chronic illnesses, including type II diabetes, obesity, and cancer. Lentil, a cool‐season food legume, is rich in protein and micronutrients while also containing a range of prebiotic carbohydrates, such as raffinose family oligosaccharides (RFOs), fructooligosaccharides, sugar alcohols (SAs), and resistant starch (RS), which contribute to lentil's health benefits. Prebiotic carbohydrates are fermented by beneficial microorganisms in the colon, which impart health benefits to the consumer. Prebiotic carbohydrates are also vital to lentil plant health, being associated with carbon transport/storage and abiotic stress tolerance. Important to both human and plant health, prebiotic carbohydrates in lentil are a prominent candidate for nutrigenomic breeding efforts. New lentil cultivars could help to combat global health problems, while also proving resilient to climate change. The objectives of this review are to: (a) discuss the benefits lentil prebiotic carbohydrates confer to human and plant health; (b) describe the biosynthesis pathways of two prominent prebiotic carbohydrate families in lentil, RFOs and SAs; and (c) consider the potential of prebiotic carbohydrates in terms of future nutritional breeding efforts.

Physical activity and the prevention of chronic illness in the BRICS nations: Issues relating to gender equality

•More than 70% of all deaths in the BRICS countries are attributable to noncommunicable diseases.•There have been marked changes in physical activity levels, time use, and energy expenditure in these nations over the last 20 years.•There are marked gender differences in physical activity in 4 of the 5 BRICS nations, which largely reflect the overall gender inequalities in these countries.

Lifestyle medicine – An evidence based approach to nutrition, sleep, physical activity, and stress management on health and chronic illness

Abstract Lifestyle-related chronic illnesses, such as metabolic syndrome, type 2 diabetes, cancer, and dementia are rising at an alarming, epidemic rate. In this modern world of increasing lifespan, we are actually decreasing our health span, placing an undue burden on healthcare costs to society. Modern medicine has largely gotten away from addressing key issues to prevent or even reverse some of these chronic conditions. Yet the evidence for successful interventions in four key areas – nutrition, sleep, physical activity and stress management – to manage and control our health are mounting. Lifestyle medicine as a part of personalized treatment and prevention of chronic illnesses is a necessary cornerstone of disease management as we look to the future. In this review, I discuss various key studies demonstrating the impact of lifestyle on epigenetic, endocrine, immunologic, and inflammatory changes which contribute to chronic disease and our overall health.