Prevalence Of Several Risk Factors Research Articles

The Prevalence of Risk Factors Among Children Diagnosed With Attention-Deficit/Hyperactivity Disorder, Aged 4-17 Years: A Cross-Sectional Study.

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder commonly observed in children. Although the etiology of ADHD is still unclear, many risk factors have been shown to increase the prevalence of ADHD, such as genetics, environmental factors, socioeconomic status, maternal smoking, and low birth weight. The current cross-sectionalstudy aimed to assess the prevalence of several risk factors associated with ADHD-diagnosed children aged 4-17 years using parent-reported data. An observational cross-section study was conducted between December 2022 and February 2023 using a self-constructed questionnaire that we sent to parents whose children were diagnosed with ADHD. The questionnaire included socioeconomic information (income, gender, parent education, number of children), child information (age, ADHD type, academic achievement), pregnancy and neonatal period (smoking status, gestation age, mode of delivery, child weight), and if there is a history of ADHD in the family. A total of 306 parents responded to the questionnaire. The majority of our study population was males (77.8%). The combined type, which includes symptoms of both hyperactivity and inattention, represented 70% of the population in our study, which is higher than the inattention type (23%) and the hyperactivity type (6%). The prevalence of several risk factors known to be associated with ADHD, such as family income, parental education, complications during pregnancy, and the low birth weight of the child, were also reported. To the best of our knowledge, this is the first study that examines the frequency of risk factors among children diagnosed with ADHD in Saudi Arabia. The study revealed that males are more likely to be diagnosed with ADHD than females. We also found that the combined type is the most diagnosed ADHD among children. Furthermore, there are no significant differences in the prevalence of the risk factors during the gestational or neonatal period among ADHD-diagnosed children. Therefore, a large-scale prospective study is needed to aid in evaluating the frequency and significance of various risk factors among diagnosed children.

Prevalence, incidence and relative risk of cardiovascular disease risk factors in adults with atopic dermatitis: A systematic review

AbstractAtopic dermatitis (AD) has been associated with cardiovascular disease (CVD). A better understanding of CVD risk factors in AD populations may help dermatologists better counsel their patients regarding potential risks and treatment choices. This systematic literature review evaluated the prevalence, absolute risk (i.e., incidence) and relative risk of CVD risk factors in adults with AD. MEDLINE, Embase and The Cochrane Library were searched for English‐language articles published between January 2005 and the search date (16–17 March 2021) using terms for AD, prevalence/risk and CVD risk factors. Observational studies that reported the prevalence, absolute risk and/or relative risk of CVD risk factors in adults with AD were eligible. Of the 1277 unique articles identified, 71 met the inclusion criteria. Most studies were cross‐sectional or retrospective cohort studies from Europe, North America or Asia; many used national databases. Studies were heterogeneous, with inconsistent definitions of AD and risk factors (especially smoking and obesity), different methodologies and different populations (e.g., ethnicity). Within most controlled studies, the prevalence of several risk factors, particularly obesity, hypertension and dyslipidemia, was higher for AD than for controls. Where assessed, the prevalence of most CVD risk factors increased with increasing AD severity. Relative risks varied across studies. Only nine studies reported the temporal relationship between AD and CVD risk factors. Six studies reported absolute or relative risk of developing CVD risk factors (diabetes, hypertension and smoking) in AD populations; only one of these reported an elevated risk (hypertension). Despite the high number of studies to date, conclusive data regarding the relationship between AD and many CVD risk factors are lacking, and additional, carefully designed, prospective studies are required. Video content can be heard at https://onlinelibrary.wiley.com/doi/10.1002/jvc2.87none

Abstract 38: Racial disparities in prostate cancer mortality rates explained by differences in dietary and lifestyle factors

Abstract Introduction: Black men have 2.1 times higher prostate cancer mortality rates than White men in the United States, yet the reasons for this disparity remain unclear. Several dietary and lifestyle factors may influence the risk of developing lethal prostate cancer. This study evaluated to what extent differences in the prevalence of modifiable risk factors by race could explain racial disparities in prostate cancer mortality. Methods: Our study utilized data from the Health Professionals Follow-up Study (HPFS, N=51,529 men, 1986-2016) and the National Health and Nutrition Examination Study (NHANES, 2000-2010). First, we used data from NHANES to estimate the prevalence of three factors among Black and White men: smoking, vitamin D, and coffee. Then, using HPFS, we generated relative risk estimates for lethal prostate cancer for each factor. To estimate the relative prostate cancer burden associated with these risk factors, we calculated the population attributable fraction (PAF) for each factor by self-identified race, defined as the reduction in mortality that would be achieved if the population had been entirely unexposed, compared with the current exposure pattern. We then calculated the difference in the PAF between Black and white men to estimate the difference in mortality reduction between the two groups if all men had been entirely unexposed, assuming causality of risk factors and no effect modification by race. Results: There were notable differences in the prevalence of several risk factors by race. For example, Black men had significantly lower levels of vitamin D[MLA1], were less likely to drink coffee, and had a higher prevalence of smoking compared to white men. We estimated that eliminating these risk factors among Black men could lead to a reduction in prostate cancer mortality that is 4-14% larger compared to eliminating these risk factors among white men. Conclusions: Modifiable lifestyle and dietary factors are potentially responsible for a proportion of the racial disparity in prostate cancer mortality. Our future work will expand the modifiable factors as well as incorporating more contemporary comparisons of the prevalence of these factors to predict future disparities in prostate cancer. Citation Format: Emily Rencsok, Michelle Sodipo, Travis Gerke, Konrad Stopsack, Lorelei Mucci. Racial disparities in prostate cancer mortality rates explained by differences in dietary and lifestyle factors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 38.

Changes in prevalence of violence and risk factors for violence and HIV among children and young people in Kenya: a comparison of the 2010 and 2019 Kenya Violence Against Children and Youth Surveys

Previous research has shown a high prevalence of violence among young people in Kenya. Violence is a known risk factor for HIV acquisition and these two public health issues could be viewed as a syndemic. In 2010, Kenya became the third country to implement the Violence Against Children and Youth Survey (VACS). The study found a high prevalence of violence in the country. Led by the Government of Kenya, stakeholders implemented several prevention and response strategies to reduce violence. In 2019, Kenya implemented a second VACS. This study examines the changes in violence and risk factors for violence and HIV between 2010 and 2019. The 2010 and 2019 VACS used a similar sampling approach and measures. Both VACS were cross-sectional national household surveys of young people aged 13-24 years, designed to produce national estimates of physical, sexual, and emotional violence. Prevalence and changes in lifetime experiences of violence and risk factors for violence and HIV were estimated. The VACS uses a three-stage cluster sampling approach with random selection of enumeration areas as the first stage, households as the second stage, and an eligible participant from the selected household as the third stage. The VACS questionnaire contains sections on demographics, risk and protective factors, violence victimisation, violence perpetration, sexual behaviour, HIV testing and services, violence service knowledge and uptake, and health outcomes. For this study, the main outcome variables were violence victimisation, context of violence, and risk factors for violence. All analyses were done with the entire sample of 13-24-year-olds stratified by sex and survey year. The prevalence of lifetime sexual, physical, and emotional violence significantly declined in 2019 compared with 2010, including unwanted sexual touching, for both females and males. Experience of pressured and forced sex among females also decreased between the surveys. Additionally, significantly more females sought and received services for sexual violence and significantly more males knew of a place to seek help in 2019 than in 2010. The prevalence of several risk factors for violence and HIV also declined, including infrequent condom use, endorsement of inequitable gender norms, endorsement of norms justifying wife beating, and never testing for HIV. Kenya observed significant declines in the prevalence of lifetime violence and some risk factors for violence and HIV, and improvements in some service seeking indicators between 2010 and 2019. Continued prioritisation of preventing and responding to violence in Kenya could contribute to further reductions in violence and its negative outcomes. Other countries in the region that have made substantial investments and implemented similar violence prevention programmes could use repeat VACS data to monitor violence and related outcomes over time. None.

Decline in Violence Among Children and Youth in Kenya — Comparison of 2010 and 2019 Kenya Violence Against Children and Youth Surveys

Background: In 2010, Kenya became the third country to implement the Violence Against Children and Youth Survey (VACS). The study found high prevalence of violence in the country. Led by the Government of Kenya, stakeholders implemented several prevention and response strategies to reduce violence. In 2019, Kenya implemented a second VACS. This study examined changes in violence and risk factors for violence between 2010 and 2019. Methods: The 2010 and 2019 VACS used a similar sampling approach and measures. Both were national household surveys of persons aged 13–24 years. Prevalence and changes in lifetime experiences of violence and risk factors for violence were estimated. Findings: The prevalence of lifetime sexual, physical, and emotional violence significantly declined in 2019 compared to 2010 for both females and males. Additionally, significantly more female survivors sought and received services for sexual violence and significantly more males knew of a place to seek help in 2019 than in 2010. Prevalence of several risk factors for violence also declined. For example, fewer females endorsed at least one inequitable gender norm and fewer males endorsed at least one inequitable gender norms and norms endorsing wife beating in 2019 compared to 2010. Interpretation: Kenya observed significant declines in the prevalence of lifetime violence victimization and some risk factors for violence between 2010 and 2019. Although low, some service seeking and receipt indicators also improved between 2010 and 2019. Prioritizing services and their uptake among survivors of childhood violence in Kenya will be important. Funding: The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the US Centers for Disease Control and Prevention (CDC) under the terms of cooperative agreements #5NU2GGH001520 and #1U2GGH001619. Declaration of Interest: The authors have no declared conflicts of interest. Ethical Approval: Protocol reviewed and approved by the Ethical Review Committee (ERC) of the Kenya Medical Research Institute and by the CDC Institutional Review Board (IRB).

HIV incidence in a multinational cohort of men and transgender women who have sex with men in sub-Saharan Africa: Findings from HPTN 075.

Few studies have assessed HIV incidence in men who have sex with men (MSM) and transgender women (TGW) in sub-Saharan Africa (SSA). We assessed HIV incidence and its correlates among MSM and TGW in SSA enrolled in the prospective, multi-country HIV Prevention Trials Network (HPTN) 075 study, conducted from 2015 to 2017. Participants were enrolled at four sites in SSA (Kisumu, Kenya; Blantyre, Malawi; Cape Town and Soweto, South Africa). Eligible participants reported male sex assignment at birth, were 18 to 44 years of age, and had engaged in anal intercourse with a man in the preceding three months. Participation involved five study visits over 12 months. Visits included behavioral assessments and testing for HIV and sexually transmitted infections. Twenty-one of 329 persons acquired HIV during the study [incidence rate: 6.96/100 person-years (PY) (95% CI: 4.3, 10.6)]. Among TGW, HIV incidence was estimated to be 8.4/100 PY (95% CI: 2.3, 21.5). Four participants were found to have acute HIV infection at their first HIV-positive visit. HIV incidence varied among the four study sites, ranging from 1.3/100 PY to 14.4/100 PY. In multivariate longitudinal analysis, factors significantly associated with HIV acquisition were engagement in unprotected receptive anal intercourse [adjusted hazard ratio (AHR) 5.8, 95% confidence interval (CI): 2.4, 14.4] and incident rectal gonorrhea and/or chlamydia (AHR: 2.7, 95% CI: 1.1, 6.8). The higher HIV incidence in Cape Town compared to Blantyre could be explained by the higher prevalence of several risk factors for HIV infection among participants in Cape Town. Annual HIV incidence observed in this study is substantially higher than reported HIV incidence in the general populations in the respective countries and among MSM in the United States. Intensification of HIV prevention efforts for MSM and TGW in SSA is urgently needed.

Abstract WP236: The Urban-Rural Divide: Risk Factor Prevalence in Ischemic Stroke Patients Across Two Decades

Introduction: Regional disparities exist in stroke incidence and stroke related mortality in the United States. We aimed to elucidate the stroke risk factor prevalence trends based on urban versus rural location. Methods: From the National Inpatient Sample database the comorbid stroke risk factors were collected among hospitalized ischemic stroke patients during 2000-2016. Crude and age-and sex-standardized prevalence estimates were calculated for each risk factor during the time periods 2000-2008 and 2009-2016. We compared risk factor prevalence over the defined time periods using regression models, and differences in risk factor trends based on patient location categorized as urban (metropolitan with population of ≥ 1 million) and rural (neither micropolitan or metropolitan) using interaction terms in the regression models. Results: Stroke risk factor prevalence significantly increased from 2000-2008 to 2009-2016. When stratified based on patient location, most risk factors increased in both urban and rural groups. In the crude model, the urban to rural trend difference across 2000-08 and 2009-16 was significant in hypertension (p<0.0001), hyperlipidemia (p=0.0008), diabetes mellitus (p<0.0001), coronary artery disease (p<0.0001), smoking (p<0.0001) and alcohol (p=0.02). With age and sex standardization, the urban to rural trend difference was significant in hypertension (p<0.0001), hyperlipidemia (p=0.0007), coronary artery disease (p=0.01) and smoking (p<0.0001). Conclusion: The prevalence of vascular risk factors among ischemic stroke patients has increased over the last two decades. There exists an urban-rural divide, with rural patients showing larger increases in prevalence of several risk factors compared to urban patients.

Atrial Fibrillation/flutter Hospitalizations among US Medicaid Recipients with and without Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a multisystem chronic inflammatory autoimmune disease with high prevalence of several risk factors for atrial fibrillation/flutter (AF). However, the incidence and risk of AF in SLE have not been well quantified. We used the United States Medicaid Analytic eXtract from 2007 to 2010 to identify beneficiaries aged 18-65 years, with prevalent SLE, each matched by age and sex to 4 non-SLE general Medicaid recipients. We estimated the incidence rates (IR) per 1000 person-years (PY) for AF hospitalizations and used multivariable Cox regression to estimate the HR for AF hospitalization. We identified 46,876 US Medicaid recipients with SLE, and 187,504 age- and sex-matched non-SLE controls (93% female; mean age 41.5 ± 12.2 yrs). Known AF risk factors such as hypertension (HTN), cardiovascular disease (CVD), and kidney disease were more prevalent in patients with SLE. During a mean followup of 1.9 ± 1.1 years for SLE, and 1.8 ± 1.1 years for controls, the IR per 1000 PY for AF was 1.4 (95% CI 1.1-1.6) among patients with SLE and 0.7 (95% CI 0.6-0.8) among non-SLE controls. In age- and sex-matched and race-adjusted Cox models, the HR for AF was 1.79 (95% CI 1.43-2.24); after adjustment for baseline HTN and CVD, the adjusted HR was reduced to 1.17 (95% CI 0.92-1.48). SLE was associated with a doubled rate of hospitalization for AF compared to age- and sex-matched general Medicaid patients. In a race-adjusted model, the risk was 80% higher. However, the AF risk factors HTN and CVD were more prevalent among patients with SLE and accounted for the excess risk.

Influence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry

Objective: We assessed the association between pre-stroke cognitive status and 90-day case-fatality. Methods: Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Association between pre-stroke cognitive status and case-fatality at 90 days was evaluated using Cox regression. Results: Seven hundred sixty-two patients were identified, and information about pre-stroke cognitive status was obtained for 716 (92.6%) of them, including 603 IS (84.2%) and 113 ICH (15.8%). Before stroke, 99 (13.8%) patients had mild cognitive impairment (MCI) and 98 (13.7%) had dementia. Patients with cognitive impairment were older, had a higher prevalence of several risk factors, more severe stroke, more frequent ICH, and less admission to stroke unit. Case-fatality rate at 90 days was 11.7% in patients without cognitive impairment, 32.3% in MCI patients, and 55.1% in patients with dementia. In multivariable analyses, pre-existing MCI (hazard ratio [HR] 2.22, 95% CI 1.21–4.05, p = 0.009) and dementia (HR 4.35, 95% CI 2.49–7.61, p < 0.001) were both associated with 90-day case-fatality. Conclusion: Pre-stroke MCI and dementia were both associated with increased mortality. These associations were not fully explained by baseline characteristics, pre-stroke dependency, stroke severity or patient management, and underlying reasons need to be investigated.

Differences in risk factors for binge eating by socioeconomic status in a community-based sample of adolescents: Findings from Project EAT.

Binge eating is prevalent across socioeconomic status (SES) groups, but it is unclear whether risk factors for binge eating vary by SES. This study examined the prevalence of several risk factors for binge eating by SES and SES as a potential moderator of these risk factors. Participants included 2,179 individuals involved in Project EAT during early/middle adolescence (EAT-I) and 5 years later during late adolescence/emerging adulthood (EAT-II). Risk ratios were computed using modified Poisson regression of incident EAT-II binge eating on EAT-I risk factors among participants of high and low SES. Interactions between each risk factor and SES were tested. Among higher SES adolescents, overweight/obesity (RR = 3.2; 95% CI: 1.8, 5.7), body dissatisfaction (RR = 2.6; 95% confidence intervals (CI): 1.2, 5.5), dieting (RR = 4.0; 95% CI: 2.0, 8.2), and family weight-teasing (RR = 2.3; 95% CI: 1.3, 4.3) predicted increased risk for binge eating. Among adolescents from low-SES backgrounds, overweight/obesity (RR = 1.5; 95% CI: 0.9, 2.5), dieting (RR = 2.2; 95% CI: 1.2, 3.9), and food insecurity (RR = 1.4; 95% CI: 0.7, 2.7) predicted increased risk for binge eating. Moderator analyses revealed that overweight/obesity, body dissatisfaction, dieting, and family weight-teasing were stronger risk factors in the high-SES group than the low-SES group; interactions with food insecurity could not be examined given the low prevalence of food insecurity in the high-SES group. Risk factors for binge eating may vary by SES, suggesting the potential utility of modifying intervention and prevention methods based on SES. In particular, the role of food insecurity must be addressed.

A cross-sectional survey of Indians in Kuwait with risk factors for coronary artery disease

Background: The Indian sub-population is the biggest among the foreigners in Kuwait. Due to the harsh weather conditions most of the time in the year there is less inclination towards a healthy lifestyle. The present study was conducted to determine the extent of the Indian population living in Kuwait having the risk factors for coronary artery disease (CAD).Methods: A cross-sectional survey was conducted including 400 subjects aged 18 years or more (346 males and 54 females). They were subjected to general physical examination, and were asked to respond to a standard questionnaire.Results: Significantly more females than males were found to be overweight (63% vs. 43.9%, p&lt;0.01) or obese (16.7% vs. 4.3%, p&lt;0.005). Females also had higher proportions than males in having inadequate physical activity (79.6% vs. 53.2%, p&lt;0.001). Significantly more males were having an inadequate intake of fruits and vegetables as compared to females (34.7% vs. 18.5%, p&lt;0.005). There was no significant difference between the genders in proportions of hypertension, smoking, and diabetes. Overweight, hypertension, and inadequate physical activity showed a rising trend with increasing age. The studied population was compared with several geographically different populations, as well as the different populations living in India.Conclusions: As the stay and the jobs of Indians in Kuwait depend upon their health-status, prevention of CAD is of paramount importance. Looking at the levels of the prevalence of several risk factors, multilevel interventions are needed for reducing the CAD-morbidity and mortality.

Population Risk of Ischemic Heart Disease Depending on the Volume of Alcohol Consumption by the Population (ЭССЕ-РФ Study in the Kemerovo Region)

to assess relationship between the prevalence of cardiovascular risk factors and associated population risk of ischemic heart disease (IHD) alcohol consumption in the Siberian region (Kemerovo Region). This work was carried out within the framework of a multicenter epidemiological study "Epidemiology of CardioVascular Diseases in the regions of the Russian Federation" (ЭССЕ-РФ in the Kemerovo region) in 2013. In the final form, the sample size was 1628 individuals aged 25-64 years. We analyzed data on frequency, volume, and type of consumed alcoholic beverages, as well as on the presence of a number of risk factors of cardiovascular diseases and IHD. Alcohol consumption was estimated by the original method, volume of alcohol consumed in a year was categorized as absent (non-drinkers), moderate, medium, and strong. The calculation of the population risk of IHD was carried out according to the author's methodology, taking into account the prevalence of risk factors and their contribution to the development of IHD. Prevalence of several risk factors among non-drinkers was significantly different (p&lt;0.05) compared with drinkers with varying degrees of alcohol consumption. In men, there were differences in low physical activity, hypertriglyceridemia, excess weight, education, in women - in anxiety, low physical activity, hypertriglyceridemia, educational qualifications, smoking. In nondrinking men, the additional risk of IHD associated with risk factors was slightly reduced (-1.1 %). In groups of moderate, moderate, and strong alcohol consumption, risk of IHD was higher than the population risk by 2.2 %, 0.7 % and 6.5 %, respectively. In non-drinking women high burden of risk factors accounted for additional risk of IHD (4.5 %). In women with moderate and medium alcohol consumption the risk of IHD was 2.5 and 1.9 %, respectively, lower compared with population risk. Abuse of alcohol in women caused significant increase in the burden of risk factors and, accordingly, was associated with high additional risk of IHD (18.7 %). Predominantly linear in men and J-shaped in women relationship between prevalence of risk factors and volume of alcohol consumption accounted for analogous tendencies in population IHD risk. Specific for men is close to linear dependence of additional IHD risk on population IHD risk with insignificant variability in non-drinkers, moderate and medial consumers, and with significant growth in alcohol abusers. Women have a J-shaped relationship: in extreme categories (non-drinkiers and alcohol abusers), the risk of IHD is higher than the population risk, while in the middle categories (moderate and medial consumers) it is lower than the population risk.

Trend in prevalence of coronary artery disease and risk factors over two decades in rural Punjab

ObjectivesThe burden of coronary artery disease (CAD) has increased in the last three decades in low-income and middle-income countries including India. CAD is responsible for 20% deaths in India. The...

Trends in Prehypertension and Hypertension Risk Factors in US Adults: 1999-2012.

Prehypertension is associated with increased risk for hypertension and cardiovascular disease. Data are limited on the temporal changes in the prevalence of prehypertension and risk factors for hypertension and cardiovascular disease among US adults with prehypertension. We analyzed data from 30 958 US adults ≥20 years of age who participated in the National Health and Nutrition Examination Surveys between 1999 and 2012. Using the mean of 3 blood pressure (BP) measurements from a study examination, prehypertension was defined as systolic BP of 120 to 139 mm Hg and diastolic BP <90 mm Hg or diastolic BP of 80 to 89 mm Hg and systolic BP <140 mm Hg among participants not taking antihypertensive medication. Between 1999-2000 and 2011-2012, the percentage of US adults with prehypertension decreased from 31.2% to 28.2% (P trend=0.007). During this time period, the prevalence of several risk factors for cardiovascular disease and incident hypertension increased among US adults with prehypertension, including prediabetes (9.6% to 21.6%), diabetes mellitus (6.0% to 8.5%), overweight (33.5% to 37.3%), and obesity (30.6% to 35.2%). There was a nonstatistically significant increase in no weekly leisure-time physical activity (40.0% to 43.9%). Also, the prevalence of adhering to the Dietary Approaches to Stop Hypertension eating pattern decreased (18.4% to 11.9%). In contrast, there was a nonstatistically significant decline in current smoking (25.9% to 23.2%). In conclusion, the prevalence of prehypertension has decreased modestly since 1999-2000. Population-level approaches directed at adults with prehypertension are needed to improve risk factors to prevent hypertension and cardiovascular disease.

The Interaction between Genetic Ancestry and Breast Cancer Risk Factors among Hispanic Women: The Breast Cancer Health Disparities Study.

Background: Hispanic women have lower breast cancer incidence rates than non-Hispanic white (NHW) women. To what extent genetic versus nongenetic factors account for this difference is unknown.Methods: Using logistic regression, we evaluated the interactive influences of established risk factors and ethnicity (self-identified and identified by ancestral informative markers) on breast cancer risk among 2,326 Hispanic and 1,854 NHW postmenopausal women from the United States and Mexico in the Breast Cancer Health Disparities Study.Results: The inverse association between the percentage of Native American (NA) ancestry and breast cancer risk was only slightly attenuated after adjusting for known risk factors [lowest versus highest quartile: odds ratio (OR) =1.39, 95% confidence interval (CI) = 1.00-1.92 among U.S. Hispanics; OR = 1.92 (95% CI, 1.29-2.86) among Mexican women]. The prevalence of several risk factors, as well as the associations with certain factors and breast cancer risk, differed according to genetic admixture. For example, higher body mass index (BMI) was associated with reduced risk among women with lower NA ancestry only [BMI <25 versus >30: OR = 0.65 (95% CI, 0.44-0.98) among U.S. Hispanics; OR = 0.53 (95% CI, 0.29-0.97) among Mexicans]. The average number of risk factors among cases was inversely related to the percentage of NA ancestry.Conclusions: The lower NA ancestry groups were more likely to have the established risk factors, with the exception of BMI. Although the majority of factors were associated with risk in the expected directions among all women, BMI had an inverse association among Hispanics with lower NA ancestry.Impact: These data suggest that the established risk factors are less relevant for breast cancer development among women with more NA ancestry. Cancer Epidemiol Biomarkers Prev; 26(5); 692-701. ©2016 AACR.

A London experience 1995-2012: demographic, dietary and biochemical characteristics of a large adult cohort of patients with renal stone disease.

Kidney stone disease has an estimated prevalence of around 10%. Genetic as well as environmental factors are thought to play an important role in the pathogenesis of renal stones. The aim of our study was to analyse and report the main characteristics of patients with kidney stones attending a large UK metabolic stone clinic in London between 1995 and 2012. A cross-sectional study. Analysis of data from stone formers attending the University College and Royal Free Hospitals' metabolic stone clinic from 1995 to 2012. Demographic, clinical, dietary and biochemical characteristics have been summarized and analysed for men and women separately; trends over time have also been analysed. Of the 2861 patients included in the analysis, 2016 (70%) were men with an average age of 47 years (range 18-87 years) and median duration of disease of 6 years (range 0-60 years). The prevalence of low urine volume, hypercalciuria, hyperoxaluria, hyperuricosuria and hypocitraturia was 5.6%, 38%, 7.9%, 18% and 23%, respectively. The prevalence of several risk factors for stones increased over time. The majority of stones were mixed, with around 90% composed of calcium salts in varying proportion. Our findings in a large cohort of patients attending a London-based stone clinic over the past 20 years show differences in distributions of risk factors for stones for men and women, as well as metabolic profiles and stone composition. The impact of most risk factors for stones appeared to change over time.

La hipertensión arterial en el paciente herniado: ¿patología concomitante o relación causal?

Nowadays, hernia is considered as a disturbance of homeostasis of cellular or matrix extracellular components in fascias and muscles. Any damage to the extracellular matrix facilitates the hernia. Hyperfunction of renin-angiotensin system will result in fibrosis; many drugs consumed by people with hypertension disrupt homeostasis of the extracellular matrix.Our objectives were to assess whether there is association between hernia and hypertension, to analyze drugs consumed by hypertensive patients and to compare the prevalence of hypertension to that of other risk factors for hernia.The sample had 1818 patients, with an average age 64 years, underwent surgery between 1998 and 2012. We compared the prevalence of hypertension between herniated people and general population. We verified the use of antifibrotic drugs by all patients in the sample. We estimated the prevalence of several risk factors for hernia.The prevalence of hypertension in the sample is 55.1%, higher than in the general population. It is also higher in all age groups. Hypertensive and herniated patients consumed 3.3 antifibrotic drugs on average; herniated non-hypertensive patients consumed on average 1.1 drugs. The prevalence of hypertension is similar to or higher than the herniosis, smoking, family history, obesity, diabetes or cancer.Hypertension, due of their means of treatment, should be considered as a acquired agent in the genesis of hernia. The risk have the same strength that other factors known to cause hernia.

Physical activity, obesity and insulin resistance

Marinou et al. overviewed the relationship between obesity and cardiovascular diseases (CVD) with special emphasis on the mechanisms of atherogenesis by focusing insulin resistance, adipokines, some metabolic components and endothelial function [1]. Ouyang et al. surveyed the prevalence of several risk factors on cardiovascular disease (CVD) for off-working population in China [2]. Among lifestyle factors, they classified physical activity into 3 groups according to the frequency and intensity. Among them, lowest level of physical activity was defined as follows; not doing any exercise or only doing light exercise such as walking and household works <7 times per week that lasted <60min in each time.

PP-009 Significant increase in the incidence of hepatocellular carcinoma in wales

Introduction Increasing mortality rates for some types of primary liver cancer have been documented in several countries in recent years. The figures published for England and Wales have described a marked increase in cases of intrahepatic cholangiocarcinoma with a static or declining rate of mortality from hepatocellular carcinoma (HCC).1 However, over the last decade, the prevalence of several risk factors for HCC (chronic viral hepatitis, alcoholic liver disease and obesity/NASH) have all dramatically increased in Wales. We therefore hypothesised that, due to the significant difference in population size between these two regions, a dilutional effect may have masked the true incidence of HCC within Wales. Methods The database of the Welsh Cancer Intelligence and Surveillance Unit was examined for all liver tumour types affecting Welsh residents regardless of treatment location across the years 1999–2008 inclusive. The incidence was recorded as the European Age Standardised Rate (EASR) per 100 000 population. Subcategory analysis was made for hepatocellular carcinoma, fibrolamellar HCC, combined HCC and cholangiocarcinoma and all liver malignant neoplasms. Patients were stratified according to age and sex and an additional 3 years moving-average EASR calculated across the whole study period. Results There was a significant and progressive increase in the incidence of HCC in Wales from 1999 to 2008. The absolute numbers of HCC cases, the EASR and the proportion of malignant liver neoplasms have all risen. In men, the EASR increased by 100% in just 8 years from 1.9 to 3.8 per 100 000. In addition, the EASR increased in women by 83% from 0.6 to 1.1 per 100 000. The rolling 3-year average rates closely followed these trends throughout the 10-year study period. Notably, in both sexes there has been a substantial rise in the number of HCC cases in patients under the age of 70 years. Conclusion In contrast to the previously published trends, we found the incidence of hepatocellular carcinoma has consistently increased over the last decade in Wales. This rise may reflect regional changes in HCC risk factors and may have been obscured by combining figures with the much larger population of England. Further research will be necessary to determine the underlying causes of this increase and to direct resources toward the prevention and early detection of HCC in Wales.

Management of Metabolic Syndrome in Young Population

Metabolic syndrome is a complex disorder associated with several cardiovascular risk factors resulting in a 2.5-fold increase in cardiovascular mortality in adults. However, over the last 20 years, the same association has been demonstrated in the young population, and it is also related to a parental history of the syndrome. However, the root of the problem could be a high risk factor profile for metabolic syndrome in children and adolescents, as it has been demonstrated over the last 20 years. It has been shown that the association of obesity, alterations of glucose and lipids metabolism, and high blood pressure are responsible for early atherosclerotic lesions at autopsy as observed in young people. The prevalence of several risk factors for cardiovascular diseases has increased in the Brazilian population, as has that of obesity, a cause of great concern because of its importance as one of the metabolic syndrome components. The anthropometric patterns of the Brazilian population have changed over the last 30 years from undernourishment to weight excess, regardless of age, sex, or socioeconomic level. The identification of such individuals, followed by primary preventive measures, changes in lifestyle, and pharmacologic treatment, should be implemented, aiming at reducing the cardiovascular risk in countries undergoing economic transition, such as Brazil. The measures recommended for that age group should focus on changing lifestyle through adoption of healthy habits such as avoiding excessive intake of calories, salt, saturated fat, and cholesterol and engagement in regular physical activity without smoking.