LDCT image denoising is crucial in medical imaging as it aims to minimize patient radiation exposure while maintaining diagnostic image quality. However, current convolutional neural network-based denoising methods struggle to incorporate global contexts, often focusing solely on local features. This limitation poses a significant challenge. To address this, a dual encoder denoising model is introduced that utilizes the Transformer model’s proficiency in capturing long-range dependencies and global context. This model integrates the Transformer branch and the convolutional branch in the encoder. By concatenating the features of these two different branches, the model can capture both global and local image features, substantially enhancing denoising efficacy. A cross-scale skip connection mechanism is introduced to integrate the encoder’ s low-level features with the decoder’ s high-level features, enriching contextual information and preserving image details. In addition, to meet the requirements of multi-scale feature fusion, the decoder is equipped with different multi-scale convolution modules to optimize feature processing. The number of layers in these modules gradually decreases as the depth of the decoder increases. In order to enhance the discriminative ability of the model, a multi-scale discriminator is also introduced, which effectively improves the recognition ability of the image by extracting features from four different scales. Consequently, our approach demonstrates remarkable performance in reducing noise and improving LDCT image quality, as evidenced by the substantial improvements in PSNR (17.75%) and SSIM (7.31%) values.