Prevalence Of Respiratory Diseases Research Articles

Predominance of A2063G mutant strains in the Mycoplasma pneumoniae epidemic in children–a clinical and epidemiological study in 2023 in Wuhan, China

ObjectivesThe prevalence of respiratory infectious diseases has changed in the post Covid-19 epidemic era, and mycoplasma pneumoniae (MP) infection in children has attracted wide attention. MethodsChildren hospitalized for pneumonia in Wuhan, China, in 2023 were enrolled. Respiratory secretions were obtained for the targeted next-generation sequencing (tNGS) including mutation of MP. Pulmonary inflammation was divided into bronchopneumonia and pulmonary consolidation/atelectasis according to lung CT imaging. ResultsOf the 667 pediatric pneumonia, 478 were MP positive (72%). The positive rate of MP detected by tNGS increased from April, and MP had become the primary pathogen of pneumonia in children in year 2023. The 23S rRNA mutations were all A2063G, accounting for 85% of detected MP. The clinical symptoms of the mutant and wild type strains were similar, with half of them experiencing atelectasis and lung consolidation. Early bronchoscopic lavage combined with azithromycin in pediatric pulmonary consolidation was an effective therapy strategy, which could be an alternative selection to MPP treatment. ConclusionA2063G mutant strain MP was the primary pathogen of mycoplasma pneumoniae in children recently, which was often complicated by extra-pulmonary symptoms and complications.

Detection Of Pulmonary Diseases in Lung Using CT & X-ray Images CNN

This study presents a deep learning approach utilizing Convolutional Neural Networks (CNNs) for the detection of pulmonary diseases from CT and X-ray images. With the rising prevalence of respiratory illnesses, accurate and efficient diagnosis is crucial for timely treatment. The proposed CNN framework leverages its ability to automatically learn discriminative features from medical images, enabling robust disease detection. By training on a diverse dataset comprising CT and X-ray scans, the model achieves high sensitivity and specificity in identifying common pulmonary conditions such as Covid-19 & Effusion Disease. The results demonstrate the potential of CNNs as a valuable tool in the early detection and management of respiratory diseases, contributing to improved patient outcomes and healthcare delivery.

Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections

BackgroundIn recent years, the prevalence of respiratory fungal diseases has increased. Polyene antifungal drugs play a pivotal role in the treatment of these conditions, with amphotericin B (AmB) being the most representative drug. This study aimed to evaluate the efficacy and safety of topical administration of AmB in the treatment of respiratory fungal infections.MethodsWe conducted a retrospective study on hospitalized patients treated with topical administered AmB for respiratory fungal infections from January 2014 to June 2023.ResultsData from 36 patients with invasive pulmonary fungal infections treated with topical administration of AmB were collected and analyzed. Nebulization was administered to 27 patients. After the treatment, 17 patients evidenced improved conditions, whereas 10 patients did not respond and died in the hospital. One patient experienced an irritating cough as an adverse reaction. Seven patients underwent tracheoscopic instillation, and two received intrapleural irrigation; they achieved good clinical therapeutic efficacy without adverse effects.ConclusionThe combined application of systemic antifungal treatment and topical administration of AmB yielded good therapeutic efficacy and was well-tolerated by the patients. Close monitoring of routine blood tests, liver and kidney function, and levels of electrolytes, troponin, and B-type natriuretic peptide supported this conclusion.

Air Pollution and Respiratory Infectious Diseases

Recent research suggests that short-term exposure to air pollution is associated with an elevated prevalence of respiratory infectious disease. In this paper, we examine the relationship between the air quality index and weekly cases of COVID-19 and influenza-like illnesses (ILI) in the United States. We address potential bias from omitted variables and measurement error with an instrumental variable approach using atmospheric temperature inversions. Unlike other recent studies, we find no relationship between air quality and either COVID-19 or ILI cases.

Impact of cotton dust, endotoxin exposure, and other occupational health risk due to indoor pollutants on textile industry workers in low and middle- income countries

The textile industry consists of several units that engage different processes namely ginning, spinning, weaving, dyeing, printing, and several other processes which required for converting raw cotton fiber into finished fabrics. Exposure to cotton dust, endotoxin, chemicals, noise, and musculoskeletal disorders causes several health-related hazards to textile workers. This review article aims to study the health issues due to various risk factors associated with the working environment in detail and its impacts on workers' health. This review article also reports dust and endotoxin concentrations in indoor environments of textile industries, as well as discusses the association between workplace exposure to cotton dust, endotoxin, and the prevalence of respiratory disorders. In this review, the focus is also given to the prevalence of indoor pollutants like Particulate Matter (PM), Carbon dioxide (CO2), Carbon monoxide (CO), and Volatile Organic Compounds (VOCs), Formaldehyde (HCHO) in the workplace and its effects on human health. The study expands to other aspects that influence human comfort and health during working hours like occupational noise, musculoskeletal disorders, and eyesight problems. In addition, the advanced technologies for monitoring indoor air quality for control and reduction of pollutants indoor environment the current regulatory limits of cotton dust and indoor pollutants, and suggestions to enhance the occupational safety and health conditions in textile sectors are also pointed out. In conclusion, the current study stresses the need to regulate and apply international standards in the textile sector to prevent short- and long-term occupational illness.

Urbanization influences the indoor transfer of airborne antibiotic resistance genes, which has a seasonally dependent pattern

Over the last few years, the cumulative use of antibiotics in healthcare institutions, as well as the rearing of livestock and poultry, has resulted in the accumulation of antibiotic resistance genes (ARGs). This presents a substantial danger to human health worldwide. The characteristics of airborne ARGs, especially those transferred from outdoors to indoors, remains largely unexplored in neighborhoods, even though a majority of human population spends most of their time there. We investigated airborne ARGs and mobile genetic element (MGE, IntI1), plant communities, and airborne microbiota transferred indoors, as well as respiratory disease (RD) prevalence using a combination of metabarcode sequencing, real-time quantitative PCR and questionnaires in 72 neighborhoods in Shanghai. We hypothesized that (i) urbanization regulates ARGs abundance, (ii) the urbanization effect on ARGs varies seasonally, and (iii) land use types are associated with ARGs abundance. Supporting these hypotheses, during the warm season, the abundance of ARGs in peri-urban areas was higher than in urban areas. The abundance of ARGs was also affected by the surrounding land use and plant communities: an increase in the proportion of gray infrastructure (e.g., residential area) around neighborhoods can lead to an increase in some ARGs (mecA, qnrA, ermB and mexD). Additionally, there were variations observed in the relationship between ARGs and bacterial genera in different seasons. Specifically, Stenotrophomonas and Campylobacter were positively correlated with vanA during warm seasons, whereas Pseudomonas, Bacteroides, Treponema and Stenotrophomonas positively correlated with tetX in the cold season. Interstingly, a noteworthy positive correlation was observed between the abundance of vanA and the occurrence of both rhinitis and rhinoconjunctivitis. Taken together, our study underlines the importance of urbanization and season in controlling the indoor transfer of airborne ARGs. Furthermore, we also highlight the augmentation of green–blue infrastructure in urban environments has the potential to mitigate an excess of ARGs.

Exposure to chemical pollutants and biological aerosol in indoor facilities for recreational and sport horses

BackgroundDue to the increasing prevalence of equine non-infectious respiratory disease, the air contamination in equine housing (Stables A-C) and training facilities (indoor riding arenas A - C) was investigated. The aim of the study was to monitor gaseous pollutants, bioaerosols, and dust concentrations at three different sites (stables and riding halls), where different floor materials were used in the riding halls.Materials and methodsAir quality was monitored in housing for horses and in riding halls in terms of dust concentration, the presence of gaseous chemical pollutants, and concentrations of biological aerosol. Statistical analysis was performed using analysis of variance (ANOVA). The levels obtained were compared with acceptable limits.ResultsAmong the gaseous pollutants identified, the highest concentration was obtained for ammonia in stables B and C (16.37 and 22.39 mg/m3, respectively). Standards for total dust were exceeded in stables B and C and in riding halls B and C. The highest numbers of bacteria and fungi were recorded in stables A and C and in riding hall B. Ulocladium sp. had the highest percentage share among the moulds identified.ConclusionsThe results confirm that the wrong choice of bedding in the stable and indoor riding arenas may contribute, even in short training periods, to equine non-infectious respiratory disease (equine asthma). Bioaerosol suspended in the air together with released gaseous pollutants can exacerbate this phenomenon, which even in the case of short training periods can lead to equine asthma of varying degrees of severity. For this reason, the choice of floor material in riding halls should be treated as a priority, as the wrong decision can shorten the period during which the horse can be used for recreational purposes.

Association of dietary flavonoid intakes with prevalence of chronic respiratory diseases in adults

Background and aimsFlavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dietary flavonoid consumption and the prevalence of chronic respiratory diseases (CRDs) in adults.Methods and resultsThe six main types of flavonoids, including isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols, were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 and 2017–2018 by the two 24-h recall interviews. The prevalence of CRDs, including asthma, emphysema, and chronic bronchitis, was determined through a self-administered questionnaire. The analysis included 15,753 participants aged 18 years or older who had completed a diet history interview. After adjustment for potential confounders, the inverse link was found with total flavonoids, anthocyanidins, flavanones, and flavones, with an OR (95%CI) of 0.86 (0.75–0.98), 0.84 (0.72–0.97), 0.80(0.69–0.92), and 0.85(0.73–0.98) for the highest group compared to the lowest group. WQS regression revealed that the mixture of flavonoids was negatively linked with the prevalence of CRDs (OR = 0.88 [0.82–0.95], P < 0.01), and the largest effect was mainly from flavanones (weight = 0.41). In addition, we found that flavonoid intake was negatively linked with inflammatory markers, and systemic inflammation significantly mediated the associations of flavonoids with CRDs, with a mediation rate of 12.64% for CRP (P < 0.01).ConclusionHigher flavonoid intake was related with a lower prevalence of CRDs in adults, and this relationship may be mediated through systemic inflammation.

Nursing Interventions for Client and Family Training in the Proper Use of Noninvasive Ventilation in the Transition from Hospital to Community: A Scoping Review.

Noninvasive ventilation is an increasingly disseminated therapeutic option, which is explained by increases in the prevalence of chronic respiratory diseases, life expectancy, and the effectiveness of this type of respiratory support. This literature review observes that upon returning home after hospital discharge, there are difficulties in adhering to and maintaining this therapy. The aim of this study is to identify nursing interventions for client and family training in the proper use of noninvasive ventilation in the transition from hospital to community. A scoping review was carried out by searching MEDLINE, CINAHL, Scopus, and Web of Science. The articles were selected by two independent reviewers by applying the predefined eligibility criteria. Regarding transitional care, the authors opted to include studies about interventions to train clients and families during hospital stay, hospital discharge, transition from hospital to home, and the first 30 days after returning home. The eight included publications allowed for identification of interventions related to masks or interfaces, prevention of complications associated with noninvasive ventilation, leakage control, maintenance and cleaning of ventilators and accessories, respiratory training, ventilator monitoring, communication, and behavioral strategies as transitional care priority interventions to guarantee proper training in the transition from hospital to community.

The association between BCG scars and self-reported chronic diseases: A cross-sectional observational study within an RCT of Danish health care workers

IntroductionThe live-attenuated vaccines Bacillus Calmette-Guérin (BCG) and Vaccinia have been associated with beneficial non-specific effects. We assessed the prevalence of BCG and Vaccinia vaccine scars in a cohort of Danish health care workers and investigated the association between the presence of vaccine scars and self-reported chronic diseases. MethodsCross-sectional study utilizing baseline data collected during 2020–2021 at enrollment in a BCG trial aiming to assess the effect of BCG vaccination on absenteeism and infectious disease morbidity during the SARS-COV-2 pandemic. In Denmark, Vaccinia was discontinued in 1977, and BCG was phased out in the early 1980s. We used logistic regression analysis (adjusted for sex, birth year, and smoking status) to estimate the association between scar status and chronic diseases, providing adjusted Odds Ratios (aORs) with 95 % Confidence Intervals, for participants born before 1977, and born from 1965 to 1976. ResultsThe cohort consisted of 1218 participants (206 males; 1012 females) with a median age of 47 years (Q1–Q3: 36–56). Among participants born 1965–1976 (n = 403), who experienced the phase-outs, having BCG and/or Vaccinia scar(s) vs. having no vaccine scars yielded an aOR of 0.51 (0.29–0.90) of self-reported chronic disease; an effect primarily driven by BCG. In the same birth cohort, having vaccine scar(s) was most strongly associated with a lower prevalence of chronic respiratory and allergic diseases; the aORs being 0.39 (0.16–0.97) and 0.39 (0.16–0.91), respectively. ConclusionHaving a BCG scar was associated with a lower prevalence of self-reported chronic disease.

Prevalence of Chronic Non-Communicable Respiratory Diseases in Mosul City

Introduction: Chronic non-communicable respiratory diseases (CNCRDs) encompass a group of conditions affecting the airways and lung structures, including Chronic Obstructive Pulmonary Disease (COPD), emphysema, allergic rhinitis, asthma, pulmonary arterial hypertension, and cystic fibrosis. CNCRDs pose a significant global health challenge, resulting in approximately four million deaths annually. This study aimed to identify the prevalence and risk factors associated with CNCRDs and measure trends in the prevalence of these risk factors over time. Methods: A cross-sectional epidemiological study was conducted using data collected from primary health centers on both sides of Mosul City. The study period extended from January 1 to July 31, 2022, with information obtained from (40) primary health centers, consisting of (20) centers on the right side and (20) centers on the left side of Mosul. Results: In 2021, the City of Mosul recorded a total of 13,005 registered cases, with 5,598 cases being attributed to asthma (43%), and 7,347 cases being associated with COPD (57%). Bronchial asthma constituted 43% of cases, with 5598 patients, and the highest incidence occurred in the age group between 20-44 years. Conclusion: The prevalence of bronchial asthma and COPD among patients with CNCRDs in Mosul is alarmingly high. It emphasizes the importance of implementing preventive policies and strategies targeting modifiable risk factors for these respiratory conditions.

The Pattern of Respiratory Diseases among Children Admitted in the Children Emergency Ward, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria

Aim: Respiratory diseases are common causes of childhood morbidity and mortality worldwide. Variations in the pattern of respiratory diseases exist globally, due to environmental conditions, poverty, hygiene and so on. This study sought to determine the pattern of respiratory diseases among children admitted into the emergency ward of the University of Port Harcourt Teaching Hospital.&#x0D; Study Design: Retrospective cross-sectional study.&#x0D; Setting and Duration of Study: Children Emergency Ward of the University of Port Harcourt Teaching Hospital, between January 2019 and January 2021.&#x0D; Methodology: This was a retrospective cross-sectional study. Data were collected from case notes of 3,851 children, aged two months to 18 years, admitted to the University of Port Harcourt Teaching Hospital, over three years.&#x0D; Results: Respiratory diseases accounted for 500 (13%) of the total admissions, and was more common among males than females (M: F = 1.3:1). The mean age of children with respiratory illnesses was 2.27±4.6 years. Infectious causes {443 (88.6%)} were significantly higher than non-infectious causes {57 (11.4%)}, p&lt;0.001. Bronchopneumonia, bronchial asthma and bronchiolitis were the commonest morbidities seen, accounting for 394 (78.8%), 34 (6.8%) and 22 (4.4%) of cases respectively.&#x0D; Conclusion: The prevalence of respiratory diseases is high. Infectious causes are still prevalent with cases presenting more during the dry season. Measures to reduce environmental pollution and enhance immunization can greatly reduce respiratory diseases among children.

Lobelia inflata L. as an Alternative Medicine for Respiratory Problems Provoked by Covid- 19: A Review

Lobelia inflata (Indian tobacco, Campanulaceae) is an herbal remedy for many respiratory conditions such as asthma, bronchitis, pneumonia, and cough. The main objective of the current review is to document the potential use of L. inflata as respiratory stimulant in patients suffering from Covid-19 infection. Native Americans smoked the plant as a treatment for asthma and today, lobelia is sometimes suggested to help clear mucus from the respiratory tract, including the throat, lungs, and bronchial tubes. Although few studies have evaluated the safety and effectiveness of lobelia, some herbalists use lobelia as part of a comprehensive treatment plan for asthma. In the 19th century, American physicians prescribed the herb to induce vomiting in order remove toxins from the body. However, because of its properties as a respiratory stimulant and expectorant, the plant should be used at the correct dose and together with herbs that are soothing to the throat and lungs, and it is often used in a synergistic herbal formula that includes L. inflata herb and seed, Zingiber officinale, and Hyssopus officinalis. The study species should not be used as a substitute for drug therapy during an asthma attack and its use is contraindicated during pregnancy. Lobelia inflata has no known adverse drug interactions and it is therefore a promising complementary therapy for the management of respiratory disorders, in particular in light of the recent increase in the prevalence of respiratory diseases associated with Covid-19. In conclusions, data of the current study has proven the possibility of using the plant in treating the respiratory disorders resulting from infection with Covid-19.

Ambient nitrogen dioxide in 47 187 neighbourhoods across 326 cities in eight Latin American countries: population exposures and associations with urban features

Health research on ambient nitrogen dioxide (NO2) is sparse in Latin America, despite the high prevalence of NO2-associated respiratory diseases in the region. This study describes within-city distributions of ambient NO2 concentrations at high spatial resolution and urban characteristics associated with neighbourhood ambient NO2 in 326 Latin American cities. We aggregated estimates of annual surface NO2 at 1 km2 spatial resolution for 2019, population counts, and urban characteristics compiled by the SALURBAL project to the neighbourhood level (ie, census tracts). We described the percentage of the urban population living with ambient NO2 concentrations exceeding WHO air quality guidelines. We used multilevel models to describe associations of neighbourhood ambient NO2 concentrations with population and urban characteristics at the neighbourhood and city levels. We examined 47 187 neighbourhoods in 326 cities from eight Latin American countries. Of the roughly 236 million urban residents observed, 85% lived in neighbourhoods with ambient annual NO2 above WHO guidelines. In adjusted models, higher neighbourhood-level educational attainment, closer proximity to the city centre, and lower neighbourhood-level greenness were associated with higher ambient NO2. At the city level, higher vehicle congestion, population size, and population density were associated with higher ambient NO2. Almost nine out of every ten residents of Latin American cities live with ambient NO2 concentrations above WHO guidelines. Increasing neighbourhood greenness and reducing reliance on fossil fuel-powered vehicles warrant further attention as potential actionable urban environmental interventions to reduce population exposure to ambient NO2. Wellcome Trust, National Institutes of Health, Cotswold Foundation.

Asthma and Other Respiratory Diseases of Children in Relation to Personal Behavior, Household, Parental and Environmental Factors in West China.

Asthma and other respiratory diseases, which are of great concern in public health, are paid less attention in areas that are less economically developed. This research aimed to study the prevalence of critical respiratory diseases of children living in West China and figure out the potential influencing factors. A total of 575 children under the age of 14 were recruited from Xinjiang, China, to participate in the study in 2022. Information on activity patterns, socioeconomic and parental factors, and household and surrounding environment situations was obtained using a questionnaire survey. Logistic regression models were applied to estimate the odds ratios of respiratory disease prevalence in relation to behavior patterns, household, parental and environmental factors, respectively. The prevalence of ever doctor-diagnosed asthma, doctor-diagnosed bronchitis and current bronchitis were 4.7%, 19.0% and 14.4%, respectively. The prevalence of doctor-diagnosed pneumonia was 8.2%, which was two times higher in urban than rural areas. Longer annual heating duration was significantly associated with higher risks in children's asthma and bronchitis, with an odds ratio (OR) and 95% confidence interval (95% CI) of 3.363 (95% CI: 1.215-9.298) and 1.267 (95% CI: 1.002-1.601), respectively. Opening the window longer in autumn would lead to higher risks of bronchitis, with ORs of 1.165 and 1.133, respectively, for doctor-diagnosed bronchitis and current bronchitis. Residential air pollution and having a residence close to waste incineration plant or garbage station were, respectively, significantly associated with higher risks of doctor-diagnosed bronchitis and asthma. Parental disease history was associated with a higher prevalence of children's asthma and respiratory diseases, whereas breastfeeding and doing physical exercise were, respectively, significantly associated with a lower risk of asthma. A high prevalence of respiratory diseases in children in West China may be partly attributed to longer annual heating time, opening windows longer in autumn, surrounding environmental pollution, as well as parental disease history, whereas promoting physical activity and breastfeeding could be an effective measure to reduce the risk of childhood asthma in West China.

Rollout of the 2022/2023 Seasonal Influenza Vaccination and Correlates of the Use of Enhanced Vaccines among Italian Adults.

In Italy, several types of seasonal influenza vaccines (SIVs) are available for older adults, but for the 2022/2023 season there were no guidelines on their specific use. This cross-sectional study assessed the frequency and determinants of the use of enhanced (adjuvanted and high-dose) SIVs in Italian older adults, as compared to standard-dose non-adjuvanted formulations. Of 1702 vaccines administered to a representative outpatient sample of adults aged ≥ 60 years and residing in Genoa, 69.5% were enhanced SIVs. Older age (adjusted odds ratio (aOR) for each 1-year increase 1.10; p < 0.001), and the presence of cardiovascular disease (aOR 1.40; p = 0.011) and diabetes (aOR 1.62; p = 0.005) were associated with the use of enhanced vaccines. Compared with the adjuvanted SIV, subjects immunized with the high-dose vaccine were older (aOR for each 1-year increase 1.05; p < 0.001) and had higher prevalence of respiratory diseases (aOR 1.85; p = 0.052). Moreover, usage of the enhanced SIVs was driven by the period of immunization campaign, place of vaccination and physician. Despite their superior immunogenicity and effectiveness, the adoption of enhanced SIVs in Italy is suboptimal, and should be increased. Enhanced formulations are mostly used in the oldest, and in subjects with some co-morbidities.

Occupational non-communicable respiratory diseases in industrial and agricultural workers

Introduction. Harmful inhalation effects in the workplace, most of which are preventable, determine more than 10% of chronic non-infectious bronchopulmonary pathology over the world at the population level. In this regard, updated information on inhalation risk factors in various sectors of the economy and the prevalence of diseases associated with them is important for the scientific justification of targeted programs for the prevention of occupational respiratory diseases. &#x0D; Materials and methods. On the basis of the competent statistical materials of the Rospotrebnadzor Department for the Saratov region, a retrospective analysis of the prevalence of occupational non-communicable respiratory diseases (ONRD) and factor inhalation effects in various industries and agriculture of the region was carried out using generally accepted methods.&#x0D; Results. For the period from 2009 to 2019 in the territory of the Saratov region one hundred sixty seven industrial workers (58 people), and agriculture &#x0D; (109 people) were established to be diagnosed with 189 ONRD. Despite a fivefold reduction in cases of detection of ONRD over the past decade, &#x0D; non-communicable respiratory diseases occupied the second rank in the structure of accumulated occupational morbidity (25.1%). The range of the contribution of ONRD to the total pool of occupational diseases for different years of observation was from 13.9 to 37.5% in the industrial sector, from &#x0D; 13.3 to 33.3% in agriculture. The largest number of ONRD cases were registered in plant-growing workers (51.9%), manufacturing industries (23.3%), and livestock (10.1%); the smallest number in those engaged in mining (2.6%). The first ranks in the structure of the accumulated ONRD were occupied by chronic obstructive pulmonary disease (33.9%), chronic dust-free non-obstructive bronchitis (31.2%), and occupational bronchial asthma (23.3%), associated with air pollution of the working environment with silicon-containing, organic dust and sensitizing agents, the genesis of which was determined by the specifics &#x0D; of working conditions.&#x0D; Limitation. The gender factor was not taken into account when analyzing the prevalence of ONRD and its nosological structure.&#x0D; Conclusion. The data obtained can be used in the development of comprehensive medical and hygienic programs to improve occupational conditions and preserve the longevity of industrial and agricultural workers.

Exploring the impact of inflammatory endotypes on olfactory function and quality of life in chronic rhinosinusitis patients

ObjectivesThe aim of this observational cross-sectional study was to determine the endotypic inflammatory pattern of a sample of patients with CRS in Brazil, correlate it with olfactory function, and evaluate the clinical severity of the disease. MethodsIn this cross-sectional study, 73 CRS patients were recruited. Patients were classified into type 2 and non-type 2 endotypic patterns based on IgE and eosinophilia levels. All subjects performed the University of Pennsylvania Smell Identification Test (UPSIT®) and responded to the Sino-Nasal Outcome Test (SNOT-22). ResultsThe majority of patients had type 2 CRS (n=57, 78.1%). Patients with type 2 CRS compared to non-type 2 CRS had a higher prevalence of nasal polyps (93% vs. 12.5%), asthma (40.3% vs. 12.5%), and non-steroidal anti-inflammatory drug exacerbated respiratory disease (NERD, 17.5% vs. 0%). Type 2 patients also had significantly lower UPSIT® and higher SNOT-22, Lund-Kennedy, and Lund-Mackay scores. ConclusionOur study provides evidence that type 2 CRS is associated with a higher prevalence of nasal polyps, asthma, and NERD, as well as decreased olfactory function and worse quality of life scores. These data will contribute to the body of knowledge on CRS and the development of treatments for this disease in Brazil. Level of evidence3.

Effect of Coal Mining on Health Outcomes Between Male and Female Miners in Southern West Virginia: A Brief Report.

There is evidence of an association between coal mining and an increased prevalence of respiratory and cardiovascular disease (CVD). Mining is significantly associated with elevated chronic CVD mortality rates. Research is limited and looks at the differences between specific health outcomes between male and female coal miners. The aim of this study was to compare the long-term health outcomes of male and female coal miners in southern West Virginia. We used the Charleston Area Medical Center (CAMC) data registry to look at specific health outcomes of coal miners. We queried the data warehouse from September 1, 2016, to January 1, 2023, to identify any coal miners coming to CAMC for any treatment. We identified adult patients aged 18-90 years with at least one visit to a clinic in the CAMC system. We identified (n=2,460) cases of coal miners, comprising of 2,280 males and 180 females. Overall, we found higher mortality rates as well as higher rates of ischemic heart disease, heart failure, cancer, and mental health disorders among male coal miners. Additional research is needed to further examine possible contributing factors that explain the differences in health outcomes between male and female coal miners. Clinicians and policymakers need to address health disparities and occupational hazards that impact the health outcomes of coal miners living in southern West Virginia.

Green spaces in highly urbanized tracts tied to lower prevalence of chronic respiratory diseases: A nationwide study across levels of urbanicity

Previous studies have found conflicting results between green space and respiratory diseases, possibly due to the use of generalized green space measures and the diverse urbanicity levels in which they were conducted. Few nationwide studies examined how urbanicity modifies the relationship between green spaces and respiratory diseases while considering the geospatial relation between green space and human population, population density, and accessibility.This study evaluates the relationships between population-weighted forest and open space exposure (inside and outside park), chronic obstructive pulmonary disease (COPD), and asthma in the contiguous United States. The COPD and asthma data were obtained from the Centers for Disease Control and Prevention. The green space exposure within an 800 m buffer was computed using National Land-cover Dataset and WorldPop Global Population Data. The associations were estimated using spatial error models and adjusted for important covariates. We also performed stratified analyses by four urbanicity levels.Green spaces inside but not outside park were associated with a lower prevalence of COPD and asthma. We found that a 1 m2 increase in forest inside park was associated with a decrease of 3.57 and 2.97 cases per 100,000 population in COPD and asthma, and a 1 m2 increase in open space inside park was associated with a decrease of 4.82 and 7.66 cases per 100,000 population in COPD and asthma. A trend of an inverse relationship was observed across urbanicity: the beneficial associations occurred in highly urbanized tracts but not in the three less-urbanized tracts.Our results provide further evidence that nearby forests and open spaces inside park, particularly in urban areas, were tied to a lower prevalence of respiratory diseases in the US. The beneficial association suggests the necessity of ensuring access to nearby green spaces, especially those in parks, to promote respiratory health.