Prevalence Of Microbial Infections Research Articles

Enrichment of creatine-gelatin cryogel with Zataria multiflora essential oil and titanium dioxide nanoparticles as a potential wound dressing

The prevalence of microbial infections in wounds, particularly burn wounds, presents a significant medical concern due to the inherent vulnerability of compromised skin to pathogen colonization and invasion. This study focused on the synthesis and evaluation of a creatine-gelatin cryogel, enriched with Zataria multiflora essential oil and titanium dioxide nanoparticles for potential wound dressing applications. The chemical and physical characteristics of the formulation were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, and mechanical tests. Further studies such as wound fluid absorptivity, water vapor transmission rate, solubility, moisture content, porosity, and release properties were investigated. The release test demonstrated an encapsulation efficiency of 98.8 % and a loading capacity of 16.45 %, signifying a suitable cryogel matrix. The disk diffusion assay demonstrated that the synthesized cryogel had excellent antimicrobial efficacy against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida species. Additionally, the cryogel exhibited great cytocompatibility and hemocompatibility (∼100 %). Our findings suggest that the creatine-gelatin cryogel blend enriched with Zataria multiflora essential oil and titanium dioxide nanoparticles possesses structural integrity, a cell-friendly nature, moisture-retaining capabilities, and biocompatible characteristics. These properties collectively render it an exceptionally suitable material for advanced wound dressings. Moreover, the demonstrated functional properties of the cryogel, including its ability to prevent infection, exhibit antioxidant activity, and retain moisture, underscore its potential for effective burn wound management.

Quinolone scaffolds as potential drug candidates against infectious microbes: a review.

Prevalence of microbial infections and new rising pathogens are signified as causative agent for variety of serious and lethal health crisis in past years. Despite medical advances, bacterial and fungal infections continue to be a rising problem in the health care system. As more bacteria develop resistance to antibiotics used in therapy, and as more invasive microbial species develop resistance to conventional antimicrobial drugs. Relevant published publications from the last two decades, up to 2024, were systematically retrieved from the MEDLINE/PubMed, SCOPUS, EMBASE, and WOS databases using keywords such as quinolones, anti-infective, antibacterial, antimicrobial resistance and patents on quinolone derivatives. With an approach of considerable interest towards novel heterocyclic derivatives as novel anti-infective agents, researchers have explored these as essential tools in vistas of drug design and development. Among heterocycles, quinolones have been regarded extremely essential for the development of novel derivatives, even able to tackle the associated resistance issues. The quinolone scaffold with its bicyclic structure and specific functional groups such as the carbonyl and acidic groups, is indeed considered a valuable functionalities for further lead generation and optimization in drug discovery. Besides, the substitution at N-1, C-3 and C-7 positions also subjected to be having a significant role in anti-infective potential. In this article, we intend to highlight recent quinolone derivatives based on the SAR approach and anti-infective potential such as antibacterial, antifungal, antimalarial, antitubercular, antitrypanosomal and antiviral activities. Moreover, some recent patents granted on quinolone-containing derivatives as anti-infective agents have also been highlighted in tabular form. Due consideration of this, future research in this scaffold is expected to be useful for aspiring scientists to get pharmacologically significant leads.