Prevention Of Depression Research Articles

F. prausnitzii potentially modulates the association between citrus intake and depression.

The gut microbiome modulates the effects of diet on host health, but it remains unclear which specific foods and microbial features interact to influence risk of depression. To understand this interplay, we leveraged decades of dietary and depression data from a longitudinal cohort of women (n = 32,427), along with fecal metagenomics and plasma metabolomics from a substudy (n = 207) nested in this cohort, as well as an independent validation cohort of men (n = 307). We report that citrus intake and its components are prospectively associated with a lower risk of depression and altered abundance of 15 gut microbial species, including enriched Faecalibacterium prausnitzii. In turn, we found a lower abundance of F. prausnitzii and its metabolic pathway, S-adenosyl-L-methionine (SAM) cycle I in participants with depression. To explore causality, we found that lower SAM production by F. prausnitzii may decrease intestinal monoamine oxidase A gene expression implicated in serotonin and dopamine synthesis. These data underscore the role of diet in the prevention of depression and offer a plausible explanation for how the intestinal microbiome modulates the influence of citrus on mental health. Video Abstract.

Reducing Vulnerability to Depression: A Route of Vitamins

This study investigates how vitamin D can lessen a person's vulnerability to depression. Given that depression is one of the most common mental health conditions in the world, it is crucial to comprehend potential preventive factors. According to recent studies, vitamin D may be important for mood management and cognitive performance since it affects the neurotransmitter systems in the brain. The relationship between vitamin D levels and depression proneness is reviewed in this paper, along with the possibility that vitamin D supplementation could lessen depressed symptoms or the chance of developing depression. The results demonstrate vitamin D's potential as an affordable, supplementary method in depression prevention techniques. But more carefully monitored researches are needed to determine optimal dosage and the precise mechanisms involved.

Adherence to the Mediterranean diet and risk of anxiety and depression in people with obesity: a cross-sectional analysis.

Anxiety and depression are common mental disorders worldwide, in particular in people with obesity. Adherence to the Mediterranean diet has been found beneficial for the prevention of anxiety and depression in the general population. We aimed to evaluate this association in a large cohort of people with obesity. A cross-sectional study of 4957 patients with obesity (63.1% women, median age 49 years, IQR 40-58 years and BMI 33.6 kg/m2, IQR 31.6-36.9 kg/m2) was carried out. Clinical history, anthropometric measurements and lifestyle-related information were investigated. A 14-item MEDAS questionnaire was used to assess adherence to the Mediterranean diet. The 20-item STAI2 questionnaire and the 24-item QD questionnaire were used to assess the presence of anxious and depressive symptoms, respectively. Clinical cases of anxiety and depression were identified among patients with a physician-made diagnosis of anxiety and depression or with STAI2 and QD score ≥95th percentiles of reference population. Overall, 11.9% of participants were positive for anxiety and 11% for depression. Multivariate linear regression models showed a decrease in STAI2 and QD scores of 0.18 points (95%CI: -0.33, -0.03) and 0.10 points (95%CI: -0.16, -0.03), respectively, for each 1-point increase in MEDAS score. The multivariate logistic regression model showed a 7% reduction in the odds of anxiety and depression for each 1-point MEDAS increase (OR = 0.93, 95%CI: 0.89, 0.99; OR = 0.93, 95%CI: 0.88, 0.98). Mediterranean diet is associated with a lower risk of anxiety and depression in people with obesity. Longitudinal studies are needed to determine causality.

Magnesium depletion score and depression: a positive correlation among US adults

BackgroundThe Magnesium depletion score (MDS) serves as a novel metric for quantifying magnesium deficiency in the human body, comprehensively assessing four indicators: diuretic use, proton pump inhibitor use, estimated glomerular filtration rate, and alcohol abuse. However, there have been no studies examining the potential association between MDS and depression.MethodsThe study population for this cross-sectional study comprised adults from the National Health and Nutrition Examination Survey database from 2009 to 2018. Participants with a score of 10 or above on the Patient Health Questionnaire-9 were defined as having depression. We employed multivariable logistic regression models to investigate the association between MDS and depression. Furthermore, subgroup analyses were conducted to assess potential differences in this association among populations with diverse characteristics.ResultsA total of 13,197 participants were included in this study. After adjusting for all covariates, a significant positive correlation was observed between MDS and depression. Specifically, for every unit increase in MDS, the likelihood of developing depression increased by 13% (OR = 1.13, 95% CI: 1.04–1.22, p = 0.0025). This positive correlation was consistent across MDS groups, with a 19% increase in depression likelihood in the medium group (OR = 1.19, 95% CI: 1.01–1.41, p = 0.0404) and a 58% increase in the high group (OR = 1.58, 95% CI: 1.21–2.07, p = 0.0007), using the low subgroup as a reference. Subgroup analyses revealed significant differences in the relationship between MDS and depression across races, marital statuses, and hypertension status.ConclusionOur study has uncovered a significant positive association between MDS and depression. Reducing MDS in individuals may play a positive role in both the prevention and treatment of depression.

Effectiveness, efficacy, acceptability, and feasibility of trauma-informed depression, anxiety, and substance use prevention programs for young people aged 12-25 years: A mixed-methods systematic review.

Mental ill-health and substance use bear significant public health burden on young people. Prevention is key. Trauma-informed approaches to prevention of mental ill-health and substance use demonstrate significant promise, yet it is unclear how well existing approaches work for young people targeting mental ill-health and substance use. This review aimed to assess the effectiveness, feasibility, and acceptability of trauma-informed mental ill-health and/or substance use prevention programs for young people. We searched the PsycINFO, CINAHL, Embase, MEDLINE, and Cochrane Library reference databases for peer-reviewed studies of trauma-informed mental ill-health and/or substance use prevention programs for young people published between 2013 and 2022. Studies in any language were included and reference lists of included articles were scanned for additional studies of relevance. In total, 30 studies were included in this review, comprising five randomized controlled trials (RCTs), seven non-RCTs, 10 quasi-experimental designs, and eight qualitative studies. Among the 30 studies, 27 unique trauma-informed prevention interventions were detailed. Eighteen studies reported statistically significant decreases in mental ill-health, and two studies reported significant decreases in substance use outcomes among participants, up to 6 months following the interventions. Most preventative interventions with statistically significant effects were selective (rather than universal or indicated) in their approach (n = 10, 55%). Broad acceptability and feasibility of trauma-informed prevention programs was observed among studies reporting this information though most quantitative studies were at high risk of bias and/or did not include a control group, whilst qualitative studies tended to report research conducted without a priori research aims. This review synthesizes for the first-time evidence on the effectiveness (or efficacy), feasibility, and acceptability of trauma-informed mental ill-health and/or substance use programs for young people, especially for those exposed to traumatic or adverse experiences. While there are promising efficacy outcomes, further research conducting rigorous, well-powered RCTs is required for large-scale evaluation and scaling of the potential preventative benefits of such programs.

Top-funded companies offering digital health interventions for the prevention and treatment of depression: a systematic market analysis

BackgroundDigital innovations can reduce the global burden of depression by facilitating timely and scalable interventions. In recent years, the number of commercial Digital Health Interventions for Depression (DHIDs) has been on the rise. However, there is limited knowledge on their content and underpinning scientific evidence. This study aimed to: (i) identify the top-funded companies offering DHIDs and (ii) provide an overview of their interventions, including scientific evidence, psychotherapeutic approaches and use of novel technologies.MethodsA systematic search was conducted using two venture capital databases to identify the top-30 funded companies offering DHIDs. In addition, studies related to the DHIDs’ were identified via academic databases and hand-searching. The methodological quality of the publications was evaluated using the Mixed Methods Appraisal Tool.ResultsThe top-30 funded companies offering DHIDs received a total funding of 2,592 million USD. Less than half of the companies produced any scientific research associated with their DHIDs, with a total of 83 publications identified. Twenty-five publications were randomised control trials, of which 15 reported moderate-to-large effects in reducing depression symptoms. Regarding novel technologies, few DHIDs incorporated the use of conversational agents or low-burden sensing technologies.ConclusionsFunding received by top-funded companies was not related to the amount of scientific evidence provided on their DHIDs. There was a strong variation in the quantity of evidence produced and an overall need for more rigorous effectiveness trials. Few DHIDs used automated approaches such as conversational agents, limiting their scalability.

Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study

BackgroundGrowing evidence suggests that depression affects gastroesophageal reflux disease (GERD). But, the relationship between depression and GERD is unclear. To examine the relationship between depression and the risk of GERD, as well as the mediating role of risk factors.MethodsWe found genetic variants associated with GERD (N = 78,707) and depression (N = 500,199 (excluding 23 and Me) from the largest genome-wide association study and we applied two-sample Mendelian randomization (MR) to find out if they are related. We further used two-step MR to find the mediating factors.ResultsThe results found a causal link between depression and GERD, inverse-variance weighted (IVW), risk OR 2.149 (95% CI, 1.910 to 2.418; P <0.001). F-statistics for all instrumental variables (IVs) were greater than 10. Multivariate MR maintained the significance of the depression-GERD link even after adjusting for body mass index (BMI), waist-to-hip ratio (WHR), and educational attainment (EA). Mediation analysis revealed that increased depression is associated with lower EA (OR = 0.94; 95% CI, 0.89 to 0.99; P = 0.03), while EA itself significantly impacts GERD risk (OR = 0.25; 95% CI, 0.18 to 0.34; P = 8.24 × 10-9). Ultimately, EA mediates the effect of depression on GERD (OR = 1.09; 95% CI, 1.01 to 1.18; P = 0.04), accounting for 11.4% of the mediated effect.ConclusionsDepression is associated with an increased risk of developing GERD, with some of the effects mediated by EA. This result may provide important information for the prevention and intervention of depression and GERD.

The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release

The role of ventral hippocampus (vHipp) astroglial gliotransmission in depression was studied using chronic restraint stress (CRS) and chronic unpredictable mild stress (CUMS) rodent models. CRS increased Cx43 hemichannel activity and extracellular glutamate levels in the vHipp and blocking astroglial Cx43 hemichannel-dependent gliotransmission during CRS prevented the development of depression and glutamate buildup. Moreover, the acute blockade of Cx43 hemichannels induced antidepressant effects in rats previously subjected to CRS or CUMS. This antidepressant effect was prevented by coinjection of glutamate and D-serine. Furthermore, Cx43 hemichannel blockade decreased postsynaptic NMDAR currents in vHipp slices in a glutamate and D-serine-dependent manner. Notably, chronic microinfusion of glutamate and D-serine, L-serine, or the NMDAR agonist NMDA, into the vHipp induced depressive-like symptoms in nonstressed rats. We also identified a small molecule, cacotheline, which blocks Cx43 hemichannels and its systemic administration induced rapid antidepressant effects, preventing stress-induced increases in astroglial Cx43 hemichannel activity and extracellular glutamate in the vHipp, without sedative or locomotor side effects. In conclusion, chronic stress increases Cx43 hemichannel-dependent release of glutamate and D-/L-serine from astrocytes in the vHipp, overactivating postsynaptic NMDARs and triggering depressive-like symptoms. This study highlights the critical role of astroglial gliotransmitter release in chronic stress-induced depression and suggests it can be used as a target for the prevention and treatment of depression.

Telehealth-delivered depression prevention: Short-term outcomes from a school-based randomized controlled trial.

To examine short-term (i.e., postintervention) outcomes from a randomized controlled trial comparing a school-based telehealth-delivered depression prevention program, Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), to services as usual (SAU). We expected IPT-AST would be acceptable and feasible and that IPT-AST adolescents would experience greater reductions in depression symptoms, anxiety symptoms, and impairment compared with SAU. Adolescents (N = 242; Mage = 14.80 years, SD = 0.70; 65% female; 21% Black; 13% Hispanic/Latinx) with elevated scores on the Center for Epidemiologic Studies Depression Scale (Radloff, 1977) at screening provided data at baseline, 2-month (midpoint of IPT-AST), and 3-month (postintervention) assessments. They reported depression symptoms on the Center for Epidemiologic Studies Depression Scale, anxiety symptoms on the Screen for Child Anxiety Related Emotional Disorders (Birmaher et al., 1997), and impairment on the Columbia Impairment Scale (Bird et al., 1993). Baseline depression diagnosis was examined as a moderator. Hierarchical linear models showed that adolescents reported significant reductions in depression symptoms and impairment across conditions. IPT-AST adolescents reported significantly greater reductions in anxiety symptoms than SAU adolescents, d = .39, 95% CI [.05, .72], p = .003. Depression diagnosis moderated outcomes (ds = .33-.34, ps ≤ .05), such that IPT-AST adolescents without a diagnosis at baseline showed greater improvements in depression and anxiety symptoms than SAU adolescents. Adolescents in SAU with a depression diagnosis at baseline showed greater improvements in impairment compared with IPT-AST. Attendance and satisfaction data demonstrated the feasibility and acceptability of telehealth-delivered IPT-AST. Results support telehealth-delivered IPT-AST as a promising intervention for improving short-term outcomes among adolescents with depression symptoms but without a depression diagnosis. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Prevention of Depression Should Be Integral to Comprehensive Head and Neck Cancer Care

This Viewpoint discusses prophylactic antidepressant use for depression prevention in patients with head and neck cancer and the need to include recommendations for depression prevention in guidelines for these patients.

Understanding Community-Specific Health Behaviors to Prevent Type 2 Diabetes and Depression in Rural Adolescents: A Qualitative Study.

Type 2 diabetes (T2D) and depression co-occur, and rates are on the rise in adolescents, disproportionately affecting teenagers in rural communities and those who identify as members of historically disadvantaged racial/ethnic groups. Addressing the promotion of health behaviors is important for prevention of these comorbid health concerns; however, disparities in their prevalence highlight that a healthy lifestyle is not equally accessible for all individuals. Thus, holistic and multi-level approaches that address structural inequities, leverage cultural and family assets, and are effectively integrated into the community are critically needed. This project is an initial phase of a broader community-academic collaboration that aims to address preventable chronic diseases and mental health in adolescents living in the rural Mountain West by tailoring an evidence-based health behavior and lifestyle intervention for these communities. Interviewers conducted semi-structured interviews with N = 19 individuals (n = 11 adolescents, 11-17years, n = 8 mothers) who lived in neighboring counties in the rural Mountain Western USA and had a family history of T2D. Interview schedules were developed by an interdisciplinary team, with community input, and covered topics such as food and staying active, stress, T2D risk, and community and culture. Using thematic analysis, data were reduced through coding, categorization, and development of themes. Data revealed three major themes: "Families Face Systemic Barriers to Health," "Family Routines Support Health," and "Connection is Crucial to Holistic Health." Findings reveal opportunities for addressing health inequities and developing effective, integrated T2D and depression prevention strategies within this specific community. They also potentially contain insights that may be applicable to others interested in adapting interventions for diverse groups.

EDUCAÇÃO EM SAÚDE E PREVENÇÃO DA DEPRESSÃO PÓS-PARTO: O papel da enfermagem obstétrica

The research addresses the importance of health education and prevention of postpartum depression in the context of obstetric care, highlighting the role of nursing in the care of pregnant and postpartum women. Postpartum depression is a condition that affects many women and can have serious consequences for the mother and the development of the baby. The general objective of the study was to investigate the impact of health education actionscarried out by obstetric nurses in the prevention and management of postpartum depression, focusing on detection strategies, emotional support and educational interventions. The methodology used was a literature review, covering scientific articles published between 2019 and 2024, resulting in 12 articles addressing the role of obstetric nursing in health education and prevention of postpartum depression, in which the inclusion criteria were articles published in Portuguese, and the Inclusion Criterion with the DeCS: Depression. Obstetric Nursing. Health Education. Studies in Portuguese that specifically addressed the role of these professionals in this context were included. The research was conducted through electronic databases such as PubMed, Scopus and VHL, using descriptors related to mental health, childbirth and health education. The results indicate that obstetric nurses play an essential role in raising awareness and supporting women, promoting preventive practices that reduce the incidence of postpartum depression. The implementation of educational and welcoming strategies in the prenatal and postpartum period, associated with continuous emotional support, proved to be effective in improving the mental health of pregnant and postpartum women.

Solutions to Adolescent Depression and Anxiety: A Exercise Based Perspective

As the pace of society continues to accelerate, the frequency of mental fatigue and emotional stress that people feel in their daily lives is becoming more frequent, which has caused the prevalence of depression and anxiety to rise rapidly and has now reached alarming levels. According to the World Health Organization, a staggering 13% of the global adolescent population has been diagnosed with depression and anxiety, a silent epidemic that casts a long shadow over our youth. Based on the above background, this paper first discusses the changing dynamics of the prevalence of depression and anxiety among young people and its negative effects on them. Subsequently, the therapeutic effects of exercise are analyzed in terms of accessibility, affordability, and potential as a complementary or alternative treatment. Finally, this paper gives some suggestions for better prevention of depression and anxiety.

Factors Influencing Depression in People with Disabilities:Individual and Interpersonal Levels

Abstract Depression is an increasingly important social problem, and this also applies to the disabled, a health-vulnerable group. Although the distribution and influencing factors of depression may be different among the disabled population (young adults vs. the elderly, older adults with disabilities vs. disabilities due to old age), only the high prevalence of depression among the disabled is generally reported. This study seeks to determine the distribution and influencing factors of depression in disabled people according to sociodemographic standards. This study employed data from the 2021 Panel Survey on People with Disabilities (National Unit Survey) to investigate the influence of individual-level factors (health behaviors, health level, environment) and interpersonal-level factors (social network) on depression. Multivariate logistic regression analysis was performed while controlling for demographic sociological factors and disability characteristic factors. The experience of depression was among elderly disabled individuals (age 50+: 40.9%) than younger ones (age 19-49: 36.1%), and in disability with aging (49.3%) versus aging with disabilities (39.2%) (P < 0.05). Chronic diseases, daily living assistance, living environment, and emotional support from family and neighbors affected both young and elderly disabled individuals. Specifically, among the elderly disabled, exercise frequency (aOR=0.78; [CI]0.63-0.97), social network size (aOR=0.87; [CI]0.82-0.93), and social interaction frequency (aOR=0.68; [CI]0.51-0.91) were significant. Disability with aging was influenced by exercise frequency (aOR=0.29; [CI]0.09-0.95) and emotional support (aOR=0.37; [CI]0.17-0.77) from peers. older adults with disabilities were affected by not only individual-level factors (exercise frequency) but also both functional (emotional support) and structural (size of social network, frequency of meetings) aspects of their interpersonal social networks. Key messages • Depression experiences among older adults with disabilities are influenced by both functional and structural social networks. • Developing depression prevention strategies for people with disabilities requires a customized approach that takes into account age-specific characteristics.

A preliminary cross-sectional and longitudinal examination of acculturation level as a moderator of perceived school discrimination on depressive symptoms among latinx adolescents

ABSTRACT Introduction In an effort to identify risk factors that are associated with depressive symptoms among Latinx adolescents, the study examined the combined concurrent and longitudinal impact of perceived school discrimination and acculturation. Method This secondary data analysis study utilized data from two waves of the Children of Immigrants Longitudinal Study. Participants were 581 Latinx adolescents [(Mage = 14.27 years. SDage = .86) at wave 1; 57.4% female]. Results More acculturated adolescents who perceived school discrimination endorsed greater depressive symptoms cross-sectionally and longitudinally (p-values < .04). The main effects of discrimination and acculturation were inconsistently associated with depressive symptoms. Conclusions This preliminary investigation supports that assessment, prevention, and intervention of depression among Latinx adolescents may benefit from taking into account the role of high acculturation on adolescents who have felt discriminated in their schools.

Conflict and Intimacy in Emerging Adults’ Romantic Relationships and Depressive Symptoms: The Mediating Role of Identity and Couple Satisfaction

Romantic relationships in emerging adulthood may be associated with depression, but the role of possible mediators of this relationship remains to be explored. The present study tested a serial mediation model where intimacy and conflict in romantic relationships were predictors of depressive symptoms through the mediation of couple satisfaction and identity satisfaction. The study was conducted on a sample of 268 Italian emerging adults, 60% female (Mage = 19, ds = 1.4), all involved in a heterosexual romantic relationship. The results showed that the association between intimacy and depressive symptoms was direct and sequentially mediated through couple satisfaction and identity satisfaction. A single mediation pathway through identity satisfaction alone also emerged. The association between conflict and depressive symptoms was direct and sequentially mediated through couple satisfaction and identity satisfaction. These findings suggest the importance of helping emerging adults develop appropriate skills in managing conflict and intimacy in romantic relationships as useful resources for identity satisfaction and depression prevention.

The Potential Role of Polyphenol Supplementation in Preventing and Managing Depression: A Review of Current Research

Depression is a common mental illness that affects 5% of the adult population globally. The most common symptoms of depression are low mood, lack of pleasure from different activities, poor concentration, and reduced energy levels for an extended period, and it affects the emotions, behaviors, and overall well-being of an individual. The complex pathophysiology of depression presents challenges for current therapeutic options involving a biopsychosocial treatment plan. These treatments may have a delayed onset, low remission and response rates, and undesirable side effects. Researchers in nutrition and food science are increasingly addressing depression, which is a significant public health concern due to the association of depression with the increased incidence of cardiovascular diseases and premature mortality. Polyphenols present in our diet may significantly impact the prevention and treatment of depression. The primary mechanisms include reducing inflammation and oxidative stress, regulating monoamine neurotransmitter levels, and modulating the microbiota–gut–brain axis and hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. This review summarizes recent advances in understanding the effects of dietary polyphenols on depression and explores the underlying mechanisms of these effects for the benefit of human health. It also highlights studies that are looking at clinical trials to help future researchers incorporate these substances into functional diets, nutritional supplements, or adjunctive therapy to prevent and treat depression.

Supplemental Material for Telehealth-Delivered Depression Prevention: Short-Term Outcomes From a School-Based Randomized Controlled Trial

Supplemental Material for Telehealth-Delivered Depression Prevention: Short-Term Outcomes From a School-Based Randomized Controlled Trial

Periconceptional omega-6 and omega-3 polyunsaturated fatty acid intake plane and postpartum depression: a nationwide birth cohort-the Japan Environment and Children's Study.

Intake of omega-3 polyunsaturated fatty acids (PUFAs) has favorable effects on the prevention of postpartum depression, but fish, the principal source of omega-3 PUFAs, are becoming a depleted resource. We therefore examined whether lower periconceptional intake of omega-6 PUFAs, whose metabolic pathways are antagonistic to those of omega-3 PUFAs, is associated with lower prevalence of postpartum depression while simultaneously considering omega-3 PUFA intake. The participants were 92,595 mothers involved in the ongoing Japan Environment and Children's Study. Periconceptional intakes of omega-6 and -3 PUFA were measured using a food frequency questionnaire. Postpartum depression was assessed using the Edinburgh Postnatal Depression Scale. Generalized additive mixed model analysis was used to draw contour plots of postpartum depression on a plane with omega-6 and omega-3 PUFA intakes on the x- and y-axes, respectively. The adjusted prevalence ranged from 11.0% to 26.3% within the respective 1st to 99th percentile intake ranges and monotonously decreased with decreasing omega-6 PUFA intake. In contrast, the prevalence decreased with increasing omega-3 PUFA intake, but the trend almost disappeared above 2 g/day. Our results highlight the potential importance of focusing on omega-6 PUFAs as well as omega-3 PUFAs prior to conception to reduce postpartum depression.

Association of sugar consumption with risk of depression and anxiety: a systematic review and meta-analysis.

Sugar consumption has increased dramatically around the world, and at the same time, the prevalence of mental illnesses such as depression and anxiety continues to increase. While previous research has explored the impact of various dietary factors on mental health, the specific impact of dietary sugar consumption on the risk of depression and anxiety disorders remains elusive. This study aimed to comprehensively assess this relationship through a systematic review and meta-analysis. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Network (CNKI), and WangFang were systematically searched for studies of the association between total dietary sugar intake and risk of depression and/or anxiety. The articles that meet the criteria are screened and included in the systematic review, and the data are extracted after assessing their quality. Stata 18.0 software was used for the meta-analysis. Forty studies with 1,212,107 participants were included in the analysis. Results showed that sugar intake increased the risk of depression by 21% (OR = 1.21, 95% CI: 1.14, 1.27), while the overall association between sugar intake and anxiety risk was not statistically significant (OR = 1.11, 95% CI: 0.93, 1.28). Despite high heterogeneity (I 2 = 99.7%), the results were statistically significant (p < 0.000). Subgroup analyses showed that the association between sugar consumption and depression risk remains consistent across different study designs (cross-sectional, cohort, and case-control studies) and different sample sizes (<5,000, 5,000-10,000, >10,000). Women have a higher risk of depression than men (OR = 1.19, 95% CI: 1.04, 1.35). Among the different exposure measures, the Food Frequency Questionnaire (FFQ) showed the most significant effect (OR = 1.32, 95% CI: 1.08, 1.67, I 2 = 99.7%, p < 0.000). The measuring tool of subgroup analysis showed that there was a significant correlation between sugar intake and risk of depression, PHQ-9 (OR = 1.29, 95% CI: 1.17, 1.42, I2 = 86.5%, p < 0.000), and CES-D (OR = 1.28, 95% CI: 1.14, 1.44, I 2 = 71.3%, p < 0.000). High-quality cross-sectional and cohort studies showed a significant association between sugar intake and depression risk, with most results being robust. While the overall analysis of sugar intake and anxiety risk was not significant, some subgroups approached significance, particularly in studies with a sample size of <5,000 (OR = 1.14, 95% CI: 0.89, 1.46) and studies using the FFQ questionnaire (OR = 1.31, 95% CI: 0.90, 1.89). Total dietary sugar consumption was significantly associated with increased risk of depression in the general population, whereas the association with risk of anxiety was not significant. Further high-quality studies are needed to verify these associations and ensure their reliability. This study highlights the impact of dietary sugar intake on mental health, identifies potentially high-risk groups through subgroup analysis, and provides new insights into the prevention of depression and anxiety. CRD42024540548.