Prevention In Africa Research Articles

Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).

Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent. HIGHLIGHTS: Dementia rates are escalating in Africa, largely due to longer life spans and increased prevalence of modifiable risk factors. Yet, few regional interventions have directly targeted lifestyle factors to reduce dementia risk. The multinational Africa-FINGERS study will address this gap by adapting the successful FINGERS lifestyle intervention to African populations. Africa-FINGERS will pioneer a culturally informed, multidomain dementia risk reduction intervention in the African region through feasibility dementia prevention trials in rural and urban sites across Kenya and Nigeria in the first instance, enrolling 600 at-risk adults (≥ 50 years). The program adoptsparticipatory research methods to develop culturally appropriate interventions and build infrastructure to evaluate dementia biomarkers from ante and post mortem samples. A cost-effectiveness analysis will be conducted to guide the strategic implementation of Africa-FINGERS into regional health systems. The Africa-FINGERS strategy aligns with the Worldwide-FINGERS framework and integrates the global Alzheimer's Disease Neuroimaging Initiative approach, emphasizing multimodal analysis.

Ethics of Mathematical Modeling in Public Health: The Case of Medical Male Circumcision for HIV Prevention in Africa

Mathematical modelling has played an increasingly prominent role in public health responses, for example by offering estimates of how infectious disease incidence over time may be affected by the adoption of certain policies and interventions. In this paper, we call for greater research and reflection into the ethics of mathematical modeling in public health. First, we present some promising ways of framing the ethics of mathematical modeling that have been offered in the very few publications specifically devoted to this subject. Second, to draw out some issues that have not yet been sufficiently considered, we bring in the case of mathematical modeling in voluntary medical male circumcision (VMMC) initiatives for HIV prevention in Africa. We argue that greater attention should be paid to ethical considerations in mathematical modeling, particularly as its use is becoming more widespread and its potential impacts are becoming greater in the ‘big data’ era, as witnessed during the COVID-19 pandemic.

Video-tracked Anopheles arabiensis entry and exit behaviour at washed and damaged pyrethroid-treated bednets.

Insecticide-treated nets (ITNs) are the most effective method for malaria prevention in Africa. Using near-infrared video tracking in a laboratory environment, we recorded and assessed bednet entry and exit by a northern Tanzanian population of Anopheles arabiensis at a human-occupied untreated net and a PermaNet® 2.0 ITN. Both had 12 holes, each 10 cm in diameter, punctured at specific locations, and the ITN was washed 20 times to further simulate the wear and tear of ageing. Washing reduced the insecticide content of ITNs by 61%, which then showed similar rates to the untreated nets for net entry (39% entered untreated net and 41% entered ITN; p = 0.84) and exit (37% and 43%, respectively; p = 0.67). Regardless of treatment, approximately 40% of mosquitoes entered nets within 20 s of first appearing in the field of view and reached the volunteer's skin within 5 s of entering the net. Mortality rates post-exposure were significantly higher (p = 0.048) at ITNs (26.6%; 95% CI 13.4%-39.7%) than at untreated controls (6.4%; 95% CI 1.8%-14.6%). The washed and aged ITN provided little additional personal protection for the sleeper over an untreated net. Simple adjustments to materials and design that could extend the effective lifespan of ITNs are discussed.

Exploring adolescent girls and young women's PrEP-user profiles: qualitative insights into differentiated PrEP delivery platform selection and engagement in Cape Town, South Africa.

Adolescent girls and young women (AGYW), a priority population for HIV prevention in Africa, show high interest but difficulty in sustained effective use of pre-exposure prophylaxis (PrEP). With ongoing PrEP scale-up focused on increasing access, it is important to understand what influences AGYW's choice of PrEP delivery platforms. The POWER implementation study in Cape Town provided PrEP between 2017 and 2020 to AGYW (16-25 years) from four differentiated delivery platforms: mobile clinic, government facility, courier delivery or community-based youth club. Healthcare providers at government and mobile clinics provided PrEP (initiation and refills) as part of comprehensive, integrated sexual and reproductive health services. Courier and youth club platforms provided light-touch PrEP refill services incorporating rapid HIV self-testing. We conducted in-depth interviews with a purposive sample of AGYW who had ≥3 months of PrEP-use and accessed ≥2 PrEP delivery platforms. The thematic analysis explored AGYW's preferences, decision-making and habits related to PrEP access to inform market segmentation. We interviewed 26 AGYW (median age 20) PrEP-users between November 2020 and March 2021. AGYW PrEP-users reported accessing different services with, 24 accessing mobile clinics, 17 courier delivery, 9 government health facilities and 6 youth clubs for their PrEP refills. Qualitative findings highlighted four potential behavioural profiles. The "Social PrEP-user" preferred PrEP delivery in peer spaces, such as youth clubs or adolescent-friendly mobile clinics, seeking affirmation and social support for continued PrEP use. The "Convenient PrEP-user" favoured PrEP delivery at easily accessible locations, providing quick (courier) or integrated contraception-PrEP refill visits (mobile and government clinic). The "Independent PrEP-user" preferred PrEP delivery that offered control over delivery times that fit into their schedule, such as the courier service. The "Discreet PrEP-user" highly valued privacy regarding their PrEP use (courier delivery) and avoided delivery options where unintentional disclosure was evident (youth club). Comfort with HIV self-testing had minimal influence on PrEP delivery choice. Market segmentation of AGYW characterizes different types of PrEP-users and has the potential to enhance tailored messaging and campaigns to reach specific segments, with the aim of improving sustained PrEP use and HIV prevention benefits.

Stroke prevention strategies in Africa: a scoping review protocol.

The objective of this scoping review is to map the existing strategies on methods and interventions for primary and secondary stroke prevention in Africa. Stroke is among the leading causes of disability globally. African nations have higher stroke mortality and case fatality rates than the industrialized world, leading to significant social and financial costs, which necessitates efficient preventative methods. Despite the high prevalence of stroke in Africa, the scope of stroke-prevention strategies in Africa is unknown. Consequently, mapping diverse approaches to preventing stroke in Africa could provide direction for future research into stroke prevention in Africa. This review will incorporate studies that report methods or strategies used for stroke prevention in Africa. All primary and gray literature will be considered for inclusion. No language or date restrictions will be applied. The JBI methodological framework for scoping reviews will be adopted for this scoping review. A 3-step search strategy consisting of an initial limited search, a full search, and a screening of the reference lists of all included articles will be undertaken. Databases such as CINAHL, Scopus, PubMed, PEDRo, DORIS, Global Health, Web of Science, and Open Access Thesis and Dissertations will be searched. All search results will be screened, and relevant data extracted by 2 independent reviewers. The findings will be presented in the final scoping review and illustrated in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. Figshare https://doi.org/10.6084/m9.figshare.21679904.v1.

Revolutionizing HIV Prevention in Africa: Landmark Innovations that Transformed the Fight

The African continent has grappled with the profound impact of the HIV/AIDS epidemic for decades, necessitating an ongoing evolution in prevention strategies. This review examines the pivotal innovations that have reshaped the landscape of HIV prevention in Africa. Highlighting advancements in treatment, pioneering educational campaigns, and community-focused interventions, this article explores the transformative initiatives that have redefined the fight against HIV/AIDS. Despite significant progress, challenges persist, including socio-economic disparities and evolving healthcare landscapes. This review aims to provide insights into the journey of HIV prevention in Africa, emphasizing the critical role of innovation and adaptation in sustaining and advancing progress towards a future free from the burden of HIV/AIDS. Keywords: HIV prevention, Africa, innovations, landmark, strategies, healthcare, epidemic, public health, treatment, education

"A Man With a Loving Heart": A Systematic Review of Male Involvement in Cervical Cancer Screening in Africa.

This review assessed men's involvement and the predictors of their involvement in cervical cancer screening. We conducted a comprehensive search of the following electronic databases: PubMed, EMBASE, CINAHL, African, Web of Science, and Scopus. The search was limited to articles published between January 2010 and January 2023. A total of 17 studies met the inclusion criteria and were included for this review. More than 50% of the studies emphasised the relevance of male involvement in cervical cancer prevention in Africa and demonstrated the critical importance of this as a strategy. The results revealed that a significant proportion of male participants had a restricted comprehension of cervical cancer. Nevertheless, they expressed their willingness to provide backing for cervical cancer screening contingent upon their informed consent.

Human papilloma virus (HPV) vaccine and cervical cancer prevention in Africa.

Cervical cancer remains a critical challenge in reproductive health worldwide, with especially high burden in Africa. A recent publication in the Lancet reported 604,127 cases of cervical cancer worldwide in 20201, of which 117,316 cases (19.4%) were in the five African regions. East Africa had the highest incidence rate followed by West Africa, while north and South Africa had the lowest rates. Similarly, the highest cervical cancer mortality rate worldwide, 28.6 deaths per 100,000 women years, was reported from East Africa, and was followed by South Africa.

Physical Activity for Health Promotion and Disease Prevention in Africa and Cameroon: A Call to Action.

Physical Activity for Health Promotion and Disease Prevention in Africa and Cameroon: A Call to Action.

High-risk human papillomavirus genotype distribution among women living with and at risk for HIV in Africa.

Cervical cancer is a common preventable cancer among African women living with HIV (WLWH). Molecular diagnostics for high-risk human papillomavirus (HR-HPV) genotypes are standard components of cervical cancer screening in resource-rich countries but not in resource-limited settings. We evaluated HR-HPV genotypes among women with and without HIV in four African countries to inform cervical cancer preventive strategies. The African Cohort Study (AFRICOS) enrolled participants with and without HIV at 12 clinics in Tanzania, Kenya, Uganda, and Nigeria. Cervical cytobrush specimens from women were genotyped for 14 HR-HPV types using the multiplex Seegene Anyplex real-time PCR assay. Robust Poisson regression was used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for factors associated with HR-HPV in WLWH. From January 2015 to March 2020, 868 WLWH and 134 women living without HIV (WLWoH) were tested for HR-HPV with prevalence of 50.9 and 38.1%, respectively ( P = 0.007). Among WLWH, 844 (97.4%) were antiretroviral therapy (ART)-experienced and 772 (89.7%) virally suppressed 1000 copies/ml or less. The most frequent HR-HPV types among WLWH were HPV-16 (13.5%), HPV-52 (9.5%), and HPV-35 (9.3%). HR-HPV infection was more common among Tanzanian WLWH (adjusted RR: 1.23, 95% CI 1.05-1.44, P = 0.012). Also, WLWH with CD4 + T cells of less than 200 cell/μl had 1.51-fold increased risk of having HR-HPV (95% CI 1.23-1.86, P < 0.001). HR-HPV was common in WLWH in four African countries, particularly among women with low CD4 + cell count. Scale up of HPV vaccines and development of vaccines with broader activity against less common HR-HPV types may improve cervical cancer prevention in Africa.

HIV prevention in Africa: is VMMC useful and acceptable?

HIV prevention in Africa: is VMMC useful and acceptable?

Cervical cancer prevention in Africa: A policy analysis

BackgroundCervical cancer is a major public health challenge in Africa. We analyzed the presence and content of policies for the primary, secondary and tertiary prevention of cervical cancer in Africa, to identify areas of opportunity for policy strengthening in the region most affected by cervical cancer globally. MethodsWe searched for publicly-available policy documents among countries in Africa. Using a data extraction form, we gathered data from these policies about key elements of primary, secondary and tertiary prevention approaches and activities based on World Health Organization (WHO) guidelines. We also contacted key stakeholders in each country to confirm these details. We summarized each country’s policy details (summed score for each prevention stage and overall), and compared these scores across individual countries and groups of countries based on economic, policy and public health characteristics. ResultsMost countries had at least one policy addressing some aspect of cervical cancer prevention. Primary and secondary prevention were more commonly addressed, and certain details like age of vaccination, screening age/interval and method, were frequently mentioned in these policies. ConclusionCountries with high HIV burden and relatively more donor financing for health had more comprehensive cervical cancer policies; there was no apparent association with cervical cancer mortality, female representation in government, or economic indicators (poverty prevalence or income inequality). Policy summaryThere is room to improve cervical cancer policy comprehensiveness in Africa, and to bring these policies in line with evidence and expert recommendations. This analysis is timely given upcoming monitoring of the WHO Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem. These findings suggest some improvements in African cervical cancer policy, including increased inclusion of vaccination, but many topics remain under-specified. The influence of internal and external factors on policymaking should also be considered.

A Scoping Review of Policies Related to the Prevention and Control of Overweight and Obesity in Africa.

To address the issue of obesity, the World Health Organization (WHO) recommends a set of comprehensive programmes aimed at changing the obesogenic environments to provide opportunities for healthy food options and increased physical activity in the school, home, and at the population level. The objectives of this study were to examine the nature and range of policies related to overweight and obesity prevention in Africa, and to assess how they align with international guidelines. An existing methodological framework was adapted for this scoping review. A search of publicly available national documents on overweight/obesity, general health, and non-communicable diseases (NCDs) was undertaken from relevant websites, including WHO, ministries, and Google Scholar. Additional requests were sent to key contacts at relevant ministries about existing policy documents. The documents were reviewed, and the policies were categorised, using the Analysis Grid for Environments Linked to Obesity (ANGELO) framework. The framework categorises the environmental drivers of obesity into four domains (physical, economic, legislative, and socio-cultural) and two scales: macro (national, regional, sectors, food industries, media, etc.) and micro (household, institutional, and community). This review included documents from 41 African countries. The policy initiatives to prevent overweight/obesity target the school, family and community settings, and macro environments, and broadly align with global recommendations. The NCD documents were in the majority, with only two on obesity. The majority of the documents detailed strategies and key interventions on unhealthy diets and physical inactivity. The physical, legislative, and sociocultural domains were largely featured, with less emphasis on the economic domain. Additionally, nutrition- and diet-related policies were in the majority. Overlaps and interactions of policies were observed in the application of the ANGELO framework. This study has provided information on national policies and programmes in Africa and can be useful as a first point of call for policymakers. The overlapping and interaction in the initiatives demonstrate the importance of multi-sectoral partnerships in providing supportive environments for healthy behaviours.

Laboratory and field evaluation of MA\xcfA\xae, an ointment containing N,N-diethyl-3-methylbenzamide (DEET) against mosquitoes in Burkina Faso

BackgroundMalaria vector control relies upon the use of insecticide-treated nets and indoor residual spraying. However, as the emergency of insecticide resistance in malaria vectors grows, the effectiveness of these measures could be limited. Alternative tools are needed. In this context, repellents can play an important role against exophagic and exophilic mosquitoes. This study evaluated the efficacy of MAÏA®, a novel repellent ointment, in laboratory and field conditions in Burkina Faso.MethodsFor laboratory and field assessment, 20 volunteers were enrolled and trained for nocturnal collection of mosquitoes using human landing catches (HLC). In the laboratory tests, 2 mg/sq cm of treatment (either MAIA® or 20 % DEET) were used to assess median complete protection time (CPT) against two species: Anopheles gambiae and Aedes aegypti, following WHO guidelines. For both species, two strains consisting of susceptible and local strains were used. The susceptible strains were Kisumu and Bora Bora for An. gambiae and Ae. aegypti, respectively. For the field test, the median CPT of MAÏA® was compared to that of a negative (70 % ethanol) and positive (20 % DEET) after carrying out HLCs in rural Burkina Faso in both indoor and outdoor settings.ResultsLaboratory tests showed median Kaplan-Meier CPT of 6 h 30 min for An. gambiae (Kisumu), 5 h 30 min for An. gambiae (Goden, local strain), and 4 h for Ae. aegypti for both the local and sensitive strain. These laboratory results suggest that MAÏA® is a good repellent against the three mosquito species. During these field tests, a total of 3979 mosquitoes were caught. In this population, anophelines represented 98.5 %, with culicines (Aedes) making up the remaining 1.5 %. Among anopheline mosquitoes, 95 % belonged to the An. gambiae complex, followed by Anopheles funestus and Anopheles pharoensis. The median CPT of 20 % DEET and MAÏA® were similar (8 h) and much longer than that of the negative control (2 h).ConclusionsResults from the present studies showed that MAÏA® offers high protection against anophelines biting indoors and outdoors and could play an important role in malaria prevention in Africa.

Evaluating the impact of larviciding with Bti and community education and mobilization as supplementary integrated vector management interventions for malaria control in Kenya and Ethiopia

BackgroundMalaria prevention in Africa is mainly through the use of long-lasting insecticide treated nets (LLINs). The objective of the study was to assess the effect of supplementing LLINs with either larviciding with Bacillus thuringiensis israelensis (Bti) or community education and mobilization (CEM), or with both interventions in the context of integrated vector management (IVM).MethodsThe study involved a factorial, cluster-randomized, controlled trial conducted in Malindi and Nyabondo sites in Kenya and Tolay site in Ethiopia, to assess the impact of the following four intervention options on mosquitoes and malaria prevalence: LLINs only (arm 1); LLINs and Bti (arm 2); LLINs and CEM (arm 3); and, LLINs combined with Bti and CEM (arm 4). Between January 2013 and December 2015, CDC light traps were used to sample adult mosquitoes during the second, third and fourth quarter of each year in 10 houses in each of 16 villages at each of the three study sites. Larvae were sampled once a fortnight from potential mosquito-breeding habitats using standard plastic dippers. Cross-sectional malaria parasite prevalence surveys were conducted involving a total of 11,846 primary school children during the 3-year period, including 4800 children in Tolay, 3000 in Malindi and 4046 in Nyabondo study sites.ResultsBaseline relative indoor anopheline density was 0.11, 0.05 and 0.02 mosquitoes per house per night in Malindi, Tolay and Nyabondo sites, respectively. Nyabondo had the highest recorded overall average malaria prevalence among school children at 32.4%, followed by Malindi with 5.7% and Tolay 1.7%. There was no significant reduction in adult anopheline density at each of the three sites, which could be attributed to adding of the supplementary interventions to the usage of LLINs. Malaria prevalence was significantly reduced by 50% in Tolay when using LLINs coupled with application of Bti, community education and mobilization. The two other sites did not reveal significant reduction of prevalence as a result of combining LLINs with any of the other supplementary interventions.ConclusionCombining LLINs with larviciding with Bti and CEM further reduced malaria infection in a low prevalence setting in Ethiopia, but not at sites with relatively higher prevalence in Kenya. More research is necessary at the selected sites in Kenya to periodically determine the suite of vector control interventions and broader disease management strategies, which when integrated would further reduce adult anopheline populations and malaria prevalence beyond what is achieved with LLINs.

Covid-19: Addressing health systems deficits and peculiarities in the african region

Covid-19: Addressing health systems deficits and peculiarities in the african region

Western and Chinese media representation of Africa in COVID-19 news coverage

ABSTRACT In news production and dissemination, media represent communities, countries, and continents by constructing concepts, images, and identities as viewed by selected information sources. It is often assumed that foreign countries are labelled ‘Others’ by global media and misrepresented. This study aims to explore how differently Western and Chinese media source and frame events in Africa. Comparative content analysis of news coverage of COVID-19 prevention in Africa revealed that Western media used African official, African non-official, and Western non-official channels as information sources whereas Chinese media mainly used African and Chinese official sources. The result demonstrated that Western media covered events in Africa in Conflict, Negativity, Human interest, Impact, Eminence, and Novelty frames in positive, neutral, and negative tones whereas Chinese media covered mainly in Impact, Eminence and Novelty frames mostly in positive tone. Overall, the results suggest that Western media coverage of the events is not predominantly negative; and Chinese media coverage is uncommonly affirmative. The findings also suggest that sourcing shapes frames, tones, and representation of ‘Others’ by news media.

Bibliometric analysis of alcohol and substance use prevention research in Africa

Background: This study was designed to give a bibliometric overview of research productivity in alcohol and substance use prevention in Africa as a response to international efforts to prevent alcohol and substance use.Methods: Original research articles authored or coauthored by investigators from African countries on alcohol and substance use prevention during the period of 2008-2018 were retrieved from Web of Science (WoS), EBSCOhost, and PubMed and reviewed. Keywords related to alcohol and substance use were used to retrieve relevant literature.Results: Our search returned 3600 hits, with 34 articles retained. Included articles were conducted in 12 countries across the five regions in Africa (Central, East, North, South, and West) and spreading over 11 years, 2008-2018. The annual published articles showed a significant rise from 2008 to 2018 with South Africa ranked number one, with a total of 9 (31%) published articles followed by Kenya 4 (13.8%). Bronwyn Myers from South Africa and Atwoli et al. from Kenya were the most prolific authors. Age and gender were the mostreported risk factors in the selected studies. The most active institutions in alcohol and substance use prevention research are The Medical Research Council of South Africa, Stellenbosch University, and Moi University.Conclusions: There were few collaborations among Africans themselves, yet these collaborations would enhance future alcohol and substance use prevention research productivity. Currently, a broad spectrum of substance use prevention interventions has beenimplemented throughout the African continent, ranging from individual to community-based interventions

A Bibliometric analysis of alcohol and substance use prevention research in Africa

Background:&#x0D; In response to international efforts to prevent alcohol and substance use we designed this study to give a bibliometric overview of research productivity in alcohol and substance use prevention in Africa.&#x0D; Methods:&#x0D; Review of original research articles authored or co-authored by investigators from African countries on substance use prevention during the period 2008-2018 were done through retrieving them from, Web of Science (WoS), Ebscohost and Pubmed (National Library of Medicine). Key words related to alcohol and substance use were used to retrieve relevant literature.&#x0D; Results:&#x0D; Our search returned 3600 hits, with 34 studies retained. Included studies were conducted in 12 countries across the five regions in Africa (Central, East, North, South and West) and spreading over an 11-year period, 2008-2018. The annual published articles showed a significant rise from 2008 to 2018 with South Africa being ranked number one with a total of 9 (31%) published articles followed by Kenya 4 (13.8%). Bronwyn Myers from South Africa and Atwoli et al from Kenya were the most prolific authors. Age and gender were the most reported risk factors in the selected studies. Medical Research Council of South Africa, Stellenbosch University and Moi University are the active Institutions in alcohol and drug use prevention research.&#x0D; Conclusions:&#x0D; There were few collaborations among Africans themselves yet these collaborations would enhance future alcohol and substance use prevention research productivity. Currently, a wide spectrum of substance use prevention interventions have been implemented throughout the African continent, ranging from individual to community based interventions.

Human Needs Satisfaction and Conflict Prevention in Africa

This article reviews literature concerning the conflict prevention strategies in some African countries. The article acknowledges that there have been numerous efforts: mediation, negotiations and military involvement employed in ensuring that the conflicts do not break out or are reignited on the continent. Nonetheless, the conflicts have remained a continental problem. This work argues that despite the commitment to preventing the conflicts on the continent, unless human needs are satisfied, the efforts may as well go to waste. Thus, using the Human Needs Theory, this paper argues that the frustration of human needs has a direct relationship with conflicts outbreak. The paper recommends adopting the Human Needs Theory to conflict prevention strategies as critical for proper diagnosis of the conflict triggering factors on the continent.