Prevalence Of Pulmonary Symptoms Research Articles

Evaluation of human vulnerability and toxic effects of chronic and acute occupational exposure to ammonia: A case study in an ice factory.

The hazardous material release has frequently occurred worldwide. As a respiratory stimulant and a toxic substance, ammonia has numerous adverse effects on human health. The purpose of this study was to evaluate the human vulnerability and toxic effects of both chronic and acute respiratory exposure to ammonia. This study was conducted in an ice factory. Ammonia reservoirs were selected as the danger center. The scenarios were evaluated from the perspective of the worst-case. The Emergency Response Planning Guidelines 1-3 was used to predict the dangerous concentrations in acute exposure. The probability of human vulnerability was estimated using the Probit model. PHAST 7.2 software was used to model consequences. As a measure of chronic exposure to ammonia, NMAM 6016 was used. A respiratory symptom questionnaire developed by the American Thoracic Society was used for collecting respiratory symptom histories. The ERPG3 level or concentration of 750 ppm was found at a distance of 617.71 and 411.01 meters from tanks, respectively, as a result of a rupture in reservoir 1 over a period of two halves of the year. It was found that the highest probit values for tank 2 at distances of zero, 25, 50, 75, 100, 125, and 150 meters were 9.55, 5.92, 5.47, 4.82, 4.23, 3.56 and 2.96, respectively. The prevalence of pulmonary symptoms, which include coughing, dyspnea, phlegm, and wheezing, was 28%, 19%, 15%, and 26% in the chronic exposure group. In the event that an ammonia reservoir ruptures catastrophically, it may cause human injury at ERPG-2 or ERPG-3 levels. Results revealed that exposure to this substance can impose many pulmonary symptoms on the respiratory system of workers in industries. In order to reduce the vulnerability of humans to potential release scenarios, control measures must be implemented. Also, preventive and mitigation measures can be designed to enhance safety and resilience against the release of hazardous materials.

Erosive Gastroesophageal reflux disease – are we missing pulmonary symptoms?

Background: Gastroesophageal reflux disease (GERD) is a common condition that affects about 20- 30% of the adult population, presenting with a broad spectrum of symptoms and varying degrees of severity and frequency. Extra esophageal manifestations like respiratory symptoms are being increasingly recognized. There are only very few studies on the prevalence of pulmonary symptoms in patients with erosive gastroesophageal reflux disease. Aim: The objective of the study was to determine the frequency of pulmonary symptoms in patients with erosive gastroesophageal reflux disease, Materials and Methods: This was a cross-sectional study done on 100 patients diagnosed based on upper gastrointestinal endoscopy findings. Patients were first interviewed about GERD symptoms using the GERD Health-Related Quality of Life questionnaire. Then the respiratory symptoms are assessed. Demographic details are recorded in a proforma. Pulmonary function tests were done on all the patients. Upper GI endoscopic findings are graded according to Los Angeles (LA) grading from A to D Results: The prevalence of pulmonary symptoms was 60%. The most prevalent symptom was a cough, then followed by dyspnoea on exertion, chest pain, wheezing, and snoring. There was a significant association found between LA grading and pulmonary symptoms like wheezing, cough, chest pain, and hoarseness of voice. No significant association was found between GERD duration and pulmonary symptoms. There was a statistically significant association found between LA grading and pulmonary function test. No association was found between quality of life scoring and pulmonary symptoms. Conclusion: There was a high prevalence of pulmonary symptoms in patients with erosive gastroesophageal reflux disease. Erosive GERD can affect pulmonary function according to severity. There was no association between prolonged GERD and pulmonary symptoms.

Prevalence of Self-Reported Pulmonary Symptoms in a Community Residing Near a Cement Factory in Chilanga, Zambia: A Cross Sectional Study

There is a paucity of information on whether exposure to emissions from a cement factory has pulmonaryill effectson the residents of communities residing close to these factories. We aimed at determining the prevalence of pulmonary symptoms in a community residing near a cement factory. Methods Using residence in a community bordering a cement factory, as proxy measure of exposure to cement dust emissions, we conducted a cross sectional study in Freedom Compound, Chilanga, Zambia. Prevalence of selfreported pulmonary symptoms was captured using a modified American Thoracic Society questionnaire administered to respondents aged 15-59 years. The prevalence of pulmonary symptoms in this community was then compared to that of a control community, Bauleni, located 18 km from the cement plant. Results Residents of Freedom were 6.00 (95% CI 3.67 – 9.79); 3.30 (95% CI 2.04-5.34), 1.74 (95% CI 1.08-2.84); 5.71 (95% CI 2.02-16.20); and 5.16 (95% CI 1.41-18.94) times more likely to suffer from cough, phlegm, wheeze, asthma and pneumonia, respectively compared to residents in Bauleni. Conclusion The study shows that the prevalence of pulmonary symptoms was higher in residents in a community near a cement factory compared to the control. Furthermore, residents of the exposed community were several times more likely to report pulmonary adverse health effect compared to the control. Characterization of air pollutant levels and source apportionment studies in the exposed community are required to determine whether the observed excessive respiratory symptoms are due to emissions from the cement plant.

Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia

Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these inconsistent findings is that the cumulative dosage of neonatal supplemental oxygen to which infants are exposure is difficult to accurately quantify. A prospective cohort study of VLBW infants without BPD was performed to test the hypothesis that cumulative oxygen exposure in the neonatal period summarized using an area under the curve analysis (Oxygen(AUC)) is predictive of later pulmonary symptoms. Risk factors tested in the analysis included both neonatal and outpatient respiratory exposures. Outcome measures included respiratory symptoms and use of medications and health services to treat those symptoms. The prevalence of pulmonary symptoms after NICU discharge was 48% (36 of 75 patients). Oxygen(AUC) as early as 72 hr of age predicts respiratory symptoms and respiratory-related health service and medication use during infancy in a dose dependent manner. Oxygen(AUC) is a stronger predictor of later respiratory symptoms than is the number of days of supplemental oxygen or positive pressure respiratory therapy or integrated mean airway pressure (MAP(AUC)). Oxygen(AUC) as early as 72 hr of age is predictive of later respiratory symptoms and use of health services and medications to treat those symptoms. Supplemental oxygen therapy should be monitored carefully to minimize oxygen exposure and risk of later respiratory symptoms in VLBW infants.

Prevalence of Respiratory Symptoms in Children with Sickle Cell Disease Compared to Children with Other Hematological Diseases.

Acute chest syndrome (ACS) and pulmonary hypertension are complications of sickle cell disease (SCD). The effects of pre-existing respiratory symptoms on the frequency of complications of SCD, such as vaso-occlusive crises and ACS, have not been fully explored. Many therapeutic options exist for patients with reactive airway disease or other recurrent respiratory problems. Control of associated symptoms may help prevent the occurrence of ACS and other sickle cell-related problems. We compared the prevalence of respiratory symptoms in SCD patients compared to patients with other hematological disorders.Methods: Two questionnaires (one for patients with SCD, one for patients with other hematological disorders) were developed, which included questions regarding respiratory symptoms (especially wheezing and cough, frequency of these symptoms, previous diagnosis of asthma), personal history and environmental exposure. The study was approved by the Institutional Review Board, and patients and their caregivers were interviewed during a routine visit to the outpatient hematology clinic after giving informed consent.Results: To date, 124 subjects have been interviewed (62 males and 58 females, ages 3–18 years, mean age 10.1yrs), and 120 questionnaires were evaluable, including 59 from patients with SCD and 61 from the comparison group. Respiratory symptoms (wheezing and cough) were more frequent in SCD patients compared to patients with other hematological diseases. Wheezing was present in 34 (58%) SCD patients and in 20 (33%) patients in the other group (p<0.01). Twelve patients (20%) in the SCD group missed school due to respiratory problems (over half of them missed more than 7 days of school) compared to 4 (6%) patients (only 1 missing school for more than 7 days) in the other group (p<0.04). Hospitalization due to respiratory problems before the age of 2 years was more common in SCD patients: 23 (39%) compared to 8 (13%) in other hematological patients (p<0.003).Conclusions: The prevalence of pulmonary symptoms is higher in patients with SCD compared to patients with other hematological disorders and associated with frequent hospitalizations and school absences.

Influence of fluoride recovery alumina on the work environment and the health of aluminum potroom workers

Dust exposure and health complaints were recorded by means of personal samplers and a questionnaire for potroom workers in a primary aluminum plant situated at the west coast of Norway. The study revealed a higher dust exposure and a higher prevalence of acute health complaints during a period when fluoride recovery alumina from a dry-cleaning process was used compared to another period when pure alumina was used. Weather conditions and work conditions were otherwise similar during the two periods. This finding indicates that the use of recovery alumina increases the pollution of the work atmosphere and thereby causes more health complaints. The study also revealed a higher prevalence of pulmonary symptoms of a chronic recurrent nature than expected, in spite of the thorough selection which takes place before and during employment, and may therefore indicate that potroom workers are under the risk of developing chronic pulmonary disease.