Prevalence Of Uremic Pruritus Research Articles

Inflammatory bio-marker changes in hemodialysis patients with pruritus receiving violet oil: A randomized controlled trial

IntroductionRecently, the role of inflammatory bio-markers in uremic pruritus (UP) has been taken into consideration. UP pathophysiology is not completely understood. The prevalence of UP has been reported from 42% to 90% worldwide and at 41.4% and 48.3% in Iran. Violet oil is an herbal remedy with anti-irritant and anti-inflammatory effects. This study aimed to evaluate the effect of violet oil and massage on the inflammatory bio-markers in UP. MethodsThis study was conducted from January to March 2019 on 44 Hemodialysis (HD) patients with UP at Montaserieh, 17 Shahrivar, and Shafa-toos HD Centers of Mashhad University of Medical Sciences in Mashhad, Iran. Patients were categorized randomly into two groups. The intervention included massages with and without violet oil (Viola odorata) for two weeks on the healthy hand, which did not have a fistula. Blood sampling and Visual Analog Scale (VAS) forms completion were performed pre and post-intervention. FindingsThere were no significant differences in serum biomarkers and the severity of pruritus and skin dryness within and between two groups before the intervention (p > 0.05 for all), but at the end of the intervention, significant differences were detected in the severity of pruritus and skin dryness within and between two groups (p < 0.001) with no significant differences in the serum level of inflammatory bio-markers (p > 0.05 for all). ConclusionThe results showed that massage with violet oil is more effective than massage without it.

Prevalence of Uremic Pruritus, Its Risk Factors and Impact on Health-Related Quality-Of-Life in Patients on Maintenance Hemodialysis

Prevalence of Uremic Pruritus, Its Risk Factors and Impact on Health-Related Quality-Of-Life in Patients on Maintenance Hemodialysis

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

Prevalence of uremic pruritus in chronic kidney patients undergoing maintenance hemodialysis at Kathmandu Medical College Teaching Hospital

Background: Uremic pruritus is a common and troublesome symptom of chronic kidney disease. It is one of the dominant dermatological manifestations of chronic kidney disease which affects the quality of life of patients.Objective: To assess the prevalence and severity of uremic pruritus in chronic kidney disease patients undergoing maintenance hemodialysis.Methodology: A prospective cross-sectional study was done over three months among chronic kidney patients undergoing maintenance hemodialysis to show the association of mineral bone disorders with uremic pruritus. Patients complaining of pruritus were taken as cases and then pruritus was quantified using a Visual Analogue Scale.Results: 144 patients participated in this study, out of which 41 (28.47%) were females. Mean age was 54.97±9.75 years and 68.06% patients were on dialysis. Uremic pruritus was seen in 80 patients (55.56%), amongst them 23 patients (28.75 %) had severe pruritus as measured by Visual Analogue Scale. Uremic pruritus was more frequent and more severe in patients having higher serum phosphorus levels (p =0.004).Conclusion: This study further substantiates the need of adequate control of phosphorus levels in hemodialysis patients to reduce complications like uremic pruritus.Journal of Kathmandu Medical College, Vol. 5, No. 4, Issue 18, Oct.-Dec., 2016, Page: 124-127

Factors associated with uremic pruritus

Background: The etiopathogenesis of uremic pruritus (UP) is multifactorial aspect, and it is thus necessary to elucidate its associated factors to develop efficient therapeutics approaches. This study aimed to verify the prevalence of UP and its associated factors.&#x0D; Methods and Findings: Prospective and cross-sectional study with patients undergoing hemodialysis at a university public hospital. The data were obtained between April 2014 and April 2015. The statistical analysis was carried out using multivariate regression models, and statistical significance was set at p&lt;0.05. A total of 164 patients were included, and pruritus was reported in 64 (39%). In the multivariate analysis, a higher creatinine level was risk factor for pruritus (β=1.09, 95% CI 1.00-1.19; p=0.048), as was a lower level of hemoglobin (β=0.85, 95% CI 0.73-0.99; p=0.043). Dyslipidemia (β=1.52, 95% CI 0.12-2.91; p=0.03), obesity (β=2.40, 95% CI 1.03-3.78; p=0.001), higher levels of C-reactive protein (β=0.26, 95% CI 0.19-0.34; p&lt;0.001) and black race (β=1.49, 95% CI -2.57 and 0.42; p&lt;0.006) were associated with a greater intensity of pruritus. The use of a high-flux dialyzer was associated with a lower intensity of pruritus (β=-1.69, 95% CI -3.05-0.34; p=0.01).&#x0D; Conclusion: Uremic pruritus has a high prevalence in hemodialysis patients, and the data suggest that the higher the creatinine and the lower the hemoglobin levels are, the greater the risk of developing pruritus is. Dyslipidemia, obesity, and higher levels of C-reactive protein were associated with a greater intensity of pruritus, whereas the use of a high-flux dialyzer was associated with lower pruritus intensity.

Uremic pruritus

Uremic pruritus

Uremic Pruritus

Renal itch is a localized or generalized itch, affecting patients with Chronic Renal Failure, where there is no primary skin disease and no systemic or psychological dysfunction that might cause pruritus. Uremic pruritus (UP) is an unpleasant sensation, rarely appearing in earlier stages of chronic kidney disease. Renal transplantation is the definite solution for that problem. The prevalence of UP has been reduced during the last years, possibly, due to a more efficient dialysis, with more biocompatible filters. During the last decades a big number of substances were considered to be etiologic factors of UP, and an even bigger number of therapeutic substances appeared with promising potentials and conflicting results in the course of their use. The main reason for this disorientation is the lack of sound evidence on the pathogenetic mechanisms that may potentiate UP. 'Inflammatory' and 'opioid' hypothesis are the best studied and the reduction of UP is a fact. Nevertheless the mechanisms of the pathogenesis of UP are still under investigation and a long way has to be done in order to achieve more definite results.