Prevalence Of Hemangioma Research Articles

Модель прогнозу ефективності лікування гемангіоми у дітей

Hemangioma is one of the most common benign tumors in newborns. It is a neoplastic proliferative tumor characterized by a period of growth (proliferation) after birth and possible spontaneous involution (regression). Despite the increased interest in the problems of hemangioma treatment and a large number of developed techniques, no clear criteria for choosing a therapy method and its effectiveness exist. Further search for effective treatment methods is necessary because of the variety of forms, localization and prevalence of hemangiomas. The purpose of this work was to develop and test models for predicting the effectiveness of hemangioma treatment in children. Material and methods. The indicators of 84 children with hemangioma who received three types of treatment were used to develop the models. Propranolol was used for the treatment of the first group of children (17 people), timolol was used in the second group (15 people), timolol with compression was used in the third group (52 children). Results and discussion. Hemangioma treatment outcome prediction models have been developed using fuzzy logic. The value of the developed models lies in the fact that indicators that are determined during the initial examination of the child are used to determine the possible outcome of treatment and to choose its optimal tactics. To predict the effectiveness of propranolol treatment the term of the treatment onset and the activity of hemangioma according to hemangioma severity scale are informative. Additional indicators are the period from the birth of a child to the appearance of hemangioma and deviations from the normal values of the clinical blood test indicators. When using timolol, the main informative indicators for predicting the effectiveness of treatment are the period from the treatment onset, the activity of hemangioma according to hemangioma severity scale and the duration of treatment, which can be selected from the interval from 5 to 11 months. The sFasL1 values and the baby’s birth weight are used as additional indicators. When using timolol with compression for predicting the effectiveness of treatment, the main informative indicators are the duration of treatment, the period of the treatment onset and the indicator according to hemangioma severity scale at the beginning of treatment. The duration of treatment can be chosen in each case, based on the desired result, from the range of 5-19 months. Data on the morphological type of hemangioma, the depth of its spread and the presence of factors provoking its growth are used as additional indicators. The average values of errors of the models of predicting indicators characterizing the effectiveness of treatment using various methods were 0.03-9.1% for the indicator according to HSS; for the indicator according to VAS1(visual analog scale) was 2.2-9.4%; for the indicator according to VAS2 was 0.98-5.0%. Conclusion. Developed models for predicting the effectiveness of hemangioma treatment allowed the doctor choosing the most effective method and determining its duration. The software module that implements a support system for a doctor’s decision making as for selecting the optimal method for treating hemangioma can be used in healthcare institutions of various levels of provision of medical aid

Polidocanol sclerotherapy for intraoral hemangioma of buccal mucosa: a rare case report

The term hemangioma derives from the Greek word, “hema” which expresses blood, “angio” implies vessel, “oma” corresponds to tumor. A hemangioma is a type of an innocuous lesion of blood vessels or vascular components defined by a proliferative growth stage and a very prolonged involutive stage. The prevalence of hemangiomas is estimated to be around 2-3% in neonates, 10-12% in the first year of life, and 22-30% found amongst babies whose weight is less than 1000g at the time of birth. Most of the hemangiomas occur as single lesion. Peripheral hemangiomas treated by surgical excision is an example of gold standard treatment for hemangiomas. Alternatively sclerosing solutions may be used as they obliterate blood vessels, thereby leading to fibrosis and disappearance of the hemangioma. It is relatively uncommon in the oral cavity. Polidocanol (aethoxysklerol) is a detergent solution which act by causing localized inflammatory reaction.

Hepatic Hemangioma in a Cluster of Iranian Population.

Introduction:Hemangioma is the most common benign lesion of the liver. It is mostly asymptomatic and may be found incidentally during cross-sectional liver or abdominal imaging. This study aimed to investigate the prevalence and clinical characteristics of hepatic hemangioma in an Iranian population.Materials and Methods:This retrospective study was conducted between July and November 2017 in Firoozgar Hospital affiliated to Iran University of Medical Sciences, Tehran, Iran. The study population consisted of adult patients (>18 years) referred for transabdominal ultrasonography to ultrasound unit of the hospital.Results:Totally, 1985 patients were included in the study. There were 1282 women (64.5%) and 703 men (35.4%). A total of 47 hemangiomas were found in 41 patients. The prevalence of hemangioma was 2.04% in our study population. Four patients had more than one hemangioma; all of them were women. Twelve men (1.70%) versus 29 women (2.26%) found to have hemangioma. The mean age of patients with hemangioma was 47.65 ± 14.84 years. Thirty-four patients (82.9%) had hemangioma in their right lobe of the liver whereas seven patients (17.1%) had hemangioma in the left lobe of the liver. The mean diameter of hemangioma was 16.70 ± 8.42 mm. The mean diameter of hemangioma in women was 17.2 ± 9.33 mm and in men was 15.25 ± 4.91 mm (P = 0.495).Conclusion:Hepatic hemangioma is prevalent in the Iranian population. It is more prevalent among women and in the VII segment of the liver.

The prevalence and risk factors of infantile haemangiomas: a case–control study in the Dutch population

Haemangiomas are considered to be the most common tumours of infancy. However, despite their frequent occurrence the aetiological determinants of their development remain unknown. Identifying these factors may provide insight on their pathogenesis. We performed cross-sectional screening for haemangiomas in newborns (0-16 months of age) in the general Dutch population. Haemangioma-specific and pregnancy-related data were collected in children with a haemangioma. These data were compared in a case-control design using multivariable logistic regression analysis. Among 2204 newborns, 219 (9.9%) had a haemangioma. The male-to-female ratio was 1:2. The majority of haemangiomas were located on the trunk (37%). The general practitioners or medical specialists were consulted in only a minority of cases (<7%). Amniocentesis [odds ratio (OR) 3.6, 95% confidence interval (CI) 1.11, 11.42], breech presentation [OR 2.3, 95% CI 1.14, 4.44], being first-born [OR 1.55, 95% CI 1.03, 2.33] and a birthweight ≤2500 g [OR 4.95, 95% CI 1.63, 15.05] were independent factors associated with the development of a haemangioma. Duration of pregnancy did not differ between study groups. Our study showed that the prevalence of a haemangioma is 9.9% in the general (Dutch) population. Four factors appear relevant in the development of haemangiomas. These factors may provide clues to its pathogenesis.

Prevalence of hepatic hemangioma in patients with focal nodular hyperplasia: MR imaging analysis.

To evaluate the prevalence of hepatic hemangioma in a large population of patients with focal nodular hyperplasia (FNH) and to determine if the prevalence is higher than that in patients with other hepatic masses. Over a period of 40 months, 247 patients with one or more hepatic masses underwent magnetic resonance (MR) imaging at our institution and met the inclusion criteria for this study. One hundred forty-eight patients received a diagnosis of FNH (study group). Ninety-nine patients had a lesion other than FNH and had no history of chronic liver disease (control group). Imaging findings of the main lesion and presence of associated hemangioma were investigated. chi2 analysis was used to determine if there was a statistically significant difference in the two groups regarding the number of patients with associated masses. Twenty-nine of 148 patients (20%) in the study group had FNH with one or more associated hepatic hemangiomas. Among the 99 patients in the control group, nine (9%) had an associated hemangioma. The prevalence of hemangioma was significantly higher (P <.02) in the study group than in the control group. The prevalence of hemangioma in patients with a solitary FNH lesion compared with that in patients with multiple FNH lesions was not significantly different. Patients with FNH are more likely to have an associated hepatic hemangioma than are those with another type of focal hepatic mass.

Association of focal nodular hyperplasia and hepatic hemangioma

The association between hepatic hemangioma and focal nodular hyperplasia has been occasionally reported. To evaluate the reality of this association, the prevalence of hemangioma was studied in 26 patients with focal nodular hyperplasia by comparison with 27 patients with hepatocellular adenoma. All of these patients underwent surgery, which provided the histologic confirmation of the type of tumor. The presence of hemangioma was assessed by preoperative ultrasonography, dynamic computed tomography, and pathological examination of resected liver specimens. No hemangioma was found in patients with hepatocellular adenoma, but 6 of the 26 patients with focal nodular hyperplasia (23%) had one or two associated hemangiomas that varied in size from 1.5 to 4 cm. All 6 patients having focal nodular hyperplasia and hemangioma were women who had previously used oral contraceptives. None of the patients who had not used oral contraceptives had this association. Moreover, oral contraceptives were taken for a significantly longer period by the women with focal nodular hyperplasia and hemangioma than by those without this association. It is concluded that (a) the association of hemangioma with focal nodular hyperplasia is frequent (23%) and not fortuitous, and (b) prolonged administration of oral contraceptives may facilitate the recognition of this association, possibly by affecting the growth of these tumors.

Epidemiology of strawberry haemangioma in low birthweight infants.

The prevalence of cutaneous haemangiomas in a representative population of low birthweight infants was determined by tracing and assessing survivors of pre-school age. Data from hospital case-notes and follow-up assessments were used to investigate whether prevalence of haemangiomas was related to perinatal factors and childhood morbidity. Eleven point one per cent of 615 infants developed a haemangioma. Haemangiomas were more common in girls than boys, and in infants of lower gestational age. Hypothermia in the first hours of life and neonatal illness were associated with lower prevalence, suggesting that neonatal skin perfusion influences haemangioma development; this is consistent with a tendency for haemangiomas to be distributed centripetally. However, the major aetiological determinants are unknown. Children with a haemangioma were more likely to have had a febrile convulsion than those without a haemangioma.