Prevalence Of Serrated Polyps Research Articles

A retrospective study on pathological and clinical characteristics of 52 cases with the colorectal serrated polyp.

Background and Objective:Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential. The aim of the study was to evaluate the endoscopic, clinic and pathologic characteristics of colorectal serrated polyps.Methods:The endoscopic, clinic and pathologic characteristics of 52 cases with colorectal serrated polyps between January 2014 and May 2018 in our hospital were analyzed. retrospectively.Results:The prevalence of serrated polyps was 0.39% (52/13,346). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 61.5%, 17.3%, and 21.2%, respectively, which showed a lower proportion of TSA and SSA/P and a higher proportion of HP.Conclusions:The overall detection rate of colorectal serrated polyps was relatively low, and it is necessary to discriminate between SSAPs and HPs during endoscopic examination because of the malignant potential.

Detection Rate, Distribution, Clinical and Pathological Features of Colorectal Serrated Polyps

Background:Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential in western countries. However, few Asian studies have investigated the comprehensive clinical features of serrated polyps in symptomatic populations. The aim of the study was to evaluate the features of colorectal serrated polyps in a Chinese symptomatic population.Methods:Data from all consecutive symptomatic patients were documented from a large colonoscopy database and were analyzed. Chi-square test or Fisher's exact test and logistic regression analysis were used for the data processing.Results:A total of 9191 (31.7%) patients were detected with at least one colorectal polyp. The prevalence of serrated polyps was 0.53% (153/28,981). The proportions of hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 41.2%, 7.2%, and 51.6%, respectively, which showed a lower proportion of HP and SSA/P and a higher proportion of TSA. Serrated polyps appeared more in males and elder patients while there was no significant difference in the subtype distribution in gender and age. The proportions of large and proximal serrated polyps were 13.7% (21/153) and 46.4% (71/153), respectively. In total, 98.9% (89/90) serrated adenomas were found with dysplasia. Moreover, 14 patients with serrated polyps were found with synchronous advanced colorectal neoplasia, and large serrated polyps (LSPs) (odds ratio: 3.446, 95% confidence interval: 1.010–11.750, P < 0.05), especially large HPs, might have an association with synchronous advanced neoplasia (AN).Conclusions:The overall detection rate of colorectal serrated polyps in Chinese symptomatic patient population was low, and distribution pattern of three subtypes is different from previous reports. Moreover, LSPs, especially large HPs, might be associated with an increased risk of synchronous AN.

Commentaire de travail de Y Hazewinkel et al., pp. 219

See also: Prevalence of serrated polyps and association with synchronous advanced neoplasia in screening colonoscopyEndoscopy 2014; 46(03): 219-224DOI: 10.1055/s-0033-1358800

Prevalence of serrated polyps: implications for significance as colorectal cancer precursors

SUMMARY Colorectal cancer remains a major cancer diagnosis, and a cause of mortality worldwide with screening and surveillance programs representing a significant healthcare commitment. The serrated pathway is responsible for 20–30% of colon cancers and evidence is accumulating for a major role in the relative failure of colonoscopy to provide high-level protection from cancer in the proximal colon. Although the significance of the serrated pathway and its precursor lesions are well established, the prevalence of the precursor lesions at colonoscopy is not. Multiple factors can impact attempts to accurately assess the prevalence of these lesions. This review discusses these factors and summarizes publications on sessile serrated adenoma and proximal serrated polyp prevalence.

Prospective Study of Sessile Serrated Adenomas Detected with Colonoscopy

About 15% of sporadic colorectal cancers exhibit high-frequency microsatellite instability (MSI-H) and inactivation of hMLH1 (a mismatch repair gene). In previous retrospective studies, similar molecular changes have been seen in hyperplastic polyps and sessile serrated adenomas in the proximal colon, leading to the theory that these lesions are precursors of sporadic MSI-H cancers in the proximal colon. In a new prospective colonoscopy study, investigators sought to determine the prevalence of serrated polyps, including hyperplastic polyps and serrated adenomas, and to describe the prevalence of BRAF and K -ras mutations in such polyps. BRAF and K -ras are involved in the same signaling pathway, and mutations in these genes are …