Prevalence Of Alopecia Research Articles

Insights into systemic lupus erythematosus: a retrospective observational study of clinical features, autoantibodies, and gender-related differences.

This study aims to analyze the clinical and immunologic features of SLE in Jordan, while also investigating the impact of age and gender on disease presentation. The study included 275 patients diagnosed with SLE. Data were collected through meticulous patient interviews and thorough examination of patient hospital records. The cohort exhibited a mean age of 36.8 ± 12.9years, with an average disease duration of 7.0 ± 7.8years. The mean age at diagnosis was 29.9 ± 12.1years, and the female to male ratio was 7.8:1. The most frequently observed symptoms were arthralgia (90.2%), fatigue (80.7%), hematologic manifestations (62%), photosensitivity (60.7%), Raynaud's phenomenon (53.5%), and malar rash (50.9%). The frequencies of various autoantibodies were as follows: ANA (96.7%), anti-dsDNA (39.6%), anti-SSA/Ro (32.8%), anti-Sm (21.8%), anti-U1-RNP (20.6%), and anti-SSB/La (15.5%). Male patients tended to receive a diagnosis at a younger age and exhibited a higher likelihood of experiencing severe manifestations compared to females. Additionally, juvenile onset patients demonstrated an increased likelihood of fever, photosensitivity, myositis, and anti-dsDNA autoantibodies, while adult onset patients were more predisposed to having anti-Ro, anti-La, and RF autoantibodies. This study reveals that the most prevalent manifestations of SLE in the Jordanian cohort encompassed arthralgia, fatigue, and hematologic manifestations. The prevalence of alopecia and Raynaud's phenomenon exceeded that observed in other published cohorts, while arthritis and discoid rash were less frequently encountered. The study highlights that males are more susceptible to developing severe manifestations of SLE compared to females.

Epidermal ET-1 signal induces activation of resting hair follicles by upregulating the PI3K/AKT pathway in the dermis.

The prevalence of alopecia has increased recently. Hair loss is often accompanied by the resting phase of hair follicles (HFs). Dermal papilla (DP) plays a crucial role in HF development, growth, and regeneration. Activating DP can revive resting HFs. Augmenting WNT/β-catenin signaling stimulates HF growth. However, the factors responsible for activating resting HFs effectively are unclear. In this study, we investigated epidermal cytokines that can activate resting HFs effectively. We overexpressed β-catenin in both invivo and invitro models to observe its effects on resting HFs. Then, we screened potential epidermal cytokines from GEO DATASETs and assessed their functions using mice models and skin-derived precursors (SKPs). Finally, we explored the molecular mechanism underlying the action of the identified cytokine. The results showed that activation of WNT/β-catenin in the epidermis prompted telogen-anagen transition. Keratinocytes infected with Ctnnb1-overexpressing lentivirus enhanced SKP expansion. Subsequently, we identified endothelin 1 (ET-1) expressed higher in hair-growing epidermis and induced the proliferation of DP cells and activates telogen-phase HFs invivo. Moreover, ET-1 promotes the proliferation and stemness of SKPs. Western blot analysis and invivo experiments revealed that ET-1 induces the transition from telogen-to-anagen phase by upregulating the PI3K/AKT pathway. These findings highlight the potential of ET-1 as a promising cytokine for HF activation and the treatment of hair loss.

Prevalence of alopecia and its contributing factors among primary healthcare attendees in the Jazan region, Saudi Arabia.

Background:Alopecia is a common health condition that can be associated with social and psychological consequences.Aims:This study aims to estimate the prevalence of hair loss and its associated risk factors among primary healthcare center (PHC) attendees in the Jazan region.Methods:This investigation was a cross-sectional study conducted in the Jazan region of southwest Saudi Arabia. A total of 23 PHCs were randomly selected from five governorates in the region. Data were collected via interviewing PHCs attendees and were asked about their demographic characteristics, presence of hair loss, and among attendees who confirmed having hair loss, they were further asked about associated clinical features, healthcare-seeking behavior, and factors that might contribute to the development of their condition.Results:A total of 729 participants consented to be involved in this study. The number of respondents who reported having hair loss was 483, representing 66.3% of the whole sample. Gender appears to have the highest level of variability, with the majority of participants reporting hair loss being female (P < 0.001). The most frequently reported type of hair loss was telogen effluvium, followed by androgenic alopecia. A total of 185 respondents reported taking medications to treat their hair loss, of whom 108 (58.3%) did not seek any medical advice to identify the cause of their condition.Limitations:The main weakness of this investigation is related to relying on a reported presence of hair loss without having it confirmed with a clinical diagnosis.Conclusion:A minority of participants who reported suffering from hair loss were further evaluated by healthcare professionals to learn the cause of their hair loss. This may indicate the presence of poor hair care and the probability of a higher risk of hair loss requiring the development of suitable preventive strategies.

Prevalence and pattern of alopecia in secondary and tertiary institutions in Ibadan

Background: Hair loss in African women appears to be on the increase and has been associated with some hair-care practices. Objectives: The aim of this study was to determine the prevalence, pattern, and possible hair-care factors associated with alopecia in females in some educational institutions in Ibadan, Nigeria. Methodology: The respondents were interviewed using a pretested questionnaire containing information about their bio-data, hair-care practices, and history of hair loss if any. Subjects were examined for the presence and pattern of hair loss. Results: The prevalence of alopecia was 46.7%, with the traction alopecia being the most common (97.5%). The age range of those with alopecia was mainly 20-29 years. Hair loss was more common in subjects who had chemically treated their hair (P < 0.001). Conclusion: Alopecia is common among female students in secondary and tertiary institutions in Ibadan. Traction alopecia was the most common pattern of hair loss in this study supporting claims of hair-care practices as important etiological factors.

Prevalence and significance of an alopecia syndrome in Australian fur seals (Arctocephalus pusillus doriferus)

Endothermic mammals in cold environments have a range of adaptations enabling them to maintain a constant core body temperature. Of critical importance to many is a thick hair coat that retains air and so acts as a barrier to minimize heat exchange between the skin and ambient environment. Disruption to the pelage can increase costs of maintaining body temperature and compromise survival of the individual. Fur seals rely on a pelage of dense, dry underfur protected by guard hairs for insulation in the aquatic environment. Since 1989 a potentially serious alopecia (hair loss) syndrome has been recognized in Australian fur seals. Between September 2007 and February 2010 we investigated the prevalence and potential impacts of the condition. The syndrome manifests as bilaterally symmetrical alopecia, which occurs predominantly in juveniles and has a strong sex bias (51 of 55 juveniles captured for examination were female). It also occurs in adult females but has never been seen on postpubescent males. Prevalence of alopecia was highest at the large Lady Julia Percy Island colony (approximately 30,000 seals) in northwestern Bass Strait where it has a distinct seasonal pattern of prevalence, peaking in spring and summer with up to 50% of juvenile females affected. Thermal images indicated that alopecic and nonalopecic areas of the dorsal thorax had a mean difference of 6.6°C, and affected animals were in significantly (P < 0.001) poorer body condition than unaffected animals.

Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients.

BackgroundThe study aimed at evaluating the prevalence of thyroid function abnormalities in patients with alopecia areata (AA) and its association with other autoimmune diseases and various autoimmune antibodies.MethodWe retrospectively analyzed medical records of 123 patients with AA. The main site of involvement, pattern, and extent of alopecia as well as presence of the similar disease in first-degree family members and serologic status of patients were recorded.ResultsParticipating in the study were 57 males and 66 females (6 to 59 years old). In the majority of patients (69.9%) the disease was manifested in the first two decades of life. Patients with family members having alopecia were recorded in 24.4%. Thyroid function abnormalities were found in 8.9% of patients. Positive autoimmune antibodies were associated with AA in 51.4% of patients with no significant association between the severity and duration of disease and presence of these antibodies.ConclusionThe incidence of positive auto-immune antibodies in Iranian patients is higher than previous reports. Concerning the female:male ratio, thyroid function tests and the prevalence of alopecia in first-degree relatives, our results are compatible with previous data obtained from different ethnic populations. Previous reports documented that a greater severity and longer duration of AA were seen in the early onset forms; however our result are relatively different which could be explained by differences in genetic factors.